Sri cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sri
Entrez Gene ID	109552
Full Name	sorcin
Synonyms	2210417O06Rik,2900070H08Rik,Sor
General protein information	Preferred Names sorcin Names sorcin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 A1\|5 3.38 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001080974.2	NP_001074443.1	sorcin isoform 1
NM_025618.3	NP_079894.2	sorcin isoform 2
XM_006503527.1	XP_006503590.1	sorcin isoform X1
XM_017320600.2	XP_017176089.1	sorcin isoform X1
XM_017320600.1	XP_017176089.1	sorcin isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SRI	XP_001164490.1
	SRI	XP_001104452.1
Bos taurus (cattle)	SRI	NP_001068818.1
Gallus gallus (chicken)	SRI	NP_001074334.1
Canis lupus familiaris (dog)	SRI	XP_532452.1
Danio rerio (zebrafish)	sri	NP_956667.1
Mus musculus (house mouse)	Sri	NP_001074443.1
Rattus norvegicus (Norway rat)	Sri	NP_001121662.1
Homo sapiens (human)	SRI	NP_003121.1
Xenopus tropicalis (tropical clawed frog)	sri	NP_001016667.1

Gene Ontology
Bibliography

Related articles in PubMed

Sorcin is involved during embryo implantation via activating VEGF/PI3K/Akt pathway in mice.
Gupta K, Sirohi VK, Kumari S, Shukla V, Manohar M, Popli P, Dwivedi A
Journal of molecular endocrinology(2017 Dec)

Sorcin ablation plus ?-adrenergic stimulation generate an arrhythmogenic substrate in mouse ventricular myocytes.
Chen X, Weber C, Farrell ET, Alvarado FJ, Zhao YT, G?mez AM, Valdivia HH
Journal of molecular and cellular cardiology114199-210(2017 Nov)

Sorcin Links Pancreatic ?-Cell Lipotoxicity to ER Ca2+ Stores.
Marmugi A, Parnis J, Chen X, Carmichael L, Hardy J, Mannan N, Marchetti P, Piemonti L, Bosco D, Johnson P, Shapiro JA, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Thorens B, Valdivia HH, Rutter GA, Leclerc I
Diabetes65(4)1009-21(2016 04)

The proximal C-terminus of ?(1C) subunits is necessary for junctional membrane targeting of cardiac L-type calcium channels.
Nakada T, Flucher BE, Kashihara T, Sheng X, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Yamada M
The Biochemical journal448(2)221-31(2012 Dec)

Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic ?-cells.
Noordeen NA, Meur G, Rutter GA, Leclerc I
Diabetes61(3)574-85(2012 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sorcin links pancreatic beta cells lipotoxicity to calcium stores and provides a target for intervention in type 2 diabetes.
Title: Sorcin Links Pancreatic ?-Cell Lipotoxicity to ER Ca2+ Stores.

Regulation of calcium signaling and cardiac contractility by miR-1 regulated sorcin expression plays a fundamental role in the maintenance of normal cardiac function and in the pathogenesis of cardiac dysfunction.
Title: miR-1 mediated suppression of Sorcin regulates myocardial contractility through modulation of Ca2+ signaling.

Interaction of calcium/calmodulin-dependent protein kinase IIdeltaC with sorcin indirectly modulates ryanodine receptor function in cardiac myocytes.
Title: Interaction of calcium/calmodulin-dependent protein kinase IIdeltaC with sorcin indirectly modulates ryanodine receptor function in cardiac myocytes.

Data further define the role of sorcin in cardiac excitation-contraction coupling and highlight its negative regulation of sarcoplasmic reticulum calcium release.
Title: Expression of a sorcin missense mutation in the heart modulates excitation-contraction coupling.

sorcin is a potent inhibitor of both spontaneous and ICa-triggered RyR activity and is kinetically capable of playing a role in terminating the positive feedback loop of Ca2+-induced Ca2+ release
Title: Sorcin inhibits calcium release and modulates excitation-contraction coupling in the heart.

