Prss1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Prss1
Entrez Gene ID	114228
Full Name	protease, serine 1 (trypsin 1)
Synonyms	Try-1,Try1,Trygn16
General protein information	Preferred Names protease, serine 1 (trypsin 1) Names protease, serine, 1 trypsin 1 trypsinogen 16
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 B1\|6 19.6 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_053243.2	NP_444473.1	protease, serine, 1 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Try10	NP_001004097.1
Rattus norvegicus (Norway rat)	LOC683849	XP_003749780.1
Rattus norvegicus (Norway rat)	LOC102554637	XP_006236448.1
Mus musculus (house mouse)	Gm10334	NP_001096623.1
Rattus norvegicus (Norway rat)	Prss2	NP_036861.1
Mus musculus (house mouse)	Prss1	NP_444473.1
Mus musculus (house mouse)	Prss3	NP_035775.1
Rattus norvegicus (Norway rat)	LOC100912089	XP_003749781.1
Mus musculus (house mouse)	Gm5771	NP_001034086.1

Gene Ontology
Bibliography

Related articles in PubMed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Modulation of PAR expression and tryptic enzyme induced IL-4 production in mast cells by IL-29.
Zhang H, Yang H, Ma W, Zhang Z, He S
Cytokine61(2)469-77(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IL-29 can regulate expression of protease activated receptors and tryptase- and trypsin-induced IL-4 production in mast cells.
Title: Modulation of PAR expression and tryptic enzyme induced IL-4 production in mast cells by IL-29.

up-regulation of trypsins is one of the key host pathological findings in influenza A-induced myocarditis.
Title: Up-regulation of ectopic trypsins in the myocardium by influenza A virus infection triggers acute myocarditis.

Results suggest that regulation of Prss1 and Spink3 expression is involved in the susceptibility to experimentally induced pancreatitis.
Title: Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression.

The experimental results are consistent with our hypothesis, suggesting that K(+) induced ion-exchanges play a critical role in the initiation of trypsin premature activation in ZGs.
Title: K+-induced ion-exchanges trigger trypsin activation in pancreas acinar zymogen granules.

The following Prss1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prss1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09423	NM_053243.2 Latest version!	Mus musculus protease, serine 1 (trypsin 1) (Prss1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Prss1 ( NM_053243.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_444473.1 Mus musculus protease, serine 1 (trypsin 1) (Prss1), mRNA.

Price & Availability↑

CloneID	OMu09423
Clone ID Related Accession (Same CDS sequence)	NM_053243.2
Accession Version	NM_053243.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Mus musculus(house mouse)
Product	protease, serine, 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC153854.7. On Sep 7, 2007 this sequence version replaced NM_053243.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC094921.1, CF580393.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGAGTGCAC TCCTGTTCCT GGCCCTTGTG GGAGCTGCTG TTGCTTTCCC TGTGGATGAT 
GATGACAAGA TCGTTGGAGG ATACACCTGC CGAGAGAATT CTGTTCCCTA CCAGGTGTCC 
CTGAACTCTG GCTACCACTT CTGTGGAGGT TCCCTCATCA ATGACCAGTG GGTGGTGTCT 
GCAGCTCATT GCTACAAGAC CCGCATCCAA GTGAGATTGG GGGAGCACAA TATCAATGTC 
CTGGAGGGCA ATGAGCAGTT TATCGATGCT GCCAAGATCA TCAAGCACCC CAACTTCAAT 
AGGAAGACCC TGAACAATGA CATCATGTTG ATCAAGCTCT CATCCCCTGT GACCCTCAAT 
GCCAGAGTGG CCACTGTGGC TCTGCCCAGC TCCTGTGCAC CTGCTGGCAC TCAGTGTCTC 
ATCTCTGGCT GGGGCAACAC TCTTAGCTTT GGTGTCAGTG AACCAGACCT GCTCCAGTGC 
CTGGATGCCC CACTGCTGCC TCAGGCTGAC TGTGAGGCTT CCTATCCTGG GAAGATCACT 
GGTAACATGG TCTGTGCTGG CTTCCTAGAG GGAGGCAAGG ATTCCTGCCA GGGTGACTCT 
GGTGGCCCTG TGGTCTGCAA TGGAGAGCTC CAGGGCATTG TCTCTTGGGG CTATGGCTGT 
GCCCTGCCAG ACAATCCTGG TGTGTACACC AAGGTCTGCA ACTATGTGGA TTGGATTCAG 
GACACAATTG CTGCCAACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444473.1
CDS	14..754
Translation	MSALLFLALVGAAVAFPVDDDDKIVGGYTCRENSVPYQVSLNSGYHFCGGSLINDQWVVSAAHCYKTRIQVRLGEHNINVLEGNEQFIDAAKIIKHPNFNRKTLNNDIMLIKLSSPVTLNARVATVALPSSCAPAGTQCLISGWGNTLSFGVSEPDLLQCLDAPLLPQADCEASYPGKITGNMVCAGFLEGGKDSCQGDSGGPVVCNGELQGIVSWGYGCALPDNPGVYTKVCNYVDWIQDTIAAN

Target ORF information:

RefSeq Version	NM_053243.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus protease, serine 1 (trypsin 1) (Prss1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053243.2

ORF Insert Sequence:

ATGAGTGCAC TCCTGTTCCT GGCCCTTGTG GGAGCTGCTG TTGCTTTCCC TGTGGATGAT 
GATGACAAGA TCGTTGGAGG ATACACCTGC CGAGAGAATT CTGTTCCCTA CCAGGTGTCC 
CTGAACTCTG GCTACCACTT CTGTGGAGGT TCCCTCATCA ATGACCAGTG GGTGGTGTCT 
GCAGCTCATT GCTACAAGAC CCGCATCCAA GTGAGATTGG GGGAGCACAA TATCAATGTC 
CTGGAGGGCA ATGAGCAGTT TATCGATGCT GCCAAGATCA TCAAGCACCC CAACTTCAAT 
AGGAAGACCC TGAACAATGA CATCATGTTG ATCAAGCTCT CATCCCCTGT GACCCTCAAT 
GCCAGAGTGG CCACTGTGGC TCTGCCCAGC TCCTGTGCAC CTGCTGGCAC TCAGTGTCTC 
ATCTCTGGCT GGGGCAACAC TCTTAGCTTT GGTGTCAGTG AACCAGACCT GCTCCAGTGC 
CTGGATGCCC CACTGCTGCC TCAGGCTGAC TGTGAGGCTT CCTATCCTGG GAAGATCACT 
GGTAACATGG TCTGTGCTGG CTTCCTAGAG GGAGGCAAGG ATTCCTGCCA GGGTGACTCT 
GGTGGCCCTG TGGTCTGCAA TGGAGAGCTC CAGGGCATTG TCTCTTGGGG CTATGGCTGT 
GCCCTGCCAG ACAATCCTGG TGTGTACACC AAGGTCTGCA ACTATGTGGA TTGGATTCAG 
GACACAATTG CTGCCAACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Scientific reports740495(2017 Jan)
Naba A,Clauser KR,Mani DR,Carr SA,Hynes RO

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Modulation of PAR expression and tryptic enzyme induced IL-4 production in mast cells by IL-29.
Cytokine61(2)469-77(2013 Feb)
Zhang H,Yang H,Ma W,Zhang Z,He S

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Prss1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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