Fntb cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fntb
Entrez Gene ID	110606
Full Name	farnesyltransferase, CAAX box, beta
Synonyms	2010013E13Rik,AA409500
General protein information	Preferred Names farnesyltransferase, CAAX box, beta Names protein farnesyltransferase subunit beta CAAX farnesyltransferase subunit beta FTase-beta ras proteins prenyltransferase subunit beta
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12 C3\|12 33.73 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006515404.2	XP_006515467.1	protein farnesyltransferase subunit beta isoform X1
XM_006515404.3	XP_006515467.1	protein farnesyltransferase subunit beta isoform X1
NM_145927.2	NP_666039.1	protein farnesyltransferase subunit beta

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Fntb	NP_742031.1
Gallus gallus (chicken)	FNTB	XP_003643828.2
Caenorhabditis elegans (roundworm)	fntb-1	NP_506580.1
	FNTB	XP_001103300.1
Bos taurus (cattle)	FNTB	NP_786999.1
Danio rerio (zebrafish)	fntb	NP_001002128.1
Homo sapiens (human)	FNTB	NP_002019.1
Canis lupus familiaris (dog)	FNTB	XP_005623566.1
Mus musculus (house mouse)	Fntb	NP_666039.1
Xenopus tropicalis (tropical clawed frog)	fntb	NP_001017258.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001729	XP_321357.4
Drosophila melanogaster (fruit fly)	CG17565	NP_650540.1
Arabidopsis thaliana (thale cress)	ERA1	NP_198844.1
Oryza sativa (rice)	Os01g0737800	NP_001044183.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Lonafarnib is a potential inhibitor for neovascularization.
Sun L, Xie S, Peng G, Wang J, Li Y, Qin J, Zhong D
PloS one10(4)e0122830(2015)

Farnesyltransferase regulates neutrophil recruitment and tissue damage in acute pancreatitis.
Merza M, Awla D, Hwaiz R, Rahman M, Appelros S, Abdulla A, Regner S, Thorlacius H
Pancreas43(3)427-35(2014 Apr)

Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease.
Cheng S, Cao D, Hottman DA, Yuan L, Bergo MO, Li L
The Journal of biological chemistry288(50)35952-60(2013 Dec)

Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria.
Ibrahim MX, Sayin VI, Akula MK, Liu M, Fong LG, Young SG, Bergo MO
Science (New York, N.Y.)340(6138)1330-3(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the catalytic b subunit of farnesyl transferase associated with a cytoskeletal protein...lonafarnib remarkably inhibited he expression of the cytoskeletal protein and interrupted its interaction with farnesyl transferase.
Title: Lonafarnib is a potential inhibitor for neovascularization.

Data suggest that farnesyltransferase might constitute a target in the management of severe acute pancreatitis (AP).
Title: Farnesyltransferase regulates neutrophil recruitment and tissue damage in acute pancreatitis.

deficiencies in either FTase or GGTase-I lead to severe hepatocellular disease. Our studies lay to rest the earlier notion that FTase is dispensable in adult tissues
Title: Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases.

Both Fntb and Pggt1b are required for the homeostasis of skin keratinocytes.
Title: Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes.

FTase is essential for embryonic development, but dispensable for adult homeostasis. Elimination of FTase during tumor progression had a limited but significant inhibitory effect on tumor development.
Title: Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.

The following Fntb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fntb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19233	NM_145927.2 Latest version!	Mus musculus farnesyltransferase, CAAX box, beta (Fntb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu47534	XM_006515404.3 Latest version!	Mus musculus farnesyltransferase, CAAX box, beta (Fntb), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu47534	XM_006515404.2	Mus musculus farnesyltransferase, CAAX box, beta (Fntb), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fntb ( NM_145927.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_666039.1 Mus musculus farnesyltransferase, CAAX box, beta (Fntb), mRNA.

Price & Availability↑

CloneID	OMu19233
Clone ID Related Accession (Same CDS sequence)	NM_145927.2
Accession Version	NM_145927.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1314bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-23
Organism	Mus musculus(house mouse)
Product	protein farnesyltransferase subunit beta
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC132331.3 and AC124556.4. On Nov 17, 2006 this sequence version replaced NM_145927.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC031417.1, AK089911.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCTTCTT CGAGTTCCTT CACCTATTAT TGTCCTCCAT CTTCCTCCCC TGTTTGGTCA 
GAACCGCTGT ATAGTCTGAG ACCTGAGCAC GTGCGGGAGC GGTTGCAAGA CGACTCAGTG 
GAAACAGTCA CATCCATAGA ACAGGCCAAA GTAGAAGAGA AGATCCAGGA GGTCTTCAGT 
TCTTACAAGT TTAACCACCT TGTACCAAGG CTCATTTTGC AGAGGGAGAA GCACTTCCAT 
TATCTGAAAA GAGGCCTTCG ACAACTGACA GATGCCTATG AGTGTCTGGA TGCCAGCCGC 
CCCTGGCTCT GCTACTGGAT CCTGCACAGC CTGGAGCTCC TTGACGAACC CATCCCCCAG 
ATAGTGGCCA CAGACGTGTG TCAGTTCCTG GAGCTGTGTC AGAGTCCAGA CGGTGGCTTT 
GGAGGGGGCC CCGGTCAGTA CCCACACCTC GCACCCACTT ATGCAGCCGT CAATGCGCTG 
TGCATCATCG GCACAGAGGA AGCCTACAAC GTCATTAACA GGGAGAAACT CCTTCAGTAT 
TTGTACTCCC TAAAGCAACC CGACGGCTCT TTTCTCATGC ACGTCGGAGG TGAGGTGGAC 
GTAAGGAGTG CATACTGTGC TGCCTCGGTA GCCTCTCTCA CCAACATCAT CACTCCAGAC 
CTCTTTGAAG GCACGGCCGA ATGGATAGCC AGGTGCCAGA ACTGGGAAGG CGGCATTGGT 
GGGGTGCCAG GGATGGAAGC CCACGGTGGC TACACCTTCT GTGGCTTGGC TGCGCTGGTT 
ATCCTCAAGA AGGAACGTTC TTTGAACCTG AAGAGCTTGC TACAATGGGT GACAAGCCGG 
CAGATGCGGT TTGAAGGAGG CTTTCAGGGC CGCTGCAACA AGCTGGTGGA CGGCTGCTAC 
TCCTTCTGGC AGGCAGGGCT CCTGCCCCTG CTGCACCGAG CCCTCCACGC TCAAGGTGAC 
CCTGCCCTCA GCATGAGCCA TTGGATGTTC CATCAGCAGG CGCTGCAGGA GTACATCCTG 
ATGTGCTGCC AGTGTCCAGC CGGGGGGCTT CTGGACAAGC CTGGCAAGTC ACGTGACTTC 
TATCATACTT GCTACTGCCT GAGCGGCCTC TCCATTGCCC AGCATTTCGG AAGCGGAGCC 
ATGTTGCACG ATATGGTCAT GGGTGTGCCC GAAAACGTTC TGCAGCCCAC ACACCCTGTG 
TACAACATTG GACCTGAGAA GGTGATCCAG GCCACCACAC ACTTTCTGCA GAAGCCAGTC 
CCAGGCTTTG AGGAATGTGA AGATGAGGTG ACCTCAGATC CTGCCACCGA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_666039.1
CDS	42..1355
Translation	MASSSSFTYYCPPSSSPVWSEPLYSLRPEHVRERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLILQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDMVMGVPENVLQPTHPVYNIGPEKVIQATTHFLQKPVPGFEECEDEVTSDPATD

Target ORF information:

RefSeq Version	NM_145927.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus farnesyltransferase, CAAX box, beta (Fntb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145927.2

ORF Insert Sequence:

