Galnt2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Galnt2
Entrez Gene ID	108148
Full Name	polypeptide N-acetylgalactosaminyltransferase 2
Synonyms	AI480629
General protein information	Preferred Names polypeptide N-acetylgalactosaminyltransferase 2 Names polypeptide N-acetylgalactosaminyltransferase 2 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 galNAc-T2 polypeptide GalNAc transferase 2 pp-GaNTase 2 ppGaNTase-T2 protein-UDP acetylgalactosaminyltransferase 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 E2

mRNA and Protein(s)

mRNA	Protein	Name
NM_139272.2	NP_644678.2	polypeptide N-acetylgalactosaminyltransferase 2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GALNT2	NP_004472.1
Pan troglodytes (chimpanzee)	GALNT2	XP_003308857.1
	GALNT2	XP_001107497.1
Canis lupus familiaris (dog)	GALNT2	XP_005618892.1
Gallus gallus (chicken)	GALNT2	XP_419581.4
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010078	XP_319236.4
Bos taurus (cattle)	GALNT2	NP_001180032.1
Rattus norvegicus (Norway rat)	Galnt2	NP_001099666.1
Mus musculus (house mouse)	Galnt2	NP_644678.2
Danio rerio (zebrafish)	galnt2	NP_001121823.1
Drosophila melanogaster (fruit fly)	pgant2	NP_608773.2
Caenorhabditis elegans (roundworm)	gly-4	NP_001024216.1
Xenopus tropicalis (tropical clawed frog)	galnt2	XP_002931524.2

Gene Ontology
Bibliography

Related articles in PubMed

Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.
Khetarpal SA, Schjoldager KT, Christoffersen C, Raghavan A, Edmondson AC, Reutter HM, Ahmed B, Ouazzani R, Peloso GM, Vitali C, Zhao W, Somasundara AV, Millar JS, Park Y, Fernando G, Livanov V, Choi S, No? E, Patel P, Ho SP, , Kirchgessner TG, Wandall HH, Hansen L, Bennett EP, Vakhrushev SY, Saleheen D, Kathiresan S, Brown CD, Abou Jamra R, LeGuern E, Clausen H, Rader DJ
Cell metabolism24(2)234-45(2016 Aug)

A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation.
Goth CK, Halim A, Khetarpal SA, Rader DJ, Clausen H, Schjoldager KT
Proceedings of the National Academy of Sciences of the United States of America112(47)14623-8(2015 Nov)

Galnt1 is required for normal heart valve development and cardiac function.
Tian E, Stevens SR, Guan Y, Springer DA, Anderson SA, Starost MF, Patel V, Ten Hagen KG, Tabak LA
PloS one10(1)e0115861(2015)

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.
Gineste C, De Winter JM, Kohl C, Witt CC, Giannesini B, Brohm K, Le Fur Y, Gretz N, Vilmen C, Pecchi E, Jubeau M, Cozzone PJ, Stienen GJ, Granzier H, Labeit S, Ottenheijm CA, Bendahan D, Gondin J
Neuromuscular disorders : NMD23(4)357-69(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results posit GALNT2 as a direct modulator of high density lipoprotein metabolism across mammals.
Title: Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.

These data suggest that the region responsible for the Mvwf1 regulatory switch lies within an approximately 30-kb genomic interval upstream of the B4galnt2 gene.
Title: The endothelial-specific regulatory mutation, Mvwf1, is a common mouse founder allele.

The following Galnt2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Galnt2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10974	NM_139272.2 Latest version!	Mus musculus polypeptide N-acetylgalactosaminyltransferase 2 (Galnt2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Galnt2 ( NM_139272.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_644678.2 Mus musculus polypeptide N-acetylgalactosaminyltransferase 2 (Galnt2), mRNA.

