Slc6a8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc6a8
Entrez Gene ID	102857
Full Name	solute carrier family 6 (neurotransmitter transporter, creatine), member 8
Synonyms	AA589632,CRT,CRTR,CT1,CTR5,Creat
General protein information	Preferred Names solute carrier family 6 (neurotransmitter transporter, creatine), member 8 Names sodium- and chloride-dependent creatine transporter 1 creatine transporter 1 creatine transporter SLC6A8 variant D creatine transporter, solute carrier family 6, member 8 solute carrier family 6, member 8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X A7.3\|X 37.38 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_133987.2	NP_598748.1	sodium- and chloride-dependent creatine transporter 1 isoform 1
NM_001142810.1	NP_001136282.1	sodium- and chloride-dependent creatine transporter 1 isoform 3
NM_001142809.1	NP_001136281.1	sodium- and chloride-dependent creatine transporter 1 isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SLC6A8	XP_529227.4
Danio rerio (zebrafish)	slc6a8	XP_695932.1
	SLC6A8	XP_001086826.2
Xenopus tropicalis (tropical clawed frog)	LOC100489909	XP_004916750.1
Rattus norvegicus (Norway rat)	Slc6a8	NP_059044.1
Bos taurus (cattle)	SLC6A8	NP_777036.1
Mus musculus (house mouse)	Slc6a8	NP_001136281.1
Homo sapiens (human)	SLC6A8	NP_005620.1
Canis lupus familiaris (dog)	SLC6A8	XP_005642051.1

Gene Ontology
Bibliography

Related articles in PubMed

Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.
Kaminski MM, Tosic J, Kresbach C, Engel H, Klockenbusch J, M?ller AL, Pichler R, Grahammer F, Kretz O, Huber TB, Walz G, Arnold SJ, Lienkamp SS
Nature cell biology18(12)1269-1280(2016 Dec)

A mouse model for creatine transporter deficiency reveals early onset cognitive impairment and neuropathology associated with brain aging.
Baroncelli L, Molinaro A, Cacciante F, Alessandr? MG, Napoli D, Putignano E, Tola J, Leuzzi V, Cioni G, Pizzorusso T
Human molecular genetics25(19)4186-4200(2016 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our data suggest that brain Cr depletion causes both early intellectual disability and late progressive cognitive decline, and identify novel targets to design intervention strategies aimed at overcoming brain CCDS1 alterations.
Title: A mouse model for creatine transporter deficiency reveals early onset cognitive impairment and neuropathology associated with brain aging.

There were no changes in mitochondrial respiration when normalized to mitochondrial number, suggesting that the increase in respiration observed could be to higher mitochondrial content in Crt (-/y) mice
Title: Creatine transporter deficiency leads to increased whole body and cellular metabolism.

Ubiquitous CrT knockout mice have learning and memory deficits resembling human CrT deficiency
Title: Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency.

AMPK inhibits apical membrane CRT/Slc6a8 expression in kidney proximal tubule cells, which could be important in reducing cellular energy expenditure and unnecessary creatine reabsorption under conditions of local and whole body metabolic stress.
Title: Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells.

myocardial creatine transporter has a role in progressive heart failure and decreased glycolytic capacity
Title: Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity.

