Cyp11b1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cyp11b1
Entrez Gene ID	110115
Full Name	cytochrome P450, family 11, subfamily b, polypeptide 1
Synonyms	AA389061,CPN1,Cyp11b,Cyp11b-1,FHI
General protein information	Preferred Names cytochrome P450, family 11, subfamily b, polypeptide 1 Names cytochrome P450, family 11, subfamily b, polypeptide 1 steroid-11-beta-hydroxylase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 D3\|15 34.29 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033229.3	NP_001028401.2	cytochrome P450, family 11, subfamily b, polypeptide 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CYP11B1	XP_005215349.1
Rattus norvegicus (Norway rat)	LOC100910462	XP_003750411.2
	CYP11B2	XP_001085034.1
Canis lupus familiaris (dog)	CYP11B2	XP_539192.3
Rattus norvegicus (Norway rat)	Cyp11b3	NP_861545.1
Homo sapiens (human)	CYP11B2	NP_000489.3
Mus musculus (house mouse)	Cyp11b1	NP_001028401.2

Gene Ontology
Bibliography

Related articles in PubMed

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.
Xing Y, Morohashi KI, Ingraham HA, Hammer GD
Development (Cambridge, England)144(20)3798-3807(2017 10)

Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function.
Berthon A, Faucz FR, Espiard S, Drougat L, Bertherat J, Stratakis CA
Human molecular genetics26(18)3495-3507(2017 Sep)

Myeloid cells are capable of synthesizing aldosterone to exacerbate damage in muscular dystrophy.
Chadwick JA, Swager SA, Lowe J, Welc SS, Tidball JG, Gomez-Sanchez CE, Gomez-Sanchez EP, Rafael-Fortney JA
Human molecular genetics25(23)5167-5177(2016 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

3-methylsulfonyl-DDE and related compounds did not alter Cyp11b1 gene expression in adrenocortical Y-1 cells indicating that compound-induced enzyme inhibition occurs on the protein level.
Title: Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.

Cyp11b1 null mouse, a model of congenital adrenal hyperplasia
Title: Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.

These data showed that in the adrenal gland, PREB regulates the transcription of the CYP11B1 gene via cAMP.
Title: The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene.

Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen.
Title: Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.

The following Cyp11b1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cyp11b1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12510	NM_001033229.3 Latest version!	Mus musculus cytochrome P450, family 11, subfamily b, polypeptide 1 (Cyp11b1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cyp11b1 ( NM_001033229.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001028401.2 Mus musculus cytochrome P450, family 11, subfamily b, polypeptide 1 (Cyp11b1), mRNA.

