Foxe1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Foxe1
Entrez Gene ID	110805
Full Name	forkhead box E1
Synonyms	Titf2
General protein information	Preferred Names forkhead box E1 Names forkhead box protein E1 TTF-2 thyroid transcription factor 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 B1\|4 24.68 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_183298.1	NP_899121.1	forkhead box protein E1
NM_183298.2	NP_899121.1	forkhead box protein E1

Pathways from BioSystems

Homologies

	LOC715656	XP_001114004.1
Mus musculus (house mouse)	Foxe1	NP_899121.1
Gallus gallus (chicken)	FOXE1	XP_003643136.2
Homo sapiens (human)	FOXE1	NP_004464.2
Danio rerio (zebrafish)	foxe1	XP_005159967.1
Bos taurus (cattle)	FOXE1	XP_005210253.1
Rattus norvegicus (Norway rat)	Foxe1	NP_620264.1
Xenopus tropicalis (tropical clawed frog)	foxe1	XP_002936729.1

Gene Ontology
Bibliography

Related articles in PubMed

Foxc2
Amin MB, Miura N, Uddin MK, Islam MJ, Yoshida N, Iseki S, Kume T, Trainor PA, Saitsu H, Aoto K
Congenital anomalies57(1)24-31(2017 Jan)

Targeted Foxe1 Overexpression in Mouse Thyroid Causes the Development of Multinodular Goiter But Does Not Promote Carcinogenesis.
Nikitski A, Saenko V, Shimamura M, Nakashima M, Matsuse M, Suzuki K, Rogounovitch T, Bogdanova T, Shibusawa N, Yamada M, Nagayama Y, Yamashita S, Mitsutake N
Endocrinology157(5)2182-95(2016 May)

A single nucleotide polymorphism associated with isolated cleft lip and palate, thyroid cancer and hypothyroidism alters the activity of an oral epithelium and thyroid enhancer near FOXE1.
Lidral AC, Liu H, Bullard SA, Bonde G, Machida J, Visel A, Uribe LM, Li X, Amendt B, Cornell RA
Human molecular genetics24(14)3895-907(2015 Jul)

DYRK1A BAC transgenic mouse: a new model of thyroid dysgenesis in Down syndrome.
Kariyawasam D, Rachdi L, Carr? A, Martin M, Houlier M, Janel N, Delabar JM, Scharfmann R, Polak M
Endocrinology156(3)1171-80(2015 Mar)

The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells.
Marotta P, Amendola E, Scarf? M, De Luca P, Zoppoli P, Amoresano A, De Felice M, Di Lauro R
Molecular and cellular endocrinology396(1-2)26-36(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate that Foxe1 overexpression is not directly involved in the development of thyroid cancer and that proper Foxe1 dosage is essential for achieving normal structure and function of the thyroid.
Title: Targeted Foxe1 Overexpression in Mouse Thyroid Causes the Development of Multinodular Goiter But Does Not Promote Carcinogenesis.

Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes.
Title: Downregulation of Foxe1 by HR suppresses Msx1 expression in the hair follicles of Hr(Hp) mice.

MSX1 and TGF-beta3 are direct targets of FOXE1.
Title: MSX1 and TGF-beta3 are novel target genes functionally regulated by FOXE1.

Foxe1 is required for hair follicle morphogenesis.
Title: Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in hair follicle morphogenesis.

Data report a detailed expression pattern of thyroid transcription factor-2 protein during mouse embryogenesis.
Title: Distribution of the titf2/foxe1 gene product is consistent with an important role in the development of foregut endoderm, palate, and hair.

The following Foxe1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Foxe1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu17559	NM_183298.2 Latest version!	Mus musculus forkhead box E1 (Foxe1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
View Old Accession Versions >>
OMu17559	NM_183298.1	Mus musculus forkhead box E1 (Foxe1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Foxe1 ( NM_183298.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_899121.1 Mus musculus forkhead box E1 (Foxe1), mRNA.

