Adssl1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adssl1
Entrez Gene ID	11565
Full Name	adenylosuccinate synthetase like 1
Synonyms	AI528595,Adss,Adss1
General protein information	Preferred Names adenylosuccinate synthetase like 1 Names adenylosuccinate synthetase isozyme 1 AMPSase 1 IMP--aspartate ligase 1 M-type adenylosuccinate synthetase adSS 1 adenylosuccinate synthetase 1, muscle adenylosuccinate synthetase, basic isozyme adenylosuccinate synthetase, muscle isozyme
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 F1

mRNA and Protein(s)

mRNA	Protein	Name
NM_007421.2	NP_031447.1	adenylosuccinate synthetase isozyme 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ADSSL1	NP_001092662.1
Danio rerio (zebrafish)	adssl1	NP_999985.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003405	XP_311692.5
Caenorhabditis elegans (roundworm)	C37H5.6	NP_741529.1
Eremothecium gossypii	AGOS_ABL186W	NP_982761.2
Magnaporthe oryzae (rice blast fungus)	MGG_17000	XP_003715886.1
Arabidopsis thaliana (thale cress)	ADSS	NP_191320.1
Canis lupus familiaris (dog)	ADSSL1	XP_005624000.1
Mus musculus (house mouse)	Adssl1	NP_031447.1
Drosophila melanogaster (fruit fly)	CG17273	NP_650918.1
Homo sapiens (human)	ADSSL1	NP_689541.1
Saccharomyces cerevisiae (baker's yeast)	ADE12	NP_014179.1
Schizosaccharomyces pombe (fission yeast)	ade2	NP_594664.1
Oryza sativa (rice)	Os03g0699300	NP_001050987.1
	LOC706585	XP_001094957.2
Kluyveromyces lactis	KLLA0D19426g	XP_453924.1
Neurospora crassa	NCU09789	XP_960187.1
Xenopus tropicalis (tropical clawed frog)	adssl1	NP_001004939.1
Rattus norvegicus (Norway rat)	Adssl1	XP_003750285.1
Gallus gallus (chicken)	ADSSL1	XP_001235680.3
Oryza sativa (rice)	Os03g0174500	NP_001049128.1

Gene Ontology
Bibliography

Related articles in PubMed

Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S
Proceedings of the National Academy of Sciences of the United States of America110(6)E507-16(2013 Feb)

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex.
Pereira JD, Sansom SN, Smith J, Dobenecker MW, Tarakhovsky A, Livesey FJ
Proceedings of the National Academy of Sciences of the United States of America107(36)15957-62(2010 Sep)

Adenylosuccinate synthetase 1 gene is a novel target of deletion in lung adenocarcinoma.
Miller JC, Blake DC Jr, Herzog CR
Molecular carcinogenesis48(12)1116-22(2009 Dec)

Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle.
Davie JK, Cho JH, Meadows E, Flynn JM, Knapp JR, Klein WH
Developmental biology311(2)650-64(2007 Nov)

Cavitation as a mechanism of substrate discrimination by adenylosuccinate synthetases.
Iancu CV, Zhou Y, Borza T, Fromm HJ, Honzatko RB
Biochemistry45(38)11703-11(2006 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Deletion of Adenylosuccinate synthetase 1 gene is associated with lung adenocarcinoma.
Title: Adenylosuccinate synthetase 1 gene is a novel target of deletion in lung adenocarcinoma.

The absence of the 2'-hydroxyl group of the deoxyribonucleotide destabilizes binding of the ligand to the L-aspartate pocket of adenylosuccinate synthetase by disrupting hydrogen bonds and by introducing a cavity into the fully ligated active site.
Title: Cavitation as a mechanism of substrate discrimination by adenylosuccinate synthetases.

there are antagonistic interactions between the active sites of the basic isozyme of adenylosuccinate synthetase
Title: Variations in the response of mouse isozymes of adenylosuccinate synthetase to inhibitors of physiological relevance.

Crystalline complexes presented of the recombinant basic isozyme from mouse
Title: IMP, GTP, and 6-phosphoryl-IMP complexes of recombinant mouse muscle adenylosuccinate synthetase.

Adss1 functions as an important component in adenine nucleotide biosynthesis. It is up-regulated in surgically induced cardiomegaly.
Title: The adenylosuccinate synthetase-1 gene is activated in the hypertrophied heart.

