Nhlrc1 cDNA ORF clone, Mus musculus(house mouse)

Abnormal glycogen chain length pattern, not hyperphosphorylation, is critical in Lafora disease.
Nitschke F, Sullivan MA, Wang P, Zhao X, Chown EE, Perri AM, Israelian L, Juana-L?pez L, Bovolenta P, Rodr?guez de C?rdoba S, Steup M, Minassian BA
EMBO molecular medicine9(7)906-917(2017 Jul)

Lafora Disease Is an Inherited Metabolic Cardiomyopathy.
Villalba-Orero M, S?nchez-Elexpuru G, L?pez-Ola?eta M, Campuzano O, Bello-Arroyo E, Garc?a-Pav?a P, Serratosa JM, Brugada R, S?nchez MP, Lara-Pezzi E
Journal of the American College of Cardiology69(24)3007-3009(2017 Jun)

Loss of malin leads to reduced proteasomal activity in the heat-shocked cells.
Title: Loss of malin, but not laforin, results in compromised autophagic flux and proteasomal dysfunction in cells exposed to heat shock.

This study also suggests a malin function independent of laforin, possibly in lysosomal biogenesis and/or lysosomal glycogen disposal.
Title: Protein degradation and quality control in cells from laforin and malin knockout mice.

Results show that a functional laforin-malin complex plays a critical role in disrupting Lafora bodies and relieving endoplasmic reticulum stres.
Title: Laforin is required for the functional activation of malin in endoplasmic reticulum stress resistance in neuronal cells.

malin functions to regulate laforin and that malin deficiency at least in part causes LB and LD through increased laforin binding to glycogen.
Title: Increased laforin and laforin binding to glycogen underlie Lafora body formation in malin-deficient Lafora disease.

Motor coordination, activity impairment, and memory deficits progressively increase with age in Epm2b deficient mice.
Title: Laforin and malin deletions in mice produce similar neurologic impairments.