Price & Availability↑

CloneID	OMu17559
Clone ID Related Accession (Same CDS sequence)	NM_183298.1 , NM_183298.2
Accession Version	NM_183298.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1116bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-28
Organism	Mus musculus(house mouse)
Product	forkhead box protein E1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ457047.2. On May 4, 2006 this sequence version replaced XM_975742.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGACGGCCG AGAGCGCGCC GCCTCCCCCG CCGCAGCCCG AGACGCTGGC GGCCGTGAAG 
GAAGAGCGCG GTGAGGCGGC GGCGGCGGGC GCGGGGGTCC CGGCGGAGGC TGCGGGTCGC 
GGCGCGGGAG GACGGCGACG CAAGCGCCCC CTGCAGCGGG GGAAGCCGCC CTACAGCTAC 
ATCGCGCTCA TCGCTATGGC CATCGCGCAC GCGCCCGAGC GCCGCCTGAC TCTGGGCGGC 
ATCTACAAGT TCATCACCGA GCGCTTCCCG TTCTACCGCG ACAACCCCAA GAAGTGGCAG 
AACAGCATCC GCCACAACCT CACCCTCAAC GACTGCTTCC TCAAGATCCC GCGCGAGGCG 
GGCCGCCCGG GCAAGGGCAA TTACTGGGCG CTCGACCCCA ACGCCGAGGA CATGTTCGAA 
AGCGGCAGCT TCCTGCGCCG CCGCAAGCGC TTCAAGCGCT CGGACCTGTC CACCTACCCG 
GCCTACATGC ACGATGCAGC CGCTGCCGCC GCCGCTGCCG CTGCCGCCAT CTTCCCGGGC 
GCCGTGCCTG CCGCAAGGCC GGCTTACCCG GGCGCCGTCT ATGCGGGCTA CGCGCCGCCA 
CTCGCCGCGC CTCCGCCGGT CTACTACCCC GCCGCGTCGC CGGGGCCCTG CCGGGTCTTC 
GGCTTGGTTC CCGAGCGGCC GCTCAGCCCC GATCTGGGCC CCGCGCCGTC AGCGGCCGGC 
GGCTCGTGCG CCTTCGCGGC TGCGGCGGGC GCGGCGGGCA CCGGGAGCTT CCAGCCGGCG 
GTGTGCACCG GAGCGCGGCC GGTCAACCCC GCCGCCTATG CCGCCGCCTA CGCGGGCCCC 
GACGGCGCGT ACCCGCAAGG AGCGAGCAGT GCGCTCTTCG CCGCTGCTGC GGGCCGCCTG 
GCCGGACCGG CCTCGCCCCC CGCGGGAGGC GGCAGCGGCG GCGTGGAGGC CACGGTGGAC 
TTCTACGGGC GCACGTCGCC GGGCCAGTTC GGAGCGGCGC TGGGACCCTG CTACAATCCC 
GGTGGGCAAC TCGGAGCCGG TGGTGGCGGT GCCTACCACT CCCGCCACGC CACCGCCTAC 
CCCGGCGCGG TGGATCGGTT CGTGTCTGCC ATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_899121.1
CDS	1..1116
Translation	MTAESAPPPPPQPETLAAVKEERGEAAAAGAGVPAEAAGRGAGGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAIFPGAVPAARPAYPGAVYAGYAPPLAAPPPVYYPAASPGPCRVFGLVPERPLSPDLGPAPSAAGGSCAFAAAAGAAGTGSFQPAVCTGARPVNPAAYAAAYAGPDGAYPQGASSALFAAAAGRLAGPASPPAGGGSGGVEATVDFYGRTSPGQFGAALGPCYNPGGQLGAGGGGAYHSRHATAYPGAVDRFVSAM

Target ORF information:

RefSeq Version	NM_183298.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus forkhead box E1 (Foxe1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_183298.1

ORF Insert Sequence:

ATGACGGCCG AGAGCGCGCC GCCTCCCCCG CCGCAGCCCG AGACGCTGGC GGCCGTGAAG 
GAAGAGCGCG GTGAGGCGGC GGCGGCGGGC GCGGGGGTCC CGGCGGAGGC TGCGGGTCGC 
GGCGCGGGAG GACGGCGACG CAAGCGCCCC CTGCAGCGGG GGAAGCCGCC CTACAGCTAC 
ATCGCGCTCA TCGCTATGGC CATCGCGCAC GCGCCCGAGC GCCGCCTGAC TCTGGGCGGC 
ATCTACAAGT TCATCACCGA GCGCTTCCCG TTCTACCGCG ACAACCCCAA GAAGTGGCAG 
AACAGCATCC GCCACAACCT CACCCTCAAC GACTGCTTCC TCAAGATCCC GCGCGAGGCG 
GGCCGCCCGG GCAAGGGCAA TTACTGGGCG CTCGACCCCA ACGCCGAGGA CATGTTCGAA 
AGCGGCAGCT TCCTGCGCCG CCGCAAGCGC TTCAAGCGCT CGGACCTGTC CACCTACCCG 
GCCTACATGC ACGATGCAGC CGCTGCCGCC GCCGCTGCCG CTGCCGCCAT CTTCCCGGGC 
GCCGTGCCTG CCGCAAGGCC GGCTTACCCG GGCGCCGTCT ATGCGGGCTA CGCGCCGCCA 
CTCGCCGCGC CTCCGCCGGT CTACTACCCC GCCGCGTCGC CGGGGCCCTG CCGGGTCTTC 
GGCTTGGTTC CCGAGCGGCC GCTCAGCCCC GATCTGGGCC CCGCGCCGTC AGCGGCCGGC 
GGCTCGTGCG CCTTCGCGGC TGCGGCGGGC GCGGCGGGCA CCGGGAGCTT CCAGCCGGCG 
GTGTGCACCG GAGCGCGGCC GGTCAACCCC GCCGCCTATG CCGCCGCCTA CGCGGGCCCC 
GACGGCGCGT ACCCGCAAGG AGCGAGCAGT GCGCTCTTCG CCGCTGCTGC GGGCCGCCTG 
GCCGGACCGG CCTCGCCCCC CGCGGGAGGC GGCAGCGGCG GCGTGGAGGC CACGGTGGAC 
TTCTACGGGC GCACGTCGCC GGGCCAGTTC GGAGCGGCGC TGGGACCCTG CTACAATCCC 
GGTGGGCAAC TCGGAGCCGG TGGTGGCGGT GCCTACCACT CCCGCCACGC CACCGCCTAC 
CCCGGCGCGG TGGATCGGTT CGTGTCTGCC ATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Foxe1 ( NM_183298.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_899121.1 Mus musculus forkhead box E1 (Foxe1), mRNA.

