Maob cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Maob
Entrez Gene ID	109731
Full Name	monoamine oxidase B
Synonyms	6330414K01Rik,MAO-B
General protein information	Preferred Names monoamine oxidase B Names amine oxidase [flavin-containing] B monoamine oxidase type B
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X A1.2\|X 11.88 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_172778.2	NP_766366.2	amine oxidase [flavin-containing] B

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	mao	NP_997992.2
Neurospora crassa	NCU05933	XP_958128.1
	MAOB	XP_002806250.1
Canis lupus familiaris (dog)	MAOB	NP_001002970.1
Gallus gallus (chicken)	MAOB	XP_416766.2
Magnaporthe oryzae (rice blast fungus)	MGG_16538	XP_003711032.1
Homo sapiens (human)	MAOB	NP_000889.3
Pan troglodytes (chimpanzee)	MAOB	XP_003317481.1
Bos taurus (cattle)	MAOB	NP_808813.2
Rattus norvegicus (Norway rat)	Maob	NP_037330.1
Mus musculus (house mouse)	Maob	NP_766366.2
Xenopus tropicalis (tropical clawed frog)	LOC100494267	XP_002932838.1

Gene Ontology
Bibliography

Related articles in PubMed

Hydralazine is involved in tele-methylhistamine metabolism by inhibiting monoamine oxidase B in pregnancy-associated hypertensive mice.
Kawasaki S, Kako K, Nagashima Y, Kanou A, Ishida J, Fukamizu A
Journal of biochemistry161(2)155-158(2017 Feb)

The mouse cortico-striatal projectome.
Hintiryan H, Foster NN, Bowman I, Bay M, Song MY, Gou L, Yamashita S, Bienkowski MS, Zingg B, Zhu M, Yang XW, Shih JC, Toga AW, Dong HW
Nature neuroscience19(8)1100-14(2016 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hydralazine (Hdz) abrogated the degradation of tele-methylhistamine (tMH) catalyzed by monoamine oxidase B (MAO-B) in vitro.
Title: Hydralazine is involved in tele-methylhistamine metabolism by inhibiting monoamine oxidase B in pregnancy-associated hypertensive mice.

These findings demonstrate that regulation of monoamine levels by Mao activity in beta cells is pivotal for physiological insulin secretion and that loss of MaoB expression may contribute to the beta cell dysfunction in type 2 diabetes.
Title: Islet-specific monoamine oxidase A and B expression depends on MafA transcriptional activity and is compromised in type 2 diabetes.

Huntington disease neural cells exhibit increased Monoamine oxidase-A and Monoamine oxidases-B expression and activity
Title: Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.

Activity of monoamine oxidase B in the striatum is reduced during the presymptomatic stage, but returns to the control level during the symptomatic stage of Parkinsonism in mice.
Title: Activity of Monoamine Oxidase in the Nigrostriatal System at Presymptomatic and Early Symptomatic Stages of Parkinsonism in Mice.

chronic elevations of monoamines, because of the absence of MAO A and MAO B, cause functional alterations that are accompanied with changes in the cellular mechanisms underlying learning and memory.
Title: Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice.

The following Maob gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Maob cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15271	NM_172778.2 Latest version!	Mus musculus monoamine oxidase B (Maob), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Maob ( NM_172778.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766366.2 Mus musculus monoamine oxidase B (Maob), mRNA.