Price & Availability↑

CloneID	OMu12510
Clone ID Related Accession (Same CDS sequence)	NM_001033229.3
Accession Version	NM_001033229.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1506bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-28
Organism	Mus musculus(house mouse)
Product	cytochrome P450, family 11, subfamily b, polypeptide 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC139671.10, AK168839.1 and AK142439.1. On Nov 25, 2009 this sequence version replaced NM_001033229.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC139248.1, AK142439.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849379 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGACAATGG CTCTCAGGGT GACAACAGAT GTGTGGCTGG CAAGACCCTG GCAGTGCCTG 
CACAGGACAA GGGCACTGGG CACCACGGCA ACACTGGCCC CAAAGACCCT GCAGCCCTTT 
GAAGCCATAC CACAGTACTC CAGGAACAAG TGGCTGAAGA TGATACAGAT CCTGAGGGAG 
CAGGGCCAAG AAAACCTACA CCTGGAGATG CATCAGGTCT TCCGGGAGCT GGGGCCCATT 
TTCAGGCACA GTGTAGGGAA AACACAGATT GTGTTTGTGA CGTTGCCGGA GGATGTTGAG 
AAGCTGTACC AGGTAGAGAG TACGCACCCT TGCCGCATGC CCTTGGAATC CTGGATAGTC 
CATAGAGAAC TCCGTGGCCT GGGACGTGGT GTGTTCTTGC TAAATGGGCC AGAATGGTAC 
TTCAACCGAC TGCAGCTGAA CCCAAATGTT CTGTCACCAA AAGCCGTTCA AAAATTTGTC 
CCCTTGGTGG ATGGGATAGC AAGGGACTTT GTGGATAACC TGAAGAAGAA AATGCTGGAA 
AGTGTCCATG GTAGCTTCTC TATGGACTTT CAGTCCAGTG TGTTCAACTA TACCATAGAA 
GCTAGCCACT TTGTTCTTTT TGGGGAGCGG CTGGGCCTCA TTGGCCGTGA TCTGAGCCCT 
GACAGCCTGA AGTTCCTCCA CACCCTGCAC TCCATGTTCA AAACCACCAC ACAGCTCTTG 
TACTTGCCCA GGAGCCTGAC CCGATGGACA AGCACCAGGG TGTGGAAAGA AAACTTAGAG 
TCCTGGGATT TCATCTCTGA ATATGTCACC AAATGTATCA AGAATGTGTA TCGAGAGCTG 
GCAGAGGGTC GTCCACAGTC CTGGAGTGTC ACAGCAGAGC TGGTAGCTGA GAGAACTCTG 
TCAATGGATG CCATCCAGGC TAACTCAATG GAACTCATTG CTGGAAGCAC TGACACGACA 
TCAACCCCCT TGGTAATGAC TTTCTTTGAG CTGGCTCGGA ACCCAGATGT TCAGCAGGCC 
CTGAGGCAGG AGAGCCTGGC AGCTGAGGCC AGCATCGCTG CAAATCCTCA GAAGGCCATG 
TCAGACCTGC CCTTGCTGAG GGCTGCCCTT AAAGAGACCT TGAGGCTCTA TCCTGTTGGT 
ACTTTTCTGG AGAGAATTCT AAGCTCAGAC TTGGTGCTTC AGAACTACCA TGTCCCTGCT 
GGGACAGTCC TCAATGTGAA TCTGTATTCC ATGGGCCGGA ACCCTGCAGT GTTCCCAAGG 
CCTGAACGCT ATATGCCTCA GCGCTGGCTG GAGAGGAAAA GGAGTTTCAA GCACCTGGCC 
TTTGGCTTTG GGGTGCGCCA GTGCCTGGGG AGGCGCCTGG CAGAGGCAGA GATGATGCTC 
CTGCTTCACC ATGTGCTGAA ATCCTTCCAC GTGGAGACAC AAGAGAAAGA GGATGTGCGG 
ATGGCCTACC GCTTCGTTTT GATGCCCAGC TCCAGTCCTC TCCTCACTTT CAGGCCTGTC 
AACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028401.2
CDS	32..1537
Translation	MTMALRVTTDVWLARPWQCLHRTRALGTTATLAPKTLQPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQVFRELGPIFRHSVGKTQIVFVTLPEDVEKLYQVESTHPCRMPLESWIVHRELRGLGRGVFLLNGPEWYFNRLQLNPNVLSPKAVQKFVPLVDGIARDFVDNLKKKMLESVHGSFSMDFQSSVFNYTIEASHFVLFGERLGLIGRDLSPDSLKFLHTLHSMFKTTTQLLYLPRSLTRWTSTRVWKENLESWDFISEYVTKCIKNVYRELAEGRPQSWSVTAELVAERTLSMDAIQANSMELIAGSTDTTSTPLVMTFFELARNPDVQQALRQESLAAEASIAANPQKAMSDLPLLRAALKETLRLYPVGTFLERILSSDLVLQNYHVPAGTVLNVNLYSMGRNPAVFPRPERYMPQRWLERKRSFKHLAFGFGVRQCLGRRLAEAEMMLLLHHVLKSFHVETQEKEDVRMAYRFVLMPSSSPLLTFRPVN

Target ORF information:

RefSeq Version	NM_001033229.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytochrome P450, family 11, subfamily b, polypeptide 1 (Cyp11b1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033229.3

ORF Insert Sequence:

ATGACAATGG CTCTCAGGGT GACAACAGAT GTGTGGCTGG CAAGACCCTG GCAGTGCCTG 
CACAGGACAA GGGCACTGGG CACCACGGCA ACACTGGCCC CAAAGACCCT GCAGCCCTTT 
GAAGCCATAC CACAGTACTC CAGGAACAAG TGGCTGAAGA TGATACAGAT CCTGAGGGAG 
CAGGGCCAAG AAAACCTACA CCTGGAGATG CATCAGGTCT TCCGGGAGCT GGGGCCCATT 
TTCAGGCACA GTGTAGGGAA AACACAGATT GTGTTTGTGA CGTTGCCGGA GGATGTTGAG 
AAGCTGTACC AGGTAGAGAG TACGCACCCT TGCCGCATGC CCTTGGAATC CTGGATAGTC 
CATAGAGAAC TCCGTGGCCT GGGACGTGGT GTGTTCTTGC TAAATGGGCC AGAATGGTAC 
TTCAACCGAC TGCAGCTGAA CCCAAATGTT CTGTCACCAA AAGCCGTTCA AAAATTTGTC 
CCCTTGGTGG ATGGGATAGC AAGGGACTTT GTGGATAACC TGAAGAAGAA AATGCTGGAA 
AGTGTCCATG GTAGCTTCTC TATGGACTTT CAGTCCAGTG TGTTCAACTA TACCATAGAA 
GCTAGCCACT TTGTTCTTTT TGGGGAGCGG CTGGGCCTCA TTGGCCGTGA TCTGAGCCCT 
GACAGCCTGA AGTTCCTCCA CACCCTGCAC TCCATGTTCA AAACCACCAC ACAGCTCTTG 
TACTTGCCCA GGAGCCTGAC CCGATGGACA AGCACCAGGG TGTGGAAAGA AAACTTAGAG 
TCCTGGGATT TCATCTCTGA ATATGTCACC AAATGTATCA AGAATGTGTA TCGAGAGCTG 
GCAGAGGGTC GTCCACAGTC CTGGAGTGTC ACAGCAGAGC TGGTAGCTGA GAGAACTCTG 
TCAATGGATG CCATCCAGGC TAACTCAATG GAACTCATTG CTGGAAGCAC TGACACGACA 
TCAACCCCCT TGGTAATGAC TTTCTTTGAG CTGGCTCGGA ACCCAGATGT TCAGCAGGCC 
CTGAGGCAGG AGAGCCTGGC AGCTGAGGCC AGCATCGCTG CAAATCCTCA GAAGGCCATG 
TCAGACCTGC CCTTGCTGAG GGCTGCCCTT AAAGAGACCT TGAGGCTCTA TCCTGTTGGT 
ACTTTTCTGG AGAGAATTCT AAGCTCAGAC TTGGTGCTTC AGAACTACCA TGTCCCTGCT 
GGGACAGTCC TCAATGTGAA TCTGTATTCC ATGGGCCGGA ACCCTGCAGT GTTCCCAAGG 
CCTGAACGCT ATATGCCTCA GCGCTGGCTG GAGAGGAAAA GGAGTTTCAA GCACCTGGCC 
TTTGGCTTTG GGGTGCGCCA GTGCCTGGGG AGGCGCCTGG CAGAGGCAGA GATGATGCTC 
CTGCTTCACC ATGTGCTGAA ATCCTTCCAC GTGGAGACAC AAGAGAAAGA GGATGTGCGG 
ATGGCCTACC GCTTCGTTTT GATGCCCAGC TCCAGTCCTC TCCTCACTTT CAGGCCTGTC 
AACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.
Development (Cambridge, England)144(20)3798-3807(2017 10)
Xing Y,Morohashi KI,Ingraham HA,Hammer GD

Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function.
Human molecular genetics26(18)3495-3507(2017 Sep)
Berthon A,Faucz FR,Espiard S,Drougat L,Bertherat J,Stratakis CA

Myeloid cells are capable of synthesizing aldosterone to exacerbate damage in muscular dystrophy.
Human molecular genetics25(23)5167-5177(2016 12)
Chadwick JA,Swager SA,Lowe J,Welc SS,Tidball JG,Gomez-Sanchez CE,Gomez-Sanchez EP,Rafael-Fortney JA

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Cyp11b1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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