Ddb2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ddb2
Entrez Gene ID	107986
Full Name	damage specific DNA binding protein 2
Synonyms	2610043A19Rik
General protein information	Preferred Names damage specific DNA binding protein 2 Names DNA damage-binding protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 E1

mRNA and Protein(s)

mRNA	Protein	Name
XM_006498547.3	XP_006498610.1	DNA damage-binding protein 2 isoform X1
NM_028119.5	NP_082395.2	DNA damage-binding protein 2 isoform 1
NM_001362705.1	NP_001349634.1	DNA damage-binding protein 2 isoform 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	DDB2	NP_001034390.1
Arabidopsis thaliana (thale cress)	DDB2	NP_200684.2
Xenopus tropicalis (tropical clawed frog)	ddb2	NP_001008203.1
Mus musculus (house mouse)	Ddb2	NP_082395.2
Rattus norvegicus (Norway rat)	Ddb2	NP_001258275.1
Homo sapiens (human)	DDB2	NP_000098.1
Pan troglodytes (chimpanzee)	DDB2	XP_001167874.2
	DDB2	XP_001109935.1
Bos taurus (cattle)	DDB2	NP_001069256.1
Oryza sativa (rice)	Os01g0141700	NP_001041985.1
Canis lupus familiaris (dog)	DDB2	XP_540746.3
Danio rerio (zebrafish)	ddb2	NP_001076530.1

Gene Ontology
Bibliography

Related articles in PubMed

DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer.
Huang S, Fantini D, Merrill BJ, Bagchi S, Guzman G, Raychaudhuri P
Cancer research77(23)6562-6575(2017 Dec)

Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase.
Yang Y, He S, Wang Q, Li F, Kwak MJ, Chen S, O'Connell D, Zhang T, Pirooz SD, Jeon Y, Chimge NO, Frenkel B, Choi Y, Aldrovandi GM, Oh BH, Yuan Z, Liang C
Molecular cell62(4)507-19(2016 05)

DDB2 suppresses epithelial-to-mesenchymal transition in colon cancer.
Roy N, Bommi PV, Bhat UG, Bhattacharjee S, Elangovan I, Li J, Patra KC, Kopanja D, Blunier A, Benya R, Bagchi S, Raychaudhuri P
Cancer research73(12)3771-82(2013 Jun)

Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair.
Robu M, Shah RG, Petitclerc N, Brind'Amour J, Kandan-Kulangara F, Shah GM
Proceedings of the National Academy of Sciences of the United States of America110(5)1658-63(2013 Jan)

DDB2 promotes chromatin decondensation at UV-induced DNA damage.
Luijsterburg MS, Lindh M, Acs K, Vrouwe MG, Pines A, van Attikum H, Mullenders LH, Dantuma NP
The Journal of cell biology197(2)267-81(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DDB2 plays a critical role in suppressing development of colon cancer at early stage by regulating Wnt signaling. Mice genetically deficient in DDB2 exhibited increased susceptibility to colon tumor development in a manner associated with higher abundance of the Wnt receptor-expressing cells and greater activation of the downstream Wnt pathway.
Title: DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer.

UVRAG is a regulator of CRL4(DDB2)-mediated nucleotide excision repair and its expression levels may influence melanoma predisposition.
Title: Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase.

Results indicate a transcriptional regulatory pathway of DDB2 that is directly linked to the mechanisms that suppress metastasis of colon cancer.
Title: DDB2 suppresses epithelial-to-mesenchymal transition in colon cancer.

Data indicate that poly(ADP-ribose) polymerase-1 (PARP-1)collaborates with DNA-binding protein 2 (DDB2) to increase the efficiency of the lesion recognition step of global genomic subpathway of NER (GG-NER).
Title: Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair.

the anti-proliferative and the pro-senescence pathways of DDB2 and p21 are critical protection mechanisms against skin malignancies.
Title: p21 cooperates with DDB2 protein in suppression of ultraviolet ray-induced skin malignancies.

