Mex3b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mex3b
Entrez Gene ID	108797
Full Name	mex3 RNA binding family member B
Synonyms	4931439A04Rik,M-04814,Rkhd3,mKIAA2009
General protein information	Preferred Names mex3 RNA binding family member B Names RNA-binding protein MEX3B RING finger and KH domain-containing protein 3 mex3 homolog B ring finger and KH domain containing 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 D3\|7 47.35 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_175366.3	NP_780575.2	RNA-binding protein MEX3B

Pathways from BioSystems

Homologies

Homo sapiens (human)	MEX3B	NP_115622.2
Canis lupus familiaris (dog)	MEX3B	XP_005618463.1
Rattus norvegicus (Norway rat)	Mex3b	NP_001178555.1
	MEX3B	XP_001110186.1
Xenopus tropicalis (tropical clawed frog)	mex3b	XP_002932296.1
Pan troglodytes (chimpanzee)	MEX3B	XP_523137.2
Danio rerio (zebrafish)	mex3b	NP_001074462.1
Bos taurus (cattle)	MEX3B	XP_005221946.1
Mus musculus (house mouse)	Mex3b	NP_780575.2

Gene Ontology
Bibliography

Related articles in PubMed

The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in the Development of Allergic Airway Inflammation.
Yamazumi Y, Sasaki O, Imamura M, Oda T, Ohno Y, Shiozaki-Sato Y, Nagai S, Suyama S, Kamoshida Y, Funato K, Yasui T, Kikutani H, Yamamoto K, Dohi M, Koyasu S, Akiyama T
Cell reports16(9)2456-71(2016 08)

An AUTS2-Polycomb complex activates gene expression in the CNS.
Gao Z, Lee P, Stafford JM, von Schimmelmann M, Schaefer A, Reinberg D
Nature516(7531)349-54(2014 Dec)

The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway.
Le Borgne M, Chartier N, Buchet-Poyau K, Destaing O, Faurobert E, Thibert C, Rouault JP, Courchet J, N?gre D, Bouvard D, Albiges-Rizo C, Rousseaux S, Khochbin S, Segretain D, Cr?pieux P, Guillou F, Durand P, Perrard MH, Billaud M
Development (Cambridge, England)141(10)2096-107(2014 May)

Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.
Bulfone A, Carotenuto P, Faedo A, Aglio V, Garzia L, Bello AM, Basile A, Andr? A, Cocchia M, Guardiola O, Ballabio A, Rubenstein JL, Zollo M
The Journal of neuroscience : the official journal of the Society for Neuroscience25(33)7586-600(2005 Aug)

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Okazaki N, F-Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H, Nagase T, Ohara O, Koga H
DNA research : an international journal for rapid publication of reports on genes and genomes11(3)205-18(2004 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mex-3B facilitates the development of allergic airway inflammation by directly upregulating IL-33 expression via inhibiting miR-487b-3p mediated repression of IL-33.
Title: The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in the Development of Allergic Airway Inflammation.

A study in Mex3b(-/-) mice suggest that Mex3B acts as a coreceptor of TLR3 in innate antiviral response.
Title: The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response.

Mex3b is involved in the spatial organization of the Rap1 pathway that orchestrates Sertoli cell functions.
Title: The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway.

The following Mex3b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mex3b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05238	NM_175366.3 Latest version!	Mus musculus mex3 RNA binding family member B (Mex3b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$335.30 $479.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mex3b ( NM_175366.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_780575.2 Mus musculus mex3 RNA binding family member B (Mex3b), mRNA.