ATGGCTTCTT CGAGTTCCTT CACCTATTAT TGTCCTCCAT CTTCCTCCCC TGTTTGGTCA 
GAACCGCTGT ATAGTCTGAG ACCTGAGCAC GTGCGGGAGC GGTTGCAAGA CGACTCAGTG 
GAAACAGTCA CATCCATAGA ACAGGCCAAA GTAGAAGAGA AGATCCAGGA GGTCTTCAGT 
TCTTACAAGT TTAACCACCT TGTACCAAGG CTCATTTTGC AGAGGGAGAA GCACTTCCAT 
TATCTGAAAA GAGGCCTTCG ACAACTGACA GATGCCTATG AGTGTCTGGA TGCCAGCCGC 
CCCTGGCTCT GCTACTGGAT CCTGCACAGC CTGGAGCTCC TTGACGAACC CATCCCCCAG 
ATAGTGGCCA CAGACGTGTG TCAGTTCCTG GAGCTGTGTC AGAGTCCAGA CGGTGGCTTT 
GGAGGGGGCC CCGGTCAGTA CCCACACCTC GCACCCACTT ATGCAGCCGT CAATGCGCTG 
TGCATCATCG GCACAGAGGA AGCCTACAAC GTCATTAACA GGGAGAAACT CCTTCAGTAT 
TTGTACTCCC TAAAGCAACC CGACGGCTCT TTTCTCATGC ACGTCGGAGG TGAGGTGGAC 
GTAAGGAGTG CATACTGTGC TGCCTCGGTA GCCTCTCTCA CCAACATCAT CACTCCAGAC 
CTCTTTGAAG GCACGGCCGA ATGGATAGCC AGGTGCCAGA ACTGGGAAGG CGGCATTGGT 
GGGGTGCCAG GGATGGAAGC CCACGGTGGC TACACCTTCT GTGGCTTGGC TGCGCTGGTT 
ATCCTCAAGA AGGAACGTTC TTTGAACCTG AAGAGCTTGC TACAATGGGT GACAAGCCGG 
CAGATGCGGT TTGAAGGAGG CTTTCAGGGC CGCTGCAACA AGCTGGTGGA CGGCTGCTAC 
TCCTTCTGGC AGGCAGGGCT CCTGCCCCTG CTGCACCGAG CCCTCCACGC TCAAGGTGAC 
CCTGCCCTCA GCATGAGCCA TTGGATGTTC CATCAGCAGG CGCTGCAGGA GTACATCCTG 
ATGTGCTGCC AGTGTCCAGC CGGGGGGCTT CTGGACAAGC CTGGCAAGTC ACGTGACTTC 
TATCATACTT GCTACTGCCT GAGCGGCCTC TCCATTGCCC AGCATTTCGG AAGCGGAGCC 
ATGTTGCACG ATATGGTCAT GGGTGTGCCC GAAAACGTTC TGCAGCCCAC ACACCCTGTG 
TACAACATTG GACCTGAGAA GGTGATCCAG GCCACCACAC ACTTTCTGCA GAAGCCAGTC 
CCAGGCTTTG AGGAATGTGA AGATGAGGTG ACCTCAGATC CTGCCACCGA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fntb ( XM_006515404.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006515467.1 Mus musculus farnesyltransferase, CAAX box, beta (Fntb), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu47534
Clone ID Related Accession (Same CDS sequence)	XM_006515404.2 , XM_006515404.3
Accession Version	XM_006515404.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	protein farnesyltransferase subunit beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006515404.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCACGTCG GAGGTGAGGT GGACGTAAGG AGTGCATACT GTGCTGCCTC GGTAGCCTCT 
CTCACCAACA TCATCACTCC AGACCTCTTT GAAGGCACGG CCGAATGGAT AGCCAGGTGC 
CAGAACTGGG AAGGCGGCAT TGGTGGGGTG CCAGGGATGG AAGCCCACGG TGGCTACACC 
TTCTGTGGCT TGGCTGCGCT GGTTATCCTC AAGAAGGAAC GTTCTTTGAA CCTGAAGAGC 
TTGCTACAAT GGGTGACAAG CCGGCAGATG CGGTTTGAAG GAGGCTTTCA GGGCCGCTGC 
AACAAGCTGG TGGACGGCTG CTACTCCTTC TGGCAGGCAG GGCTCCTGCC CCTGCTGCAC 
CGAGCCCTCC ACGCTCAAGG TGACCCTGCC CTCAGCATGA GCCATTGGAT GTTCCATCAG 
CAGGCGCTGC AGGAGTACAT CCTGATGTGC TGCCAGTGTC CAGCCGGGGG GCTTCTGGAC 
AAGCCTGGCA AGTCACGTGA CTTCTATCAT ACTTGCTACT GCCTGAGCGG CCTCTCCATT 
GCCCAGCATT TCGGAAGCGG AGCCATGTTG CACGATATGG TCATGGGTGT GCCCGAAAAC 
GTTCTGCAGC CCACACACCC TGTGTACAAC ATTGGACCTG AGAAGGTGAT CCAGGCCACC 
ACACACTTTC TGCAGAAGCC AGTCCCAGGC TTTGAGGAAT GTGAAGATGA GGTGACCTCA 
GATCCTGCCA CCGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006515467.1
CDS	726..1463
Translation	MHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDMVMGVPENVLQPTHPVYNIGPEKVIQATTHFLQKPVPGFEECEDEVTSDPATD