The following Sri gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sri cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu34629	XM_006503527.1 Latest version!	Mus musculus sorcin (Sri), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu00774	NM_025618.3 Latest version!	Mus musculus sorcin (Sri), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu01507	NM_001080974.2 Latest version!	Mus musculus sorcin (Sri), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu34629	XM_017320600.2 Latest version!	Mus musculus sorcin (Sri), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu34629	XM_017320600.1	Mus musculus sorcin (Sri), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sri ( XM_006503527.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006503590.1 Mus musculus sorcin (Sri), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu34629
Clone ID Related Accession (Same CDS sequence)	XM_006503527.1 , XM_017320600.2 , XM_017320600.1
Accession Version	XM_006503527.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	sorcin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCGGCA CGATGGGGTT CAATGAATTC AAAGAGCTCT GGGCTGTGCT GAATGGCTGG 
AGACAACACT TCATCAGTTT CGATAGCGAT AGGAGTGGCA CCGTGGATCC CCAGGAGCTA 
CAGAAGGCCC TGACGACTAT GGGATTCAGG TTGAGCCCCC AAACTGTGAA TTCAGTTGCA 
AAGCGATACA GCACCAGCGG GAAGATCACG TTTGATGACT ACATTGCCTG CTGTGTCAAA 
CTGAGGGCTC TCACAGATAG CTTTCGCAGA CGGGATTCGG GTCAACAAGG AGTTGTGAAT 
TTCTCGTATG ATGATTTCAT CCAGTGTGTC ATGACCGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006503590.1
CDS	642..983
Translation	MSGTMGFNEFKELWAVLNGWRQHFISFDSDRSGTVDPQELQKALTTMGFRLSPQTVNSVAKRYSTSGKITFDDYIACCVKLRALTDSFRRRDSGQQGVVNFSYDDFIQCVMTV

Target ORF information:

RefSeq Version	XM_006503527.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus sorcin (Sri), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006503527.1

ORF Insert Sequence:

ATGTCCGGCA CGATGGGGTT CAATGAATTC AAAGAGCTCT GGGCTGTGCT GAATGGCTGG 
AGACAACACT TCATCAGTTT CGATAGCGAT AGGAGTGGCA CCGTGGATCC CCAGGAGCTA 
CAGAAGGCCC TGACGACTAT GGGATTCAGG TTGAGCCCCC AAACTGTGAA TTCAGTTGCA 
AAGCGATACA GCACCAGCGG GAAGATCACG TTTGATGACT ACATTGCCTG CTGTGTCAAA 
CTGAGGGCTC TCACAGATAG CTTTCGCAGA CGGGATTCGG GTCAACAAGG AGTTGTGAAT 
TTCTCGTATG ATGATTTCAT CCAGTGTGTC ATGACCGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sri ( XM_017320600.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017176089.1 Mus musculus sorcin (Sri), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu34629
Clone ID Related Accession (Same CDS sequence)	XM_006503527.1 , XM_017320600.2 , XM_017320600.1
Accession Version	XM_017320600.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	sorcin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCGGCA CGATGGGGTT CAATGAATTC AAAGAGCTCT GGGCTGTGCT GAATGGCTGG 
AGACAACACT TCATCAGTTT CGATAGCGAT AGGAGTGGCA CCGTGGATCC CCAGGAGCTA 
CAGAAGGCCC TGACGACTAT GGGATTCAGG TTGAGCCCCC AAACTGTGAA TTCAGTTGCA 
AAGCGATACA GCACCAGCGG GAAGATCACG TTTGATGACT ACATTGCCTG CTGTGTCAAA 
CTGAGGGCTC TCACAGATAG CTTTCGCAGA CGGGATTCGG GTCAACAAGG AGTTGTGAAT 
TTCTCGTATG ATGATTTCAT CCAGTGTGTC ATGACCGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017176089.1
CDS	509..850
Translation	MSGTMGFNEFKELWAVLNGWRQHFISFDSDRSGTVDPQELQKALTTMGFRLSPQTVNSVAKRYSTSGKITFDDYIACCVKLRALTDSFRRRDSGQQGVVNFSYDDFIQCVMTV

