Asmt cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Asmt
Entrez Gene ID	107626
Full Name	acetylserotonin O-methyltransferase
Synonyms	Hiomt
General protein information	Preferred Names acetylserotonin O-methyltransferase Names acetylserotonin O-methyltransferase hydroxyindole O-methyltransfease
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X F5\|X
Summary	This gene belongs to the methyltransferase superfamily and is located in the pseudoautosomal region (PAR) of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin and is abundant in the pineal gland. Two amino acid substitutions (R78G and R242C) are present in the encoded protein derived from the reference strain, C57BL/6J, and this protein shows low enzyme activity relative to the protein derived from other strains. [provided by RefSeq, May 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001308488.1	NP_001295417.1	acetylserotonin O-methyltransferase isoform 2
NM_001199212.1	NP_001186141.1	acetylserotonin O-methyltransferase isoform 1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder.
Trent S, Fry JP, Ojarikre OA, Davies W
Molecular autism5(1)21(2014 Mar)

Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder.
Trent S, Dean R, Veit B, Cassano T, Bedse G, Ojarikre OA, Humby T, Davies W
Psychoneuroendocrinology38(8)1370-80(2013 Aug)

Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth.
Han Y, Demorrow S, Invernizzi P, Jing Q, Glaser S, Renzi A, Meng F, Venter J, Bernuzzi F, White M, Francis H, Lleo A, Marzioni M, Onori P, Alvaro D, Torzilli G, Gaudio E, Alpini G
American journal of physiology. Gastrointestinal and liver physiology301(4)G623-33(2011 Oct)

Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway.
Shimomura K, Lowrey PL, Vitaterna MH, Buhr ED, Kumar V, Hanna P, Omura C, Izumo M, Low SS, Barrett RK, LaRue SI, Green CB, Takahashi JS
Proceedings of the National Academy of Sciences of the United States of America107(18)8399-403(2010 May)

Genetic variation of melatonin productivity in laboratory mice under domestication.
Kasahara T, Abe K, Mekada K, Yoshiki A, Kato T
Proceedings of the National Academy of Sciences of the United States of America107(14)6412-7(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Asmt gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Asmt cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02104	NM_001199212.1 Latest version!	Mus musculus acetylserotonin O-methyltransferase (Asmt), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OMu72189	NM_001308488.1 Latest version!	Mus musculus acetylserotonin O-methyltransferase (Asmt), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Asmt ( NM_001199212.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001186141.1 Mus musculus acetylserotonin O-methyltransferase (Asmt), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu02104
Clone ID Related Accession (Same CDS sequence)	NM_001199212.1
Accession Version	NM_001199212.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1164bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	acetylserotonin O-methyltransferase isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB512671.1. Transcript Variant: This variant (1) is based on a transcript from the C3H/HeJ strain and encodes an isoform (1) with high enzyme activity. ##Evidence-Data-START## Transcript exon combination :: AB512671.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGCACAGGG GCCGCTCGGC CTCCGCCCGC CAGGAGCGCG ACTTCCGGGC CCTCATGGAC 
CTGGCCCACG GCTTCATGGC CTCCCAGGTG CTGTTCGCGG GCTGCGCGCT CCGCGTGTTC 
GACGCCGCGG CCCTGGGCCC CGTGGACGCC GCGGCGCTGG CGAGGTCGTC GGGCCTGAGC 
CCCCGGGGGA CGCGGCTGCT GCTCGACGCC TGCGCGGGGC TGGGGCTGCT GCGGAGACGC 
AGGGGGGCGG GGCCTCGCGG CCCCGCCTAC ACCAACTCCC CCCTGGCGTC CACCTTCCTG 
GTCGCGGGCA GCCCCCTGTC TCAGCGCAGC CTCCTGCTCT ACCTGGCGGG CACCACCTAC 
CTGTGCTGGG GGCACCTGGC GGACGGCGTG AGGGAAGGGC GGAGCCAGTA CGCGAGGGCC 
GTGGGCGTCG ACGCGGACGA CCCCTTCACC GCCATCTACA GGTCGGAGGC CGAGCGCCTG 
CTGTTCATGC GGGGCCTGCA GGAGACCTGG AGCCTGTGCG GGGGGCGGGT CCTCACGGCC 
TTCGACCTCT CGCCCTTCAG GGTCATCTGC GACCTCGGTG GTGGGTCCGG GGCGCTGGCC 
CGCATGGCCG CCCGGCTCTA CCCGGGCAGC GAGGTCACCG TGTTCGAGAC GCCCGACGTC 
GTCGCCGCCG CCCGCGCCCA CTTCCCGCCC CCAGCGGACG AGGACGGGGC GGAGCCTCGT 
GTGCGCTTCC TGTCAGGCGA CTTCTTCCGC TCGCCGCTGC CGCCCGCCGA CCTCTACGTC 
CTGGCCCGGG TCCTGCACGA CTGGGCGGAC GCCGCCTGCG TGGAGCTGCT GCGGCGCGTG 
CGGGGCGCCC TGCGGCCAGG CGGCGCGGTG CTGCTGGTGG AGAGCGTGCT GTCCCCGGGA 
GGGGCGGGGC CGACGCGGAC GCTGCTGCTG TCGCTCACGA TGCTGCTGCA GGCCCGGGGC 
CGCGAGCGCA CGGAGGCCGA GTACCGGGCG CTGACCGCGC GCGCCGGCTT CTCCCGCCTG 
CGGCTGCGGC GCCCGCGGGG CCCCTACCAC GCCATGATGG CCGCCCGGGG GGGCGGGGCC 
GGGGCGCGGA GCGACGGCGG CGGCGGGGAC GCGACGTCAC AGACAGGAAG TGGGACAGGA 
AGTGAGGTCG GCGCCCAGGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186141.1
CDS	49..1212
Translation	MHRGRSASARQERDFRALMDLAHGFMASQVLFAGCALRVFDAAALGPVDAAALARSSGLSPRGTRLLLDACAGLGLLRRRRGAGPRGPAYTNSPLASTFLVAGSPLSQRSLLLYLAGTTYLCWGHLADGVREGRSQYARAVGVDADDPFTAIYRSEAERLLFMRGLQETWSLCGGRVLTAFDLSPFRVICDLGGGSGALARMAARLYPGSEVTVFETPDVVAAARAHFPPPADEDGAEPRVRFLSGDFFRSPLPPADLYVLARVLHDWADAACVELLRRVRGALRPGGAVLLVESVLSPGGAGPTRTLLLSLTMLLQARGRERTEAEYRALTARAGFSRLRLRRPRGPYHAMMAARGGGAGARSDGGGGDATSQTGSGTGSEVGAQD

