Mmrn2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmrn2
Entrez Gene ID	105450
Full Name	multimerin 2
Synonyms	AA986839,ENDOGLYX1,Emilin3,EndoGlyx-1
General protein information	Preferred Names multimerin 2 Names multimerin-2 elastin microfibril interfacer 3 mmrn2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 B

mRNA and Protein(s)

mRNA	Protein	Name
NM_153127.3	NP_694767.3	multimerin-2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MMRN2	XP_507890.2
Rattus norvegicus (Norway rat)	Mmrn2	XP_003751598.2
Gallus gallus (chicken)	MMRN2	XP_421496.3
Xenopus tropicalis (tropical clawed frog)	mmrn2	XP_002937618.2
Canis lupus familiaris (dog)	MMRN2	XP_546195.3
Bos taurus (cattle)	MMRN2	XP_002698984.1
Mus musculus (house mouse)	Mmrn2	NP_694767.3
Danio rerio (zebrafish)	mmrn2a	NP_001139178.1
Homo sapiens (human)	MMRN2	NP_079032.2
Danio rerio (zebrafish)	mmrn2b	XP_694616.4

Gene Ontology
Bibliography

Related articles in PubMed

Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with
Lacko LA, Hurtado R, Hinds S, Poulos MG, Butler JM, Stuhlmann H
Development (Cambridge, England)144(13)2469-2479(2017 07)

Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth.
Noy PJ, Lodhia P, Khan K, Zhuang X, Ward DG, Verissimo AR, Bacon A, Bicknell R
Oncogene34(47)5821-31(2015 Nov)

MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway.
Lorenzon E, Colladel R, Andreuzzi E, Marastoni S, Todaro F, Schiappacassi M, Ligresti G, Colombatti A, Mongiat M
Oncogene31(26)3136-47(2012 Jun)

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.
Naba A, Clauser KR, Hoersch S, Liu H, Carr SA, Hynes RO
Molecular & cellular proteomics : MCP11(4)M111.014647(2012 Apr)

Transcriptome-based systematic identification of extracellular matrix proteins.
Manabe R, Tsutsui K, Yamada T, Kimura M, Nakano I, Shimono C, Sanzen N, Furutani Y, Fukuda T, Oguri Y, Shimamoto K, Kiyozumi D, Sato Y, Sado Y, Senoo H, Yamashina S, Fukuda S, Kawai J, Sugiura N, Kimata K, Hayashizaki Y, Sekiguchi K
Proceedings of the National Academy of Sciences of the United States of America105(35)12849-54(2008 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MMRN2 as a crucial player in the regulation of EC function, neo-angiogenesis and hence tumor growth
Title: MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway.

Mmrn2 interacts with anthrax protective antigen.
Title: EMILINs interact with anthrax protective antigen and inhibit toxin action in vitro.

The following Mmrn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmrn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20800	NM_153127.3 Latest version!	Mus musculus multimerin 2 (Mmrn2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$552.30 $789.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmrn2 ( NM_153127.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_694767.3 Mus musculus multimerin 2 (Mmrn2), mRNA.