The following Ddb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ddb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu05148	NM_028119.5 Latest version!	Mus musculus damage specific DNA binding protein 2 (Ddb2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu29898	NM_001362705.1 Latest version!	Mus musculus damage specific DNA binding protein 2 (Ddb2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu29898	XM_006498547.3 Latest version!	Mus musculus damage specific DNA binding protein 2 (Ddb2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ddb2 ( NM_028119.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082395.2 Mus musculus damage specific DNA binding protein 2 (Ddb2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu05148
Clone ID Related Accession (Same CDS sequence)	NM_028119.5
Accession Version	NM_028119.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	DNA damage-binding protein 2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK627126.1, BU515611.1 and BC058589.1. On Apr 23, 2010 this sequence version replaced NM_028119.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY027937.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCCA AGAAATGCCC AGAAACCCAG AAGTCCCCCG ACGTTGCGGT GCTCCTCAGG 
AGCAAAAGTC GCAGAGGTCC TCAGGAGCTG GAGCCCGAAG CCAAGAAGCT GCGTGTGCAG 
GGTCCCGTTT CTAGCAGGAC ATGTGAGTCG TGCTGCCTTC TGGCAGAGTT GTCCAGCCTG 
CAGATCCCTT CACGGAGTAG CAGCATTGTC AGGGATCTTT ACCAGCATAA GTTGGGCAAA 
GCCACCTGGT CATCACTACA GCAGGGTCTG CAGAAGTCCT TTTTGCACTC TCTAGCTTCT 
TACCAGGTAT TCCGAAAAGC TGCCCCCTTT GACAGGAGGA CTACGTCCTT GGCATGGCAC 
CCGACTCATC CCAGTACCCT GGCTGTGGGC TCCAAAGGGG GAGATATTAT GATCTGGAAC 
TTTGGCATCA AGGACAAACC TATCTTCCTT AAAGGGATTG GAGCTGGAGG AAGCATCACT 
GGGCTGAAGT TTAACCATCT CAATACCAAC CAGTTTTTTG CCTCCTCAAT GGAGGGAACA 
ACCAGGCTGC AGGATTTTAA AGGCAACATT CTCAGAGTTT ATACCAGCTC AAACTCTTGC 
AAGGTCTGGT TTTGCAGCCT TGATGTTTCT GCCAAGAGCA GAGTGGTGGT TACAGGAGAC 
AATATGGGAC ATGTGATCCT GTTGAGCACA GATGGCAAGG AGCTTTGGAA CCTCCGAATG 
CACAAGAAGA AAGTAGCCCA CGTGGCCCTG AATCCCTGCT GTGATTGGCT TCTGGCCACA 
GCCTCCATAG ATCAAACAGT GAAGATTTGG GACCTGCGCC AAATTAAAGG GAAAGACAGC 
TTCCTCTACT CACTGCCTCA CAGGCATCCT GTCAATGCAG CTTGTTTTAG CCCAGATGGA 
GCTCGGCTCC TGACTACTGA CCAGAACAAT GAGATTCGGG TTTACTCTGC CTCCCAGTGG 
GATAGCCCCC TGAATCTGAT CTCCCACCCT CACCGCCATT TTCAGCACCT CACACCCATC 
AAGGCGACCT GGCATTCACG GCACAACCTC ATTGTTGTGG GCCGATACCC AGATCCTAAT 
CTTAAAAGTT GTGTTCCCTA TGAACTAAGG ACAATAGATG TGTTTGATGG AAGCTCAGGG 
AAGATGATGT GTCAGCTCTA TGATCCAGGA TACTCCGGTA TTACTTCGCT CAATGAGTTC 
AATCCTATGG GAGACACACT GGCCTCTACT ATGGGTTATC ATATTCTCAT TTGGAGCCAA 
GAGGAAGATG GGTCACAGAA AGATCATGAA AGACTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082395.2
CDS	251..1549
Translation	MAPKKCPETQKSPDVAVLLRSKSRRGPQELEPEAKKLRVQGPVSSRTCESCCLLAELSSLQIPSRSSSIVRDLYQHKLGKATWSSLQQGLQKSFLHSLASYQVFRKAAPFDRRTTSLAWHPTHPSTLAVGSKGGDIMIWNFGIKDKPIFLKGIGAGGSITGLKFNHLNTNQFFASSMEGTTRLQDFKGNILRVYTSSNSCKVWFCSLDVSAKSRVVVTGDNMGHVILLSTDGKELWNLRMHKKKVAHVALNPCCDWLLATASIDQTVKIWDLRQIKGKDSFLYSLPHRHPVNAACFSPDGARLLTTDQNNEIRVYSASQWDSPLNLISHPHRHFQHLTPIKATWHSRHNLIVVGRYPDPNLKSCVPYELRTIDVFDGSSGKMMCQLYDPGYSGITSLNEFNPMGDTLASTMGYHILIWSQEEDGSQKDHERL

Target ORF information:

RefSeq Version	NM_028119.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus damage specific DNA binding protein 2 (Ddb2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028119.5

ORF Insert Sequence:

ATGGCTCCCA AGAAATGCCC AGAAACCCAG AAGTCCCCCG ACGTTGCGGT GCTCCTCAGG 
AGCAAAAGTC GCAGAGGTCC TCAGGAGCTG GAGCCCGAAG CCAAGAAGCT GCGTGTGCAG 
GGTCCCGTTT CTAGCAGGAC ATGTGAGTCG TGCTGCCTTC TGGCAGAGTT GTCCAGCCTG 
CAGATCCCTT CACGGAGTAG CAGCATTGTC AGGGATCTTT ACCAGCATAA GTTGGGCAAA 
GCCACCTGGT CATCACTACA GCAGGGTCTG CAGAAGTCCT TTTTGCACTC TCTAGCTTCT 
TACCAGGTAT TCCGAAAAGC TGCCCCCTTT GACAGGAGGA CTACGTCCTT GGCATGGCAC 
CCGACTCATC CCAGTACCCT GGCTGTGGGC TCCAAAGGGG GAGATATTAT GATCTGGAAC 
TTTGGCATCA AGGACAAACC TATCTTCCTT AAAGGGATTG GAGCTGGAGG AAGCATCACT 
GGGCTGAAGT TTAACCATCT CAATACCAAC CAGTTTTTTG CCTCCTCAAT GGAGGGAACA 
ACCAGGCTGC AGGATTTTAA AGGCAACATT CTCAGAGTTT ATACCAGCTC AAACTCTTGC 
AAGGTCTGGT TTTGCAGCCT TGATGTTTCT GCCAAGAGCA GAGTGGTGGT TACAGGAGAC 
AATATGGGAC ATGTGATCCT GTTGAGCACA GATGGCAAGG AGCTTTGGAA CCTCCGAATG 
CACAAGAAGA AAGTAGCCCA CGTGGCCCTG AATCCCTGCT GTGATTGGCT TCTGGCCACA 
GCCTCCATAG ATCAAACAGT GAAGATTTGG GACCTGCGCC AAATTAAAGG GAAAGACAGC 
TTCCTCTACT CACTGCCTCA CAGGCATCCT GTCAATGCAG CTTGTTTTAG CCCAGATGGA 
GCTCGGCTCC TGACTACTGA CCAGAACAAT GAGATTCGGG TTTACTCTGC CTCCCAGTGG 
GATAGCCCCC TGAATCTGAT CTCCCACCCT CACCGCCATT TTCAGCACCT CACACCCATC 
AAGGCGACCT GGCATTCACG GCACAACCTC ATTGTTGTGG GCCGATACCC AGATCCTAAT 
CTTAAAAGTT GTGTTCCCTA TGAACTAAGG ACAATAGATG TGTTTGATGG AAGCTCAGGG 
AAGATGATGT GTCAGCTCTA TGATCCAGGA TACTCCGGTA TTACTTCGCT CAATGAGTTC 
AATCCTATGG GAGACACACT GGCCTCTACT ATGGGTTATC ATATTCTCAT TTGGAGCCAA 
GAGGAAGATG GGTCACAGAA AGATCATGAA AGACTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ddb2 ( NM_001362705.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001349634.1 Mus musculus damage specific DNA binding protein 2 (Ddb2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu29898
Clone ID Related Accession (Same CDS sequence)	XM_006498547.3 , NM_001362705.1
Accession Version	NM_001362705.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-13
Organism	Mus musculus(house mouse)
Product	DNA damage-binding protein 2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK627126.1, AK158770.1 and BC099410.1. On Apr 25, 2018 this sequence version replaced XM_006498547.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC099410.1, AK158770.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCCA AGAAATGCCC AGAAACCCAG AAGTCCCCCG ACGTTGCGGT GCTCCTCAGG 
AGCAAAAGTC GCAGAGGTCC TCAGGAGCTG GAGCCCGAAG CCAAGAAGCT GCGTGTGCAG 
GGTCCCGTTT CTAGCAGGAC ATGTGAGTCG TGCTGCCTTC TGGCAGAGTT GTCCAGCCTG 
CAGATCCCTT CACGGAGTAG CAGCATTGTC AGGGATCTTT ACCAGCATAA GTTGGGCAAA 
GCCACCTGGT CATCACTACA GCAGGGTCTG CAGAAGTCCT TTTTGCACTC TCTAGCTTCT 
TACCAGGTAT TCCGAAAAGC TGCCCCCTTT GACAGGAGGA CTACGTCCTT GGCATGGCAC 
CCGACTCATC CCAGTACCCT GGCTGTGGGC TCCAAAGGGG GAGATATTAT GATCTGGAAC 
TTTGGCATCA AGGACAAACC TATCTTCCTT AAAGGGGCGA CCTGGCATTC ACGGCACAAC 
CTCATTGTTG TGGGCCGATA CCCAGATCCT AATCTTAAAA GTTGTGTTCC CTATGAACTA 
AGGACAATAG ATGTGTTTGA TGGAAGCTCA GGGAAGATGA TGTGTCAGCT CTATGATCCA 
GGATACTCCG GTATTACTTC GCTCAATGAG TTCAATCCTA TGGGAGACAC ACTGGCCTCT 
ACTATGGGTT ATCATATTCT CATTTGGAGC CAAGAGGAAG ATGGGTCACA GAAAGATCAT 
GAAAGACTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001349634.1
CDS	251..982
Translation	MAPKKCPETQKSPDVAVLLRSKSRRGPQELEPEAKKLRVQGPVSSRTCESCCLLAELSSLQIPSRSSSIVRDLYQHKLGKATWSSLQQGLQKSFLHSLASYQVFRKAAPFDRRTTSLAWHPTHPSTLAVGSKGGDIMIWNFGIKDKPIFLKGATWHSRHNLIVVGRYPDPNLKSCVPYELRTIDVFDGSSGKMMCQLYDPGYSGITSLNEFNPMGDTLASTMGYHILIWSQEEDGSQKDHERL