Price & Availability↑

CloneID	OMu17559
Clone ID Related Accession (Same CDS sequence)	NM_183298.1 , NM_183298.2
Accession Version	NM_183298.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1116bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Mus musculus(house mouse)
Product	forkhead box protein E1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL806523.14. On May 5, 2018 this sequence version replaced NM_183298.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGACGGCCG AGAGCGCGCC GCCTCCCCCG CCGCAGCCCG AGACGCTGGC GGCCGTGAAG 
GAAGAGCGCG GTGAGGCGGC GGCGGCGGGC GCGGGGGTCC CGGCGGAGGC TGCGGGTCGC 
GGCGCGGGAG GACGGCGACG CAAGCGCCCC CTGCAGCGGG GGAAGCCGCC CTACAGCTAC 
ATCGCGCTCA TCGCTATGGC CATCGCGCAC GCGCCCGAGC GCCGCCTGAC TCTGGGCGGC 
ATCTACAAGT TCATCACCGA GCGCTTCCCG TTCTACCGCG ACAACCCCAA GAAGTGGCAG 
AACAGCATCC GCCACAACCT CACCCTCAAC GACTGCTTCC TCAAGATCCC GCGCGAGGCG 
GGCCGCCCGG GCAAGGGCAA TTACTGGGCG CTCGACCCCA ACGCCGAGGA CATGTTCGAA 
AGCGGCAGCT TCCTGCGCCG CCGCAAGCGC TTCAAGCGCT CGGACCTGTC CACCTACCCG 
GCCTACATGC ACGATGCAGC CGCTGCCGCC GCCGCTGCCG CTGCCGCCAT CTTCCCGGGC 
GCCGTGCCTG CCGCAAGGCC GGCTTACCCG GGCGCCGTCT ATGCGGGCTA CGCGCCGCCA 
CTCGCCGCGC CTCCGCCGGT CTACTACCCC GCCGCGTCGC CGGGGCCCTG CCGGGTCTTC 
GGCTTGGTTC CCGAGCGGCC GCTCAGCCCC GATCTGGGCC CCGCGCCGTC AGCGGCCGGC 
GGCTCGTGCG CCTTCGCGGC TGCGGCGGGC GCGGCGGGCA CCGGGAGCTT CCAGCCGGCG 
GTGTGCACCG GAGCGCGGCC GGTCAACCCC GCCGCCTATG CCGCCGCCTA CGCGGGCCCC 
GACGGCGCGT ACCCGCAAGG AGCGAGCAGT GCGCTCTTCG CCGCTGCTGC GGGCCGCCTG 
GCCGGACCGG CCTCGCCCCC CGCGGGAGGC GGCAGCGGCG GCGTGGAGGC CACGGTGGAC 
TTCTACGGGC GCACGTCGCC GGGCCAGTTC GGAGCGGCGC TGGGACCCTG CTACAATCCC 
GGTGGGCAAC TCGGAGCCGG TGGTGGCGGT GCCTACCACT CCCGCCACGC CACCGCCTAC 
CCCGGCGCGG TGGATCGGTT CGTGTCTGCC ATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_899121.1
CDS	551..1666
Translation	MTAESAPPPPPQPETLAAVKEERGEAAAAGAGVPAEAAGRGAGGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAIFPGAVPAARPAYPGAVYAGYAPPLAAPPPVYYPAASPGPCRVFGLVPERPLSPDLGPAPSAAGGSCAFAAAAGAAGTGSFQPAVCTGARPVNPAAYAAAYAGPDGAYPQGASSALFAAAAGRLAGPASPPAGGGSGGVEATVDFYGRTSPGQFGAALGPCYNPGGQLGAGGGGAYHSRHATAYPGAVDRFVSAM