Price & Availability↑

CloneID	OMu20800
Clone ID Related Accession (Same CDS sequence)	NM_153127.3
Accession Version	NM_153127.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2832bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Mus musculus(house mouse)
Product	multimerin-2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK077884.1, AK134285.1 and AC160930.2. On Jan 18, 2007 this sequence version replaced NM_153127.2. ##Evidence-Data-START## Transcript exon combination :: AK077884.1, AK134285.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCCCGA CACTGCTGCT GGGCTTTGGG GTGTACCTGA GCTGGGGACT GCTAGGGTCC 
TGGGCACAGG ACCCCGGTAC CAAGTTCTCC CATCTCAATA GGCCCGGCAT GCCTGAAGGC 
TGGAGACTAG GGGCTGAGGA TACCAGCAGA GACCCCATCA GACGGAACTG GTGTCCTTAC 
CAGAAGTCCA GGCTAGTCAC CTTTGTAGCT GCTTGCAAAA CAGAGAAATT CCTGGTCCAT 
TCACAGCAGC CATGTCCACA GGGAGCCCCT GACTGCCAGG GAGTCAGAGT CATGTATCGA 
GTGGCCCAGA AGCCAGTGTA CCAGGTCCAG CAGAAGGTGC TGATCTCTGT GGACTGGCGG 
TGCTGCCCAG GGTTCCAGGG ACCAGACTGC CAGGACCACA ATCCCACAGC AAACCCTGAG 
CCCACAGAGC CAAGTGGTAA ACTCCAGGAG ACTTGGGACT CGATGGATGG CTTTGAACTT 
GGTCACCCTG TCCCAGAGTT TAATGAGATT AAGGTGCCAC AAGAACAACA GGAAAACCTG 
CTTCAAAATC TCCAGAATGA TGCCCAGTCA GTAGAAGATG GCTTTCCAGG CTCTTGGGAA 
GCCCCACCCA GCAACCTCAC AGATGAGATG ACAGAAGCCA ATCTAACAGA ATTCGAGTTT 
CCTGGCAGGA CATCAGAGCA CCTGCTGCAG CCCCATATTG ATGCATTCCT GAAAGCACAC 
TTCAGTCCCA TCTGGAAGAA CTTCAACGAC AGCTTGCACA GCCTCTCCCA GGCCATCAGA 
AACTTGTCTC TTGATGTGGA GGCCAATCAC CAGGCCATCA AGATGATCCA GGAGGGCACA 
GTGGCTAGGG CTGACTTCCA AGAGCTTGGT GCCAAGTTTG AGGCCAAGGT CCAGCAGAAT 
AGCCAGAGAC TGGGCCAACT GTGGCAGGAT GTGGAGGACC AGCTGCATGC CCAGCGCCGA 
TCGGTGCATC ATGCCCTCTC TGATGTCCAG GCTGAGGTGA GCACCAAGTT AAAGCAGCTT 
GTCAAGGCTC AGGAACTTCC AGGGGCCAAT GGCAGCCTGG TGATGGCATC TGCAGCAGCG 
GCAGCAAGGC CAGAGCCAGA GAGCCTGCAG GCCAGGCTAG GGCAGCTGCA GAGAAACCTC 
TCTGCTCTGC ACATGGTCAC TAGCCAGAGG GAGGAGGAGT TGCAGAGCAC CCTCAAGAAC 
ATGGACAGCG TCCTGAAGCA GCACGCCGAA GAGATCAAAG AGCTCTATTC TGAATCGGAT 
GAGACCTTCG ACCAGATCAG CAAGGTAGAG AGGCAGGTGG AGGAGCTGCT GGTGAACCAC 
ACCGGGCTTC GAGAGCTGCG GGTGATCCTA ATGGAAAAGT CCCTGATCAT GGAGGAGAAC 
AAAGAGGAGA TAGAGCGGCA ACTGTTGGAA CTCAACCTTA CCCTGCAGCA TCTGCATGCG 
GGTCATGCAG ACCTCATTAA GTATGTCAAG GACTGCAACT GCCAAAGGGT CAACTCTGAC 
GTGGATGTCG CTCCGGAGGG CCACAGGGAT GTCATGCACA CCCTAGAAGA GACCCAAGTG 
AGCCTGGACG AACAGCACCA GCTAGACGGT TCTTCTTTGC AGGCCCTGCA AAGCACTGTA 