Target ORF information:

RefSeq Version	XM_006515404.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus farnesyltransferase, CAAX box, beta (Fntb), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006515404.2

ORF Insert Sequence:

ATGCACGTCG GAGGTGAGGT GGACGTAAGG AGTGCATACT GTGCTGCCTC GGTAGCCTCT 
CTCACCAACA TCATCACTCC AGACCTCTTT GAAGGCACGG CCGAATGGAT AGCCAGGTGC 
CAGAACTGGG AAGGCGGCAT TGGTGGGGTG CCAGGGATGG AAGCCCACGG TGGCTACACC 
TTCTGTGGCT TGGCTGCGCT GGTTATCCTC AAGAAGGAAC GTTCTTTGAA CCTGAAGAGC 
TTGCTACAAT GGGTGACAAG CCGGCAGATG CGGTTTGAAG GAGGCTTTCA GGGCCGCTGC 
AACAAGCTGG TGGACGGCTG CTACTCCTTC TGGCAGGCAG GGCTCCTGCC CCTGCTGCAC 
CGAGCCCTCC ACGCTCAAGG TGACCCTGCC CTCAGCATGA GCCATTGGAT GTTCCATCAG 
CAGGCGCTGC AGGAGTACAT CCTGATGTGC TGCCAGTGTC CAGCCGGGGG GCTTCTGGAC 
AAGCCTGGCA AGTCACGTGA CTTCTATCAT ACTTGCTACT GCCTGAGCGG CCTCTCCATT 
GCCCAGCATT TCGGAAGCGG AGCCATGTTG CACGATATGG TCATGGGTGT GCCCGAAAAC 
GTTCTGCAGC CCACACACCC TGTGTACAAC ATTGGACCTG AGAAGGTGAT CCAGGCCACC 
ACACACTTTC TGCAGAAGCC AGTCCCAGGC TTTGAGGAAT GTGAAGATGA GGTGACCTCA 
GATCCTGCCA CCGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fntb ( XM_006515404.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006515467.1 Mus musculus farnesyltransferase, CAAX box, beta (Fntb), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu47534
Clone ID Related Accession (Same CDS sequence)	XM_006515404.2 , XM_006515404.3
Accession Version	XM_006515404.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	protein farnesyltransferase subunit beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006515404.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCACGTCG GAGGTGAGGT GGACGTAAGG AGTGCATACT GTGCTGCCTC GGTAGCCTCT 
CTCACCAACA TCATCACTCC AGACCTCTTT GAAGGCACGG CCGAATGGAT AGCCAGGTGC 
CAGAACTGGG AAGGCGGCAT TGGTGGGGTG CCAGGGATGG AAGCCCACGG TGGCTACACC 
TTCTGTGGCT TGGCTGCGCT GGTTATCCTC AAGAAGGAAC GTTCTTTGAA CCTGAAGAGC 
TTGCTACAAT GGGTGACAAG CCGGCAGATG CGGTTTGAAG GAGGCTTTCA GGGCCGCTGC 
AACAAGCTGG TGGACGGCTG CTACTCCTTC TGGCAGGCAG GGCTCCTGCC CCTGCTGCAC 
CGAGCCCTCC ACGCTCAAGG TGACCCTGCC CTCAGCATGA GCCATTGGAT GTTCCATCAG 
CAGGCGCTGC AGGAGTACAT CCTGATGTGC TGCCAGTGTC CAGCCGGGGG GCTTCTGGAC 
AAGCCTGGCA AGTCACGTGA CTTCTATCAT ACTTGCTACT GCCTGAGCGG CCTCTCCATT 
GCCCAGCATT TCGGAAGCGG AGCCATGTTG CACGATATGG TCATGGGTGT GCCCGAAAAC 
GTTCTGCAGC CCACACACCC TGTGTACAAC ATTGGACCTG AGAAGGTGAT CCAGGCCACC 
ACACACTTTC TGCAGAAGCC AGTCCCAGGC TTTGAGGAAT GTGAAGATGA GGTGACCTCA 
GATCCTGCCA CCGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006515467.1
CDS	705..1442
Translation	MHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDMVMGVPENVLQPTHPVYNIGPEKVIQATTHFLQKPVPGFEECEDEVTSDPATD

Target ORF information:

RefSeq Version	XM_006515404.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus farnesyltransferase, CAAX box, beta (Fntb), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006515404.3

ORF Insert Sequence:

ATGCACGTCG GAGGTGAGGT GGACGTAAGG AGTGCATACT GTGCTGCCTC GGTAGCCTCT 
CTCACCAACA TCATCACTCC AGACCTCTTT GAAGGCACGG CCGAATGGAT AGCCAGGTGC 
CAGAACTGGG AAGGCGGCAT TGGTGGGGTG CCAGGGATGG AAGCCCACGG TGGCTACACC 
TTCTGTGGCT TGGCTGCGCT GGTTATCCTC AAGAAGGAAC GTTCTTTGAA CCTGAAGAGC 
TTGCTACAAT GGGTGACAAG CCGGCAGATG CGGTTTGAAG GAGGCTTTCA GGGCCGCTGC 
AACAAGCTGG TGGACGGCTG CTACTCCTTC TGGCAGGCAG GGCTCCTGCC CCTGCTGCAC 
CGAGCCCTCC ACGCTCAAGG TGACCCTGCC CTCAGCATGA GCCATTGGAT GTTCCATCAG 
CAGGCGCTGC AGGAGTACAT CCTGATGTGC TGCCAGTGTC CAGCCGGGGG GCTTCTGGAC 
AAGCCTGGCA AGTCACGTGA CTTCTATCAT ACTTGCTACT GCCTGAGCGG CCTCTCCATT 
GCCCAGCATT TCGGAAGCGG AGCCATGTTG CACGATATGG TCATGGGTGT GCCCGAAAAC 
GTTCTGCAGC CCACACACCC TGTGTACAAC ATTGGACCTG AGAAGGTGAT CCAGGCCACC 
ACACACTTTC TGCAGAAGCC AGTCCCAGGC TTTGAGGAAT GTGAAGATGA GGTGACCTCA 
GATCCTGCCA CCGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Lonafarnib is a potential inhibitor for neovascularization.
PloS one10(4)e0122830(2015)
Sun L,Xie S,Peng G,Wang J,Li Y,Qin J,Zhong D

Farnesyltransferase regulates neutrophil recruitment and tissue damage in acute pancreatitis.
Pancreas43(3)427-35(2014 Apr)
Merza M,Awla D,Hwaiz R,Rahman M,Appelros S,Abdulla A,Regner S,Thorlacius H

Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease.
The Journal of biological chemistry288(50)35952-60(2013 Dec)
Cheng S,Cao D,Hottman DA,Yuan L,Bergo MO,Li L

Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria.
Science (New York, N.Y.)340(6138)1330-3(2013 Jun)
Ibrahim MX,Sayin VI,Akula MK,Liu M,Fong LG,Young SG,Bergo MO

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Fntb cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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