Target ORF information:

RefSeq Version	NM_001199212.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus acetylserotonin O-methyltransferase (Asmt), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199212.1

ORF Insert Sequence:

ATGCACAGGG GCCGCTCGGC CTCCGCCCGC CAGGAGCGCG ACTTCCGGGC CCTCATGGAC 
CTGGCCCACG GCTTCATGGC CTCCCAGGTG CTGTTCGCGG GCTGCGCGCT CCGCGTGTTC 
GACGCCGCGG CCCTGGGCCC CGTGGACGCC GCGGCGCTGG CGAGGTCGTC GGGCCTGAGC 
CCCCGGGGGA CGCGGCTGCT GCTCGACGCC TGCGCGGGGC TGGGGCTGCT GCGGAGACGC 
AGGGGGGCGG GGCCTCGCGG CCCCGCCTAC ACCAACTCCC CCCTGGCGTC CACCTTCCTG 
GTCGCGGGCA GCCCCCTGTC TCAGCGCAGC CTCCTGCTCT ACCTGGCGGG CACCACCTAC 
CTGTGCTGGG GGCACCTGGC GGACGGCGTG AGGGAAGGGC GGAGCCAGTA CGCGAGGGCC 
GTGGGCGTCG ACGCGGACGA CCCCTTCACC GCCATCTACA GGTCGGAGGC CGAGCGCCTG 
CTGTTCATGC GGGGCCTGCA GGAGACCTGG AGCCTGTGCG GGGGGCGGGT CCTCACGGCC 
TTCGACCTCT CGCCCTTCAG GGTCATCTGC GACCTCGGTG GTGGGTCCGG GGCGCTGGCC 
CGCATGGCCG CCCGGCTCTA CCCGGGCAGC GAGGTCACCG TGTTCGAGAC GCCCGACGTC 
GTCGCCGCCG CCCGCGCCCA CTTCCCGCCC CCAGCGGACG AGGACGGGGC GGAGCCTCGT 
GTGCGCTTCC TGTCAGGCGA CTTCTTCCGC TCGCCGCTGC CGCCCGCCGA CCTCTACGTC 
CTGGCCCGGG TCCTGCACGA CTGGGCGGAC GCCGCCTGCG TGGAGCTGCT GCGGCGCGTG 
CGGGGCGCCC TGCGGCCAGG CGGCGCGGTG CTGCTGGTGG AGAGCGTGCT GTCCCCGGGA 
GGGGCGGGGC CGACGCGGAC GCTGCTGCTG TCGCTCACGA TGCTGCTGCA GGCCCGGGGC 
CGCGAGCGCA CGGAGGCCGA GTACCGGGCG CTGACCGCGC GCGCCGGCTT CTCCCGCCTG 
CGGCTGCGGC GCCCGCGGGG CCCCTACCAC GCCATGATGG CCGCCCGGGG GGGCGGGGCC 
GGGGCGCGGA GCGACGGCGG CGGCGGGGAC GCGACGTCAC AGACAGGAAG TGGGACAGGA 
AGTGAGGTCG GCGCCCAGGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Asmt ( NM_001308488.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001295417.1 Mus musculus acetylserotonin O-methyltransferase (Asmt), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu72189
Clone ID Related Accession (Same CDS sequence)	NM_001308488.1
