Grm3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Grm3
Entrez Gene ID	108069
Full Name	glutamate receptor, metabotropic 3
Synonyms	0710001G23Rik,Gprc1c,mGlu3,mGluR3
General protein information	Preferred Names glutamate receptor, metabotropic 3 Names metabotropic glutamate receptor 3 G protein-coupled receptor, family C, group 1, member C
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 A1

mRNA and Protein(s)

mRNA	Protein	Name
NM_181850.2	NP_862898.1	metabotropic glutamate receptor 3 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GRM3	NP_000831.2
Bos taurus (cattle)	GRM3	NP_001091592.1
Rattus norvegicus (Norway rat)	Grm3	NP_001099182.1
Pan troglodytes (chimpanzee)	GRM3	XP_001161278.1
	GRM3	XP_001107588.1
Mus musculus (house mouse)	Grm3	NP_862898.1
Danio rerio (zebrafish)	grm3	NP_001121815.1
Drosophila melanogaster (fruit fly)	mGluRA	NP_001259076.1
Xenopus tropicalis (tropical clawed frog)	grm3	XP_002935292.2
Canis lupus familiaris (dog)	GRM3	XP_005628844.1
Gallus gallus (chicken)	GRM3	XP_416842.3
Caenorhabditis elegans (roundworm)	mgl-1	NP_001123193.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress.
Nasca C, Bigio B, Zelli D, de Angelis P, Lau T, Okamoto M, Soya H, Ni J, Brichta L, Greengard P, Neve RL, Lee FS, McEwen BS
Neuron96(2)402-413.e5(2017 Oct)

NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.
Olszewski RT, Janczura KJ, Bzdega T, Der EK, Venzor F, O'Rourke B, Hark TJ, Craddock KE, Balasubramanian S, Moussa C, Neale JH
Neurochemical research42(9)2646-2657(2017 Sep)

Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors.
Rosenberg N, Gerber U, Ster J
The Journal of neuroscience : the official journal of the Society for Neuroscience36(45)11521-11531(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These studies provide a foundation for future research seeking to parse out the roles of mGlu2 from mGlu3, paving the way for better understanding of how these receptors regulate activity in the brain.
Title: Developmental expression of mGlu2 and mGlu3 in the mouse brain.

Activation of Grm3 ameliorates lupus-like disease in mice by reducing B cell numbers. Grm3 expression on B-cells is decreased in lupus-prone mice.
Title: Ligation of metabotropic glutamate receptor 3 (Grm3) ameliorates lupus-like disease by reducing B cells.

The number of mGluR3-immunoractive cells was significantly reduced in the dorsal and intermediate but not ventral parts of the lateral septum in postpartum versus virgin females.
Title: Metabotropic glutamate receptor 3 is downregulated and its expression is shifted from neurons to astrocytes in the mouse lateral septum during the postpartum period.

Activation of GABA(B) or mGlu2/3 receptors inhibited both evoked presynaptic Ca(2+) transients and striatal field potentials.
Title: Inhibition of presynaptic calcium transients in cortical inputs to the dorsolateral striatum by metabotropic GABA(B) and mGlu2/3 receptors.

provided evidence that JARID1B via modulation of stemness-related signaling is a putative novel therapeutic target for treating malignant NB
Title: Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.

The following Grm3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Grm3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17682	NM_181850.2 Latest version!	Mus musculus glutamate receptor, metabotropic 3 (Grm3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Grm3 ( NM_181850.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_862898.1 Mus musculus glutamate receptor, metabotropic 3 (Grm3), mRNA.

Price & Availability↑

CloneID	OMu17682
Clone ID Related Accession (Same CDS sequence)	NM_181850.2
Accession Version	NM_181850.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2640bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	metabotropic glutamate receptor 3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC162520.7 and AC157555.9. On Nov 17, 2006 this sequence version replaced NM_181850.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.71651.1, SRR1660813.213753.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164138 [ECO:0000348] ##Evidence-Data-END##

