Krt75 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Krt75
Entrez Gene ID	109052
Full Name	keratin 75
Synonyms	4732468K03Rik,AA589387,K6hf,Krt2-6hf,Krtcap1
General protein information	Preferred Names keratin 75 Names keratin, type II cytoskeletal 75 CK-75 K75 cytokeratin KRT2-6HF cytokeratin-75 keratin-6 hair follicle keratinocyte associated protein 1 mK6hf type II keratin-K6hf type-II keratin Kb18
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 F2\|15 56.91 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_133357.3	NP_579935.1	keratin, type II cytoskeletal 75

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Krt75	NP_579935.1
	LOC699682	XP_001098580.2
Rattus norvegicus (Norway rat)	Krt75	NP_001008828.1
Gallus gallus (chicken)	KRT6A	NP_001001313.1
Homo sapiens (human)	KRT75	NP_004684.2
Bos taurus (cattle)	KRT75	NP_001070385.1
Gallus gallus (chicken)	KRT75	NP_001001314.1
Pan troglodytes (chimpanzee)	KRT75	XP_522391.3
Canis lupus familiaris (dog)	KRT75	XP_003433551.2

Gene Ontology
Bibliography

Related articles in PubMed

Deletion of the epidermis derived laminin ?1 chain leads to defects in the regulation of late hair morphogenesis.
Fleger-Weckmann A, ?st?n Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R
Matrix biology : journal of the International Society for Matrix Biology5642-56(2016 Dec)

Gorab Is Required for Dermal Condensate Cells to Respond to Hedgehog Signals during Hair Follicle Morphogenesis.
Liu Y, Snedecor ER, Choi YJ, Yang N, Zhang X, Xu Y, Han Y, Jones EC, Shroyer KR, Clark RA, Zhang L, Qin C, Chen J
The Journal of investigative dermatology136(2)378-86(2016 Feb)

Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75.
Liu Y, Snedecor ER, Zhang X, Xu Y, Huang L, Jones EC, Zhang L, Clark RA, Roop DR, Qin C, Chen J
The Journal of investigative dermatology136(1)45-51(2016 Jan)

Transcription Factor CTIP2 Maintains Hair Follicle Stem Cell Pool and Contributes to Altered Expression of LHX2 and NFATC1.
Bhattacharya S, Wheeler H, Leid M, Ganguli-Indra G, Indra AK
The Journal of investigative dermatology135(11)2593-2602(2015 Nov)

Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis.
Yang N, Li L, Eguether T, Sundberg JP, Pazour GJ, Chen J
Development (Cambridge, England)142(12)2194-202(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mice expressing mutant form of Krt75 developed hair and nail defects resembling pachyonychia congenita
Title: Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita.

mK6a and mK75 thus exhibit temporally distinct, and spatially opposed, expression patterns in the companion layer (Cl) during postnatal anagen.
Title: Keratin expression provides novel insight into the morphogenesis and function of the companion layer in hair follicles.

The following Krt75 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Krt75 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19503	NM_133357.3 Latest version!	Mus musculus keratin 75 (Krt75), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Krt75 ( NM_133357.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_579935.1 Mus musculus keratin 75 (Krt75), mRNA.

Price & Availability↑

CloneID	OMu19503
Clone ID Related Accession (Same CDS sequence)	NM_133357.3
Accession Version	NM_133357.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1656bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	keratin, type II cytoskeletal 75
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC120787.14 and AC103674.10. On May 1, 2007 this sequence version replaced NM_133357.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK028972.1, BC137935.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137 [ECO:0000348] ##Evidence-Data-END##