Target ORF information:

RefSeq Version	NM_001362705.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus damage specific DNA binding protein 2 (Ddb2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001362705.1

ORF Insert Sequence:

ATGGCTCCCA AGAAATGCCC AGAAACCCAG AAGTCCCCCG ACGTTGCGGT GCTCCTCAGG 
AGCAAAAGTC GCAGAGGTCC TCAGGAGCTG GAGCCCGAAG CCAAGAAGCT GCGTGTGCAG 
GGTCCCGTTT CTAGCAGGAC ATGTGAGTCG TGCTGCCTTC TGGCAGAGTT GTCCAGCCTG 
CAGATCCCTT CACGGAGTAG CAGCATTGTC AGGGATCTTT ACCAGCATAA GTTGGGCAAA 
GCCACCTGGT CATCACTACA GCAGGGTCTG CAGAAGTCCT TTTTGCACTC TCTAGCTTCT 
TACCAGGTAT TCCGAAAAGC TGCCCCCTTT GACAGGAGGA CTACGTCCTT GGCATGGCAC 
CCGACTCATC CCAGTACCCT GGCTGTGGGC TCCAAAGGGG GAGATATTAT GATCTGGAAC 
TTTGGCATCA AGGACAAACC TATCTTCCTT AAAGGGGCGA CCTGGCATTC ACGGCACAAC 
CTCATTGTTG TGGGCCGATA CCCAGATCCT AATCTTAAAA GTTGTGTTCC CTATGAACTA 
AGGACAATAG ATGTGTTTGA TGGAAGCTCA GGGAAGATGA TGTGTCAGCT CTATGATCCA 
GGATACTCCG GTATTACTTC GCTCAATGAG TTCAATCCTA TGGGAGACAC ACTGGCCTCT 
ACTATGGGTT ATCATATTCT CATTTGGAGC CAAGAGGAAG ATGGGTCACA GAAAGATCAT 
GAAAGACTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ddb2 ( XM_006498547.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006498610.1 Mus musculus damage specific DNA binding protein 2 (Ddb2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OMu29898
Clone ID Related Accession (Same CDS sequence)	XM_006498547.3 , NM_001362705.1
Accession Version	XM_006498547.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	DNA damage-binding protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006498547.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCCCA AGAAATGCCC AGAAACCCAG AAGTCCCCCG ACGTTGCGGT GCTCCTCAGG 
AGCAAAAGTC GCAGAGGTCC TCAGGAGCTG GAGCCCGAAG CCAAGAAGCT GCGTGTGCAG 
GGTCCCGTTT CTAGCAGGAC ATGTGAGTCG TGCTGCCTTC TGGCAGAGTT GTCCAGCCTG 
CAGATCCCTT CACGGAGTAG CAGCATTGTC AGGGATCTTT ACCAGCATAA GTTGGGCAAA 
GCCACCTGGT CATCACTACA GCAGGGTCTG CAGAAGTCCT TTTTGCACTC TCTAGCTTCT 
TACCAGGTAT TCCGAAAAGC TGCCCCCTTT GACAGGAGGA CTACGTCCTT GGCATGGCAC 
CCGACTCATC CCAGTACCCT GGCTGTGGGC TCCAAAGGGG GAGATATTAT GATCTGGAAC 
TTTGGCATCA AGGACAAACC TATCTTCCTT AAAGGGGCGA CCTGGCATTC ACGGCACAAC 
CTCATTGTTG TGGGCCGATA CCCAGATCCT AATCTTAAAA GTTGTGTTCC CTATGAACTA 
AGGACAATAG ATGTGTTTGA TGGAAGCTCA GGGAAGATGA TGTGTCAGCT CTATGATCCA 
GGATACTCCG GTATTACTTC GCTCAATGAG TTCAATCCTA TGGGAGACAC ACTGGCCTCT 
ACTATGGGTT ATCATATTCT CATTTGGAGC CAAGAGGAAG ATGGGTCACA GAAAGATCAT 
GAAAGACTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006498610.1
CDS	317..1048
Translation	MAPKKCPETQKSPDVAVLLRSKSRRGPQELEPEAKKLRVQGPVSSRTCESCCLLAELSSLQIPSRSSSIVRDLYQHKLGKATWSSLQQGLQKSFLHSLASYQVFRKAAPFDRRTTSLAWHPTHPSTLAVGSKGGDIMIWNFGIKDKPIFLKGATWHSRHNLIVVGRYPDPNLKSCVPYELRTIDVFDGSSGKMMCQLYDPGYSGITSLNEFNPMGDTLASTMGYHILIWSQEEDGSQKDHERL