ATGAAGATGT TGACAAGACT ACAAGTTCTT ATGTTAGCTT TGTTTTCAAA GGGATTTTTA 
GTCTCTTTAG GAGATCACAA CTTTATGAGG AGAGAAATTA AAATAGAAGG AGACCTTGTT 
TTAGGGGGCT TATTTCCTAT TAATGAAAAA GGCACTGGAA CTGAAGAGTG TGGACGAATC 
AATGAAGACA GAGGTATCCA ACGCCTGGAG GCCATGTTGT TTGCCATTGA TGAAATCAAC 
AAAGACAATT ACTTGCTTCC AGGAGTGAAG CTGGGGGTTC ACATTTTGGA TACATGTTCA 
AGAGACACCT ATGCATTAGA GCAGTCACTG GAGTTTGTCA GAGCATCGTT GACTAAAGTG 
GATGAAGCTG AATATATGTG TCCTGATGGA TCATATGCTA TTCAAGAAAA CATCCCACTA 
CTCATTGCAG GAGTCATTGG CGGTTCGTAC AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGAGGCTCT TCCAGATCCC TCAGATAAGC TACGCCTCCA CCAGTGCCAA ACTCAGCGAC 
AAATCGCGCT ATGATTATTT TGCCAGGACC GTGCCCCCTG ACTTCTACCA GGCCAAAGCC 
ATGGCCGAGA TCTTGCGCTA CTTTAACTGG ACCTATGTGT CCACTGTTGC CTCTGAAGGT 
GACTATGGGG AGACAGGGAT TGAGGCCTTC GAGCAGGAAG CAAGGCTACG CAACATCTGC 
ATCGCCACTG CTGAAAAGGT GGGGCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATC 
CGTGAGCTCC TGCAGAAACC TAACGCGCGA GTTGTGGTCC TGTTCATGCG CAGTGATGAC 
TCACGAGAGT TGATCGCTGC AGCCAGCCGC GTGAATGCTT CCTTCACCTG GGTGGCCAGC 
GATGGCTGGG GTGCACAGGA GAGCATTGTC AAGGGCAGTG AGCACGTCGC CTATGGAGCC 
ATCACCCTGG AGCTGGCGTC CCACCCTGTT CGTCAGTTTG ATCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAATCATCG TAACCCCTGG TTCCGAGACT TCTGGGAGCA GAAGTTCCAG 
TGCAGCCTCC AGAACAAGAG AAACCACAGA CAGATTTGTG ACAAGCACCT GGCCATTGAC 
AGCAGCAACT ATGAACAAGA ATCCAAGATC ATGTTTGTGG TGAATGCAGT GTATGCCATG 
GCGCATGCGC TGCACAAAAT GCAACGCACC CTCTGTCCCA ACACCACCAA GCTCTGTGAT 
GCAATGAAGA TCCTGGATGG AAAGAAGTTG TACAAAGATT ATTTGCTGAA AATCAACTTC 
ACAGCTCCAT TCAACCCAAA TAAAGGAGCA GACAGCATTG TGAAGTTTGA CACTTACGGA 
GACGGGATGG GAAGATACAA CGTGTTCAAC TTCCAGCATA TAGGTGGAAA GTATTCCTAC 
TTAAAAGTTG GCCACTGGGC AGAAACTTTA TATCTAGATG TGGACTCTAT TCATTGGTCC 
CGGAACTCAG TCCCCACTTC CCAGTGCAGT GATCCCTGTG CCCCCAATGA AATGAAAAAC 
ATGCAGCCAG GAGATGTTTG CTGCTGGATC TGCATCCCAT GTGAGCCCTA TGAATACCTG 
GTTGATGAGT TCACCTGCAT GGATTGTGGC CCTGGCCAGT GGCCCACTGC AGACCTATCT 
GGATGCTACA ACCTTCCAGA GGATTACATC AGGTGGGAAG ATGCCTGGGC AATAGGCCCA 
GTCACTATTG CCTGCCTGGG TTTTATGTGT ACATGCATAG TCATAACTGT TTTTATCAAG 
CACAACAACA CACCCTTGGT CAAAGCATCA GGCCGAGAAC TCTGCTACAT CTTGTTATTT 
GGAGTTAGCC TGTCCTATTG CATGACATTC TTCTTCATTG CTAAGCCATC GCCTGTCATC 
TGTGCATTGC GCCGACTTGG GCTTGGGACC TCCTTTGCCA TCTGTTATTC AGCTCTCCTG 
ACCAAGACAA ACTGCATCGC TCGCATCTTT GATGGGGTCA AGAATGGCGC TCAGAGGCCA 
AAATTCATCA GCCCCAGTTC TCAGGTTTTT ATCTGCCTGG GTTTGATACT GGTGCAAATT 
GTGATGGTGT CTGTGTGGCT TATCTTGGAG ACTCCAGGTA CTAGAAGATA CACCCTGCCA 
GAGAAGCGGG AAACAGTCAT CCTAAAATGC AATGTCAAAG ATTCCAGCAT GTTGATCTCT 
CTGACCTATG ACGTGGTTCT GGTGATTCTA TGCACTGTGT ATGCCTTCAA AACAAGGAAG 
TGTCCTGAAA ACTTCAATGA AGCCAAGTTC ATAGGCTTCA CCATGTACAC CACCTGCATC 
ATCTGGTTGG CATTCCTCCC TATATTTTAT GTGACATCAA GTGACTACAG AGTGCAGACG 
ACAACAATGT GCATCTCCGT TAGCTTGAGT GGTTTCGTGG TCTTGGGCTG TTTGTTTGCC 
CCCAAGGTGC ACATTGTCCT GTTCCAACCC CAGAAGAATG TGGTCACACA CAGACTTCAC 
CTCAACAGGT TCAGTGTCAG TGGAACTGCG ACCACATATT CTCAGTCCTC TGCAAGCACA 
TATGTCCCGA CAGTGTGCAA CGGAAGGGAA GTCCTGGACT CCACCACCTC ATCTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_862898.1
CDS	365..3004
Translation	MKMLTRLQVLMLALFSKGFLVSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRYFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQICDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKGADSIVKFDTYGDGMGRYNVFNFQHIGGKYSYLKVGHWAETLYLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIRWEDAWAIGPVTIACLGFMCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL

Target ORF information:

RefSeq Version	NM_181850.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutamate receptor, metabotropic 3 (Grm3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181850.2

ORF Insert Sequence:

ATGAAGATGT TGACAAGACT ACAAGTTCTT ATGTTAGCTT TGTTTTCAAA GGGATTTTTA 
GTCTCTTTAG GAGATCACAA CTTTATGAGG AGAGAAATTA AAATAGAAGG AGACCTTGTT 
TTAGGGGGCT TATTTCCTAT TAATGAAAAA GGCACTGGAA CTGAAGAGTG TGGACGAATC 
AATGAAGACA GAGGTATCCA ACGCCTGGAG GCCATGTTGT TTGCCATTGA TGAAATCAAC 
AAAGACAATT ACTTGCTTCC AGGAGTGAAG CTGGGGGTTC ACATTTTGGA TACATGTTCA 
AGAGACACCT ATGCATTAGA GCAGTCACTG GAGTTTGTCA GAGCATCGTT GACTAAAGTG 
GATGAAGCTG AATATATGTG TCCTGATGGA TCATATGCTA TTCAAGAAAA CATCCCACTA 
CTCATTGCAG GAGTCATTGG CGGTTCGTAC AGCAGTGTTT CCATACAGGT GGCAAACCTG 
CTGAGGCTCT TCCAGATCCC TCAGATAAGC TACGCCTCCA CCAGTGCCAA ACTCAGCGAC 
AAATCGCGCT ATGATTATTT TGCCAGGACC GTGCCCCCTG ACTTCTACCA GGCCAAAGCC 
ATGGCCGAGA TCTTGCGCTA CTTTAACTGG ACCTATGTGT CCACTGTTGC CTCTGAAGGT 
GACTATGGGG AGACAGGGAT TGAGGCCTTC GAGCAGGAAG CAAGGCTACG CAACATCTGC 
ATCGCCACTG CTGAAAAGGT GGGGCGCTCC AACATCCGCA AGTCCTACGA CAGCGTGATC 
CGTGAGCTCC TGCAGAAACC TAACGCGCGA GTTGTGGTCC TGTTCATGCG CAGTGATGAC 
TCACGAGAGT TGATCGCTGC AGCCAGCCGC GTGAATGCTT CCTTCACCTG GGTGGCCAGC 
GATGGCTGGG GTGCACAGGA GAGCATTGTC AAGGGCAGTG AGCACGTCGC CTATGGAGCC 
ATCACCCTGG AGCTGGCGTC CCACCCTGTT CGTCAGTTTG ATCGCTACTT CCAGAGCCTC 
AACCCCTACA ACAATCATCG TAACCCCTGG TTCCGAGACT TCTGGGAGCA GAAGTTCCAG 
TGCAGCCTCC AGAACAAGAG AAACCACAGA CAGATTTGTG ACAAGCACCT GGCCATTGAC 
AGCAGCAACT ATGAACAAGA ATCCAAGATC ATGTTTGTGG TGAATGCAGT GTATGCCATG 
GCGCATGCGC TGCACAAAAT GCAACGCACC CTCTGTCCCA ACACCACCAA GCTCTGTGAT 
GCAATGAAGA TCCTGGATGG AAAGAAGTTG TACAAAGATT ATTTGCTGAA AATCAACTTC 
ACAGCTCCAT TCAACCCAAA TAAAGGAGCA GACAGCATTG TGAAGTTTGA CACTTACGGA 
GACGGGATGG GAAGATACAA CGTGTTCAAC TTCCAGCATA TAGGTGGAAA GTATTCCTAC 
TTAAAAGTTG GCCACTGGGC AGAAACTTTA TATCTAGATG TGGACTCTAT TCATTGGTCC 
