Bmp3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bmp3
Entrez Gene ID	110075
Full Name	bone morphogenetic protein 3
Synonyms	9530029I04Rik
General protein information	Preferred Names bone morphogenetic protein 3 Names bone morphogenetic protein 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 E3\|5 48.24 cM
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. Homozygous knockout mice for this gene exhibit increased bone density and volume, while overexpression of this gene in a transgenic mouse causes bone defects resulting in spontaneous rib fractures. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_173404.4	NP_775580.1	bone morphogenetic protein 3 isoform 2 precursor
NM_173404.5	NP_775580.1	bone morphogenetic protein 3 isoform 2 preproprotein
NM_001310677.2	NP_001297606.1	bone morphogenetic protein 3 isoform 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	BMP3	NP_001192.2
Pan troglodytes (chimpanzee)	BMP3	XP_001144027.1
	BMP3	XP_001089525.1
Bos taurus (cattle)	BMP3	NP_001179197.1
Mus musculus (house mouse)	Bmp3	NP_775580.1
Gallus gallus (chicken)	BMP3	NP_001029991.1
Danio rerio (zebrafish)	bmp3	NP_001071233.1
Canis lupus familiaris (dog)	BMP3	XP_005639168.1
Rattus norvegicus (Norway rat)	Bmp3	NP_058801.1
Xenopus tropicalis (tropical clawed frog)	bmp3	XP_002934044.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of Osr2 Transcriptional Target Genes in Palate Development.
Fu X, Xu J, Chaturvedi P, Liu H, Jiang R, Lan Y
Journal of dental research96(12)1451-1458(2017 Nov)

Deletion of the sclerotome-enriched lncRNA PEAT augments ribosomal protein expression.
Stafford DA, Dichmann DS, Chang JK, Harland RM
Proceedings of the National Academy of Sciences of the United States of America114(1)101-106(2017 Jan)

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.
Bibollet-Bahena O, Okafuji T, Hokamp K, Tear G, Mitchell KJ
PloS one12(5)e0177977(2017)

Inflammation in arthritis induces expression of BMP3, an inhibitor of bone formation.
Matzelle MM, Shaw AT, Baum R, Maeda Y, Li J, Karmakar S, Manning CA, Walsh NC, Rosen V, Gravallese EM
Scandinavian journal of rheumatology45(5)379-83(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In two murine models of rheumatoid arthritis, BMP3 mRNA and protein are highly expressed by osteoblasts lining inflammation-bone interfaces late in the course of arthritis.
Title: Inflammation in arthritis induces expression of BMP3, an inhibitor of bone formation.

the Bmp3/Wisp1 signaling pathway play a key role in mesenchymal stem cell proliferation, and consequently adipogenesis.
Title: Wisp1 mediates Bmp3-stimulated mesenchymal stem cell proliferation.

This region may preserve common cis-regulatory elements that govern Bmp3 expression across eutherian mammals.
Title: Comparative genomics identifies the mouse Bmp3 promoter and an upstream evolutionary conserved region (ECR) in mammals.

findings best fit a model in which BMP3, produced by mature bone cells, acts to reduce BMP signaling through Acvr2b in skeletal progenitor cells, limiting their differentiation to mature osteoblasts
Title: BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b.

Data suggest that BMP3 exerts its effects in the skeleton by altering signaling through ActRIIB in chondrocytes and the periosteum, and this results in defects in bone collar formation and late hypertrophic chondrocyte maturation.
Title: Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fractures.

The following Bmp3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bmp3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu04576	NM_173404.5 Latest version!	Mus musculus bone morphogenetic protein 3 (Bmp3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OMu72324	NM_001310677.2 Latest version!	Mus musculus bone morphogenetic protein 3 (Bmp3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OMu04576	NM_173404.4	Mus musculus bone morphogenetic protein 3 (Bmp3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bmp3 ( NM_173404.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_775580.1 Mus musculus bone morphogenetic protein 3 (Bmp3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu04576
Clone ID Related Accession (Same CDS sequence)	NM_173404.4 , NM_173404.5
Accession Version	NM_173404.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1407bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-07-16
Organism	Mus musculus(House mouse)
Product	bone morphogenetic protein 3 isoform 2 precursor
Comment