Accession Version	NM_001308488.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1164bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	acetylserotonin O-methyltransferase isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB512670.1. Transcript Variant: This variant (2) is based on a transcript from the reference strain and includes seven nucleotide substitutions in the coding sequence compared to variant 1. Two of these nucleotide substitutions result in amino acid substitutions (R78G and R242C) in the encoded isoform (2), which shows low enzyme activity. ##Evidence-Data-START## Transcript exon combination :: AB512670.1, AB512671.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGCACAGGG GCCGCTCGGC CTCCGCTCGC CAGGAGCGCG ACTTCCGGGC CCTCATGGAC 
CTGGCCCACG GCTTCATGGC CTCCCAGGTG CTGTTCGCGG GCTGCGCGCT CCGCGTGTTC 
GACGCCGCGG CCCTGGGCCC CGTGGACGCC GCGGCGCTGG CGAGGTCGTC GGGCCTGAGC 
CCCCGGGGGA CGCGGCTGCT GCTCGACGCC TGCGCGGGGC TGGGGCTGCT GGGGAGACGC 
AGGGGGGCGG GGCCGCGCGG CCCCGCCTAC ACCAACTCCC CCCTGGCGTC CACCTTCCTG 
GTCGCGGGCA GCCCCCTGTC TCAGCGCAGC CTCCTGCTCT ACCTGGCGGG CACCACCTAC 
CTGTGCTGGG GGCACCTGGC GGACGGCGTG AGGGAAGGGC GGAGCCAGTA CGCGAGGGCC 
GTGGGCGTCG ACGCGGACGA CCCCTTCACC GCCATCTACA GGTCGGAGGC CGAGCGCCTG 
CTGTTCATGC GGGGCCTGCA GGAGACCTGG AGCCTGTGCG GGGGGCGGGT CCTCACGGCC 
TTCGACCTCT CGCCCTTCAG GGTCATCTGC GACCTCGGTG GTGGGTCCGG GGCGCTGGCC 
CGCATGGCCG CCCGGCTCTA CCCGGGCAGC GAGGTCACCG TGTTCGAGAC GCCCGACGTC 
GTCGCTGCCG CCCGCGCCCA CTTCCCGCCC CCAGCGGACG AGGACGGGGC GGAGCCTCGT 
GTGTGCTTCC TGTCAGGCGA CTTCTTCCGC TCGCCGCTGC CGCCCGCCGA CCTCTACGTC 
CTGGCCCGGG TCCTGCACGA CTGGGCGGAC GCCGCCTGCG TGGAGCTGCT GCGGCGCGTG 
CGGGGTGCCC TGCGGCCAGG CGGCGCGGTG CTGCTGGTGG AGAGCGTGCT GTCCCCGGGA 
GGGGCGGGGC CGACGCGGAC GCTGCTGCTG TCGCTCACGA TGCTGCTGCA GGCCCGGGGC 
CGCGAGCGCA CGGAGGCCGA GTACCGGGCG CTGACCGCGC GTGCCGGCTT CTCCCGCCTG 
CGGCTGCGGC GCCCGCGGGG CCCCTACCAC GCCATGATGG CCGCCCGGGG GGGCGGGGCC 
GGGGCGCGGA GCGACGGCGG CGGCGGGGAC GCGACGTCAC AGACAGGAAG TGGGACAGGA 
AGTGAGGTCG GCGCCCAGGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001295417.1
CDS	24..1187
Translation	MHRGRSASARQERDFRALMDLAHGFMASQVLFAGCALRVFDAAALGPVDAAALARSSGLSPRGTRLLLDACAGLGLLGRRRGAGPRGPAYTNSPLASTFLVAGSPLSQRSLLLYLAGTTYLCWGHLADGVREGRSQYARAVGVDADDPFTAIYRSEAERLLFMRGLQETWSLCGGRVLTAFDLSPFRVICDLGGGSGALARMAARLYPGSEVTVFETPDVVAAARAHFPPPADEDGAEPRVCFLSGDFFRSPLPPADLYVLARVLHDWADAACVELLRRVRGALRPGGAVLLVESVLSPGGAGPTRTLLLSLTMLLQARGRERTEAEYRALTARAGFSRLRLRRPRGPYHAMMAARGGGAGARSDGGGGDATSQTGSGTGSEVGAQD

