Selenom cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Selenom
Entrez Gene ID	114679
Full Name	selenoprotein M
Synonyms	1500040L08Rik,A230103K18,Selm,Sepm
General protein information	Preferred Names selenoprotein M Names selenoprotein M
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 A1
Summary	The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053267.3	NP_444497.1	selenoprotein M precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	SELM	NP_536355.1
Mus musculus (house mouse)	Selm	NP_444497.1
Pan troglodytes (chimpanzee)	SELM	NP_001140172.1
Xenopus tropicalis (tropical clawed frog)	selm	NP_001165078.1
	SELM	NP_001152871.1
Canis lupus familiaris (dog)	SELM	NP_001108486.1
Rattus norvegicus (Norway rat)	Selm	NP_001108485.1
Danio rerio (zebrafish)	selm	NP_840071.2
Gallus gallus (chicken)	SELM	NP_001264788.1
Bos taurus (cattle)	SELM	NP_001156643.1

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Deletion of selenoprotein M leads to obesity without cognitive deficits.
Pitts MW, Reeves MA, Hashimoto AC, Ogawa A, Kremer P, Seale LA, Berry MJ
The Journal of biological chemistry288(36)26121-34(2013 Sep)

In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord.
Lai HC, Klisch TJ, Roberts R, Zoghbi HY, Johnson JE
The Journal of neuroscience : the official journal of the Society for Neuroscience31(30)10859-71(2011 Jul)

The neuroprotective functions of selenoprotein M and its role in cytosolic calcium regulation.
Reeves MA, Bellinger FP, Berry MJ
Antioxidants & redox signaling12(7)809-18(2010 Apr)

NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.
Ferguson AD, Labunskyy VM, Fomenko DE, Ara? D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J
The Journal of biological chemistry281(6)3536-43(2006 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SelM plays an important role in the regulation of body weight and energy metabolism.
Title: Deletion of selenoprotein M leads to obesity without cognitive deficits.

These results suggest that selenoprotein M may have an important role in protecting against oxidative damage in the brain and may potentially function in calcium regulation.
Title: The neuroprotective functions of selenoprotein M and its role in cytosolic calcium regulation.

Sep15 and SelM have roles as thiol-disulfide oxidoreductases
Title: NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.

mouse SelM had significantly suppressed on its transcriptional products in transgenic brains
Title: Differentially expressed genes in transgenic mice carrying human mutant presenilin-2 (N141I): correlation of selenoprotein M with Alzheimer's disease.

The following Selenom gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Selenom cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18836	NM_053267.3 Latest version!	Mus musculus selenoprotein M (Selenom), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Selenom ( NM_053267.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_444497.1 Mus musculus selenoprotein M (Selenom), mRNA.

Price & Availability↑

CloneID	OMu18836
Clone ID Related Accession (Same CDS sequence)	NM_053267.3
Accession Version	NM_053267.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	selenoprotein M precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BB589016.2, BC147333.1 and AW049879.1. On Dec 13, 2016 this sequence version replaced NM_053267.2. ##Evidence-Data-START## Transcript exon combination :: BQ939285.1, AK018791.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 11839807 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGCATCC TACTGTCGCC GCCGTCGCTG CTGCTGCTTC TTGCAGCCCT TGTGGCTCCA 
GCCACCTCCA CCACCAACTA CCGACCGGAT TGGAACCGTC TTCGAGGCCT GGCCAGGGGG 
CGGGTGGAGA CCTGTGGAGG ATGACAGTTG AATCGCCTAA AGGAGGTGAA GGCCTTTGTC 
ACCGAGGACA TTCAACTGTA CCACAACCTG GTGATGAAGC ACCTCCCTGG GGCAGACCCC 
GAACTCGTGC TGTTAAGCCG AAATTACCAG GAACTAGAGC GAATCCCACT CAGCCAAATG 
ACCCGGGACG AGATCAATGC GCTGGTACAG GAGCTCGGCT TCTACCGCAA GTCGGCGCCG 
GAAGCTCAGG TGCCCCCCGA GTACCTGTGG GCGCCCGCTA AGCCCCCCGA GGAAGCTTCA 
GAACACGACG ACCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444497.1
CDS	262..699
Translation	MSILLSPPSLLLLLAALVAPATSTTNYRPDWNRLRGLARGRVETCGG*QLNRLKEVKAFVTEDIQLYHNLVMKHLPGADPELVLLSRNYQELERIPLSQMTRDEINALVQELGFYRKSAPEAQVPPEYLWAPAKPPEEASEHDDL

Target ORF information:

RefSeq Version	NM_053267.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus selenoprotein M (Selenom), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053267.3

ORF Insert Sequence:

ATGAGCATCC TACTGTCGCC GCCGTCGCTG CTGCTGCTTC TTGCAGCCCT TGTGGCTCCA 
GCCACCTCCA CCACCAACTA CCGACCGGAT TGGAACCGTC TTCGAGGCCT GGCCAGGGGG 
CGGGTGGAGA CCTGTGGAGG ATGACAGTTG AATCGCCTAA AGGAGGTGAA GGCCTTTGTC 
ACCGAGGACA TTCAACTGTA CCACAACCTG GTGATGAAGC ACCTCCCTGG GGCAGACCCC 
GAACTCGTGC TGTTAAGCCG AAATTACCAG GAACTAGAGC GAATCCCACT CAGCCAAATG 
ACCCGGGACG AGATCAATGC GCTGGTACAG GAGCTCGGCT TCTACCGCAA GTCGGCGCCG 
GAAGCTCAGG TGCCCCCCGA GTACCTGTGG GCGCCCGCTA AGCCCCCCGA GGAAGCTTCA 
GAACACGACG ACCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Deletion of selenoprotein M leads to obesity without cognitive deficits.
The Journal of biological chemistry288(36)26121-34(2013 Sep)
Pitts MW,Reeves MA,Hashimoto AC,Ogawa A,Kremer P,Seale LA,Berry MJ

In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord.
The Journal of neuroscience : the official journal of the Society for Neuroscience31(30)10859-71(2011 Jul)
Lai HC,Klisch TJ,Roberts R,Zoghbi HY,Johnson JE

The neuroprotective functions of selenoprotein M and its role in cytosolic calcium regulation.
Antioxidants & redox signaling12(7)809-18(2010 Apr)
Reeves MA,Bellinger FP,Berry MJ

NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.
The Journal of biological chemistry281(6)3536-43(2006 Feb)
Ferguson AD,Labunskyy VM,Fomenko DE,Ara? D,Chelliah Y,Amezcua CA,Rizo J,Gladyshev VN,Deisenhofer J

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Selenom cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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