ATGGCCGGGG CGCGCGGGCT GCTCTGTCTA TGGCTAGGTT ACTTCTGCCT GAACCTGGCA 
CAGGGACAGA GACCAAACTT GCACCTCCCG GGACTCCGTG AGACTGAGCC AAGCGACCGC 
GCGACAGGTG GTAGCCCGAG TCCGGACCTG AGGCCGCACG ACAAGGTGTC GGAGCATATG 
CTGTGGCTCT ATGACAGGTA CAGCGGCAGC AGTAGAGTCC AGGCTACCCG GACACCGGGC 
TCGCAGCTCC CGGGTCCTCA GCCCCTGCGC GGTGGTAACA CGGTCCGCAG CTTCAGAGCC 
GCAGCCGCAG GAACTCCTCA AACGAAGGGG TTACACACCT TCAATCTGAC TTCTCTAACC 
AAGTCGGAGA ACATTTTGTC AGCCACACTG TATTTCTACG TTGGAGAATT AGTGAACATC 
AGCTTGAGCT GTCCAGAACC CCAAGGATGC TCCCATCACA CTCAGAGACA ACACATCCAG 
ATAGACCTCT CTGCATGGAT CCTCAAATCC AACCAAAGCC AGCTCTTGGG TCATCTGTCT 
GTAGATGTGG TCAGACCTTA TAGAGACAGC GTGTCTTGGC TGTCAAAAGA CATCACTCAG 
CTCTTAAGAA AGGCCAAGCA AAATGAAGAG TTTCTCATAG GGTTTAACAT TACCTCCAGA 
GCACACGAGC TACCCAAGAG GATGCTGTTT TTCCCGGAAC CTTATATCTT GGTATACGCC 
AACGATGCTG CCATTTCTGA GCCAGAAAGC GTGGTATCCA GCTTACAGAG ACACCGAGAT 
TTCACAGCGG GAACTGGGCC CAGACTGGAT AGCCACGTCA GAGAAGCCCT CTCGGTTGAG 
AGGAGGAAGA AGCGCTCTAC TGGGATCTTG CTGCCCTTGC AGAACAATGA GCTACCTGGG 
GCAGAGTATC AGTACAAGGA GGAGGGAGCG TGGGAGGAGA GAAAGCCTTA TAAGAGCCTT 
CAGACTCAGC CCCCTGAGAA GAGTAGGAAC AAAAAGAAAC AGAGGAAAGG GTCCCATCAG 
AAGGGACAGA CGCTGCAATT TGATGAGCAG ACCCTGAAGA AGGCAAGGCG AAAGCAGTGG 
GTCGAACCTC GGAACTGTGC CAGGAGGTAC CTTAAAGTGG ACTTTGCTGA TATCGGCTGG 
AGCGAATGGA TTATCTCTCC CAAGTCATTT GATGCTTTCT ACTGCTCTGG AGCCTGCCAG 
TTCCCCATGC CAAAGTCTTT GAAACCATCA AATCACGCCA CCATCCAGAG CATAGTGCGA 
GCGGTGGGGG TCGTCTCCGG GATTCCCGAG CCTTGCTGTG TGCCGGAAAA GATGTCCTCA 
CTCAGCATCT TGTTCTTTGA TGAAAACAAG AATGTAGTGC TCAAAGTCTA CCCTAACATG 
ACAGTCGACT CCTGTGCTTG TAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_775580.1

Translation

MAGARGLLCLWLGYFCLNLAQGQRPNLHLPGLRETEPSDRATGGSPSPDLRPHDKVSEHMLWLYDRYSGSSRVQATRTPGSQLPGPQPLRGGNTVRSFRAAAAGTPQTKGLHTFNLTSLTKSENILSATLYFYVGELVNISLSCPEPQGCSHHTQRQHIQIDLSAWILKSNQSQLLGHLSVDVVRPYRDSVSWLSKDITQLLRKAKQNEEFLIGFNITSRAHELPKRMLFFPEPYILVYANDAAISEPESVVSSLQRHRDFTAGTGPRLDSHVREALSVERRKKRSTGILLPLQNNELPGAEYQYKEEGAWEERKPYKSLQTQPPEKSRNKKKQRKGSHQKGQTLQFDEQTLKKARRKQWVEPRNCARRYLKVDFADIGWSEWIISPKSFDAFYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVSGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVDSCACR

Target ORF information:

RefSeq Version	NM_173404.4
Organism	Mus musculus(House mouse)
Definition	Mus musculus bone morphogenetic protein 3 (Bmp3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173404.4

ORF Insert Sequence:

ATGGCCGGGG CGCGCGGGCT GCTCTGTCTA TGGCTAGGTT ACTTCTGCCT GAACCTGGCA 
CAGGGACAGA GACCAAACTT GCACCTCCCG GGACTCCGTG AGACTGAGCC AAGCGACCGC 
GCGACAGGTG GTAGCCCGAG TCCGGACCTG AGGCCGCACG ACAAGGTGTC GGAGCATATG 
CTGTGGCTCT ATGACAGGTA CAGCGGCAGC AGTAGAGTCC AGGCTACCCG GACACCGGGC 
TCGCAGCTCC CGGGTCCTCA GCCCCTGCGC GGTGGTAACA CGGTCCGCAG CTTCAGAGCC 
GCAGCCGCAG GAACTCCTCA AACGAAGGGG TTACACACCT TCAATCTGAC TTCTCTAACC 
AAGTCGGAGA ACATTTTGTC AGCCACACTG TATTTCTACG TTGGAGAATT AGTGAACATC 
AGCTTGAGCT GTCCAGAACC CCAAGGATGC TCCCATCACA CTCAGAGACA ACACATCCAG 
ATAGACCTCT CTGCATGGAT CCTCAAATCC AACCAAAGCC AGCTCTTGGG TCATCTGTCT 
GTAGATGTGG TCAGACCTTA TAGAGACAGC GTGTCTTGGC TGTCAAAAGA CATCACTCAG 
CTCTTAAGAA AGGCCAAGCA AAATGAAGAG TTTCTCATAG GGTTTAACAT TACCTCCAGA 
GCACACGAGC TACCCAAGAG GATGCTGTTT TTCCCGGAAC CTTATATCTT GGTATACGCC 
AACGATGCTG CCATTTCTGA GCCAGAAAGC GTGGTATCCA GCTTACAGAG ACACCGAGAT 
TTCACAGCGG GAACTGGGCC CAGACTGGAT AGCCACGTCA GAGAAGCCCT CTCGGTTGAG 
AGGAGGAAGA AGCGCTCTAC TGGGATCTTG CTGCCCTTGC AGAACAATGA GCTACCTGGG 
GCAGAGTATC AGTACAAGGA GGAGGGAGCG TGGGAGGAGA GAAAGCCTTA TAAGAGCCTT 
CAGACTCAGC CCCCTGAGAA GAGTAGGAAC AAAAAGAAAC AGAGGAAAGG GTCCCATCAG 
AAGGGACAGA CGCTGCAATT TGATGAGCAG ACCCTGAAGA AGGCAAGGCG AAAGCAGTGG 
GTCGAACCTC GGAACTGTGC CAGGAGGTAC CTTAAAGTGG ACTTTGCTGA TATCGGCTGG 
AGCGAATGGA TTATCTCTCC CAAGTCATTT GATGCTTTCT ACTGCTCTGG AGCCTGCCAG 
TTCCCCATGC CAAAGTCTTT GAAACCATCA AATCACGCCA CCATCCAGAG CATAGTGCGA 
GCGGTGGGGG TCGTCTCCGG GATTCCCGAG CCTTGCTGTG TGCCGGAAAA GATGTCCTCA 
CTCAGCATCT TGTTCTTTGA TGAAAACAAG AATGTAGTGC TCAAAGTCTA CCCTAACATG 
ACAGTCGACT CCTGTGCTTG TAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bmp3 ( NM_173404.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_775580.1 Mus musculus bone morphogenetic protein 3 (Bmp3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu04576
Clone ID Related Accession (Same CDS sequence)	NM_173404.4 , NM_173404.5
Accession Version	NM_173404.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1407bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Mus musculus(house mouse)
Product	bone morphogenetic protein 3 isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK035299.1, AK040389.1 and AC141896.5. On Oct 17, 2015 this sequence version replaced NM_173404.4. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct, shorter C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK040389.1, AK037225.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGGGG CGCGCGGGCT GCTCTGTCTA TGGCTAGGTT ACTTCTGCCT GAACCTGGCA 
