Clps cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Clps
Entrez Gene ID	109791
Full Name	colipase, pancreatic
Synonyms	2200003J09Rik
General protein information	Preferred Names colipase, pancreatic Names colipase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 A3.3
Summary	This gene encodes a member of the colipase family of coenzymes that is required for the optimal activity of pancreatic lipase. The encoded protein undergoes proteolytic processing to generate a mature polypeptide that binds to the lipase and prevents inhibition by bile acids. Over half of the mice lacking the encoded protein die within two weeks of birth while the remaining ones exhibit fat malabsorption and altered body weight regulation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001317065.1	NP_001303994.1	colipase isoform 2 precursor
NM_025469.3	NP_079745.1	colipase isoform 1 preproprotein

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Clps	NP_037271.1
	CLPS	XP_001116700.1
Canis lupus familiaris (dog)	CLPS	NP_001003287.1
Mus musculus (house mouse)	Clps	NP_079745.1
Gallus gallus (chicken)	CLPS	NP_001138963.1
Homo sapiens (human)	CLPS	NP_001823.1
Pan troglodytes (chimpanzee)	CLPS	XP_527612.1
Bos taurus (cattle)	CLPS	NP_001071435.1
Xenopus tropicalis (tropical clawed frog)	clps	NP_001107327.1

Gene Ontology
Bibliography

Related articles in PubMed

Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice.
Chang I, Bramall AN, Baynash AG, Rattner A, Rakheja D, Post M, Joza S, McKerlie C, Stewart DJ, McInnes RR, Yanagisawa M
The Journal of clinical investigation123(6)2643-53(2013 Jun)

Impact of lactobacilli on orally acquired listeriosis.
Archambaud C, Nahori MA, Soubigou G, B?cavin C, Laval L, Lechat P, Smokvina T, Langella P, Lecuit M, Cossart P
Proceedings of the National Academy of Sciences of the United States of America109(41)16684-9(2012 Oct)

The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver.
Pang W, Zhang Y, Wang S, Jia A, Dong W, Cai C, Hua Z, Zhang J
Journal of lipid research52(5)934-41(2011 May)

Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice.
Miller R, D'Agostino D, Erlanson-Albertsson C, Lowe ME
American journal of physiology. Endocrinology and metabolism297(4)E856-65(2009 Oct)

Identification of transcripts with enriched expression in the developing and adult pancreas.
Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD
Genome biology9(6)R99(2008)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that the conditional expression of mPlrp2 and mClps is involved in the hydrolysis of retinyl esters in the mouse liver.
Title: The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver.

colipase (-/-)mice develop diet-induced obesity, as do colipase (+/+) mice, and have normal responses to a two-macronutrient choice diet and to a switch from a high-fat to a low-fat diet
Title: Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice.

We conclude that, in addition to its critical role in fat digestion, procolipase has essential functions in postnatal development and in regulating body weight set point.
Title: Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice.

The following Clps gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clps cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00541	NM_025469.3 Latest version!	Mus musculus colipase, pancreatic (Clps), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu83427	NM_001317065.1 Latest version!	Mus musculus colipase, pancreatic (Clps), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Clps ( NM_025469.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_079745.1 Mus musculus colipase, pancreatic (Clps), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu00541
Clone ID Related Accession (Same CDS sequence)	NM_025469.3
Accession Version	NM_025469.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	colipase isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ126290.1, AK008815.1 and BM570078.1. On Nov 11, 2015 this sequence version replaced NM_025469.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ128832.1, BQ128542.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAGG TCCTTGTTCT TCTGCTTGTG TCCCTCCTTG CAGTGGCCTA TGCAGCTCCC 
GGACCCCGGG GTCTTATTAT CAACCTGGAG GACGGTGAGA TCTGTTTGAA CAGTATGCAG 
TGTAAGAGCA GATGCTGCCA ACATGACACC ATCCTGGGCA TTGCCCGTTG CACACACAAG 
GCCATGGAGA ACAGCGAGTG CTCCCCAAAG ACCCTCTATG GGATCTACTA CCGGTGTCCC 
TGTGAGCGGG GCCTGACCTG TGAGGGGGAC AGGAGCATCA TCGGCGCCAT CACCAACACC 
AACTATGGCA TCTGCCTCGA CTCCAGGCGC TCCAAGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079745.1
CDS	110..451
Translation	MEKVLVLLLVSLLAVAYAAPGPRGLIINLEDGEICLNSMQCKSRCCQHDTILGIARCTHKAMENSECSPKTLYGIYYRCPCERGLTCEGDRSIIGAITNTNYGICLDSRRSKQ