Target ORF information:

RefSeq Version	NM_183298.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus forkhead box E1 (Foxe1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_183298.2

ORF Insert Sequence:

ATGACGGCCG AGAGCGCGCC GCCTCCCCCG CCGCAGCCCG AGACGCTGGC GGCCGTGAAG 
GAAGAGCGCG GTGAGGCGGC GGCGGCGGGC GCGGGGGTCC CGGCGGAGGC TGCGGGTCGC 
GGCGCGGGAG GACGGCGACG CAAGCGCCCC CTGCAGCGGG GGAAGCCGCC CTACAGCTAC 
ATCGCGCTCA TCGCTATGGC CATCGCGCAC GCGCCCGAGC GCCGCCTGAC TCTGGGCGGC 
ATCTACAAGT TCATCACCGA GCGCTTCCCG TTCTACCGCG ACAACCCCAA GAAGTGGCAG 
AACAGCATCC GCCACAACCT CACCCTCAAC GACTGCTTCC TCAAGATCCC GCGCGAGGCG 
GGCCGCCCGG GCAAGGGCAA TTACTGGGCG CTCGACCCCA ACGCCGAGGA CATGTTCGAA 
AGCGGCAGCT TCCTGCGCCG CCGCAAGCGC TTCAAGCGCT CGGACCTGTC CACCTACCCG 
GCCTACATGC ACGATGCAGC CGCTGCCGCC GCCGCTGCCG CTGCCGCCAT CTTCCCGGGC 
GCCGTGCCTG CCGCAAGGCC GGCTTACCCG GGCGCCGTCT ATGCGGGCTA CGCGCCGCCA 
CTCGCCGCGC CTCCGCCGGT CTACTACCCC GCCGCGTCGC CGGGGCCCTG CCGGGTCTTC 
GGCTTGGTTC CCGAGCGGCC GCTCAGCCCC GATCTGGGCC CCGCGCCGTC AGCGGCCGGC 
GGCTCGTGCG CCTTCGCGGC TGCGGCGGGC GCGGCGGGCA CCGGGAGCTT CCAGCCGGCG 
GTGTGCACCG GAGCGCGGCC GGTCAACCCC GCCGCCTATG CCGCCGCCTA CGCGGGCCCC 
GACGGCGCGT ACCCGCAAGG AGCGAGCAGT GCGCTCTTCG CCGCTGCTGC GGGCCGCCTG 
GCCGGACCGG CCTCGCCCCC CGCGGGAGGC GGCAGCGGCG GCGTGGAGGC CACGGTGGAC 
TTCTACGGGC GCACGTCGCC GGGCCAGTTC GGAGCGGCGC TGGGACCCTG CTACAATCCC 
GGTGGGCAAC TCGGAGCCGG TGGTGGCGGT GCCTACCACT CCCGCCACGC CACCGCCTAC 
CCCGGCGCGG TGGATCGGTT CGTGTCTGCC ATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Foxc2
Congenital anomalies57(1)24-31(2017 Jan)
Amin MB,Miura N,Uddin MK,Islam MJ,Yoshida N,Iseki S,Kume T,Trainor PA,Saitsu H,Aoto K

Targeted Foxe1 Overexpression in Mouse Thyroid Causes the Development of Multinodular Goiter But Does Not Promote Carcinogenesis.
Endocrinology157(5)2182-95(2016 May)
Nikitski A,Saenko V,Shimamura M,Nakashima M,Matsuse M,Suzuki K,Rogounovitch T,Bogdanova T,Shibusawa N,Yamada M,Nagayama Y,Yamashita S,Mitsutake N

A single nucleotide polymorphism associated with isolated cleft lip and palate, thyroid cancer and hypothyroidism alters the activity of an oral epithelium and thyroid enhancer near FOXE1.
Human molecular genetics24(14)3895-907(2015 Jul)
Lidral AC,Liu H,Bullard SA,Bonde G,Machida J,Visel A,Uribe LM,Li X,Amendt B,Cornell RA

DYRK1A BAC transgenic mouse: a new model of thyroid dysgenesis in Down syndrome.
Endocrinology156(3)1171-80(2015 Mar)
Kariyawasam D,Rachdi L,Carr? A,Martin M,Houlier M,Janel N,Delabar JM,Scharfmann R,Polak M

The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells.
Molecular and cellular endocrinology396(1-2)26-36(2014 Oct)
Marotta P,Amendola E,Scarf? M,De Luca P,Zoppoli P,Amoresano A,De Felice M,Di Lauro R

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Foxe1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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