Cebpe cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cebpe
Entrez Gene ID	110794
Full Name	CCAAT/enhancer binding protein (C/EBP), epsilon
Synonyms	C/EBPe,CRP1,Gm294
General protein information	Preferred Names CCAAT/enhancer binding protein (C/EBP), epsilon Names CCAAT/enhancer-binding protein epsilon C/EBP-related protein 1 C/EBPepsilon c/EBP epsilon
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14 C2\|14 27.9 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_207131.1	NP_997014.1	CCAAT/enhancer-binding protein epsilon

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CEBPE	XP_547729.1
Rattus norvegicus (Norway rat)	Cebpe	NP_058791.1
Xenopus tropicalis (tropical clawed frog)	cebpe	XP_002939064.1
Homo sapiens (human)	CEBPE	NP_001796.2
Bos taurus (cattle)	CEBPE	NP_001179737.1
Pan troglodytes (chimpanzee)	CEBPE	XP_001161080.2
Mus musculus (house mouse)	Cebpe	NP_997014.1
	CEBPE	XP_001106328.1

Gene Ontology
Bibliography

Related articles in PubMed

Loss of Dnmt3b accelerates MLL-AF9 leukemia progression.
Zheng Y, Zhang H, Wang Y, Li X, Lu P, Dong F, Pang Y, Ma S, Cheng H, Hao S, Tang F, Yuan W, Zhang X, Cheng T
Leukemia30(12)2373-2384(2016 Dec)

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors.
Paul F, Arkin Y, Giladi A, Jaitin DA, Kenigsberg E, Keren-Shaul H, Winter D, Lara-Astiaso D, Gury M, Weiner A, David E, Cohen N, Lauridsen FK, Haas S, Schlitzer A, Mildner A, Ginhoux F, Jung S, Trumpp A, Porse BT, Tanay A, Amit I
Cell163(7)1663-77(2015 Dec)

The transcription factor XBP1 is selectively required for eosinophil differentiation.
Bettigole SE, Lis R, Adoro S, Lee AH, Spencer LA, Weller PF, Glimcher LH
Nature immunology16(8)829-37(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study suggests that the myeloid specific factor C/EBPepsilon is involved in systemic lipid metabolism and that silencing of C/EBPepsilon could decrease the development of atherosclerosis.
Title: Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice.

Data show that macrophages from bbee compared to single knockout mice revealed decreased expression of essential immune response-related genes and networks.
Title: In vivo deficiency of both C/EBP? and C/EBP? results in highly defective myeloid differentiation and lack of cytokine response.

in the absence of CCAAT enhancer binding protein epsilon (C/EBPepsilon), there is not only incomplete differentiation of granulocytes, but myelopoiesis is disrupted and neutrophils have abnormal chemotaxis
Title: C/EBPepsilon directs granulocytic-vs-monocytic lineage determination and confers chemotactic function via Hlx.

Lbr, under transcriptional regulation of C/EBPepsilon, is necessary for morphological but not necessarily functional granulocyte
Title: The lamin B receptor under transcriptional control of C/EBPepsilon is required for morphological but not functional maturation of neutrophils.

Phosphorylation of PML was required for stimulating C/EBP epsilon-dependent transcription and accelerating C/EBP epsilon-induced granulocytic differentiation.
Title: Phosphorylation of PML is essential for activation of C/EBP epsilon and PU.1 to accelerate granulocytic differentiation.

The following Cebpe gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cebpe cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09723	NM_207131.1 Latest version!	Mus musculus CCAAT/enhancer binding protein (C/EBP), epsilon (Cebpe), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cebpe ( NM_207131.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_997014.1 Mus musculus CCAAT/enhancer binding protein (C/EBP), epsilon (Cebpe), mRNA.