The following Adssl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adssl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00139	NM_007421.2 Latest version!	Mus musculus adenylosuccinate synthetase like 1 (Adssl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$272.30 $389.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adssl1 ( NM_007421.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031447.1 Mus musculus adenylosuccinate synthetase like 1 (Adssl1), mRNA.

Price & Availability↑

CloneID	OMu00139
Clone ID Related Accession (Same CDS sequence)	NM_007421.2
Accession Version	NM_007421.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1374bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	adenylosuccinate synthetase isozyme 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK146907.1 and BY629115.1. On Oct 31, 2007 this sequence version replaced NM_007421.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146907.1, AK149634.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCGGGA CCCGAGCCTC CAACGACCGG CCCCCCGGCA CAGGCGGAGT CAAGAGGGGG 
CGGCTGCAGC AGGAGGCGGC GGCGACAGGC TCCCGCGTGA CCGTGGTGCT GGGCGCGCAG 
TGGGGGGACG AGGGCAAAGG CAAGGTGGTG GACCTGCTGG CCACGGACGC CGACATCGTC 
AGTCGCTGCC AGGGGGGCAA CAATGCGGGG CACACAGTAG TGGTGGACGG CAAGGAGTAT 
GACTTTCACC TGCTCCCCAG CGGCATCATC AACACCAAGG CCGTGTCATT CATTGGCAAT 
GGCGTGGTCA TCCACTTGCC GGGCTTGTTT GAAGAGGCAG AGAAGAACGA GAAGAAAGGG 
CTGAAGGACT GGGAGAAGCG TCTCATCATC TCTGACCGGG CTCACCTTGT GTTCGACTTC 
CACCAGGCAG TGGACGGGCT GCAGGAAGTA CAACGTCAAG CACAAGAGGG GAAGAATATC 
GGCACCACCA AGAAGGGAAT CGGACCAACT TACTCCTCCA AAGCTGCCCG GACAGGCCTC 
CGCATCTGTG ACCTTCTCTC GGATTTTGAC GAGTTTTCTG CCAGATTCAA GAACCTGGCC 
CACCAGCACC AGTCCATGTT CCCCACCCTG GAAATAGATG TGGAAGGTCA ACTCAAAAGG 
CTCAAGGGCT TTGCTGAGCG CATCAGACCC ATGGTTCGAG ATGGTGTCTA CTTCATGTAT 
GAAGCCCTGC ATGGTCCCCC CAAAAAGGTC CTGGTGGAAG GTGCCAACGC GGCCCTGCTC 
GACATCGATT TCGGGACCTA CCCCTTTGTG ACTTCTTCCA ACTGCACTGT GGGTGGTGTG 
TGCACCGGCC TGGGCATCCC GCCCCAGAAC ATAGGCGATG TGTATGGTGT GGTAAAGGCC 
TACACCACCC GTGTGGGCAT TGGGGCCTTC CCCACGGAGC AGATCAATGA AATTGGAGAT 
CTGCTGCAGA ACCGTGGCCA TGAGTGGGGG GTGACCACAG GCAGGAAGAG GCGCTGCGGC 
TGGCTGGACC TGATGATCCT CCGATACGCT CACATGGTCA ATGGCTTCAC TGCGCTGGCA 
TTGACCAAGC TGGACATACT GGATGTCCTG AGCGAGATTA AAGTTGGCAT CTCCTACAAG 
CTCAACGGAA AGAGGATTCC CTACTTCCCT GCTAACCAGG AGATCCTGCA GAAGGTGGAG 
GTCGAGTATG AAACACTGCC TGGATGGAAA GCAGACACCA CAGGCGCCAG GAAGTGGGAG 
GACCTGCCTC CGCAGGCCCA AAGCTACGTG CGCTTCGTGG AGAATCACAT GGGTGTTGCA 
GTCAAATGGG TCGGCGTTGG GAAGTCCAGA GAGTCCATGA TCCAGCTTTT TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031447.1
CDS	73..1446
Translation	MSGTRASNDRPPGTGGVKRGRLQQEAAATGSRVTVVLGAQWGDEGKGKVVDLLATDADIVSRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLVFDFHQAVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDFDEFSARFKNLAHQHQSMFPTLEIDVEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKVLVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGDLLQNRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLSEIKVGISYKLNGKRIPYFPANQEILQKVEVEYETLPGWKADTTGARKWEDLPPQAQSYVRFVENHMGVAVKWVGVGKSRESMIQLF

Target ORF information:

RefSeq Version	NM_007421.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus adenylosuccinate synthetase like 1 (Adssl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007421.2

ORF Insert Sequence:

ATGTCCGGGA CCCGAGCCTC CAACGACCGG CCCCCCGGCA CAGGCGGAGT CAAGAGGGGG 
CGGCTGCAGC AGGAGGCGGC GGCGACAGGC TCCCGCGTGA CCGTGGTGCT GGGCGCGCAG 
TGGGGGGACG AGGGCAAAGG CAAGGTGGTG GACCTGCTGG CCACGGACGC CGACATCGTC 
AGTCGCTGCC AGGGGGGCAA CAATGCGGGG CACACAGTAG TGGTGGACGG CAAGGAGTAT 
GACTTTCACC TGCTCCCCAG CGGCATCATC AACACCAAGG CCGTGTCATT CATTGGCAAT 
GGCGTGGTCA TCCACTTGCC GGGCTTGTTT GAAGAGGCAG AGAAGAACGA GAAGAAAGGG 
CTGAAGGACT GGGAGAAGCG TCTCATCATC TCTGACCGGG CTCACCTTGT GTTCGACTTC 
CACCAGGCAG TGGACGGGCT GCAGGAAGTA CAACGTCAAG CACAAGAGGG GAAGAATATC 
GGCACCACCA AGAAGGGAAT CGGACCAACT TACTCCTCCA AAGCTGCCCG GACAGGCCTC 
CGCATCTGTG ACCTTCTCTC GGATTTTGAC GAGTTTTCTG CCAGATTCAA GAACCTGGCC 
CACCAGCACC AGTCCATGTT CCCCACCCTG GAAATAGATG TGGAAGGTCA ACTCAAAAGG 
CTCAAGGGCT TTGCTGAGCG CATCAGACCC ATGGTTCGAG ATGGTGTCTA CTTCATGTAT 
GAAGCCCTGC ATGGTCCCCC CAAAAAGGTC CTGGTGGAAG GTGCCAACGC GGCCCTGCTC 
GACATCGATT TCGGGACCTA CCCCTTTGTG ACTTCTTCCA ACTGCACTGT GGGTGGTGTG 
TGCACCGGCC TGGGCATCCC GCCCCAGAAC ATAGGCGATG TGTATGGTGT GGTAAAGGCC 
TACACCACCC GTGTGGGCAT TGGGGCCTTC CCCACGGAGC AGATCAATGA AATTGGAGAT 
CTGCTGCAGA ACCGTGGCCA TGAGTGGGGG GTGACCACAG GCAGGAAGAG GCGCTGCGGC 
TGGCTGGACC TGATGATCCT CCGATACGCT CACATGGTCA ATGGCTTCAC TGCGCTGGCA 
TTGACCAAGC TGGACATACT GGATGTCCTG AGCGAGATTA AAGTTGGCAT CTCCTACAAG 
CTCAACGGAA AGAGGATTCC CTACTTCCCT GCTAACCAGG AGATCCTGCA GAAGGTGGAG 
GTCGAGTATG AAACACTGCC TGGATGGAAA GCAGACACCA CAGGCGCCAG GAAGTGGGAG 
GACCTGCCTC CGCAGGCCCA AAGCTACGTG CGCTTCGTGG AGAATCACAT GGGTGTTGCA 
GTCAAATGGG TCGGCGTTGG GAAGTCCAGA GAGTCCATGA TCCAGCTTTT TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
Proceedings of the National Academy of Sciences of the United States of America110(6)E507-16(2013 Feb)
Lumayag S,Haldin CE,Corbett NJ,Wahlin KJ,Cowan C,Turturro S,Larsen PE,Kovacs B,Witmer PD,Valle D,Zack DJ,Nicholson DA,Xu S

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex.
Proceedings of the National Academy of Sciences of the United States of America107(36)15957-62(2010 Sep)
Pereira JD,Sansom SN,Smith J,Dobenecker MW,Tarakhovsky A,Livesey FJ

Adenylosuccinate synthetase 1 gene is a novel target of deletion in lung adenocarcinoma.
Molecular carcinogenesis48(12)1116-22(2009 Dec)
Miller JC,Blake DC Jr,Herzog CR

Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle.
Developmental biology311(2)650-64(2007 Nov)
Davie JK,Cho JH,Meadows E,Flynn JM,Knapp JR,Klein WH

Cavitation as a mechanism of substrate discrimination by adenylosuccinate synthetases.
Biochemistry45(38)11703-11(2006 Sep)
Iancu CV,Zhou Y,Borza T,Fromm HJ,Honzatko RB

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Adssl1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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