CAGGGACAGA GACCAAACTT GCACCTCCCG GGACTCCGTG AGACTGAGCC AAGCGACCGC 
GCGACAGGTG GTAGCCCGAG TCCGGACCTG AGGCCGCACG ACAAGGTGTC GGAGCATATG 
CTGTGGCTCT ATGACAGGTA CAGCGGCAGC AGTAGAGTCC AGGCTACCCG GACACCGGGC 
TCGCAGCTCC CGGGTCCTCA GCCCCTGCGC GGTGGTAACA CGGTCCGCAG CTTCAGAGCC 
GCAGCCGCAG GAACTCCTCA AACGAAGGGG TTACACACCT TCAATCTGAC TTCTCTAACC 
AAGTCGGAGA ACATTTTGTC AGCCACACTG TATTTCTACG TTGGAGAATT AGTGAACATC 
AGCTTGAGCT GTCCAGAACC CCAAGGATGC TCCCATCACA CTCAGAGACA ACACATCCAG 
ATAGACCTCT CTGCATGGAT CCTCAAATCC AACCAAAGCC AGCTCTTGGG TCATCTGTCT 
GTAGATGTGG TCAGACCTTA TAGAGACAGC GTGTCTTGGC TGTCAAAAGA CATCACTCAG 
CTCTTAAGAA AGGCCAAGCA AAATGAAGAG TTTCTCATAG GGTTTAACAT TACCTCCAGA 
GCACACGAGC TACCCAAGAG GATGCTGTTT TTCCCGGAAC CTTATATCTT GGTATACGCC 
AACGATGCTG CCATTTCTGA GCCAGAAAGC GTGGTATCCA GCTTACAGAG ACACCGAGAT 
TTCACAGCGG GAACTGGGCC CAGACTGGAT AGCCACGTCA GAGAAGCCCT CTCGGTTGAG 
AGGAGGAAGA AGCGCTCTAC TGGGATCTTG CTGCCCTTGC AGAACAATGA GCTACCTGGG 
GCAGAGTATC AGTACAAGGA GGAGGGAGCG TGGGAGGAGA GAAAGCCTTA TAAGAGCCTT 
CAGACTCAGC CCCCTGAGAA GAGTAGGAAC AAAAAGAAAC AGAGGAAAGG GTCCCATCAG 
AAGGGACAGA CGCTGCAATT TGATGAGCAG ACCCTGAAGA AGGCAAGGCG AAAGCAGTGG 
GTCGAACCTC GGAACTGTGC CAGGAGGTAC CTTAAAGTGG ACTTTGCTGA TATCGGCTGG 
AGCGAATGGA TTATCTCTCC CAAGTCATTT GATGCTTTCT ACTGCTCTGG AGCCTGCCAG 
TTCCCCATGC CAAAGTCTTT GAAACCATCA AATCACGCCA CCATCCAGAG CATAGTGCGA 
GCGGTGGGGG TCGTCTCCGG GATTCCCGAG CCTTGCTGTG TGCCGGAAAA GATGTCCTCA 
CTCAGCATCT TGTTCTTTGA TGAAAACAAG AATGTAGTGC TCAAAGTCTA CCCTAACATG 
ACAGTCGACT CCTGTGCTTG TAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775580.1
CDS	699..2105
Translation	MAGARGLLCLWLGYFCLNLAQGQRPNLHLPGLRETEPSDRATGGSPSPDLRPHDKVSEHMLWLYDRYSGSSRVQATRTPGSQLPGPQPLRGGNTVRSFRAAAAGTPQTKGLHTFNLTSLTKSENILSATLYFYVGELVNISLSCPEPQGCSHHTQRQHIQIDLSAWILKSNQSQLLGHLSVDVVRPYRDSVSWLSKDITQLLRKAKQNEEFLIGFNITSRAHELPKRMLFFPEPYILVYANDAAISEPESVVSSLQRHRDFTAGTGPRLDSHVREALSVERRKKRSTGILLPLQNNELPGAEYQYKEEGAWEERKPYKSLQTQPPEKSRNKKKQRKGSHQKGQTLQFDEQTLKKARRKQWVEPRNCARRYLKVDFADIGWSEWIISPKSFDAFYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVSGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVDSCACR

Target ORF information:

RefSeq Version	NM_173404.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus bone morphogenetic protein 3 (Bmp3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173404.5