Target ORF information:

RefSeq Version	XM_006498547.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus damage specific DNA binding protein 2 (Ddb2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006498547.3

ORF Insert Sequence:

ATGGCTCCCA AGAAATGCCC AGAAACCCAG AAGTCCCCCG ACGTTGCGGT GCTCCTCAGG 
AGCAAAAGTC GCAGAGGTCC TCAGGAGCTG GAGCCCGAAG CCAAGAAGCT GCGTGTGCAG 
GGTCCCGTTT CTAGCAGGAC ATGTGAGTCG TGCTGCCTTC TGGCAGAGTT GTCCAGCCTG 
CAGATCCCTT CACGGAGTAG CAGCATTGTC AGGGATCTTT ACCAGCATAA GTTGGGCAAA 
GCCACCTGGT CATCACTACA GCAGGGTCTG CAGAAGTCCT TTTTGCACTC TCTAGCTTCT 
TACCAGGTAT TCCGAAAAGC TGCCCCCTTT GACAGGAGGA CTACGTCCTT GGCATGGCAC 
CCGACTCATC CCAGTACCCT GGCTGTGGGC TCCAAAGGGG GAGATATTAT GATCTGGAAC 
TTTGGCATCA AGGACAAACC TATCTTCCTT AAAGGGGCGA CCTGGCATTC ACGGCACAAC 
CTCATTGTTG TGGGCCGATA CCCAGATCCT AATCTTAAAA GTTGTGTTCC CTATGAACTA 
AGGACAATAG ATGTGTTTGA TGGAAGCTCA GGGAAGATGA TGTGTCAGCT CTATGATCCA 
GGATACTCCG GTATTACTTC GCTCAATGAG TTCAATCCTA TGGGAGACAC ACTGGCCTCT 
ACTATGGGTT ATCATATTCT CATTTGGAGC CAAGAGGAAG ATGGGTCACA GAAAGATCAT 
GAAAGACTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer.
Cancer research77(23)6562-6575(2017 Dec)
Huang S,Fantini D,Merrill BJ,Bagchi S,Guzman G,Raychaudhuri P

Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase.
Molecular cell62(4)507-19(2016 05)
Yang Y,He S,Wang Q,Li F,Kwak MJ,Chen S,O'Connell D,Zhang T,Pirooz SD,Jeon Y,Chimge NO,Frenkel B,Choi Y,Aldrovandi GM,Oh BH,Yuan Z,Liang C

DDB2 suppresses epithelial-to-mesenchymal transition in colon cancer.
Cancer research73(12)3771-82(2013 Jun)
Roy N,Bommi PV,Bhat UG,Bhattacharjee S,Elangovan I,Li J,Patra KC,Kopanja D,Blunier A,Benya R,Bagchi S,Raychaudhuri P

Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair.
Proceedings of the National Academy of Sciences of the United States of America110(5)1658-63(2013 Jan)
Robu M,Shah RG,Petitclerc N,Brind'Amour J,Kandan-Kulangara F,Shah GM

DDB2 promotes chromatin decondensation at UV-induced DNA damage.
The Journal of cell biology197(2)267-81(2012 Apr)
Luijsterburg MS,Lindh M,Acs K,Vrouwe MG,Pines A,van Attikum H,Mullenders LH,Dantuma NP

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Ddb2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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