Price & Availability↑

CloneID	OMu10974
Clone ID Related Accession (Same CDS sequence)	NM_139272.2
Accession Version	NM_139272.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1713bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	polypeptide N-acetylgalactosaminyltransferase 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ770019.1, BC059818.1 and BC053063.1. On Apr 29, 2004 this sequence version replaced NM_139272.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC059818.1, AK145122.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCGGCGGC GCTCGCGGAT GCTGCTGTGC TTCGCGCTGC TCTGGGTCCT GGGCATCGCC 
TACTACATGT ACTCGGGGGG CGGCTCCGCG CTGGCCGCGG GCGGGGGCGG CGCCGGCAGG 
AAGGGTGACT GGAATGACAT CGACTCCATT AAGAAGAAAG ACCTTCACCA CAGCAGAGGA 
GATGAGAAAG CACAGGGTGT GGAGACCCTC CCTCCAGGCA AAGTCCGGTG GCCAGACTTT 
AACCAGGAGG CATACGTTGG CGGTACAATG GTTCGCTCTG GGCAGGACCC GTACGCACGC 
AACAAGTTCA ACCAGGTGGA GAGTGACAAG CTGCACATGG ACAGAGGCAT CCCCGACACC 
CGGCATGACC AGTGTCAGCG CAAGCAGTGG CGAGTGGACC TGCCAGCCAC CAGCGTGGTG 
ATCACATTCC ACAATGAAGC CAGGTCGGCC CTGCTGCGGA CGGTGGTCAG TGTCCTCAAG 
AGGAGTCCAC CTCACCTCAT CAAGGAGATA ATCCTGGTGG ATGACTACAG CAACGACCCT 
GAGGACGGGG CCCTCTTGGG GAAAATCGAG AAGGTGCGGG TCCTCAGAAA TGACCGGAGA 
GAAGGTCTAA TGCGCTCTCG GGTCCGGGGT GCCGACGCCG CCCAGGCCAA GGTCCTGACC 
TTCCTAGACA GTCACTGCGA GTGTAACGAG CGATGGCTGG AGCCACTCTT GGAGCGGGTT 
GCTGAGGACA GGACCCGAGT TGTATCCCCC ATTATCGATG TCATTAACAT GGATAATTTC 
CAGTATGTGG GCGCCTCTGC TGACCTCAAG GGTGGTTTTG ACTGGAACTT GGTGTTCAAG 
TGGGATTACA TGACACCAGA GCAGAGGCGA TCCCGGCAGG GGAACCCAGT TGCCCCTATA 
AAAACTCCGA TGATCGCTGG CGGCCTCTTC GTGATGGACA AGCTCTATTT TGAAGAGCTG 
GGGAAGTACG ACATGATGAT GGACGTGTGG GGAGGAGAGA ACTTGGAGAT CTCATTCCGA 
GTGTGGCAGT GTGGTGGCAG CCTGGAGATC ATCCCGTGCA GCCGCGTGGG CCACGTGTTC 
CGGAAGCAGC ATCCCTACAC GTTCCCCGGT GGCAGCGGCA CTGTCTTTGC CCGGAACACA 
CGCCGGGCAG CTGAAGTCTG GATGGATGAG TACAAACATT TCTACTACGC AGCGGTGCCT 
TCTGCACGAA ACGTGCCCTA TGGGAATATT CAGAGCAGGC TGGAGCTCAG GAAAAAGCTG 
GGCTGCAAGC CCTTCAAGTG GTACCTGGAC AACGTCTACC CGGAGCTGAG GGTTCCAGAC 
CACCAGGACA TAGCTTTCGG GGCCTTACAG CAGGGAACCA ACTGCCTGGA CACCTTGGGA 
CACTTCGCGG ATGGAGTTGT TGGAATTTAT GAGTGTCACA ACGCTGGAGG AAACCAGGAA 
TGGGCCTTGA CAAAGGAGAA GTCGGTGAAG CACATGGACC TGTGCCTTAC TGTGGTGGAC 
CGTTCGCCTG GGTCACTCAT CAGGCTGCAG GGCTGCCGGG AGAACGACAG CAGACAGAAG 
TGGGAGCAGA TCGAAGGCAA CTCCAAACTG CGACACGTGG GCAGCAACCT GTGCCTGGAT 
AGCCGCACTG CCAAGAGCGG AGGCCTGAGT GTGGAGGTGT GTGGCCCGGC CCTGTCACAA 
CAGTGGAAGT TCTCACTCAA CCTGCAGCAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_644678.2
CDS	134..1846
Translation	MRRRSRMLLCFALLWVLGIAYYMYSGGGSALAAGGGGAGRKGDWNDIDSIKKKDLHHSRGDEKAQGVETLPPGKVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLHMDRGIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKRSPPHLIKEIILVDDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNERWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKLYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKHFYYAAVPSARNVPYGNIQSRLELRKKLGCKPFKWYLDNVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGIYECHNAGGNQEWALTKEKSVKHMDLCLTVVDRSPGSLIRLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFSLNLQQ

Target ORF information:

RefSeq Version	NM_139272.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus polypeptide N-acetylgalactosaminyltransferase 2 (Galnt2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139272.2

ORF Insert Sequence:

ATGCGGCGGC GCTCGCGGAT GCTGCTGTGC TTCGCGCTGC TCTGGGTCCT GGGCATCGCC 
TACTACATGT ACTCGGGGGG CGGCTCCGCG CTGGCCGCGG GCGGGGGCGG CGCCGGCAGG 
AAGGGTGACT GGAATGACAT CGACTCCATT AAGAAGAAAG ACCTTCACCA CAGCAGAGGA 
GATGAGAAAG CACAGGGTGT GGAGACCCTC CCTCCAGGCA AAGTCCGGTG GCCAGACTTT 
AACCAGGAGG CATACGTTGG CGGTACAATG GTTCGCTCTG GGCAGGACCC GTACGCACGC 
AACAAGTTCA ACCAGGTGGA GAGTGACAAG CTGCACATGG ACAGAGGCAT CCCCGACACC 
CGGCATGACC AGTGTCAGCG CAAGCAGTGG CGAGTGGACC TGCCAGCCAC CAGCGTGGTG 
ATCACATTCC ACAATGAAGC CAGGTCGGCC CTGCTGCGGA CGGTGGTCAG TGTCCTCAAG 
AGGAGTCCAC CTCACCTCAT CAAGGAGATA ATCCTGGTGG ATGACTACAG CAACGACCCT 
GAGGACGGGG CCCTCTTGGG GAAAATCGAG AAGGTGCGGG TCCTCAGAAA TGACCGGAGA 
GAAGGTCTAA TGCGCTCTCG GGTCCGGGGT GCCGACGCCG CCCAGGCCAA GGTCCTGACC 
TTCCTAGACA GTCACTGCGA GTGTAACGAG CGATGGCTGG AGCCACTCTT GGAGCGGGTT 
GCTGAGGACA GGACCCGAGT TGTATCCCCC ATTATCGATG TCATTAACAT GGATAATTTC 
CAGTATGTGG GCGCCTCTGC TGACCTCAAG GGTGGTTTTG ACTGGAACTT GGTGTTCAAG 
TGGGATTACA TGACACCAGA GCAGAGGCGA TCCCGGCAGG GGAACCCAGT TGCCCCTATA 
AAAACTCCGA TGATCGCTGG CGGCCTCTTC GTGATGGACA AGCTCTATTT TGAAGAGCTG 
GGGAAGTACG ACATGATGAT GGACGTGTGG GGAGGAGAGA ACTTGGAGAT CTCATTCCGA 
GTGTGGCAGT GTGGTGGCAG CCTGGAGATC ATCCCGTGCA GCCGCGTGGG CCACGTGTTC 
CGGAAGCAGC ATCCCTACAC GTTCCCCGGT GGCAGCGGCA CTGTCTTTGC CCGGAACACA 
CGCCGGGCAG CTGAAGTCTG GATGGATGAG TACAAACATT TCTACTACGC AGCGGTGCCT 
TCTGCACGAA ACGTGCCCTA TGGGAATATT CAGAGCAGGC TGGAGCTCAG GAAAAAGCTG 
GGCTGCAAGC CCTTCAAGTG GTACCTGGAC AACGTCTACC CGGAGCTGAG GGTTCCAGAC 
CACCAGGACA TAGCTTTCGG GGCCTTACAG CAGGGAACCA ACTGCCTGGA CACCTTGGGA 
CACTTCGCGG ATGGAGTTGT TGGAATTTAT GAGTGTCACA ACGCTGGAGG AAACCAGGAA 
TGGGCCTTGA CAAAGGAGAA GTCGGTGAAG CACATGGACC TGTGCCTTAC TGTGGTGGAC 
CGTTCGCCTG GGTCACTCAT CAGGCTGCAG GGCTGCCGGG AGAACGACAG CAGACAGAAG 
TGGGAGCAGA TCGAAGGCAA CTCCAAACTG CGACACGTGG GCAGCAACCT GTGCCTGGAT 
AGCCGCACTG CCAAGAGCGG AGGCCTGAGT GTGGAGGTGT GTGGCCCGGC CCTGTCACAA 
CAGTGGAAGT TCTCACTCAA CCTGCAGCAA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.
Cell metabolism24(2)234-45(2016 Aug)
Khetarpal SA,Schjoldager KT,Christoffersen C,Raghavan A,Edmondson AC,Reutter HM,Ahmed B,Ouazzani R,Peloso GM,Vitali C,Zhao W,Somasundara AV,Millar JS,Park Y,Fernando G,Livanov V,Choi S,No? E,Patel P,Ho SP,,Kirchgessner TG,Wandall HH,Hansen L,Bennett EP,Vakhrushev SY,Saleheen D,Kathiresan S,Brown CD,Abou Jamra R,LeGuern E,Clausen H,Rader DJ

A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation.
Proceedings of the National Academy of Sciences of the United States of America112(47)14623-8(2015 Nov)
Goth CK,Halim A,Khetarpal SA,Rader DJ,Clausen H,Schjoldager KT

Galnt1 is required for normal heart valve development and cardiac function.
PloS one10(1)e0115861(2015)
Tian E,Stevens SR,Guan Y,Springer DA,Anderson SA,Starost MF,Patel V,Ten Hagen KG,Tabak LA

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Circulation research113(10)1138-47(2013 Oct)
Abonnenc M,Nabeebaccus AA,Mayr U,Barallobre-Barreiro J,Dong X,Cuello F,Sur S,Drozdov I,Langley SR,Lu R,Stathopoulou K,Didangelos A,Yin X,Zimmermann WH,Shah AM,Zampetaki A,Mayr M

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.
Neuromuscular disorders : NMD23(4)357-69(2013 Apr)
Gineste C,De Winter JM,Kohl C,Witt CC,Giannesini B,Brohm K,Le Fur Y,Gretz N,Vilmen C,Pecchi E,Jubeau M,Cozzone PJ,Stienen GJ,Granzier H,Labeit S,Ottenheijm CA,Bendahan D,Gondin J

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Galnt2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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