ORF Insert Sequence:

ATGGCCGGGG CGCGCGGGCT GCTCTGTCTA TGGCTAGGTT ACTTCTGCCT GAACCTGGCA 
CAGGGACAGA GACCAAACTT GCACCTCCCG GGACTCCGTG AGACTGAGCC AAGCGACCGC 
GCGACAGGTG GTAGCCCGAG TCCGGACCTG AGGCCGCACG ACAAGGTGTC GGAGCATATG 
CTGTGGCTCT ATGACAGGTA CAGCGGCAGC AGTAGAGTCC AGGCTACCCG GACACCGGGC 
TCGCAGCTCC CGGGTCCTCA GCCCCTGCGC GGTGGTAACA CGGTCCGCAG CTTCAGAGCC 
GCAGCCGCAG GAACTCCTCA AACGAAGGGG TTACACACCT TCAATCTGAC TTCTCTAACC 
AAGTCGGAGA ACATTTTGTC AGCCACACTG TATTTCTACG TTGGAGAATT AGTGAACATC 
AGCTTGAGCT GTCCAGAACC CCAAGGATGC TCCCATCACA CTCAGAGACA ACACATCCAG 
ATAGACCTCT CTGCATGGAT CCTCAAATCC AACCAAAGCC AGCTCTTGGG TCATCTGTCT 
GTAGATGTGG TCAGACCTTA TAGAGACAGC GTGTCTTGGC TGTCAAAAGA CATCACTCAG 
CTCTTAAGAA AGGCCAAGCA AAATGAAGAG TTTCTCATAG GGTTTAACAT TACCTCCAGA 
GCACACGAGC TACCCAAGAG GATGCTGTTT TTCCCGGAAC CTTATATCTT GGTATACGCC 
AACGATGCTG CCATTTCTGA GCCAGAAAGC GTGGTATCCA GCTTACAGAG ACACCGAGAT 
TTCACAGCGG GAACTGGGCC CAGACTGGAT AGCCACGTCA GAGAAGCCCT CTCGGTTGAG 
AGGAGGAAGA AGCGCTCTAC TGGGATCTTG CTGCCCTTGC AGAACAATGA GCTACCTGGG 
GCAGAGTATC AGTACAAGGA GGAGGGAGCG TGGGAGGAGA GAAAGCCTTA TAAGAGCCTT 
CAGACTCAGC CCCCTGAGAA GAGTAGGAAC AAAAAGAAAC AGAGGAAAGG GTCCCATCAG 
AAGGGACAGA CGCTGCAATT TGATGAGCAG ACCCTGAAGA AGGCAAGGCG AAAGCAGTGG 
GTCGAACCTC GGAACTGTGC CAGGAGGTAC CTTAAAGTGG ACTTTGCTGA TATCGGCTGG 
AGCGAATGGA TTATCTCTCC CAAGTCATTT GATGCTTTCT ACTGCTCTGG AGCCTGCCAG 
TTCCCCATGC CAAAGTCTTT GAAACCATCA AATCACGCCA CCATCCAGAG CATAGTGCGA 
GCGGTGGGGG TCGTCTCCGG GATTCCCGAG CCTTGCTGTG TGCCGGAAAA GATGTCCTCA 
CTCAGCATCT TGTTCTTTGA TGAAAACAAG AATGTAGTGC TCAAAGTCTA CCCTAACATG 
ACAGTCGACT CCTGTGCTTG TAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bmp3 ( NM_001310677.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001297606.1 Mus musculus bone morphogenetic protein 3 (Bmp3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu72324
Clone ID Related Accession (Same CDS sequence)	NM_001310677.2
Accession Version	NM_001310677.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1413bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	bone morphogenetic protein 3 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK035299.1, AK035393.1 and AC141896.5. On Oct 17, 2015 this sequence version replaced NM_001310677.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK035393.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGGGG CGCGCGGGCT GCTCTGTCTA TGGCTAGGTT ACTTCTGCCT GAACCTGGCA 