Target ORF information:

RefSeq Version	XM_017320600.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus sorcin (Sri), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017320600.1

ORF Insert Sequence:

ATGTCCGGCA CGATGGGGTT CAATGAATTC AAAGAGCTCT GGGCTGTGCT GAATGGCTGG 
AGACAACACT TCATCAGTTT CGATAGCGAT AGGAGTGGCA CCGTGGATCC CCAGGAGCTA 
CAGAAGGCCC TGACGACTAT GGGATTCAGG TTGAGCCCCC AAACTGTGAA TTCAGTTGCA 
AAGCGATACA GCACCAGCGG GAAGATCACG TTTGATGACT ACATTGCCTG CTGTGTCAAA 
CTGAGGGCTC TCACAGATAG CTTTCGCAGA CGGGATTCGG GTCAACAAGG AGTTGTGAAT 
TTCTCGTATG ATGATTTCAT CCAGTGTGTC ATGACCGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sri ( NM_025618.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_079894.2 Mus musculus sorcin (Sri), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu00774
Clone ID Related Accession (Same CDS sequence)	NM_025618.3
Accession Version	NM_025618.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Mus musculus(house mouse)
Product	sorcin isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK008783.1, AK008404.1, AK168572.1 and BQ033487.1. On Oct 22, 2013 this sequence version replaced NM_025618.2. Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK008783.1, AK008970.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGTATG GTGGGGCTCC CGGAGGGCCT GCGTTCCCTG GACAAACTCA GGATCCGCTA 
TATGGTTACT TTGCTGCTGT GGCTGGACAG GACGGACAAA TTGATGCTGA CGAATTGCAG 
AGATGCCTAA CACAGTCTGG CATTGCGGGA GGATACAAGC CTTTTAACCT GGAGACTTGT 
CGCCTTATGG TTTCAATGTT GGATAGAGAT ATGTCCGGCA CGATGGGGTT CAATGAATTC 
AAAGAGCTCT GGGCTGTGCT GAATGGCTGG AGACAACACT TCATCAGTTT CGATAGCGAT 
AGGAGTGGCA CCGTGGATCC CCAGGAGCTA CAGAAGGCCC TGACGACTAT GGGATTCAGG 
TTGAGCCCCC AAACTGTGAA TTCAGTTGCA AAGCGATACA GCACCAGCGG GAAGATCACG 
TTTGATGACT ACATTGCCTG CTGTGTCAAA CTGAGGGCTC TCACAGATAG CTTTCGCAGA 
CGGGATTCGG GTCAACAAGG AGTTGTGAAT TTCTCGTATG ATGATTTCAT CCAGTGTGTC 
ATGACCGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079894.2
CDS	133..684
Translation	MQYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDSDRSGTVDPQELQKALTTMGFRLSPQTVNSVAKRYSTSGKITFDDYIACCVKLRALTDSFRRRDSGQQGVVNFSYDDFIQCVMTV

Target ORF information:

RefSeq Version	NM_025618.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus sorcin (Sri), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025618.3

ORF Insert Sequence:

ATGCAGTATG GTGGGGCTCC CGGAGGGCCT GCGTTCCCTG GACAAACTCA GGATCCGCTA 
TATGGTTACT TTGCTGCTGT GGCTGGACAG GACGGACAAA TTGATGCTGA CGAATTGCAG 
AGATGCCTAA CACAGTCTGG CATTGCGGGA GGATACAAGC CTTTTAACCT GGAGACTTGT 
CGCCTTATGG TTTCAATGTT GGATAGAGAT ATGTCCGGCA CGATGGGGTT CAATGAATTC 
AAAGAGCTCT GGGCTGTGCT GAATGGCTGG AGACAACACT TCATCAGTTT CGATAGCGAT 
AGGAGTGGCA CCGTGGATCC CCAGGAGCTA CAGAAGGCCC TGACGACTAT GGGATTCAGG 
TTGAGCCCCC AAACTGTGAA TTCAGTTGCA AAGCGATACA GCACCAGCGG GAAGATCACG 
TTTGATGACT ACATTGCCTG CTGTGTCAAA CTGAGGGCTC TCACAGATAG CTTTCGCAGA 
CGGGATTCGG GTCAACAAGG AGTTGTGAAT TTCTCGTATG ATGATTTCAT CCAGTGTGTC 
ATGACCGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sri ( NM_001080974.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001074443.1 Mus musculus sorcin (Sri), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu01507
Clone ID Related Accession (Same CDS sequence)	NM_001080974.2
Accession Version	NM_001080974.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Mus musculus(house mouse)
Product	sorcin isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK134747.1, AK168572.1 and BQ033487.1. On Oct 22, 2013 this sequence version replaced NM_001080974.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU562693.1, SRR1660815.273466.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGTATC CCGGGCACCC TGGCGCGGGC GGAGGGTACT ACCCAGGCGG GTATGGTGGG 
GCTCCCGGAG GGCCTGCGTT CCCTGGACAA ACTCAGGATC CGCTATATGG TTACTTTGCT 
GCTGTGGCTG GACAGGACGG ACAAATTGAT GCTGACGAAT TGCAGAGATG CCTAACACAG 
TCTGGCATTG CGGGAGGATA CAAGCCTTTT AACCTGGAGA CTTGTCGCCT TATGGTTTCA 
ATGTTGGATA GAGATATGTC CGGCACGATG GGGTTCAATG AATTCAAAGA GCTCTGGGCT 
GTGCTGAATG GCTGGAGACA ACACTTCATC AGTTTCGATA GCGATAGGAG TGGCACCGTG 
GATCCCCAGG AGCTACAGAA GGCCCTGACG ACTATGGGAT TCAGGTTGAG CCCCCAAACT 
GTGAATTCAG TTGCAAAGCG ATACAGCACC AGCGGGAAGA TCACGTTTGA TGACTACATT 
GCCTGCTGTG TCAAACTGAG GGCTCTCACA GATAGCTTTC GCAGACGGGA TTCGGGTCAA 
CAAGGAGTTG TGAATTTCTC GTATGATGAT TTCATCCAGT GTGTCATGAC CGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001074443.1
CDS	48..644
Translation	MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDSDRSGTVDPQELQKALTTMGFRLSPQTVNSVAKRYSTSGKITFDDYIACCVKLRALTDSFRRRDSGQQGVVNFSYDDFIQCVMTV

Target ORF information:

RefSeq Version	NM_001080974.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus sorcin (Sri), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001080974.2

ORF Insert Sequence:

ATGGCGTATC CCGGGCACCC TGGCGCGGGC GGAGGGTACT ACCCAGGCGG GTATGGTGGG 
GCTCCCGGAG GGCCTGCGTT CCCTGGACAA ACTCAGGATC CGCTATATGG TTACTTTGCT 
GCTGTGGCTG GACAGGACGG ACAAATTGAT GCTGACGAAT TGCAGAGATG CCTAACACAG 
TCTGGCATTG CGGGAGGATA CAAGCCTTTT AACCTGGAGA CTTGTCGCCT TATGGTTTCA 
ATGTTGGATA GAGATATGTC CGGCACGATG GGGTTCAATG AATTCAAAGA GCTCTGGGCT 
GTGCTGAATG GCTGGAGACA ACACTTCATC AGTTTCGATA GCGATAGGAG TGGCACCGTG 
GATCCCCAGG AGCTACAGAA GGCCCTGACG ACTATGGGAT TCAGGTTGAG CCCCCAAACT 
GTGAATTCAG TTGCAAAGCG ATACAGCACC AGCGGGAAGA TCACGTTTGA TGACTACATT 
GCCTGCTGTG TCAAACTGAG GGCTCTCACA GATAGCTTTC GCAGACGGGA TTCGGGTCAA 
CAAGGAGTTG TGAATTTCTC GTATGATGAT TTCATCCAGT GTGTCATGAC CGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sri ( XM_017320600.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017176089.1 Mus musculus sorcin (Sri), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu34629
Clone ID Related Accession (Same CDS sequence)	XM_006503527.1 , XM_017320600.2 , XM_017320600.1
Accession Version	XM_017320600.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	sorcin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017320600.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCGGCA CGATGGGGTT CAATGAATTC AAAGAGCTCT GGGCTGTGCT GAATGGCTGG 
AGACAACACT TCATCAGTTT CGATAGCGAT AGGAGTGGCA CCGTGGATCC CCAGGAGCTA 
CAGAAGGCCC TGACGACTAT GGGATTCAGG TTGAGCCCCC AAACTGTGAA TTCAGTTGCA 
AAGCGATACA GCACCAGCGG GAAGATCACG TTTGATGACT ACATTGCCTG CTGTGTCAAA 
CTGAGGGCTC TCACAGATAG CTTTCGCAGA CGGGATTCGG GTCAACAAGG AGTTGTGAAT 
TTCTCGTATG ATGATTTCAT CCAGTGTGTC ATGACCGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017176089.1
CDS	510..851
Translation	MSGTMGFNEFKELWAVLNGWRQHFISFDSDRSGTVDPQELQKALTTMGFRLSPQTVNSVAKRYSTSGKITFDDYIACCVKLRALTDSFRRRDSGQQGVVNFSYDDFIQCVMTV

Target ORF information:

RefSeq Version	XM_017320600.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus sorcin (Sri), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017320600.2

ORF Insert Sequence:

ATGTCCGGCA CGATGGGGTT CAATGAATTC AAAGAGCTCT GGGCTGTGCT GAATGGCTGG 
AGACAACACT TCATCAGTTT CGATAGCGAT AGGAGTGGCA CCGTGGATCC CCAGGAGCTA 
CAGAAGGCCC TGACGACTAT GGGATTCAGG TTGAGCCCCC AAACTGTGAA TTCAGTTGCA 
AAGCGATACA GCACCAGCGG GAAGATCACG TTTGATGACT ACATTGCCTG CTGTGTCAAA 
CTGAGGGCTC TCACAGATAG CTTTCGCAGA CGGGATTCGG GTCAACAAGG AGTTGTGAAT 
TTCTCGTATG ATGATTTCAT CCAGTGTGTC ATGACCGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sorcin is involved during embryo implantation via activating VEGF/PI3K/Akt pathway in mice.
Journal of molecular endocrinology(2017 Dec)
Gupta K,Sirohi VK,Kumari S,Shukla V,Manohar M,Popli P,Dwivedi A

Sorcin ablation plus ?-adrenergic stimulation generate an arrhythmogenic substrate in mouse ventricular myocytes.
Journal of molecular and cellular cardiology114199-210(2017 Nov)
Chen X,Weber C,Farrell ET,Alvarado FJ,Zhao YT,G?mez AM,Valdivia HH

Sorcin Links Pancreatic ?-Cell Lipotoxicity to ER Ca2+ Stores.
Diabetes65(4)1009-21(2016 04)
Marmugi A,Parnis J,Chen X,Carmichael L,Hardy J,Mannan N,Marchetti P,Piemonti L,Bosco D,Johnson P,Shapiro JA,Cruciani-Guglielmacci C,Magnan C,Ibberson M,Thorens B,Valdivia HH,Rutter GA,Leclerc I

The proximal C-terminus of ?(1C) subunits is necessary for junctional membrane targeting of cardiac L-type calcium channels.
The Biochemical journal448(2)221-31(2012 Dec)
Nakada T,Flucher BE,Kashihara T,Sheng X,Shibazaki T,Horiuchi-Hirose M,Gomi S,Hirose M,Yamada M

Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic ?-cells.
Diabetes61(3)574-85(2012 Mar)
Noordeen NA,Meur G,Rutter GA,Leclerc I

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Sri cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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