Target ORF information:

RefSeq Version	NM_001308488.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus acetylserotonin O-methyltransferase (Asmt), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308488.1

ORF Insert Sequence:

ATGCACAGGG GCCGCTCGGC CTCCGCTCGC CAGGAGCGCG ACTTCCGGGC CCTCATGGAC 
CTGGCCCACG GCTTCATGGC CTCCCAGGTG CTGTTCGCGG GCTGCGCGCT CCGCGTGTTC 
GACGCCGCGG CCCTGGGCCC CGTGGACGCC GCGGCGCTGG CGAGGTCGTC GGGCCTGAGC 
CCCCGGGGGA CGCGGCTGCT GCTCGACGCC TGCGCGGGGC TGGGGCTGCT GGGGAGACGC 
AGGGGGGCGG GGCCGCGCGG CCCCGCCTAC ACCAACTCCC CCCTGGCGTC CACCTTCCTG 
GTCGCGGGCA GCCCCCTGTC TCAGCGCAGC CTCCTGCTCT ACCTGGCGGG CACCACCTAC 
CTGTGCTGGG GGCACCTGGC GGACGGCGTG AGGGAAGGGC GGAGCCAGTA CGCGAGGGCC 
GTGGGCGTCG ACGCGGACGA CCCCTTCACC GCCATCTACA GGTCGGAGGC CGAGCGCCTG 
CTGTTCATGC GGGGCCTGCA GGAGACCTGG AGCCTGTGCG GGGGGCGGGT CCTCACGGCC 
TTCGACCTCT CGCCCTTCAG GGTCATCTGC GACCTCGGTG GTGGGTCCGG GGCGCTGGCC 
CGCATGGCCG CCCGGCTCTA CCCGGGCAGC GAGGTCACCG TGTTCGAGAC GCCCGACGTC 
GTCGCTGCCG CCCGCGCCCA CTTCCCGCCC CCAGCGGACG AGGACGGGGC GGAGCCTCGT 
GTGTGCTTCC TGTCAGGCGA CTTCTTCCGC TCGCCGCTGC CGCCCGCCGA CCTCTACGTC 
CTGGCCCGGG TCCTGCACGA CTGGGCGGAC GCCGCCTGCG TGGAGCTGCT GCGGCGCGTG 
CGGGGTGCCC TGCGGCCAGG CGGCGCGGTG CTGCTGGTGG AGAGCGTGCT GTCCCCGGGA 
GGGGCGGGGC CGACGCGGAC GCTGCTGCTG TCGCTCACGA TGCTGCTGCA GGCCCGGGGC 
CGCGAGCGCA CGGAGGCCGA GTACCGGGCG CTGACCGCGC GTGCCGGCTT CTCCCGCCTG 
CGGCTGCGGC GCCCGCGGGG CCCCTACCAC GCCATGATGG CCGCCCGGGG GGGCGGGGCC 
GGGGCGCGGA GCGACGGCGG CGGCGGGGAC GCGACGTCAC AGACAGGAAG TGGGACAGGA 
AGTGAGGTCG GCGCCCAGGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder.
Molecular autism5(1)21(2014 Mar)
Trent S,Fry JP,Ojarikre OA,Davies W

Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder.
Psychoneuroendocrinology38(8)1370-80(2013 Aug)
Trent S,Dean R,Veit B,Cassano T,Bedse G,Ojarikre OA,Humby T,Davies W

Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth.
American journal of physiology. Gastrointestinal and liver physiology301(4)G623-33(2011 Oct)
Han Y,Demorrow S,Invernizzi P,Jing Q,Glaser S,Renzi A,Meng F,Venter J,Bernuzzi F,White M,Francis H,Lleo A,Marzioni M,Onori P,Alvaro D,Torzilli G,Gaudio E,Alpini G

Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway.
Proceedings of the National Academy of Sciences of the United States of America107(18)8399-403(2010 May)
Shimomura K,Lowrey PL,Vitaterna MH,Buhr ED,Kumar V,Hanna P,Omura C,Izumo M,Low SS,Barrett RK,LaRue SI,Green CB,Takahashi JS

Genetic variation of melatonin productivity in laboratory mice under domestication.
Proceedings of the National Academy of Sciences of the United States of America107(14)6412-7(2010 Apr)
Kasahara T,Abe K,Mekada K,Yoshiki A,Kato T

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Asmt cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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