CAGGGACAGA GACCAAACTT GCACCTCCCG GGACTCCGTG AGACTGAGCC AAGCGACCGC 
GCGACAGGTG GTAGCCCGAG TCCGGACCTG AGGCCGCACG ACAAGGTGTC GGAGCATATG 
CTGTGGCTCT ATGACAGGTA CAGCGGCAGC AGTAGAGTCC AGGCTACCCG GACACCGGGC 
TCGCAGCTCC CGGGTCCTCA GCCCCTGCGC GGTGGTAACA CGGTCCGCAG CTTCAGAGCC 
GCAGCCGCAG GAACTCCTCA AACGAAGGGG TTACACACCT TCAATCTGAC TTCTCTAACC 
AAGTCGGAGA ACATTTTGTC AGCCACACTG TATTTCTACG TTGGAGAATT AGTGAACATC 
AGCTTGAGCT GTCCAGAACC CCAAGGATGC TCCCATCACA CTCAGAGACA ACACATCCAG 
ATAGACCTCT CTGCATGGAT CCTCAAATCC AACCAAAGCC AGCTCTTGGG TCATCTGTCT 
GTAGATGTGG TCAGACCTTA TAGAGACAGC GTGTCTTGGC TGTCAAAAGA CATCACTCAG 
CTCTTAAGAA AGGCCAAGCA AAATGAAGAG TTTCTCATAG GGTTTAACAT TACCTCCAGA 
GCACACGAGC TACCCAAGAG GATGCTGTTT TTCCCGGAAC CTTATATCTT GGTATACGCC 
AACGATGCTG CCATTTCTGA GCCAGAAAGC GTGGTATCCA GCTTACAGAG ACACCGAGAT 
TTCACAGCGG GAACTGGGCC CAGACTGGAT AGCCACGTCA GAGAAGCCCT CTCGGTTGAG 
AGGAGGAAGA AGCGCTCTAC TGGGATCTTG CTGCCCTTGC AGAACAATGA GCTACCTGGG 
GCAGAGTATC AGTACAAGGA GGAGGGAGCG TGGGAGGAGA GAAAGCCTTA TAAGAGCCTT 
CAGACTCAGC CCCCTGAGAA GAGTAGGAAC AAAAAGAAAC AGAGGAAAGG GTCCCATCAG 
AAGGGACAGA CGCTGCAATT TGATGAGCAG ACCCTGAAGA AGGCAAGGCG AAAGCAGTGG 
GTCGAACCTC GGAACTGTGC CAGGAGGTAC CTTAAAGTGG ACTTTGCTGA TATCGGCTGG 
AGCGAATGGA TTATCTCTCC CAAGTCATTT GATGCTTTCT ACTGCTCTGG AGCCTGCCAG 
TTCCCCATGC CAAAGGTAGC CGCCGCCGCC GCCGCCCTTC ACCTTGTGCT CATTTCATTT 
TTGCACGGGG TAGAGGAGTA TGCTAAGTTC TTTGAAACCA TCAAATCACG CCACCATCCA 
GAGCATAGTG CGAGCGGTGG GGGTCGTCTC CGGGATTCCC GAGCCTTGCT GTGTGCCGGA 
AAAGATGTCC TCACTCAGCA TCTTGTTCTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001297606.1
CDS	699..2111
Translation	MAGARGLLCLWLGYFCLNLAQGQRPNLHLPGLRETEPSDRATGGSPSPDLRPHDKVSEHMLWLYDRYSGSSRVQATRTPGSQLPGPQPLRGGNTVRSFRAAAAGTPQTKGLHTFNLTSLTKSENILSATLYFYVGELVNISLSCPEPQGCSHHTQRQHIQIDLSAWILKSNQSQLLGHLSVDVVRPYRDSVSWLSKDITQLLRKAKQNEEFLIGFNITSRAHELPKRMLFFPEPYILVYANDAAISEPESVVSSLQRHRDFTAGTGPRLDSHVREALSVERRKKRSTGILLPLQNNELPGAEYQYKEEGAWEERKPYKSLQTQPPEKSRNKKKQRKGSHQKGQTLQFDEQTLKKARRKQWVEPRNCARRYLKVDFADIGWSEWIISPKSFDAFYCSGACQFPMPKVAAAAAALHLVLISFLHGVEEYAKFFETIKSRHHPEHSASGGGRLRDSRALLCAGKDVLTQHLVL

