Apoc4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Apoc4
Entrez Gene ID	11425
Full Name	apolipoprotein C-IV
Synonyms	Acl,apo-CIV,apoC-IV
General protein information	Preferred Names apolipoprotein C-IV Names apolipoprotein C-IV apolipoprotein C2-linked apolipoprotein C4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 A3\|7 9.94 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007385.3	NP_031411.1	apolipoprotein C-IV precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	APOC4	NP_001029979.1
Mus musculus (house mouse)	Apoc4	NP_031411.1
Rattus norvegicus (Norway rat)	Apoc4	NP_001102889.1
Homo sapiens (human)	APOC4	NP_001637.1
Pan troglodytes (chimpanzee)	APOC4	XP_003316494.1
Canis lupus familiaris (dog)	APOC4	XP_855163.1

Gene Ontology
Bibliography

Related articles in PubMed

Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells.
Luo X, Liao R, Hanley KL, Zhu HH, Malo KN, Hernandez C, Wei X, Varki NM, Alderson N, Chu C, Li S, Fan J, Loomba R, Qiu SJ, Feng GS
Cell reports17(11)2979-2993(2016 12)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.
Chen L, Chen Q, Xie B, Quan C, Sheng Y, Zhu S, Rong P, Zhou S, Sakamoto K, MacKintosh C, Wang HY, Chen S
Proceedings of the National Academy of Sciences of the United States of America113(26)7219-24(2016 06)

Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins.
Kotite L, Zhang LH, Yu Z, Burlingame AL, Havel RJ
Journal of lipid research44(7)1387-94(2003 Jul)

Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.
Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA
The Journal of biological chemistry277(35)31900-8(2002 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

regulated exprsesion of gene cluster in macrophages
Title: Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.

The following Apoc4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Apoc4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00081	NM_007385.3 Latest version!	Mus musculus apolipoprotein C-IV (Apoc4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Apoc4 ( NM_007385.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031411.1 Mus musculus apolipoprotein C-IV (Apoc4), mRNA.

Price & Availability↑

CloneID	OMu00081
Clone ID Related Accession (Same CDS sequence)	NM_007385.3
Accession Version	NM_007385.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Mus musculus(house mouse)
Product	apolipoprotein C-IV precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC100593.1, BB872041.1 and AC149282.2. On Jan 3, 2013 this sequence version replaced NM_007385.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. ##Evidence-Data-START## Transcript exon combination :: W13915.1, BI246934.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCTGC TGAGGTGCAG GCCACGGGAC CTGCCATCAG TCTCCCTTTC TGTGCTGTTC 
TTGGTCAGCT TTGTAGCATC CATGTCTACA GAAAGCCTGA GCCCCACGCC TGGCCCTGAG 
AGCAGCCGCT GGAGCCTGGT AAGGGCCAGG GTGTTGGAGA TGGTGGAGCC ACTGGTGACC 
AGAACCAGGG ACAGATGGCA GTGGTTCTGG GGCCCTGGAG CTGTCCAGGG CTTTATGCAG 
ACCTACTATG AAGATCACCT GAAAGACCTG GGTCCCCGAA CTCAGGCCTG GCTGCAGAGC 
TCCAGAGACC ACCTCCTAAA CAAGACCCAC AGCCTGTGTC CCAGACTGCT CTGCAAAGAC 
CGGACTCAGG GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031411.1
CDS	81..455
Translation	MSLLRCRPRDLPSVSLSVLFLVSFVASMSTESLSPTPGPESSRWSLVRARVLEMVEPLVTRTRDRWQWFWGPGAVQGFMQTYYEDHLKDLGPRTQAWLQSSRDHLLNKTHSLCPRLLCKDRTQG

Target ORF information:

RefSeq Version	NM_007385.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus apolipoprotein C-IV (Apoc4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007385.3

ORF Insert Sequence:

ATGTCCCTGC TGAGGTGCAG GCCACGGGAC CTGCCATCAG TCTCCCTTTC TGTGCTGTTC 
TTGGTCAGCT TTGTAGCATC CATGTCTACA GAAAGCCTGA GCCCCACGCC TGGCCCTGAG 
AGCAGCCGCT GGAGCCTGGT AAGGGCCAGG GTGTTGGAGA TGGTGGAGCC ACTGGTGACC 
AGAACCAGGG ACAGATGGCA GTGGTTCTGG GGCCCTGGAG CTGTCCAGGG CTTTATGCAG 
ACCTACTATG AAGATCACCT GAAAGACCTG GGTCCCCGAA CTCAGGCCTG GCTGCAGAGC 
TCCAGAGACC ACCTCCTAAA CAAGACCCAC AGCCTGTGTC CCAGACTGCT CTGCAAAGAC 
CGGACTCAGG GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells.
Cell reports17(11)2979-2993(2016 12)
Luo X,Liao R,Hanley KL,Zhu HH,Malo KN,Hernandez C,Wei X,Varki NM,Alderson N,Chu C,Li S,Fan J,Loomba R,Qiu SJ,Feng GS

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.
Proceedings of the National Academy of Sciences of the United States of America113(26)7219-24(2016 06)
Chen L,Chen Q,Xie B,Quan C,Sheng Y,Zhu S,Rong P,Zhou S,Sakamoto K,MacKintosh C,Wang HY,Chen S

Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins.
Journal of lipid research44(7)1387-94(2003 Jul)
Kotite L,Zhang LH,Yu Z,Burlingame AL,Havel RJ

Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.
The Journal of biological chemistry277(35)31900-8(2002 Aug)
Mak PA,Laffitte BA,Desrumaux C,Joseph SB,Curtiss LK,Mangelsdorf DJ,Tontonoz P,Edwards PA

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Apoc4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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