Target ORF information:

RefSeq Version	NM_025469.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus colipase, pancreatic (Clps), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025469.3

ORF Insert Sequence:

ATGGAGAAGG TCCTTGTTCT TCTGCTTGTG TCCCTCCTTG CAGTGGCCTA TGCAGCTCCC 
GGACCCCGGG GTCTTATTAT CAACCTGGAG GACGGTGAGA TCTGTTTGAA CAGTATGCAG 
TGTAAGAGCA GATGCTGCCA ACATGACACC ATCCTGGGCA TTGCCCGTTG CACACACAAG 
GCCATGGAGA ACAGCGAGTG CTCCCCAAAG ACCCTCTATG GGATCTACTA CCGGTGTCCC 
TGTGAGCGGG GCCTGACCTG TGAGGGGGAC AGGAGCATCA TCGGCGCCAT CACCAACACC 
AACTATGGCA TCTGCCTCGA CTCCAGGCGC TCCAAGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Clps ( NM_001317065.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001303994.1 Mus musculus colipase, pancreatic (Clps), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu83427
Clone ID Related Accession (Same CDS sequence)	NM_001317065.1
Accession Version	NM_001317065.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 219bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	colipase isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ126290.1, AK008815.1 and BM570078.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF577909.1, BG879326.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAGG TCCTTGTTCT TCTGCTTGTG TCCCTCCTTG CAGTGGCCTA TGCAGCTCCC 
GGACCCCGGG GTCTTATTAT CAACCTGACC CTCTATGGGA TCTACTACCG GTGTCCCTGT 
GAGCGGGGCC TGACCTGTGA GGGGGACAGG AGCATCATCG GCGCCATCAC CAACACCAAC 
TATGGCATCT GCCTCGACTC CAGGCGCTCC AAGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001303994.1
CDS	110..328
Translation	MEKVLVLLLVSLLAVAYAAPGPRGLIINLTLYGIYYRCPCERGLTCEGDRSIIGAITNTNYGICLDSRRSKQ

Target ORF information:

RefSeq Version	NM_001317065.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus colipase, pancreatic (Clps), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317065.1

ORF Insert Sequence:

ATGGAGAAGG TCCTTGTTCT TCTGCTTGTG TCCCTCCTTG CAGTGGCCTA TGCAGCTCCC 
GGACCCCGGG GTCTTATTAT CAACCTGACC CTCTATGGGA TCTACTACCG GTGTCCCTGT 
GAGCGGGGCC TGACCTGTGA GGGGGACAGG AGCATCATCG GCGCCATCAC CAACACCAAC 
TATGGCATCT GCCTCGACTC CAGGCGCTCC AAGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice.
The Journal of clinical investigation123(6)2643-53(2013 Jun)
Chang I,Bramall AN,Baynash AG,Rattner A,Rakheja D,Post M,Joza S,McKerlie C,Stewart DJ,McInnes RR,Yanagisawa M

Impact of lactobacilli on orally acquired listeriosis.
Proceedings of the National Academy of Sciences of the United States of America109(41)16684-9(2012 Oct)
Archambaud C,Nahori MA,Soubigou G,B?cavin C,Laval L,Lechat P,Smokvina T,Langella P,Lecuit M,Cossart P

The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver.
Journal of lipid research52(5)934-41(2011 May)
Pang W,Zhang Y,Wang S,Jia A,Dong W,Cai C,Hua Z,Zhang J

Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice.
American journal of physiology. Endocrinology and metabolism297(4)E856-65(2009 Oct)
Miller R,D'Agostino D,Erlanson-Albertsson C,Lowe ME

Identification of transcripts with enriched expression in the developing and adult pancreas.
Genome biology9(6)R99(2008)
Hoffman BG,Zavaglia B,Witzsche J,Ruiz de Algara T,Beach M,Hoodless PA,Jones SJ,Marra MA,Helgason CD

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Clps cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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