Price & Availability↑

CloneID	OMu05238
Clone ID Related Accession (Same CDS sequence)	NM_175366.3
Accession Version	NM_175366.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1731bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	RNA-binding protein MEX3B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC122736.13. On or before Apr 14, 2009 this sequence version replaced XM_912460.3, XM_620516.4, NM_175366.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.30101.1, SRR1660821.141470.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAGCT CGCTGTTTGC AGACCTGGAG CGCAACGGCA GCGGCGGCGG CGGGGGAGGC 
GGCGGCGGGG GAGGCGGCGG TGGCAGCGGC GGGGGAGAGA CTCTGGATGA CCAAAGAGCC 
CTGCAGCTTG CGCTCGATCA GCTCTCCCTG TTGGGACTGG ACAGTGATGA GGGCGCCTCT 
TTGTACGACA GCGAACCGCG CAAGAAGAGC GTGAACATGA CCGAGTGCGT GCCGGTACCC 
AGTTCCGAAC ACGTCGCGGA GATCGTAGGG AGGCAAGGTT GTAAAATCAA AGCTTTGAGG 
GCGAAGACCA ACACTTACAT CAAGACCCCA GTTCGCGGGG AGGAGCCTGT CTTTGTTGTG 
ACGGGCAGGA AGGAGGATGT GGCTATGGCT CGGAGGGAGA TCATCTCTGC CGCAGAGCAC 
TTCTCCATGA TCCGAGCCTC TCGTAACAAG AACACGGCTC TCAACGGAGC TGTGCCCGGA 
CCGCCCAACC TGCCGGGACA GACCACTATC CAAGTGAGGG TGCCATACCG CGTGGTAGGG 
CTCGTGGTGG GTCCAAAGGG CGCCACGATC AAGCGCATTC AACAGCAGAC ACATACATAT 
ATTGTGACAC CCAGCCGAGA CAAGGAGCCA GTTTTCGAGG TGACTGGCAT GCCAGAGAAC 
GTGGATCGCG CTAGAGAGGA GATCGAAGCT CACATCGCGC TGCGCACCGG TGGCATCATC 
GAGCTGACAG ACGAGAACGA CTTCCATGCC AATGGCACAG ACGTGGGCTT TGATCTGCAT 
CACGGGTCCG GCGGGTCCGG GCCGGGCAGC CTCTGGAGCA AGCCCACCCC AAGCATCACT 
CCTACACCTG GCCGCAAGCC CTTCTCCAGC TATCGCAACG ACAGCTCCAG CTCGCTTGGC 
AGCGCATCCA CAGACTCTTA CTTCGGTGGT GGGACCAGCG GCAGCGCAGC TGCTACTTCA 
CGCCTGGCGG ACTATAGCCC TCCCAGCCCT GCACTCAGCT TTGCTCACAA TGGGAACAAC 
AACAATAACG GCAATGGTTA CACCTACACA GCGGGGGAAG CCTCAGTACC TTCCCCAGAT 
GGGGGTCCTG AGCTGCAGCC TACTTTCGAC CCAGCTCCCG CCCCACCACC TGGGACACCC 
CTTCTCTGGG CCCAGTTCGA GCGCTCTCCA GGAGGTGGAT CTGCAGCACC AGTATCCTCT 
TCCTGCTCTT CTTCGGCATC CTCATCTGCC TCGTCGTCCT CTGTGGTCTT TCCCGGGGGT 
GGCGCCAGCA GCACACCCTC CAATGCCAAT CTGGGGCTGC TGGTGCACCG TCGACTGCAC 
CCGGGCACCA GCTGCCCGCG CCTGTCTCCG CCCTTGCACA TGGCCACGGG GGCGGGAGAG 
CACCACCTTG CTCGCCGCGT GCGCAGCGAC CCGGGCGGTG GAGGCCTGGC CTACGCTGCC 
TATGCTAATG GGCTAGGGAC GCAGCTCCCT GGCCTGCCCT CGTCGGACAC TTCGGGCTCC 
TCCTCGTCCT CTAGCTCCTC CTCCAGCTCT TCCTCCTCTT CCTCTGGGCT GAGGCGCAAA 
GGCAGCCGCG ACTGCTCTGT GTGCTTCGAG AGTGAAGTGA TCGCCGCGCT GGTGCCCTGT 
GGCCACAACC TCTTCTGCAT GGAGTGTGCC AACCGCATTT GTGAGAAGAG CGAGCCCGAG 
TGTCCCGTCT GCCACACGGC GGTCACTCAG GCCATCCGCA TTTTTTCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_780575.2
CDS	319..2049
Translation	MPSSLFADLERNGSGGGGGGGGGGGGGGSGGGETLDDQRALQLALDQLSLLGLDSDEGASLYDSEPRKKSVNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFVVTGRKEDVAMARREIISAAEHFSMIRASRNKNTALNGAVPGPPNLPGQTTIQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEAHIALRTGGIIELTDENDFHANGTDVGFDLHHGSGGSGPGSLWSKPTPSITPTPGRKPFSSYRNDSSSSLGSASTDSYFGGGTSGSAAATSRLADYSPPSPALSFAHNGNNNNNGNGYTYTAGEASVPSPDGGPELQPTFDPAPAPPPGTPLLWAQFERSPGGGSAAPVSSSCSSSASSSASSSSVVFPGGGASSTPSNANLGLLVHRRLHPGTSCPRLSPPLHMATGAGEHHLARRVRSDPGGGGLAYAAYANGLGTQLPGLPSSDTSGSSSSSSSSSSSSSSSSGLRRKGSRDCSVCFESEVIAALVPCGHNLFCMECANRICEKSEPECPVCHTAVTQAIRIFS

Target ORF information:

RefSeq Version	NM_175366.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus mex3 RNA binding family member B (Mex3b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175366.3

ORF Insert Sequence:

ATGCCCAGCT CGCTGTTTGC AGACCTGGAG CGCAACGGCA GCGGCGGCGG CGGGGGAGGC 
GGCGGCGGGG GAGGCGGCGG TGGCAGCGGC GGGGGAGAGA CTCTGGATGA CCAAAGAGCC 
CTGCAGCTTG CGCTCGATCA GCTCTCCCTG TTGGGACTGG ACAGTGATGA GGGCGCCTCT 
TTGTACGACA GCGAACCGCG CAAGAAGAGC GTGAACATGA CCGAGTGCGT GCCGGTACCC 
AGTTCCGAAC ACGTCGCGGA GATCGTAGGG AGGCAAGGTT GTAAAATCAA AGCTTTGAGG 
GCGAAGACCA ACACTTACAT CAAGACCCCA GTTCGCGGGG AGGAGCCTGT CTTTGTTGTG 
ACGGGCAGGA AGGAGGATGT GGCTATGGCT CGGAGGGAGA TCATCTCTGC CGCAGAGCAC 
TTCTCCATGA TCCGAGCCTC TCGTAACAAG AACACGGCTC TCAACGGAGC TGTGCCCGGA 
CCGCCCAACC TGCCGGGACA GACCACTATC CAAGTGAGGG TGCCATACCG CGTGGTAGGG 
CTCGTGGTGG GTCCAAAGGG CGCCACGATC AAGCGCATTC AACAGCAGAC ACATACATAT 
ATTGTGACAC CCAGCCGAGA CAAGGAGCCA GTTTTCGAGG TGACTGGCAT GCCAGAGAAC 
GTGGATCGCG CTAGAGAGGA GATCGAAGCT CACATCGCGC TGCGCACCGG TGGCATCATC 
GAGCTGACAG ACGAGAACGA CTTCCATGCC AATGGCACAG ACGTGGGCTT TGATCTGCAT 
CACGGGTCCG GCGGGTCCGG GCCGGGCAGC CTCTGGAGCA AGCCCACCCC AAGCATCACT 
CCTACACCTG GCCGCAAGCC CTTCTCCAGC TATCGCAACG ACAGCTCCAG CTCGCTTGGC 
AGCGCATCCA CAGACTCTTA CTTCGGTGGT GGGACCAGCG GCAGCGCAGC TGCTACTTCA 
CGCCTGGCGG ACTATAGCCC TCCCAGCCCT GCACTCAGCT TTGCTCACAA TGGGAACAAC 
AACAATAACG GCAATGGTTA CACCTACACA GCGGGGGAAG CCTCAGTACC TTCCCCAGAT 
GGGGGTCCTG AGCTGCAGCC TACTTTCGAC CCAGCTCCCG CCCCACCACC TGGGACACCC 
CTTCTCTGGG CCCAGTTCGA GCGCTCTCCA GGAGGTGGAT CTGCAGCACC AGTATCCTCT 
TCCTGCTCTT CTTCGGCATC CTCATCTGCC TCGTCGTCCT CTGTGGTCTT TCCCGGGGGT 
GGCGCCAGCA GCACACCCTC CAATGCCAAT CTGGGGCTGC TGGTGCACCG TCGACTGCAC 
CCGGGCACCA GCTGCCCGCG CCTGTCTCCG CCCTTGCACA TGGCCACGGG GGCGGGAGAG 
CACCACCTTG CTCGCCGCGT GCGCAGCGAC CCGGGCGGTG GAGGCCTGGC CTACGCTGCC 
TATGCTAATG GGCTAGGGAC GCAGCTCCCT GGCCTGCCCT CGTCGGACAC TTCGGGCTCC 
TCCTCGTCCT CTAGCTCCTC CTCCAGCTCT TCCTCCTCTT CCTCTGGGCT GAGGCGCAAA 
GGCAGCCGCG ACTGCTCTGT GTGCTTCGAG AGTGAAGTGA TCGCCGCGCT GGTGCCCTGT 
GGCCACAACC TCTTCTGCAT GGAGTGTGCC AACCGCATTT GTGAGAAGAG CGAGCCCGAG 
TGTCCCGTCT GCCACACGGC GGTCACTCAG GCCATCCGCA TTTTTTCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in the Development of Allergic Airway Inflammation.
Cell reports16(9)2456-71(2016 08)
Yamazumi Y,Sasaki O,Imamura M,Oda T,Ohno Y,Shiozaki-Sato Y,Nagai S,Suyama S,Kamoshida Y,Funato K,Yasui T,Kikutani H,Yamamoto K,Dohi M,Koyasu S,Akiyama T

An AUTS2-Polycomb complex activates gene expression in the CNS.
Nature516(7531)349-54(2014 Dec)
Gao Z,Lee P,Stafford JM,von Schimmelmann M,Schaefer A,Reinberg D

The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway.
Development (Cambridge, England)141(10)2096-107(2014 May)
Le Borgne M,Chartier N,Buchet-Poyau K,Destaing O,Faurobert E,Thibert C,Rouault JP,Courchet J,N?gre D,Bouvard D,Albiges-Rizo C,Rousseaux S,Khochbin S,Segretain D,Cr?pieux P,Guillou F,Durand P,Perrard MH,Billaud M

Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.
The Journal of neuroscience : the official journal of the Society for Neuroscience25(33)7586-600(2005 Aug)
Bulfone A,Carotenuto P,Faedo A,Aglio V,Garzia L,Bello AM,Basile A,Andr? A,Cocchia M,Guardiola O,Ballabio A,Rubenstein JL,Zollo M

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
DNA research : an international journal for rapid publication of reports on genes and genomes11(3)205-18(2004 Jun)
Okazaki N,F-Kikuno R,Ohara R,Inamoto S,Koseki H,Hiraoka S,Saga Y,Seino S,Nishimura M,Kaisho T,Hoshino K,Kitamura H,Nagase T,Ohara O,Koga H

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Mex3b cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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