Price & Availability↑

CloneID	OMu09723
Clone ID Related Accession (Same CDS sequence)	NM_207131.1
Accession Version	NM_207131.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 846bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Mus musculus(house mouse)
Product	CCAAT/enhancer-binding protein epsilon
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY570294.1. On Aug 30, 2004 this sequence version replaced XM_139135.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY570294.1, AK143561.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCACG GGACCTACTA TGAGTGCGAG CCTCGGGGTG GCCAGCAGCC ACTTGAGTTC 
TCAGGGGGTC GAGCTGGGCC CGGGGAGCTG GGGGACATGT GTGAGCATGA GGCCTCCATC 
GACCTCTCCG CCTACATCGA GTCTGGGGAA GAACAGCTAC TTTCTGACCT CTTTGCCATG 
AAGCCAACGC CTGAAGCCCG AAGCCTTAAG GGCCCAGGAG CCCCCTCGTT TCCTCACTAC 
CTGCCGGCTG ACCCTCGGCC ATTCGCCTAT CCCTCACACA CATTTGGCCC AGATAGGAAG 
GCTTTGGGGC CTGGCATCTA CAGCAACCCA GGGAGCTACG ACCCCAGGGC TGTGGCGGTG 
AAGGAGGAGC CTCGTGGGCC AGAGGGCAAC CGAGGCACCA GTCGAGGCAG CTACAATCCC 
CTGCAGTACC AAGTGGCACA CTGCGGGCAG ACAGCCGTGC ACCTCCCCCC GACCCTGGCA 
GCACCTGGCC AGCCCTTGCG TGTCCTCAAG GCCCCTGTGG CAGCTGCTGC CCCTCCCTGC 
AGTCCCCTTC TCAAGGCACC CTCCCCTGCT GGCCCCTCAC ACAAGGGCAA GAAGGCAGTG 
AACAAAGATA GCCTGGAGTA CCGACTGCGA CGTGAACGTA ACAACATCGC GGTGCGCAAG 
AGCCGGGACA AGGCCAAGAG GCGCATTATG GAGACTCAGC AGAAGGTCCT GGAGTACATG 
GCTGAAAACG AGCGTCTGCG CAACCGCGTA GACCAGCTCA CTCAGGAGCT AGACACTCTG 
CGCAACCTCT TCCGCCAGAT CCCTGAGGCT GCTAGCCTCA TCAAGGGTGT CGGGGGCTGC 
AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997014.1
CDS	217..1062
Translation	MSHGTYYECEPRGGQQPLEFSGGRAGPGELGDMCEHEASIDLSAYIESGEEQLLSDLFAMKPTPEARSLKGPGAPSFPHYLPADPRPFAYPSHTFGPDRKALGPGIYSNPGSYDPRAVAVKEEPRGPEGNRGTSRGSYNPLQYQVAHCGQTAVHLPPTLAAPGQPLRVLKAPVAAAAPPCSPLLKAPSPAGPSHKGKKAVNKDSLEYRLRRERNNIAVRKSRDKAKRRIMETQQKVLEYMAENERLRNRVDQLTQELDTLRNLFRQIPEAASLIKGVGGCS

Target ORF information:

RefSeq Version	NM_207131.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus CCAAT/enhancer binding protein (C/EBP), epsilon (Cebpe), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207131.1

ORF Insert Sequence:

ATGTCCCACG GGACCTACTA TGAGTGCGAG CCTCGGGGTG GCCAGCAGCC ACTTGAGTTC 
TCAGGGGGTC GAGCTGGGCC CGGGGAGCTG GGGGACATGT GTGAGCATGA GGCCTCCATC 
GACCTCTCCG CCTACATCGA GTCTGGGGAA GAACAGCTAC TTTCTGACCT CTTTGCCATG 
AAGCCAACGC CTGAAGCCCG AAGCCTTAAG GGCCCAGGAG CCCCCTCGTT TCCTCACTAC 
CTGCCGGCTG ACCCTCGGCC ATTCGCCTAT CCCTCACACA CATTTGGCCC AGATAGGAAG 
GCTTTGGGGC CTGGCATCTA CAGCAACCCA GGGAGCTACG ACCCCAGGGC TGTGGCGGTG 
AAGGAGGAGC CTCGTGGGCC AGAGGGCAAC CGAGGCACCA GTCGAGGCAG CTACAATCCC 
CTGCAGTACC AAGTGGCACA CTGCGGGCAG ACAGCCGTGC ACCTCCCCCC GACCCTGGCA 
GCACCTGGCC AGCCCTTGCG TGTCCTCAAG GCCCCTGTGG CAGCTGCTGC CCCTCCCTGC 
AGTCCCCTTC TCAAGGCACC CTCCCCTGCT GGCCCCTCAC ACAAGGGCAA GAAGGCAGTG 
AACAAAGATA GCCTGGAGTA CCGACTGCGA CGTGAACGTA ACAACATCGC GGTGCGCAAG 
AGCCGGGACA AGGCCAAGAG GCGCATTATG GAGACTCAGC AGAAGGTCCT GGAGTACATG 
GCTGAAAACG AGCGTCTGCG CAACCGCGTA GACCAGCTCA CTCAGGAGCT AGACACTCTG 
CGCAACCTCT TCCGCCAGAT CCCTGAGGCT GCTAGCCTCA TCAAGGGTGT CGGGGGCTGC 
AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of Dnmt3b accelerates MLL-AF9 leukemia progression.
Leukemia30(12)2373-2384(2016 Dec)
Zheng Y,Zhang H,Wang Y,Li X,Lu P,Dong F,Pang Y,Ma S,Cheng H,Hao S,Tang F,Yuan W,Zhang X,Cheng T

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors.
Cell163(7)1663-77(2015 Dec)
Paul F,Arkin Y,Giladi A,Jaitin DA,Kenigsberg E,Keren-Shaul H,Winter D,Lara-Astiaso D,Gury M,Weiner A,David E,Cohen N,Lauridsen FK,Haas S,Schlitzer A,Mildner A,Ginhoux F,Jung S,Trumpp A,Porse BT,Tanay A,Amit I

The transcription factor XBP1 is selectively required for eosinophil differentiation.
Nature immunology16(8)829-37(2015 Aug)
Bettigole SE,Lis R,Adoro S,Lee AH,Spencer LA,Weller PF,Glimcher LH

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Cebpe cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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