CGGAACTCAG TCCCCACTTC CCAGTGCAGT GATCCCTGTG CCCCCAATGA AATGAAAAAC 
ATGCAGCCAG GAGATGTTTG CTGCTGGATC TGCATCCCAT GTGAGCCCTA TGAATACCTG 
GTTGATGAGT TCACCTGCAT GGATTGTGGC CCTGGCCAGT GGCCCACTGC AGACCTATCT 
GGATGCTACA ACCTTCCAGA GGATTACATC AGGTGGGAAG ATGCCTGGGC AATAGGCCCA 
GTCACTATTG CCTGCCTGGG TTTTATGTGT ACATGCATAG TCATAACTGT TTTTATCAAG 
CACAACAACA CACCCTTGGT CAAAGCATCA GGCCGAGAAC TCTGCTACAT CTTGTTATTT 
GGAGTTAGCC TGTCCTATTG CATGACATTC TTCTTCATTG CTAAGCCATC GCCTGTCATC 
TGTGCATTGC GCCGACTTGG GCTTGGGACC TCCTTTGCCA TCTGTTATTC AGCTCTCCTG 
ACCAAGACAA ACTGCATCGC TCGCATCTTT GATGGGGTCA AGAATGGCGC TCAGAGGCCA 
AAATTCATCA GCCCCAGTTC TCAGGTTTTT ATCTGCCTGG GTTTGATACT GGTGCAAATT 
GTGATGGTGT CTGTGTGGCT TATCTTGGAG ACTCCAGGTA CTAGAAGATA CACCCTGCCA 
GAGAAGCGGG AAACAGTCAT CCTAAAATGC AATGTCAAAG ATTCCAGCAT GTTGATCTCT 
CTGACCTATG ACGTGGTTCT GGTGATTCTA TGCACTGTGT ATGCCTTCAA AACAAGGAAG 
TGTCCTGAAA ACTTCAATGA AGCCAAGTTC ATAGGCTTCA CCATGTACAC CACCTGCATC 
ATCTGGTTGG CATTCCTCCC TATATTTTAT GTGACATCAA GTGACTACAG AGTGCAGACG 
ACAACAATGT GCATCTCCGT TAGCTTGAGT GGTTTCGTGG TCTTGGGCTG TTTGTTTGCC 
CCCAAGGTGC ACATTGTCCT GTTCCAACCC CAGAAGAATG TGGTCACACA CAGACTTCAC 
CTCAACAGGT TCAGTGTCAG TGGAACTGCG ACCACATATT CTCAGTCCTC TGCAAGCACA 
TATGTCCCGA CAGTGTGCAA CGGAAGGGAA GTCCTGGACT CCACCACCTC ATCTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress.
Neuron96(2)402-413.e5(2017 Oct)
Nasca C,Bigio B,Zelli D,de Angelis P,Lau T,Okamoto M,Soya H,Ni J,Brichta L,Greengard P,Neve RL,Lee FS,McEwen BS

NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.
Neurochemical research42(9)2646-2657(2017 Sep)
Olszewski RT,Janczura KJ,Bzdega T,Der EK,Venzor F,O'Rourke B,Hark TJ,Craddock KE,Balasubramanian S,Moussa C,Neale JH

Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience36(45)11521-11531(2016 Nov)
Rosenberg N,Gerber U,Ster J

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Grm3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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