ATGTCCCGGC AATCCACCAT CACCTTCCAC TCCGGCAGCC GCAGGGGCTT CAGCACAGCC 
TCAGCCACCA CACCTACGGC TGGACGCTCC CGCTTCAGCT CCGTGTCTGT GGCCCGCTCC 
TCAGGAAACA GTGGGGGACT GGGCAGGATC AGTGGTATTG GTTCTGGCTT TGGAAGCCGC 
AGCCTCTACA ACCTAGGGGG GACCCGGCGG GTCTCCATTG GTGGCTGTGC TGGCAGTGGC 
TTCAGGGGTG GCTTTGGTGG CAGGACTAGC AGTGGCTTTG GGGGCAGCAG TGGCTTTGCT 
TATGGAGGTG GCATTGGAGG GGGCTTTGGT GGCCCTGGCT TCTCTGTCTG TCCCTCTGGA 
GGCATTCAGG AAGTTACTGT CAACCAGAGC CTCCTGACTC CCCTCAACCT GCAAATCGAC 
CCCACTATCC AGCGGGTGCG GAAAGAAGAA CGGGAGCAGA TCAAGACTCT GAACAACAAG 
TTCGCCTCCT TCATTGACAA GGTACGCTTC CTGGAGCAGC AGAACAAGGT CCTGGAGACC 
AAGTGGAATC TCCTGCAGGA GCAGGGCTCT AGGACAGTCA GACAGAACCT GGAGCCTTTC 
TTCGATACAT ATGTCAATGA CCTCCGCCGG CAGCTGGATG GCATCACAGC TGAAAGAGGC 
AGACTGGATG CTGAACTGAG GAACATGCAG GAGGTTGTAG AAGACTTCAA AGTCAGGTAT 
GAAGACGAAA TTAACAAGCG TGCGGCTGCC GAGAATGAGT TCGTGGGCCT GAAAAAGGAC 
GTAGACAGTG CCTACATGAA CAAGGTGGAG CTGGAAGCGA AGGTCGACTC TCTGACTGAC 
CAGATCAACT TCTACCGGAT GATCTATGAG GCAGAGCTGT CTCAGATGCA GAACCAGGTG 
AGTGACACCT CTGTGGTCCT CTCCATGGAC AACAACCGCA GCCTGGACCT GGACAGCATC 
ATCGCCGAGG TCAAGGCCCA GTACGAGGAC ATTGCCAACC GAAGCCGGGC AGAGGCTGAG 
TCCTGGTACC AGACGAAGTA TGAGGAGCTG CAGGTGACCG CAGGCCGGCA TGGTGATGAC 
CTCCGCAACA CCAAACAAGA GATTTCAGAG ATGAACCGGA TGATCCAGAG GCTCAGATCT 
GAGATTGATG CCGTCAAGAA GCAGTGCTCC AGCTTACAAA CTGCTATCTC TGACGCTGAG 
CAGCGTGGAG AGCTAGCTCT CAAGGATGCC CGGGCCAAGC TGATGGAGCT TGAAGATGCC 
CTACAGAAAG CCAAGCAGGA CATGGCCAGG TTGCTTCGAG AGTACCAGGA ACTCATGAAC 
GTCAAACTGG CCTTGGATGT GGAGATCGCC ACCTACAGGA AGCTGCTGGA AGGCGAGGAG 
TGCAGGCTGA GCGGAGAGGG AGTTTCCCCA GTGAACATCT CTGTGGTCAC TTCTACGGTT 
TCCAGTGGCT ATGGCGGTGG TGCCAACATT GGAGGTGGAA GCCTGGGTCT TGGTGGGAAC 
AGTGGCTACT CCTTCACGAC CAGTGGTGGG CACAGCCTGG GCACAGGTCT GGGAGGCTCT 
GGCTTTACCA CCACCAGCAG CCGGGGCCCA GTGGGCAGTG GCTCCAGCAT CAAGTTTGTC 
TCCAGCACAT CATCCAGAAA GAGTTACAAG CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_579935.1
CDS	74..1729
Translation	MSRQSTITFHSGSRRGFSTASATTPTAGRSRFSSVSVARSSGNSGGLGRISGIGSGFGSRSLYNLGGTRRVSIGGCAGSGFRGGFGGRTSSGFGGSSGFAYGGGIGGGFGGPGFSVCPSGGIQEVTVNQSLLTPLNLQIDPTIQRVRKEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQEQGSRTVRQNLEPFFDTYVNDLRRQLDGITAERGRLDAELRNMQEVVEDFKVRYEDEINKRAAAENEFVGLKKDVDSAYMNKVELEAKVDSLTDQINFYRMIYEAELSQMQNQVSDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRSEIDAVKKQCSSLQTAISDAEQRGELALKDARAKLMELEDALQKAKQDMARLLREYQELMNVKLALDVEIATYRKLLEGEECRLSGEGVSPVNISVVTSTVSSGYGGGANIGGGSLGLGGNSGYSFTTSGGHSLGTGLGGSGFTTTSSRGPVGSGSSIKFVSSTSSRKSYKH

Target ORF information:

RefSeq Version	NM_133357.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus keratin 75 (Krt75), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133357.3

ORF Insert Sequence:

ATGTCCCGGC AATCCACCAT CACCTTCCAC TCCGGCAGCC GCAGGGGCTT CAGCACAGCC 
TCAGCCACCA CACCTACGGC TGGACGCTCC CGCTTCAGCT CCGTGTCTGT GGCCCGCTCC 
TCAGGAAACA GTGGGGGACT GGGCAGGATC AGTGGTATTG GTTCTGGCTT TGGAAGCCGC 
AGCCTCTACA ACCTAGGGGG GACCCGGCGG GTCTCCATTG GTGGCTGTGC TGGCAGTGGC 
TTCAGGGGTG GCTTTGGTGG CAGGACTAGC AGTGGCTTTG GGGGCAGCAG TGGCTTTGCT 
TATGGAGGTG GCATTGGAGG GGGCTTTGGT GGCCCTGGCT TCTCTGTCTG TCCCTCTGGA 
GGCATTCAGG AAGTTACTGT CAACCAGAGC CTCCTGACTC CCCTCAACCT GCAAATCGAC 
CCCACTATCC AGCGGGTGCG GAAAGAAGAA CGGGAGCAGA TCAAGACTCT GAACAACAAG 
TTCGCCTCCT TCATTGACAA GGTACGCTTC CTGGAGCAGC AGAACAAGGT CCTGGAGACC 
AAGTGGAATC TCCTGCAGGA GCAGGGCTCT AGGACAGTCA GACAGAACCT GGAGCCTTTC 
TTCGATACAT ATGTCAATGA CCTCCGCCGG CAGCTGGATG GCATCACAGC TGAAAGAGGC 
AGACTGGATG CTGAACTGAG GAACATGCAG GAGGTTGTAG AAGACTTCAA AGTCAGGTAT 
GAAGACGAAA TTAACAAGCG TGCGGCTGCC GAGAATGAGT TCGTGGGCCT GAAAAAGGAC 
GTAGACAGTG CCTACATGAA CAAGGTGGAG CTGGAAGCGA AGGTCGACTC TCTGACTGAC 
CAGATCAACT TCTACCGGAT GATCTATGAG GCAGAGCTGT CTCAGATGCA GAACCAGGTG 
AGTGACACCT CTGTGGTCCT CTCCATGGAC AACAACCGCA GCCTGGACCT GGACAGCATC 
ATCGCCGAGG TCAAGGCCCA GTACGAGGAC ATTGCCAACC GAAGCCGGGC AGAGGCTGAG 
TCCTGGTACC AGACGAAGTA TGAGGAGCTG CAGGTGACCG CAGGCCGGCA TGGTGATGAC 
CTCCGCAACA CCAAACAAGA GATTTCAGAG ATGAACCGGA TGATCCAGAG GCTCAGATCT 
GAGATTGATG CCGTCAAGAA GCAGTGCTCC AGCTTACAAA CTGCTATCTC TGACGCTGAG 
CAGCGTGGAG AGCTAGCTCT CAAGGATGCC CGGGCCAAGC TGATGGAGCT TGAAGATGCC 
CTACAGAAAG CCAAGCAGGA CATGGCCAGG TTGCTTCGAG AGTACCAGGA ACTCATGAAC 
GTCAAACTGG CCTTGGATGT GGAGATCGCC ACCTACAGGA AGCTGCTGGA AGGCGAGGAG 
TGCAGGCTGA GCGGAGAGGG AGTTTCCCCA GTGAACATCT CTGTGGTCAC TTCTACGGTT 
TCCAGTGGCT ATGGCGGTGG TGCCAACATT GGAGGTGGAA GCCTGGGTCT TGGTGGGAAC 
AGTGGCTACT CCTTCACGAC CAGTGGTGGG CACAGCCTGG GCACAGGTCT GGGAGGCTCT 
GGCTTTACCA CCACCAGCAG CCGGGGCCCA GTGGGCAGTG GCTCCAGCAT CAAGTTTGTC 
TCCAGCACAT CATCCAGAAA GAGTTACAAG CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deletion of the epidermis derived laminin ?1 chain leads to defects in the regulation of late hair morphogenesis.
Matrix biology : journal of the International Society for Matrix Biology5642-56(2016 Dec)
Fleger-Weckmann A,?st?n Y,Kloepper J,Paus R,Bloch W,Chen ZL,Wegner J,Sorokin L,Langbein L,Eckes B,Zigrino P,Krieg T,Nischt R

Gorab Is Required for Dermal Condensate Cells to Respond to Hedgehog Signals during Hair Follicle Morphogenesis.
The Journal of investigative dermatology136(2)378-86(2016 Feb)
Liu Y,Snedecor ER,Choi YJ,Yang N,Zhang X,Xu Y,Han Y,Jones EC,Shroyer KR,Clark RA,Zhang L,Qin C,Chen J

Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75.
The Journal of investigative dermatology136(1)45-51(2016 Jan)
Liu Y,Snedecor ER,Zhang X,Xu Y,Huang L,Jones EC,Zhang L,Clark RA,Roop DR,Qin C,Chen J

Transcription Factor CTIP2 Maintains Hair Follicle Stem Cell Pool and Contributes to Altered Expression of LHX2 and NFATC1.
The Journal of investigative dermatology135(11)2593-2602(2015 Nov)
Bhattacharya S,Wheeler H,Leid M,Ganguli-Indra G,Indra AK

Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis.
Development (Cambridge, England)142(12)2194-202(2015 Jun)
Yang N,Li L,Eguether T,Sundberg JP,Pazour GJ,Chen J

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Krt75 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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