Chrnd cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Chrnd
Entrez Gene ID	11447
Full Name	cholinergic receptor, nicotinic, delta polypeptide
Synonyms	Achr-4,Acrd,L10076
General protein information	Preferred Names cholinergic receptor, nicotinic, delta polypeptide Names acetylcholine receptor subunit delta AChR delta subunit
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 C5\|1 44.07 cM
Summary	This gene encodes the delta subunit of the muscle-derived nicotinic acetylcholine receptor, a pentameric neurotransmitter receptor and member of the ligand-gated ion channel superfamily. The delta subunit together with the alpha subunit forms the ligand-binding site. [provided by RefSeq, Nov 2012].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021600.3	NP_067611.2	acetylcholine receptor subunit delta precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	chrnd	NP_001015814.1
Canis lupus familiaris (dog)	CHRND	XP_543288.2
Gallus gallus (chicken)	CHRND	NP_001026488.1
Bos taurus (cattle)	CHRND	NP_776696.1
Danio rerio (zebrafish)	chrnd	NP_996947.1
Homo sapiens (human)	CHRND	NP_000742.1
Mus musculus (house mouse)	Chrnd	NP_067611.2
Pan troglodytes (chimpanzee)	CHRND	XP_001146467.2
	CHRND	XP_001114108.1
Rattus norvegicus (Norway rat)	Chrnd	NP_062171.1

Gene Ontology
Bibliography

Related articles in PubMed

Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS.
Watson JA, Bhattacharyya BJ, Vaden JH, Wilson JA, Icyuz M, Howard AD, Phillips E, DeSilva TM, Siegal GP, Bean AJ, King GD, Phillips SE, Miller RJ, Wilson SM
PLoS genetics11(6)e1005290(2015 Jun)

Determinants in the ? and ? subunit cytoplasmic loop regulate Golgi trafficking and surface expression of the muscle acetylcholine receptor.
Rudell JC, Borges LS, Rudell JB, Beck KA, Ferns MJ
The Journal of biological chemistry289(1)203-14(2014 Jan)

Function of interfacial prolines at the transmitter-binding sites of the neuromuscular acetylcholine receptor.
Gupta S, Purohit P, Auerbach A
The Journal of biological chemistry288(18)12667-79(2013 May)

A role for the calmodulin kinase II-related anchoring protein (?kap) in maintaining the stability of nicotinic acetylcholine receptors.
Mouslim C, Aittaleb M, Hume RI, Akaaboune M
The Journal of neuroscience : the official journal of the Society for Neuroscience32(15)5177-85(2012 Apr)

Isolation and characterization of a cDNA clone for the complete protein coding region of the delta subunit of the mouse acetylcholine receptor.
LaPolla RJ, Mayne KM, Davidson N
Proceedings of the National Academy of Sciences of the United States of America81(24)7970-4(1984 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings identify novel Golgi retention signals in the beta and delta subunit loops that regulate surface trafficking of assembled AChR and may help prevent surface expression of unassembled subunits.
Title: Determinants in the ? and ? subunit cytoplasmic loop regulate Golgi trafficking and surface expression of the muscle acetylcholine receptor.

Bone marrow-derived mesenchymal stem cells up-regulate skeletal muscle acetylcholine receptor delta subunit through NRG/ErbB3-mediated mitogen-activated protein kinase pathway.
Title: Bone marrow-derived mesenchymal stem cells up-regulate acetylcholine receptor delta subunit through NRG/ErbB3-mediated mitogen-activated protein kinase pathway.

Delay in maturation of the nAChR clusters during the early postnatal synapse elimination period in protein kinase C (PKCtheta; deficient mice coincides with a reduction in PKCtheta;-mediated phosphorylation of the nAChR delta subunit.
Title: Decreased phosphorylation of ? and ? subunits of the acetylcholine receptor coincides with delayed postsynaptic maturation in PKC ? deficient mouse.

The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms.
Title: The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms.

The following Chrnd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Chrnd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15805	NM_021600.3 Latest version!	Mus musculus cholinergic receptor, nicotinic, delta polypeptide (Chrnd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Chrnd ( NM_021600.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067611.2 Mus musculus cholinergic receptor, nicotinic, delta polypeptide (Chrnd), mRNA.