GATGCCATGT CTTCAGCAAT GGATGCCTAT AGAGGAGAGG GTGAACGGGC CCGGGCTGAA 
AGGGCACGGA TACGGAGCCA ACTGCGGGCT CTGGATCATG CTGTGGAAGC GCTGAAGACA 
GCGGCGAATG GAACCCGCAA AGAGATACGC CTACTGCACG GCTCCTTCAC AGCCCTGCTG 
GAGGATGCCC TGCGACATCA GGCCGTGCTA GCTGCACTCT TCGGGGAGGA GATGATAGAC 
GAGATGTCAG AGGAGGCCCC TCGCCCTCTG CCACTGGATT ATGAGCAGAT CCGCCTAGCC 
CTGCAGGACG CGGCCAGTGG GCTACAGGAA CAGGCGATTG GTTGGGAGGA CTTGGCCACC 
CGGGTGGAGG CATTGGAGAA GGCCGCAGGT GGCTTTGTGG AGCAGCACCC ACAGTTGGCA 
GAGGGACTTG AGCCCAGCCA CGACTCTGGG AGAGAGGAGG AAGCCATGAC TTTGGCGGAG 
CTGGAGCAGG AGATTCGGCG CCTGAGTTCT GATGTCAAGC AGATTGGGCA GTGCTGTGAG 
GCCTCCTGGG CTGCCTCCCT CAATAGCTCC CTTGAAGACC TACACAGCAT GCTCTTGGAC 
ACCCAGCACG GCCTGAGACA GCACCGGCAG CTCTTCCACA ACCTCTTCCA GAACTTCCAA 
GGTCTGGTGG CAAGCAACAT CAGCCTAGAC TTGGGGAAGC TGCAGGCCAT GTTGAGTAAG 
AAAGATAAGA AGCAACCGAG AGGCCCAGGA GAATCCCGGA AGAGGGATAA GAAGCAAGTG 
GTGATGTCTA CAGATGCACA CGCCAAAGGT CTGGAGCTCT GGGAGACAGG CTCCCCTGTG 
GCCTTCTATG CCGGTTCTTC AGAAGGGGCC ACTGCTCTGC AGATGGTGAA GTTCAACACC 
ACATCCATCA ATGTGGGCAG CAGCTACTTT CCTGAACATG GCTACTTCCG AGCTCCCAAA 
CGTGGCGTCT ACTTGTTTGC TGTGAGCATT ACATTTGGCC CAGGCCCAGG AATGGGGCAG 
CTGGTATTTG AAGGTCATCA CCGGGTTCCA GTCTACAGTA CGGAACAGAG GGGCGGGAGC 
ACAGCCACCA CTTTTGCTAT GGTAGAGCTA CAAAAGGGTG AGAGAGCGTG GTTTGAGTTA 
ATCCAAGGGT CAGCAACCAA AGGGAGCCAA CCAGGCACTG CATTTGGGGG CTTCCTGATG 
TTCAAGACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694767.3
CDS	112..2943
Translation	MIPTLLLGFGVYLSWGLLGSWAQDPGTKFSHLNRPGMPEGWRLGAEDTSRDPIRRNWCPYQKSRLVTFVAACKTEKFLVHSQQPCPQGAPDCQGVRVMYRVAQKPVYQVQQKVLISVDWRCCPGFQGPDCQDHNPTANPEPTEPSGKLQETWDSMDGFELGHPVPEFNEIKVPQEQQENLLQNLQNDAQSVEDGFPGSWEAPPSNLTDEMTEANLTEFEFPGRTSEHLLQPHIDAFLKAHFSPIWKNFNDSLHSLSQAIRNLSLDVEANHQAIKMIQEGTVARADFQELGAKFEAKVQQNSQRLGQLWQDVEDQLHAQRRSVHHALSDVQAEVSTKLKQLVKAQELPGANGSLVMASAAAAARPEPESLQARLGQLQRNLSALHMVTSQREEELQSTLKNMDSVLKQHAEEIKELYSESDETFDQISKVERQVEELLVNHTGLRELRVILMEKSLIMEENKEEIERQLLELNLTLQHLHAGHADLIKYVKDCNCQRVNSDVDVAPEGHRDVMHTLEETQVSLDEQHQLDGSSLQALQSTVDAMSSAMDAYRGEGERARAERARIRSQLRALDHAVEALKTAANGTRKEIRLLHGSFTALLEDALRHQAVLAALFGEEMIDEMSEEAPRPLPLDYEQIRLALQDAASGLQEQAIGWEDLATRVEALEKAAGGFVEQHPQLAEGLEPSHDSGREEEAMTLAELEQEIRRLSSDVKQIGQCCEASWAASLNSSLEDLHSMLLDTQHGLRQHRQLFHNLFQNFQGLVASNISLDLGKLQAMLSKKDKKQPRGPGESRKRDKKQVVMSTDAHAKGLELWETGSPVAFYAGSSEGATALQMVKFNTTSINVGSSYFPEHGYFRAPKRGVYLFAVSITFGPGPGMGQLVFEGHHRVPVYSTEQRGGSTATTFAMVELQKGERAWFELIQGSATKGSQPGTAFGGFLMFKT