Price & Availability↑

CloneID	OMu15271
Clone ID Related Accession (Same CDS sequence)	NM_172778.2
Accession Version	NM_172778.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	amine oxidase [flavin-containing] B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY257414.1, AK054050.1, AK031833.1 and BE943751.1. On Sep 3, 2009 this sequence version replaced NM_172778.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK054050.1, AK031833.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGAGCAACA AAAGCGATGT GATCGTGGTG GGGGGCGGCA TCTCAGGTAT GGCGGCAGCC 
AAACTTCTGC ATGATTGTGG CCTCAGTGTG GTGGTTCTGG AAGCACGGGA CCGTGTAGGA 
GGCAGGACTT ACACAATTAG GAATAAAAAC GTTAAATATG TGGACCTTGG AGGATCTTAT 
GTTGGGCCAA CCCAGAATCG TATCTTACGA TTGGCCAAAG AGCTAGGATT GGAGACCTAT 
AAAGTTAATG AAGTTGAGCG GCTGATACAC TTTGTAAAGG GAAAATCATA TGCCTTCAGG 
GGCCCATTTC CACCAGTATG GAATCCTATC ACCTACCTAG ATAATAACAA CCTCTGGAGG 
ACAATGGATG AGATGGGCCA AGAGATTCCC AGTGATGCTC CATGGAAAGC ACCCCTTGCT 
GAAGAGTGGG ACTACATGAC AATGAAAGAA TTGCTAGATA AGATCTGCTG GACCAAATCT 
ACAAAGCAGA TTGCCACGCT CTTTGTGAAC CTGTGTGTAA CTGCAGAGAC CCATGAGGTC 
TCTGCACTAT GGTTCCTGTG GTATGTGAAG CAGTGTGGAG GTACAACCAG AATCATCTCA 
ACAACCAATG GAGGACAGGA GAGGAAATTT ATTGGTGGAT CTGGTCAAGT GAGTGAACGG 
ATAAAGGATA TACTTGGGGA CCGAGTGAAG CTGGAGAGGC CTGTGATCCA CATTGACCAG 
ACAGGGGAAA ATGTTATTGT GAAAACCCTA AACCATGAAA TATATGAGGC TAAATATGTG 
ATTAGTGCCA TTCCACCTGC TTTGGGCATG AAGATTCACT ATAGTCCTCC TCTGCCCATG 
CTAAGAAACC AGCTGATCTC TCGTGTGCCT TTGGGTTCAG TTATTAAATG CATGGTTTAT 
TACAAAGAGC CCTTCTGGAG GAAAAAGGAT TTCTGTGGAA CCATGGTTAT CGAAGGAGAG 
GAAGCTCCAA TTGCATACAC ATTGGATGAT ACCAAACCAG ATGGCACCTA TGCTGCTATA 
ATGGGATTTA TCCTTGCTCA CAAAGCTAGA AAACTGGTAC GTCTCACCAA AGAAGAAAGA 
CTGAGGAAAC TTTGTGAGCT ATATGCAAAA GTGCTGAACT CCCAAGAAGC TCTGCAGCCC 
GTCCATTATG AAGAGAAGAA CTGGTGTGAG GAACAGTATT CTGGGGGCTG CTACACAACC 
TACTTCCCTC CCGGCATCTT GACCCAGTAT GGAAGGGTTC TACGTCAGCC AGTGGGCAAG 
ATTTTCTTTG CAGGCACTGA AACAGCCTCA CACTGGAGCG GCTACATGGA GGGGGCTGTG 
GAGGCTGGGG AGAGAGCAGC CAGAGAGATT CTTCATGCCA TTGGGAAGAT TCCAGAAGAT 
GAAATTTGGC AGCCAGAACC AGAATCTTTG GATGTCCCTG CACGACCCAT TACCAGTACC 
TTCCTGGAGA GACACCTGCC TTCTGTACCA GGCCTGCTAA AGCTGTTTGG ATTGACCACC 
ATCTTGTCAG CAACAGCTCT TGGTTTCCTG GCCCACAAAA GGGGCCTGTT TGTACATTTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766366.2
CDS	92..1654
Translation	MSNKSDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDNNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTKSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVIVKTLNHEIYEAKYVISAIPPALGMKIHYSPPLPMLRNQLISRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGTYAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESLDVPARPITSTFLERHLPSVPGLLKLFGLTTILSATALGFLAHKRGLFVHF

Target ORF information:

RefSeq Version	NM_172778.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus monoamine oxidase B (Maob), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172778.2

ORF Insert Sequence:

ATGAGCAACA AAAGCGATGT GATCGTGGTG GGGGGCGGCA TCTCAGGTAT GGCGGCAGCC 
AAACTTCTGC ATGATTGTGG CCTCAGTGTG GTGGTTCTGG AAGCACGGGA CCGTGTAGGA 
GGCAGGACTT ACACAATTAG GAATAAAAAC GTTAAATATG TGGACCTTGG AGGATCTTAT 
GTTGGGCCAA CCCAGAATCG TATCTTACGA TTGGCCAAAG AGCTAGGATT GGAGACCTAT 
AAAGTTAATG AAGTTGAGCG GCTGATACAC TTTGTAAAGG GAAAATCATA TGCCTTCAGG 
GGCCCATTTC CACCAGTATG GAATCCTATC ACCTACCTAG ATAATAACAA CCTCTGGAGG 
ACAATGGATG AGATGGGCCA AGAGATTCCC AGTGATGCTC CATGGAAAGC ACCCCTTGCT 
GAAGAGTGGG ACTACATGAC AATGAAAGAA TTGCTAGATA AGATCTGCTG GACCAAATCT 
ACAAAGCAGA TTGCCACGCT CTTTGTGAAC CTGTGTGTAA CTGCAGAGAC CCATGAGGTC 
TCTGCACTAT GGTTCCTGTG GTATGTGAAG CAGTGTGGAG GTACAACCAG AATCATCTCA 
ACAACCAATG GAGGACAGGA GAGGAAATTT ATTGGTGGAT CTGGTCAAGT GAGTGAACGG 
ATAAAGGATA TACTTGGGGA CCGAGTGAAG CTGGAGAGGC CTGTGATCCA CATTGACCAG 
ACAGGGGAAA ATGTTATTGT GAAAACCCTA AACCATGAAA TATATGAGGC TAAATATGTG 
ATTAGTGCCA TTCCACCTGC TTTGGGCATG AAGATTCACT ATAGTCCTCC TCTGCCCATG 
CTAAGAAACC AGCTGATCTC TCGTGTGCCT TTGGGTTCAG TTATTAAATG CATGGTTTAT 
TACAAAGAGC CCTTCTGGAG GAAAAAGGAT TTCTGTGGAA CCATGGTTAT CGAAGGAGAG 
GAAGCTCCAA TTGCATACAC ATTGGATGAT ACCAAACCAG ATGGCACCTA TGCTGCTATA 
ATGGGATTTA TCCTTGCTCA CAAAGCTAGA AAACTGGTAC GTCTCACCAA AGAAGAAAGA 
CTGAGGAAAC TTTGTGAGCT ATATGCAAAA GTGCTGAACT CCCAAGAAGC TCTGCAGCCC 
GTCCATTATG AAGAGAAGAA CTGGTGTGAG GAACAGTATT CTGGGGGCTG CTACACAACC 
TACTTCCCTC CCGGCATCTT GACCCAGTAT GGAAGGGTTC TACGTCAGCC AGTGGGCAAG 
ATTTTCTTTG CAGGCACTGA AACAGCCTCA CACTGGAGCG GCTACATGGA GGGGGCTGTG 
GAGGCTGGGG AGAGAGCAGC CAGAGAGATT CTTCATGCCA TTGGGAAGAT TCCAGAAGAT 
GAAATTTGGC AGCCAGAACC AGAATCTTTG GATGTCCCTG CACGACCCAT TACCAGTACC 
TTCCTGGAGA GACACCTGCC TTCTGTACCA GGCCTGCTAA AGCTGTTTGG ATTGACCACC 
ATCTTGTCAG CAACAGCTCT TGGTTTCCTG GCCCACAAAA GGGGCCTGTT TGTACATTTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hydralazine is involved in tele-methylhistamine metabolism by inhibiting monoamine oxidase B in pregnancy-associated hypertensive mice.
Journal of biochemistry161(2)155-158(2017 Feb)
Kawasaki S,Kako K,Nagashima Y,Kanou A,Ishida J,Fukamizu A

The mouse cortico-striatal projectome.
Nature neuroscience19(8)1100-14(2016 08)
Hintiryan H,Foster NN,Bowman I,Bay M,Song MY,Gou L,Yamashita S,Bienkowski MS,Zingg B,Zhu M,Yang XW,Shih JC,Toga AW,Dong HW

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Maob cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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