Gene Symbol | Adamts1 |
Entrez Gene ID | 11504 |
Full Name | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 |
Synonyms | ADAM-TS1,ADAMTS,ADAMTS-1,C3-C5,METH-1,METH1 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome | |
Summary | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The encoded protein may enhance tumorigenesis in a mouse model of breast cancer. Homozygous knockout mice for this gene exhibit enhanced perinatal lethality, impaired growth and adipose tissue development, and impaired ovulation in females. [provided by RefSeq, Oct 2015]. |