Price & Availability↑

CloneID	OMu15805
Clone ID Related Accession (Same CDS sequence)	NM_021600.3
Accession Version	NM_021600.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	acetylcholine receptor subunit delta precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC102611.10 and BC052153.1. On Dec 1, 2012 this sequence version replaced NM_021600.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052153.1, BC141376.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCAGGGC CTGTGCTCAC ACTGGGGCTG CTGGCTGCCC TTGTTGTGTG TGCCCTCCCA 
GGCAGTTGGG GCCTGAATGA GGAACAAAGG CTGATCCAGC ACCTATTCAA TGAGAAGGGC 
TACGACAAAG ACCTGCGGCC GGTGGCTCGA AAGGAGGACA AAGTGGATGT CGCCCTAAGT 
CTCACCCTCT CCAACCTCAT CTCCCTGAAA GAAGTGGAGG AGACCCTCAC CACCAACGTG 
TGGATAGATC ATGCCTGGGT AGACAGCCGT CTACAGTGGG ATGCCAACGA CTTCGGGAAC 
ATCACTGTCC TGCGCCTGCC CCCTGACATG GTGTGGCTAC CAGAGATTGT ACTGGAGAAC 
AACAATGATG GCTCGTTCCA GATTTCTTAT GCCTGCAATG TGCTTGTCTA TGACTCGGGC 
TATGTGACCT GGCTGCCGCC CGCCATCTTC CGCTCCTCCT GCCCCATCTC AGTCACCTAC 
TTCCCTTTCG ACTGGCAGAA CTGCTCCCTC AAATTCAGTT CACTCAAGTA TACAGCCAAG 
GAGATCACAC TTAGCCTGAA GCAGGAGGAG GAAAACAACC GCTCTTACCC CATCGAGTGG 
ATCATCATTG ACCCTGAAGG TTTCACAGAG AACGGTGAGT GGGAGATAGT GCATCGGGCA 
GCCAAGCTCA ATGTGGACCC CAGTGTCCCG ATGGACAGCA CCAACCACCA AGATGTCACC 
TTCTACCTTA TCATCCGCCG CAAGCCCCTC TTCTACATCA TCAACATTCT GGTACCCTGC 
GTGCTCATCT CCTTCATGAT CAACCTAGTC TTCTACCTGC CAGGCGACTG TGGAGAGAAG 
ACCTCCGTGG CCATCTCAGT GCTCCTGGCC CAATCTGTCT TCCTGCTGCT TATCTCCAAG 
AGGCTGCCGG CCACTTCCAT GGCCATCCCC TTGGTAGGCA AGTTCCTGCT TTTCGGCATG 
GTGCTGGTCA CCATGGTGGT GGTGATCTGT GTCATCGTAC TGAACATCCA CTTCCGGACG 
CCCAGCACCC ATGTGCTGTC TGAGGGAGTC AAGAAGTTCT TCCTGGAGAC CCTGCCCAAG 
CTCCTGCACA TGTCCCGCCC AGCAGAGGAA GACCCAGGCC CCAGGGCTCT CATCCGGAGA 
AGCAGCTCTC TGGGATACAT CTGCAAAGCA GAGGAGTATT TCTCACTTAA GTCCCGCAGT 
GACCTCATGT TTGAGAAGCA ATCAGAGCGG CATGGGCTGG CCCGGCGCCT CACCACAGCC 
CGCAGGCCTC CAGCAAGCTC TGAGCAGGTC CAACAGGAGC TCTTCAATGA GATGAAGCCA 
GCTGTGGATG GGGCAAACTT CATCGTCAAC CATATGAGAG ACCAAAACAG TTACAATGAG 
GAGAAGGACA ACTGGAACCA GGTGGCCCGC ACAGTGGACC GTCTCTGCCT GTTTGTGGTG 
ACACCCGTCA TGGTGGTGGG CACAGCCTGG ATCTTCCTGC AGGGTGTCTA CAACCAGCCC 
CCACTCCAGC CTTTCCCTGG GGACCCCTTC TCCTATAGCG AACAGGACAA GCGCTTCATC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067611.2
CDS	95..1657
Translation	MAGPVLTLGLLAALVVCALPGSWGLNEEQRLIQHLFNEKGYDKDLRPVARKEDKVDVALSLTLSNLISLKEVEETLTTNVWIDHAWVDSRLQWDANDFGNITVLRLPPDMVWLPEIVLENNNDGSFQISYACNVLVYDSGYVTWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQEEENNRSYPIEWIIIDPEGFTENGEWEIVHRAAKLNVDPSVPMDSTNHQDVTFYLIIRRKPLFYIINILVPCVLISFMINLVFYLPGDCGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLVGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKFFLETLPKLLHMSRPAEEDPGPRALIRRSSSLGYICKAEEYFSLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQVQQELFNEMKPAVDGANFIVNHMRDQNSYNEEKDNWNQVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPLQPFPGDPFSYSEQDKRFI

Target ORF information:

RefSeq Version	NM_021600.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cholinergic receptor, nicotinic, delta polypeptide (Chrnd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021600.3

ORF Insert Sequence:

ATGGCAGGGC CTGTGCTCAC ACTGGGGCTG CTGGCTGCCC TTGTTGTGTG TGCCCTCCCA 
GGCAGTTGGG GCCTGAATGA GGAACAAAGG CTGATCCAGC ACCTATTCAA TGAGAAGGGC 
TACGACAAAG ACCTGCGGCC GGTGGCTCGA AAGGAGGACA AAGTGGATGT CGCCCTAAGT 
CTCACCCTCT CCAACCTCAT CTCCCTGAAA GAAGTGGAGG AGACCCTCAC CACCAACGTG 
TGGATAGATC ATGCCTGGGT AGACAGCCGT CTACAGTGGG ATGCCAACGA CTTCGGGAAC 
ATCACTGTCC TGCGCCTGCC CCCTGACATG GTGTGGCTAC CAGAGATTGT ACTGGAGAAC 
AACAATGATG GCTCGTTCCA GATTTCTTAT GCCTGCAATG TGCTTGTCTA TGACTCGGGC 
TATGTGACCT GGCTGCCGCC CGCCATCTTC CGCTCCTCCT GCCCCATCTC AGTCACCTAC 
TTCCCTTTCG ACTGGCAGAA CTGCTCCCTC AAATTCAGTT CACTCAAGTA TACAGCCAAG 
GAGATCACAC TTAGCCTGAA GCAGGAGGAG GAAAACAACC GCTCTTACCC CATCGAGTGG 
ATCATCATTG ACCCTGAAGG TTTCACAGAG AACGGTGAGT GGGAGATAGT GCATCGGGCA 
GCCAAGCTCA ATGTGGACCC CAGTGTCCCG ATGGACAGCA CCAACCACCA AGATGTCACC 
TTCTACCTTA TCATCCGCCG CAAGCCCCTC TTCTACATCA TCAACATTCT GGTACCCTGC 
GTGCTCATCT CCTTCATGAT CAACCTAGTC TTCTACCTGC CAGGCGACTG TGGAGAGAAG 
ACCTCCGTGG CCATCTCAGT GCTCCTGGCC CAATCTGTCT TCCTGCTGCT TATCTCCAAG 
AGGCTGCCGG CCACTTCCAT GGCCATCCCC TTGGTAGGCA AGTTCCTGCT TTTCGGCATG 
GTGCTGGTCA CCATGGTGGT GGTGATCTGT GTCATCGTAC TGAACATCCA CTTCCGGACG 
CCCAGCACCC ATGTGCTGTC TGAGGGAGTC AAGAAGTTCT TCCTGGAGAC CCTGCCCAAG 
CTCCTGCACA TGTCCCGCCC AGCAGAGGAA GACCCAGGCC CCAGGGCTCT CATCCGGAGA 
AGCAGCTCTC TGGGATACAT CTGCAAAGCA GAGGAGTATT TCTCACTTAA GTCCCGCAGT 
GACCTCATGT TTGAGAAGCA ATCAGAGCGG CATGGGCTGG CCCGGCGCCT CACCACAGCC 
CGCAGGCCTC CAGCAAGCTC TGAGCAGGTC CAACAGGAGC TCTTCAATGA GATGAAGCCA 
GCTGTGGATG GGGCAAACTT CATCGTCAAC CATATGAGAG ACCAAAACAG TTACAATGAG 
GAGAAGGACA ACTGGAACCA GGTGGCCCGC ACAGTGGACC GTCTCTGCCT GTTTGTGGTG 
ACACCCGTCA TGGTGGTGGG CACAGCCTGG ATCTTCCTGC AGGGTGTCTA CAACCAGCCC 
CCACTCCAGC CTTTCCCTGG GGACCCCTTC TCCTATAGCG AACAGGACAA GCGCTTCATC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS.
PLoS genetics11(6)e1005290(2015 Jun)
Watson JA,Bhattacharyya BJ,Vaden JH,Wilson JA,Icyuz M,Howard AD,Phillips E,DeSilva TM,Siegal GP,Bean AJ,King GD,Phillips SE,Miller RJ,Wilson SM

Determinants in the ? and ? subunit cytoplasmic loop regulate Golgi trafficking and surface expression of the muscle acetylcholine receptor.
The Journal of biological chemistry289(1)203-14(2014 Jan)
Rudell JC,Borges LS,Rudell JB,Beck KA,Ferns MJ

Function of interfacial prolines at the transmitter-binding sites of the neuromuscular acetylcholine receptor.
The Journal of biological chemistry288(18)12667-79(2013 May)
Gupta S,Purohit P,Auerbach A

A role for the calmodulin kinase II-related anchoring protein (?kap) in maintaining the stability of nicotinic acetylcholine receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience32(15)5177-85(2012 Apr)
Mouslim C,Aittaleb M,Hume RI,Akaaboune M

Isolation and characterization of a cDNA clone for the complete protein coding region of the delta subunit of the mouse acetylcholine receptor.
Proceedings of the National Academy of Sciences of the United States of America81(24)7970-4(1984 Dec)
LaPolla RJ,Mayne KM,Davidson N

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Chrnd cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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