Rrn3 cDNA ORF clone, Mus musculus(house mouse)

A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription.
Herdman C, Mars JC, Stefanovsky VY, Tremblay MG, Sabourin-Felix M, Lindsay H, Robinson MD, Moss T
PLoS genetics13(7)e1006899(2017 Jul)

Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models.
Evsyukov V, Domanskyi A, Bierhoff H, Gispert S, Mustafa R, Schlaudraff F, Liss B, Parlato R
Disease models & mechanisms10(5)633-643(2017 May)

Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning.
Zhao Z, Dammert MA, Hoppe S, Bierhoff H, Grummt I
Nucleic acids research44(17)8144-52(2016 Sep)

Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA.
Nguyen le XT, Mitchell BS
Proceedings of the National Academy of Sciences of the United States of America110(51)20681-6(2013 Dec)

Conditional deletion of the Rrn3 gene inhibits RNA polymerase I transcription but does not affect pre-initiation complex formation.
Title: A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription.

The results exemplify how stress-induced inactivation of TIF-IA and long non-coding RNA -dependent changes of chromatin structure ensure repression of ribosomal RNA synthesis in response to thermo-stress.
Title: Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning.

These data support a model in which activated Akt enhances rRNA synthesis both by preventing TIF-IA degradation and phosphorylating CK2alpha, which in turn phosphorylates TIF-IA.
Title: Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA.

DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription
Title: DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.

Ablation of TIF-IA leads to impaired nucleolar activity and results in increased levels of the proapoptotic transcription factor p53 in both neural progenitors and hippocampal neurons but induces rapid apoptosis only in neural progenitors.
Title: Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice.