Dusp22 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dusp22
Entrez Gene ID	105352
Full Name	dual specificity phosphatase 22
Synonyms	JKAP,JSP1,LMW-DSP2,MKPX
General protein information	Preferred Names dual specificity phosphatase 22 Names dual specificity protein phosphatase 22 low molecular weight dual specificity phosphatase 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 A3.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_134068.3	NP_598829.1	dual specificity protein phosphatase 22 isoform b
NM_001037955.4	NP_001033044.1	dual specificity protein phosphatase 22 isoform a
XM_006516519.1	XP_006516582.1	dual specificity protein phosphatase 22 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	DUSP22	XP_005640025.1
Gallus gallus (chicken)	DUSP22	XP_418974.2
Danio rerio (zebrafish)	dusp22b	NP_001017742.2
Xenopus tropicalis (tropical clawed frog)	dusp22	NP_001011043.1
Pan troglodytes (chimpanzee)	DUSP22	NP_001153523.1
Mus musculus (house mouse)	Dusp22	NP_001033044.1
Homo sapiens (human)	DUSP22	NP_001273484.1
Rattus norvegicus (Norway rat)	Dusp22	NP_001101882.1
Bos taurus (cattle)	DUSP22	XP_002697658.2
Drosophila melanogaster (fruit fly)	CG10089	NP_648654.1
	DUSP22	XP_002803616.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression analyses of Dusp22 (Dual-specificity phosphatase 22) in mouse tissues.
Hamada N, Mizuno M, Tomita H, Iwamoto I, Hara A, Nagata KI
Medical molecular morphology(2017 Dec)

The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck.
Li JP, Yang CY, Chuang HC, Lan JL, Chen DY, Chen YM, Wang X, Chen AJ, Belmont JW, Tan TH
Nature communications53618(2014 Apr)

Regulation of STAT3-mediated signaling by LMW-DSP2.
Sekine Y, Tsuji S, Ikeda O, Sato N, Aoki N, Aoyama K, Sugiyama K, Matsuda T
Oncogene25(42)5801-6(2006 Sep)

The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway.
Chen AJ, Zhou G, Juan T, Colicos SM, Cannon JP, Cabriera-Hansen M, Meyer CF, Jurecic R, Copeland NG, Gilbert DJ, Jenkins NA, Fletcher F, Tan TH, Belmont JW
The Journal of biological chemistry277(39)36592-601(2002 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DSP2 acts as a negative regulator of the IL-6/LIF/STAT3-mediated signaling pathway.
Title: Regulation of STAT3-mediated signaling by LMW-DSP2.

cloning and characterization of JKAP, a positive regulator of the JNK pathway
Title: The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway.

The following Dusp22 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dusp22 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu00173	NM_001037955.4 Latest version!	Mus musculus dual specificity phosphatase 22 (Dusp22), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu10497	NM_134068.3 Latest version!	Mus musculus dual specificity phosphatase 22 (Dusp22), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu48304	XM_006516519.1 Latest version!	Mus musculus dual specificity phosphatase 22 (Dusp22), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dusp22 ( NM_001037955.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001033044.1 Mus musculus dual specificity phosphatase 22 (Dusp22), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu00173
Clone ID Related Accession (Same CDS sequence)	NM_001037955.4
Accession Version	NM_001037955.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Mus musculus(house mouse)
Product	dual specificity protein phosphatase 22 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX236611.1, AK148708.1, AK149363.1, AA137950.1, AK003947.1 and BY477408.1. On Oct 30, 2013 this sequence version replaced NM_001037955.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: BC080718.1, AK149363.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGAGTG GGATGAGCCA GATCCTGCCG GGCCTGTACA TTGGCAACTT CAAAGACGCA 
AGAGATGCAG AACAGTTGAG CAGGAACAAG GTGACACACA TTCTTTCTGT GCACGATACT 
GCCAGGCCCA TGTTGGAGGG AGTTAAATAC CTGTGTATTC CAGCGGCAGA CACACCATCT 
CAAAACCTGA CAAGACATTT CAAAGAAAGC ATTAAATTCA TTCATGAGTG CCGACTCCAG 
GGTGAGAGCT GTCTTGTACA TTGCCTGGCT GGGGTCTCCA GGAGTGTGAC ATTGGTGATC 
GCATACATCA TGACTGTCAC CGACTTTGGC TGGGAAGATG CCTTGCACAC TGTTCGTGCG 
GGGAGGTCCT GTGCCAACCC CAACCTGGGC TTTCAAAGGC AGCTGCAGGA GTTTGAGAAA 
CATGAAGTGC ACCAGTATCG GCAATGGCTG AGAGAAGAGT ATGGAGAGAA CCCTTTGCGG 
GATGCAGAAG AAGCCAAAAA TATTCTGGGT AAATATAAAG AGCAAGGGCG CATGGAGCCC 
CGGCCTAGCA GCAGGCGGTG GAGCAGCTTC TCAACCCTGC CTCCTCTCAC CTACAATAAC 
TACACAACAG AGACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001033044.1
CDS	68..685
Translation	MGSGMSQILPGLYIGNFKDARDAEQLSRNKVTHILSVHDTARPMLEGVKYLCIPAADTPSQNLTRHFKESIKFIHECRLQGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNLGFQRQLQEFEKHEVHQYRQWLREEYGENPLRDAEEAKNILGKYKEQGRMEPRPSSRRWSSFSTLPPLTYNNYTTET

Target ORF information:

RefSeq Version	NM_001037955.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus dual specificity phosphatase 22 (Dusp22), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037955.4

ORF Insert Sequence:

ATGGGGAGTG GGATGAGCCA GATCCTGCCG GGCCTGTACA TTGGCAACTT CAAAGACGCA 
AGAGATGCAG AACAGTTGAG CAGGAACAAG GTGACACACA TTCTTTCTGT GCACGATACT 
GCCAGGCCCA TGTTGGAGGG AGTTAAATAC CTGTGTATTC CAGCGGCAGA CACACCATCT 
CAAAACCTGA CAAGACATTT CAAAGAAAGC ATTAAATTCA TTCATGAGTG CCGACTCCAG 
GGTGAGAGCT GTCTTGTACA TTGCCTGGCT GGGGTCTCCA GGAGTGTGAC ATTGGTGATC 
GCATACATCA TGACTGTCAC CGACTTTGGC TGGGAAGATG CCTTGCACAC TGTTCGTGCG 
GGGAGGTCCT GTGCCAACCC CAACCTGGGC TTTCAAAGGC AGCTGCAGGA GTTTGAGAAA 
CATGAAGTGC ACCAGTATCG GCAATGGCTG AGAGAAGAGT ATGGAGAGAA CCCTTTGCGG 
GATGCAGAAG AAGCCAAAAA TATTCTGGGT AAATATAAAG AGCAAGGGCG CATGGAGCCC 
CGGCCTAGCA GCAGGCGGTG GAGCAGCTTC TCAACCCTGC CTCCTCTCAC CTACAATAAC 
TACACAACAG AGACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dusp22 ( NM_134068.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598829.1 Mus musculus dual specificity phosphatase 22 (Dusp22), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu10497
Clone ID Related Accession (Same CDS sequence)	NM_134068.3
Accession Version	NM_134068.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Mus musculus(house mouse)
Product	dual specificity protein phosphatase 22 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX236611.1, AK148708.1, AA137950.1, AK003947.1 and BY477408.1. On Oct 30, 2013 this sequence version replaced NM_134068.2. Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: CX236611.1, AF237619.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGAGTG GGATGAGCCA GATCCTGCCG GGCCTGTACA TTGGCAACTT CAAAGACGCA 
AGAGATGCAG AACAGTTGAG CAGGAACAAG GTGACACACA TTCTTTCTGT GCACGATACT 
GCCAGGCCCA TGTTGGAGGG AGTTAAATAC CTGTGTATTC CAGCGGCAGA CACACCATCT 
CAAAACCTGA CAAGACATTT CAAAGAAAGC ATTAAATTCA TTCATGAGTG CCGACTCCAG 
GGTGAGAGCT GTCTTGTACA TTGCCTGGCT GGGGTCTCCA GGAGTGTGAC ATTGGTGATC 
GCATACATCA TGACTGTCAC CGACTTTGGC TGGGAAGATG CCTTGCACAC TGTTCGTGCG 
GGGAGGTCCT GTGCCAACCC CAACCTGGGC TTTCAAAGGC AGCTGCAGGA GTTTGAGAAA 
CATGAAGTGC ACCAGTATCG GCAATGGCTG AGAGAAGAGT ATGGAGAGAA CCCTTTGCGG 
GATGCAGAAG AAGCCAAAAA TATTCTGGCT GCCCCGGGAA TTCTGAAGTA CTGGGCCTTT 
CTCAGAAGAC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598829.1
CDS	68..622
Translation	MGSGMSQILPGLYIGNFKDARDAEQLSRNKVTHILSVHDTARPMLEGVKYLCIPAADTPSQNLTRHFKESIKFIHECRLQGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNLGFQRQLQEFEKHEVHQYRQWLREEYGENPLRDAEEAKNILAAPGILKYWAFLRRL

Target ORF information:

RefSeq Version	NM_134068.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus dual specificity phosphatase 22 (Dusp22), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134068.3

ORF Insert Sequence:

ATGGGGAGTG GGATGAGCCA GATCCTGCCG GGCCTGTACA TTGGCAACTT CAAAGACGCA 
AGAGATGCAG AACAGTTGAG CAGGAACAAG GTGACACACA TTCTTTCTGT GCACGATACT 
GCCAGGCCCA TGTTGGAGGG AGTTAAATAC CTGTGTATTC CAGCGGCAGA CACACCATCT 
CAAAACCTGA CAAGACATTT CAAAGAAAGC ATTAAATTCA TTCATGAGTG CCGACTCCAG 
GGTGAGAGCT GTCTTGTACA TTGCCTGGCT GGGGTCTCCA GGAGTGTGAC ATTGGTGATC 
GCATACATCA TGACTGTCAC CGACTTTGGC TGGGAAGATG CCTTGCACAC TGTTCGTGCG 
GGGAGGTCCT GTGCCAACCC CAACCTGGGC TTTCAAAGGC AGCTGCAGGA GTTTGAGAAA 
CATGAAGTGC ACCAGTATCG GCAATGGCTG AGAGAAGAGT ATGGAGAGAA CCCTTTGCGG 
GATGCAGAAG AAGCCAAAAA TATTCTGGCT GCCCCGGGAA TTCTGAAGTA CTGGGCCTTT 
CTCAGAAGAC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dusp22 ( XM_006516519.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006516582.1 Mus musculus dual specificity phosphatase 22 (Dusp22), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu48304
Clone ID Related Accession (Same CDS sequence)	XM_006516519.1
Accession Version	XM_006516519.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 609bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	dual specificity protein phosphatase 22 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000079.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGGAGC TGATCCTGCC GGGCCTGTAC ATTGGCAACT TCAAAGACGC AAGAGATGCA 
GAACAGTTGA GCAGGAACAA GGTGACACAC ATTCTTTCTG TGCACGATAC TGCCAGGCCC 
ATGTTGGAGG GAGTTAAATA CCTGTGTATT CCAGCGGCAG ACACACCATC TCAAAACCTG 
ACAAGACATT TCAAAGAAAG CATTAAATTC ATTCATGAGT GCCGACTCCA GGGTGAGAGC 
TGTCTTGTAC ATTGCCTGGC TGGGGTCTCC AGGAGTGTGA CATTGGTGAT CGCATACATC 
ATGACTGTCA CCGACTTTGG CTGGGAAGAT GCCTTGCACA CTGTTCGTGC GGGGAGGTCC 
TGTGCCAACC CCAACCTGGG CTTTCAAAGG CAGCTGCAGG AGTTTGAGAA ACATGAAGTG 
CACCAGTATC GGCAATGGCT GAGAGAAGAG TATGGAGAGA ACCCTTTGCG GGATGCAGAA 
GAAGCCAAAA ATATTCTGGG TAAATATAAA GAGCAAGGGC GCATGGAGCC CCGGCCTAGC 
AGCAGGCGGT GGAGCAGCTT CTCAACCCTG CCTCCTCTCA CCTACAATAA CTACACAACA 
GAGACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006516582.1
CDS	81..689
Translation	MLELILPGLYIGNFKDARDAEQLSRNKVTHILSVHDTARPMLEGVKYLCIPAADTPSQNLTRHFKESIKFIHECRLQGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNLGFQRQLQEFEKHEVHQYRQWLREEYGENPLRDAEEAKNILGKYKEQGRMEPRPSSRRWSSFSTLPPLTYNNYTTET