Target ORF information:

RefSeq Version	NM_001310677.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus bone morphogenetic protein 3 (Bmp3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001310677.2

ORF Insert Sequence:

ATGGCCGGGG CGCGCGGGCT GCTCTGTCTA TGGCTAGGTT ACTTCTGCCT GAACCTGGCA 
CAGGGACAGA GACCAAACTT GCACCTCCCG GGACTCCGTG AGACTGAGCC AAGCGACCGC 
GCGACAGGTG GTAGCCCGAG TCCGGACCTG AGGCCGCACG ACAAGGTGTC GGAGCATATG 
CTGTGGCTCT ATGACAGGTA CAGCGGCAGC AGTAGAGTCC AGGCTACCCG GACACCGGGC 
TCGCAGCTCC CGGGTCCTCA GCCCCTGCGC GGTGGTAACA CGGTCCGCAG CTTCAGAGCC 
GCAGCCGCAG GAACTCCTCA AACGAAGGGG TTACACACCT TCAATCTGAC TTCTCTAACC 
AAGTCGGAGA ACATTTTGTC AGCCACACTG TATTTCTACG TTGGAGAATT AGTGAACATC 
AGCTTGAGCT GTCCAGAACC CCAAGGATGC TCCCATCACA CTCAGAGACA ACACATCCAG 
ATAGACCTCT CTGCATGGAT CCTCAAATCC AACCAAAGCC AGCTCTTGGG TCATCTGTCT 
GTAGATGTGG TCAGACCTTA TAGAGACAGC GTGTCTTGGC TGTCAAAAGA CATCACTCAG 
CTCTTAAGAA AGGCCAAGCA AAATGAAGAG TTTCTCATAG GGTTTAACAT TACCTCCAGA 
GCACACGAGC TACCCAAGAG GATGCTGTTT TTCCCGGAAC CTTATATCTT GGTATACGCC 
AACGATGCTG CCATTTCTGA GCCAGAAAGC GTGGTATCCA GCTTACAGAG ACACCGAGAT 
TTCACAGCGG GAACTGGGCC CAGACTGGAT AGCCACGTCA GAGAAGCCCT CTCGGTTGAG 
AGGAGGAAGA AGCGCTCTAC TGGGATCTTG CTGCCCTTGC AGAACAATGA GCTACCTGGG 
GCAGAGTATC AGTACAAGGA GGAGGGAGCG TGGGAGGAGA GAAAGCCTTA TAAGAGCCTT 
CAGACTCAGC CCCCTGAGAA GAGTAGGAAC AAAAAGAAAC AGAGGAAAGG GTCCCATCAG 
AAGGGACAGA CGCTGCAATT TGATGAGCAG ACCCTGAAGA AGGCAAGGCG AAAGCAGTGG 
GTCGAACCTC GGAACTGTGC CAGGAGGTAC CTTAAAGTGG ACTTTGCTGA TATCGGCTGG 
AGCGAATGGA TTATCTCTCC CAAGTCATTT GATGCTTTCT ACTGCTCTGG AGCCTGCCAG 
TTCCCCATGC CAAAGGTAGC CGCCGCCGCC GCCGCCCTTC ACCTTGTGCT CATTTCATTT 
TTGCACGGGG TAGAGGAGTA TGCTAAGTTC TTTGAAACCA TCAAATCACG CCACCATCCA 
GAGCATAGTG CGAGCGGTGG GGGTCGTCTC CGGGATTCCC GAGCCTTGCT GTGTGCCGGA 
AAAGATGTCC TCACTCAGCA TCTTGTTCTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of Osr2 Transcriptional Target Genes in Palate Development.
Journal of dental research96(12)1451-1458(2017 Nov)
Fu X,Xu J,Chaturvedi P,Liu H,Jiang R,Lan Y

Deletion of the sclerotome-enriched lncRNA PEAT augments ribosomal protein expression.
Proceedings of the National Academy of Sciences of the United States of America114(1)101-106(2017 Jan)
Stafford DA,Dichmann DS,Chang JK,Harland RM

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.
PloS one12(5)e0177977(2017)
Bibollet-Bahena O,Okafuji T,Hokamp K,Tear G,Mitchell KJ

Inflammation in arthritis induces expression of BMP3, an inhibitor of bone formation.
Scandinavian journal of rheumatology45(5)379-83(2016 Oct)
Matzelle MM,Shaw AT,Baum R,Maeda Y,Li J,Karmakar S,Manning CA,Walsh NC,Rosen V,Gravallese EM

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Bmp3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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