Target ORF information:

RefSeq Version	NM_153127.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus multimerin 2 (Mmrn2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153127.3

ORF Insert Sequence:

ATGATCCCGA CACTGCTGCT GGGCTTTGGG GTGTACCTGA GCTGGGGACT GCTAGGGTCC 
TGGGCACAGG ACCCCGGTAC CAAGTTCTCC CATCTCAATA GGCCCGGCAT GCCTGAAGGC 
TGGAGACTAG GGGCTGAGGA TACCAGCAGA GACCCCATCA GACGGAACTG GTGTCCTTAC 
CAGAAGTCCA GGCTAGTCAC CTTTGTAGCT GCTTGCAAAA CAGAGAAATT CCTGGTCCAT 
TCACAGCAGC CATGTCCACA GGGAGCCCCT GACTGCCAGG GAGTCAGAGT CATGTATCGA 
GTGGCCCAGA AGCCAGTGTA CCAGGTCCAG CAGAAGGTGC TGATCTCTGT GGACTGGCGG 
TGCTGCCCAG GGTTCCAGGG ACCAGACTGC CAGGACCACA ATCCCACAGC AAACCCTGAG 
CCCACAGAGC CAAGTGGTAA ACTCCAGGAG ACTTGGGACT CGATGGATGG CTTTGAACTT 
GGTCACCCTG TCCCAGAGTT TAATGAGATT AAGGTGCCAC AAGAACAACA GGAAAACCTG 
CTTCAAAATC TCCAGAATGA TGCCCAGTCA GTAGAAGATG GCTTTCCAGG CTCTTGGGAA 
GCCCCACCCA GCAACCTCAC AGATGAGATG ACAGAAGCCA ATCTAACAGA ATTCGAGTTT 
CCTGGCAGGA CATCAGAGCA CCTGCTGCAG CCCCATATTG ATGCATTCCT GAAAGCACAC 
TTCAGTCCCA TCTGGAAGAA CTTCAACGAC AGCTTGCACA GCCTCTCCCA GGCCATCAGA 
AACTTGTCTC TTGATGTGGA GGCCAATCAC CAGGCCATCA AGATGATCCA GGAGGGCACA 
GTGGCTAGGG CTGACTTCCA AGAGCTTGGT GCCAAGTTTG AGGCCAAGGT CCAGCAGAAT 
AGCCAGAGAC TGGGCCAACT GTGGCAGGAT GTGGAGGACC AGCTGCATGC CCAGCGCCGA 
TCGGTGCATC ATGCCCTCTC TGATGTCCAG GCTGAGGTGA GCACCAAGTT AAAGCAGCTT 
GTCAAGGCTC AGGAACTTCC AGGGGCCAAT GGCAGCCTGG TGATGGCATC TGCAGCAGCG 
GCAGCAAGGC CAGAGCCAGA GAGCCTGCAG GCCAGGCTAG GGCAGCTGCA GAGAAACCTC 
TCTGCTCTGC ACATGGTCAC TAGCCAGAGG GAGGAGGAGT TGCAGAGCAC CCTCAAGAAC 
ATGGACAGCG TCCTGAAGCA GCACGCCGAA GAGATCAAAG AGCTCTATTC TGAATCGGAT 
GAGACCTTCG ACCAGATCAG CAAGGTAGAG AGGCAGGTGG AGGAGCTGCT GGTGAACCAC 
ACCGGGCTTC GAGAGCTGCG GGTGATCCTA ATGGAAAAGT CCCTGATCAT GGAGGAGAAC 
AAAGAGGAGA TAGAGCGGCA ACTGTTGGAA CTCAACCTTA CCCTGCAGCA TCTGCATGCG 
GGTCATGCAG ACCTCATTAA GTATGTCAAG GACTGCAACT GCCAAAGGGT CAACTCTGAC 
GTGGATGTCG CTCCGGAGGG CCACAGGGAT GTCATGCACA CCCTAGAAGA GACCCAAGTG 
AGCCTGGACG AACAGCACCA GCTAGACGGT TCTTCTTTGC AGGCCCTGCA AAGCACTGTA 
GATGCCATGT CTTCAGCAAT GGATGCCTAT AGAGGAGAGG GTGAACGGGC CCGGGCTGAA 
AGGGCACGGA TACGGAGCCA ACTGCGGGCT CTGGATCATG CTGTGGAAGC GCTGAAGACA 
GCGGCGAATG GAACCCGCAA AGAGATACGC CTACTGCACG GCTCCTTCAC AGCCCTGCTG 
GAGGATGCCC TGCGACATCA GGCCGTGCTA GCTGCACTCT TCGGGGAGGA GATGATAGAC 