Target ORF information:

RefSeq Version	XM_006516519.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dual specificity phosphatase 22 (Dusp22), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006516519.1

ORF Insert Sequence:

ATGCTGGAGC TGATCCTGCC GGGCCTGTAC ATTGGCAACT TCAAAGACGC AAGAGATGCA 
GAACAGTTGA GCAGGAACAA GGTGACACAC ATTCTTTCTG TGCACGATAC TGCCAGGCCC 
ATGTTGGAGG GAGTTAAATA CCTGTGTATT CCAGCGGCAG ACACACCATC TCAAAACCTG 
ACAAGACATT TCAAAGAAAG CATTAAATTC ATTCATGAGT GCCGACTCCA GGGTGAGAGC 
TGTCTTGTAC ATTGCCTGGC TGGGGTCTCC AGGAGTGTGA CATTGGTGAT CGCATACATC 
ATGACTGTCA CCGACTTTGG CTGGGAAGAT GCCTTGCACA CTGTTCGTGC GGGGAGGTCC 
TGTGCCAACC CCAACCTGGG CTTTCAAAGG CAGCTGCAGG AGTTTGAGAA ACATGAAGTG 
CACCAGTATC GGCAATGGCT GAGAGAAGAG TATGGAGAGA ACCCTTTGCG GGATGCAGAA 
GAAGCCAAAA ATATTCTGGG TAAATATAAA GAGCAAGGGC GCATGGAGCC CCGGCCTAGC 
AGCAGGCGGT GGAGCAGCTT CTCAACCCTG CCTCCTCTCA CCTACAATAA CTACACAACA 
GAGACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression analyses of Dusp22 (Dual-specificity phosphatase 22) in mouse tissues.
Medical molecular morphology(2017 Dec)
Hamada N,Mizuno M,Tomita H,Iwamoto I,Hara A,Nagata KI

The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck.
Nature communications53618(2014 Apr)
Li JP,Yang CY,Chuang HC,Lan JL,Chen DY,Chen YM,Wang X,Chen AJ,Belmont JW,Tan TH

Regulation of STAT3-mediated signaling by LMW-DSP2.
Oncogene25(42)5801-6(2006 Sep)
Sekine Y,Tsuji S,Ikeda O,Sato N,Aoki N,Aoyama K,Sugiyama K,Matsuda T

The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway.
The Journal of biological chemistry277(39)36592-601(2002 Sep)
Chen AJ,Zhou G,Juan T,Colicos SM,Cannon JP,Cabriera-Hansen M,Meyer CF,Jurecic R,Copeland NG,Gilbert DJ,Jenkins NA,Fletcher F,Tan TH,Belmont JW

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Dusp22 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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