GAGATGTCAG AGGAGGCCCC TCGCCCTCTG CCACTGGATT ATGAGCAGAT CCGCCTAGCC 
CTGCAGGACG CGGCCAGTGG GCTACAGGAA CAGGCGATTG GTTGGGAGGA CTTGGCCACC 
CGGGTGGAGG CATTGGAGAA GGCCGCAGGT GGCTTTGTGG AGCAGCACCC ACAGTTGGCA 
GAGGGACTTG AGCCCAGCCA CGACTCTGGG AGAGAGGAGG AAGCCATGAC TTTGGCGGAG 
CTGGAGCAGG AGATTCGGCG CCTGAGTTCT GATGTCAAGC AGATTGGGCA GTGCTGTGAG 
GCCTCCTGGG CTGCCTCCCT CAATAGCTCC CTTGAAGACC TACACAGCAT GCTCTTGGAC 
ACCCAGCACG GCCTGAGACA GCACCGGCAG CTCTTCCACA ACCTCTTCCA GAACTTCCAA 
GGTCTGGTGG CAAGCAACAT CAGCCTAGAC TTGGGGAAGC TGCAGGCCAT GTTGAGTAAG 
AAAGATAAGA AGCAACCGAG AGGCCCAGGA GAATCCCGGA AGAGGGATAA GAAGCAAGTG 
GTGATGTCTA CAGATGCACA CGCCAAAGGT CTGGAGCTCT GGGAGACAGG CTCCCCTGTG 
GCCTTCTATG CCGGTTCTTC AGAAGGGGCC ACTGCTCTGC AGATGGTGAA GTTCAACACC 
ACATCCATCA ATGTGGGCAG CAGCTACTTT CCTGAACATG GCTACTTCCG AGCTCCCAAA 
CGTGGCGTCT ACTTGTTTGC TGTGAGCATT ACATTTGGCC CAGGCCCAGG AATGGGGCAG 
CTGGTATTTG AAGGTCATCA CCGGGTTCCA GTCTACAGTA CGGAACAGAG GGGCGGGAGC 
ACAGCCACCA CTTTTGCTAT GGTAGAGCTA CAAAAGGGTG AGAGAGCGTG GTTTGAGTTA 
ATCCAAGGGT CAGCAACCAA AGGGAGCCAA CCAGGCACTG CATTTGGGGG CTTCCTGATG 
TTCAAGACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with
Development (Cambridge, England)144(13)2469-2479(2017 07)
Lacko LA,Hurtado R,Hinds S,Poulos MG,Butler JM,Stuhlmann H

Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth.
Oncogene34(47)5821-31(2015 Nov)
Noy PJ,Lodhia P,Khan K,Zhuang X,Ward DG,Verissimo AR,Bacon A,Bicknell R

MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway.
Oncogene31(26)3136-47(2012 Jun)
Lorenzon E,Colladel R,Andreuzzi E,Marastoni S,Todaro F,Schiappacassi M,Ligresti G,Colombatti A,Mongiat M

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.
Molecular & cellular proteomics : MCP11(4)M111.014647(2012 Apr)
Naba A,Clauser KR,Hoersch S,Liu H,Carr SA,Hynes RO

Transcriptome-based systematic identification of extracellular matrix proteins.
Proceedings of the National Academy of Sciences of the United States of America105(35)12849-54(2008 Sep)
Manabe R,Tsutsui K,Yamada T,Kimura M,Nakano I,Shimono C,Sanzen N,Furutani Y,Fukuda T,Oguri Y,Shimamoto K,Kiyozumi D,Sato Y,Sado Y,Senoo H,Yamashina S,Fukuda S,Kawai J,Sugiura N,Kimata K,Hayashizaki Y,Sekiguchi K

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Mmrn2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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