The following Slc6a8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc6a8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu22156	NM_001142810.1 Latest version!	Mus musculus solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (Slc6a8), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu22160	NM_133987.2 Latest version!	Mus musculus solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (Slc6a8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu22155	NM_001142809.1 Latest version!	Mus musculus solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (Slc6a8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$370.30 $529.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc6a8 ( NM_001142810.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001136282.1 Mus musculus solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (Slc6a8), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu22156
Clone ID Related Accession (Same CDS sequence)	NM_001142810.1
Accession Version	NM_001142810.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1899bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	sodium- and chloride-dependent creatine transporter 1 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB245363.1, AF459435.1 and BC049801.1. Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 2. The resulting isoform (3) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC049801.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGAAAA AGAGCGCTGA AAACGGTATC TATAGCGTGT CTGGTGACGA GAAGAAGGGT 
CCTCTCATCG TGTCCGGGCC CGACGGTGCC CCAGCCAAGG GCGATGGCCC TGCGGGCCTG 
GGGGCGCCTG GCGGCCGCCT TGCAGTGCCA CCGCGAGAGA CTTGGACACG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCCTCGGTA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ATGTCCTGAT TGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CCTGGAAATC TCATTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTATTC AAAGGTCTGG GCTATGCCTC CATGGTGATT 
GTCTTCTACT GCAACACTTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CTACCACTTT GCCATGGGCT ACATGTGGCC ACACCTGGAA CACTCCTGAC 
TGTGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACATGT 
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTATTGAGG 
CTCTCCACGG GGCTGGAGGT TCCAGGAGCC CTCAACTGGG AGGTGACCTT GTGCCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTG TGGAAGGGGG TCAAGTCAAC AGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTCGTTG TGCTGCTGGT GCGAGGGGTG 
CTGCTGCCTG GAGCCCTGGA TGGTATCATC TACTATCTCA AGCCTGACTG GTCAAAGCTA 
GGGTCCCCTC AGGTATGGAT AGATGCTGGG ACCCAGATTT TCTTCTCTTA TGCCATAGGC 
CTGGGGGCCC TCACAGCCCT AGGCAGCTAC AATCGCTTCA ACAACAACTG CTACAAGGAT 
GCCATCATCC TGGCACTCAT CAACAGCGGG ACCAGCTTCT TTGCTGGCTT TGTGGTCTTC 
TCCATCCTGG GCTTCATGGC CACAGAGCAG GGTGTGCATA TCTCCAAGGT GGCAGAATCA 
GGGCCTGGTC TAGCCTTCAT TGCCTACCCA CGGGCTGTCA CACTGATGCC TGTGGCCCCA 
CTCTGGGCTG CCTTGTTCTT CTTCATGCTG CTGCTGCTCG GTCTGGACAG CCAGTTTGTA 
GGTGTGGAGG GCTTCATTAC CGGGCTCCTG GATCTCCTCC CGGCCTCCTA CTACTTCCGT 
TTCCAAAGGG AGATCTCCGT TGCTCTCTGC TGCGCCCTCT GCTTTGTCAT CGATCTCTCC 
ATGGGTGGAA TGTACGTCTT CCAGCTATTT GACTACTACT CAGCTAGTGG CACTACCCTG 
CTTTGGCAAG CCTTTTGGGA GTGTGTAGTT GTGGCTTGGG TTTATGGAGC TGACCGCTTC 
ATGGATGACA TTGCCTGTAT GATTGGGTAC CGACCTTGCC CCTGGATGAA ATGGTGCTGG 
TCCTTCTTCA CCCCATTGGT CTGCATGGGC ATCTTCATCT TCAACATTGT GTACTACGAG 
CCACTGGTCT ACAACAACAC CTACGTGTAC CCATGGTGGG GTGAAGCTAT GGGCTGGGCC 
TTTGCACTCT CTTCTATGCT ATGTGTACCC CTCCACCTCC TGGGCTGTCT CCTCAGGGCA 
AAAGGAACCA TGGCAGAGCG ATGGCAGCAC CTGACCCAGC CTATCTGGGG CCTCCATCAC 
TTGGAATACA GAGCTCAGGA TGCAGATGTC AGGGGCCTGA CCACCCTGAC TCCCGTGTCC 
GAGAGCAGCA AGGTCGTCGT GGTGGAGAGT GTCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001136282.1
CDS	657..2555
Translation	MAKKSAENGIYSVSGDEKKGPLIVSGPDGAPAKGDGPAGLGAPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSTGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNIVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM

Target ORF information:

RefSeq Version	NM_001142810.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (Slc6a8), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142810.1

ORF Insert Sequence:

ATGGCGAAAA AGAGCGCTGA AAACGGTATC TATAGCGTGT CTGGTGACGA GAAGAAGGGT 
CCTCTCATCG TGTCCGGGCC CGACGGTGCC CCAGCCAAGG GCGATGGCCC TGCGGGCCTG 
GGGGCGCCTG GCGGCCGCCT TGCAGTGCCA CCGCGAGAGA CTTGGACACG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCCTCGGTA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ATGTCCTGAT TGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CCTGGAAATC TCATTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTATTC AAAGGTCTGG GCTATGCCTC CATGGTGATT 
GTCTTCTACT GCAACACTTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CTACCACTTT GCCATGGGCT ACATGTGGCC ACACCTGGAA CACTCCTGAC 
TGTGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACATGT 
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTATTGAGG 
CTCTCCACGG GGCTGGAGGT TCCAGGAGCC CTCAACTGGG AGGTGACCTT GTGCCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTG TGGAAGGGGG TCAAGTCAAC AGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTCGTTG TGCTGCTGGT GCGAGGGGTG 
CTGCTGCCTG GAGCCCTGGA TGGTATCATC TACTATCTCA AGCCTGACTG GTCAAAGCTA 
GGGTCCCCTC AGGTATGGAT AGATGCTGGG ACCCAGATTT TCTTCTCTTA TGCCATAGGC 
CTGGGGGCCC TCACAGCCCT AGGCAGCTAC AATCGCTTCA ACAACAACTG CTACAAGGAT 
GCCATCATCC TGGCACTCAT CAACAGCGGG ACCAGCTTCT TTGCTGGCTT TGTGGTCTTC 
TCCATCCTGG GCTTCATGGC CACAGAGCAG GGTGTGCATA TCTCCAAGGT GGCAGAATCA 
GGGCCTGGTC TAGCCTTCAT TGCCTACCCA CGGGCTGTCA CACTGATGCC TGTGGCCCCA 
CTCTGGGCTG CCTTGTTCTT CTTCATGCTG CTGCTGCTCG GTCTGGACAG CCAGTTTGTA 
GGTGTGGAGG GCTTCATTAC CGGGCTCCTG GATCTCCTCC CGGCCTCCTA CTACTTCCGT 
TTCCAAAGGG AGATCTCCGT TGCTCTCTGC TGCGCCCTCT GCTTTGTCAT CGATCTCTCC 
ATGGGTGGAA TGTACGTCTT CCAGCTATTT GACTACTACT CAGCTAGTGG CACTACCCTG 
CTTTGGCAAG CCTTTTGGGA GTGTGTAGTT GTGGCTTGGG TTTATGGAGC TGACCGCTTC 
ATGGATGACA TTGCCTGTAT GATTGGGTAC CGACCTTGCC CCTGGATGAA ATGGTGCTGG 
TCCTTCTTCA CCCCATTGGT CTGCATGGGC ATCTTCATCT TCAACATTGT GTACTACGAG 
CCACTGGTCT ACAACAACAC CTACGTGTAC CCATGGTGGG GTGAAGCTAT GGGCTGGGCC 
TTTGCACTCT CTTCTATGCT ATGTGTACCC CTCCACCTCC TGGGCTGTCT CCTCAGGGCA 
AAAGGAACCA TGGCAGAGCG ATGGCAGCAC CTGACCCAGC CTATCTGGGG CCTCCATCAC 
TTGGAATACA GAGCTCAGGA TGCAGATGTC AGGGGCCTGA CCACCCTGAC TCCCGTGTCC 
GAGAGCAGCA AGGTCGTCGT GGTGGAGAGT GTCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc6a8 ( NM_133987.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598748.1 Mus musculus solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (Slc6a8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu22160
Clone ID Related Accession (Same CDS sequence)	NM_133987.2
Accession Version	NM_133987.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1923bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	sodium- and chloride-dependent creatine transporter 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB245363.1 and AF459435.1. On Dec 20, 2008 this sequence version replaced NM_133987.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF459435.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGAAAA AGAGCGCTGA AAACGGTATC TATAGCGTGT CTGGTGACGA GAAGAAGGGT 
CCTCTCATCG TGTCCGGGCC CGACGGTGCC CCAGCCAAGG GCGATGGCCC TGCGGGCCTG 
GGGGCGCCTG GCGGCCGCCT TGCAGTGCCA CCGCGAGAGA CTTGGACACG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCCTCGGTA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ATGTCCTGAT TGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CCTGGAAATC TCATTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTATTC AAAGGTCTGG GCTATGCCTC CATGGTGATT 
GTCTTCTACT GCAACACTTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CTACCACTTT GCCATGGGCT ACATGTGGCC ACACCTGGAA CACTCCTGAC 
TGTGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACATGT 
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTATTGAGG 
CTCTCCACGG GGCTGGAGGT TCCAGGAGCC CTCAACTGGG AGGTGACCTT GTGCCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTG TGGAAGGGGG TCAAGTCAAC AGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTCGTTG TGCTGCTGGT GCGAGGGGTG 
CTGCTGCCTG GAGCCCTGGA TGGTATCATC TACTATCTCA AGCCTGACTG GTCAAAGCTA 
GGGTCCCCTC AGGTATGGAT AGATGCTGGG ACCCAGATTT TCTTCTCTTA TGCCATAGGC 
CTGGGGGCCC TCACAGCCCT AGGCAGCTAC AATCGCTTCA ACAACAACTG CTACAAGGAT 
GCCATCATCC TGGCACTCAT CAACAGCGGG ACCAGCTTCT TTGCTGGCTT TGTGGTCTTC 
TCCATCCTGG GCTTCATGGC CACAGAGCAG GGTGTGCATA TCTCCAAGGT GGCAGAATCA 
GGGCCTGGTC TAGCCTTCAT TGCCTACCCA CGGGCTGTCA CACTGATGCC TGTGGCCCCA 
CTCTGGGCTG CCTTGTTCTT CTTCATGCTG CTGCTGCTCG GTCTGGACAG CCAGTTTGTA 
GGTGTGGAGG GCTTCATTAC CGGGCTCCTG GATCTCCTCC CGGCCTCCTA CTACTTCCGT 
TTCCAAAGGG AGATCTCCGT TGCTCTCTGC TGCGCCCTCT GCTTTGTCAT CGATCTCTCC 
ATGGTGACTG ATGTGAGTGG GGGTAAGGGT GGAATGTACG TCTTCCAGCT ATTTGACTAC 
TACTCAGCTA GTGGCACTAC CCTGCTTTGG CAAGCCTTTT GGGAGTGTGT AGTTGTGGCT 
TGGGTTTATG GAGCTGACCG CTTCATGGAT GACATTGCCT GTATGATTGG GTACCGACCT 
TGCCCCTGGA TGAAATGGTG CTGGTCCTTC TTCACCCCAT TGGTCTGCAT GGGCATCTTC 
ATCTTCAACA TTGTGTACTA CGAGCCACTG GTCTACAACA ACACCTACGT GTACCCATGG 
TGGGGTGAAG CTATGGGCTG GGCCTTTGCA CTCTCTTCTA TGCTATGTGT ACCCCTCCAC 
CTCCTGGGCT GTCTCCTCAG GGCAAAAGGA ACCATGGCAG AGCGATGGCA GCACCTGACC 
CAGCCTATCT GGGGCCTCCA TCACTTGGAA TACAGAGCTC AGGATGCAGA TGTCAGGGGC 
CTGACCACCC TGACTCCCGT GTCCGAGAGC AGCAAGGTCG TCGTGGTGGA GAGTGTCATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598748.1
CDS	657..2579
Translation	MAKKSAENGIYSVSGDEKKGPLIVSGPDGAPAKGDGPAGLGAPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSTGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDVSGGKGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNIVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM

Target ORF information:

RefSeq Version	NM_133987.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (Slc6a8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133987.2

ORF Insert Sequence:

ATGGCGAAAA AGAGCGCTGA AAACGGTATC TATAGCGTGT CTGGTGACGA GAAGAAGGGT 
CCTCTCATCG TGTCCGGGCC CGACGGTGCC CCAGCCAAGG GCGATGGCCC TGCGGGCCTG 
GGGGCGCCTG GCGGCCGCCT TGCAGTGCCA CCGCGAGAGA CTTGGACACG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCCTCGGTA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ATGTCCTGAT TGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CCTGGAAATC TCATTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTATTC AAAGGTCTGG GCTATGCCTC CATGGTGATT 
GTCTTCTACT GCAACACTTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CTACCACTTT GCCATGGGCT ACATGTGGCC ACACCTGGAA CACTCCTGAC 
TGTGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACATGT 
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTATTGAGG 
CTCTCCACGG GGCTGGAGGT TCCAGGAGCC CTCAACTGGG AGGTGACCTT GTGCCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTG TGGAAGGGGG TCAAGTCAAC AGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTCGTTG TGCTGCTGGT GCGAGGGGTG 
CTGCTGCCTG GAGCCCTGGA TGGTATCATC TACTATCTCA AGCCTGACTG GTCAAAGCTA 
GGGTCCCCTC AGGTATGGAT AGATGCTGGG ACCCAGATTT TCTTCTCTTA TGCCATAGGC 
CTGGGGGCCC TCACAGCCCT AGGCAGCTAC AATCGCTTCA ACAACAACTG CTACAAGGAT 
GCCATCATCC TGGCACTCAT CAACAGCGGG ACCAGCTTCT TTGCTGGCTT TGTGGTCTTC 
TCCATCCTGG GCTTCATGGC CACAGAGCAG GGTGTGCATA TCTCCAAGGT GGCAGAATCA 
GGGCCTGGTC TAGCCTTCAT TGCCTACCCA CGGGCTGTCA CACTGATGCC TGTGGCCCCA 
CTCTGGGCTG CCTTGTTCTT CTTCATGCTG CTGCTGCTCG GTCTGGACAG CCAGTTTGTA 
GGTGTGGAGG GCTTCATTAC CGGGCTCCTG GATCTCCTCC CGGCCTCCTA CTACTTCCGT 
TTCCAAAGGG AGATCTCCGT TGCTCTCTGC TGCGCCCTCT GCTTTGTCAT CGATCTCTCC 
ATGGTGACTG ATGTGAGTGG GGGTAAGGGT GGAATGTACG TCTTCCAGCT ATTTGACTAC 
TACTCAGCTA GTGGCACTAC CCTGCTTTGG CAAGCCTTTT GGGAGTGTGT AGTTGTGGCT 
TGGGTTTATG GAGCTGACCG CTTCATGGAT GACATTGCCT GTATGATTGG GTACCGACCT 
TGCCCCTGGA TGAAATGGTG CTGGTCCTTC TTCACCCCAT TGGTCTGCAT GGGCATCTTC 
ATCTTCAACA TTGTGTACTA CGAGCCACTG GTCTACAACA ACACCTACGT GTACCCATGG 
TGGGGTGAAG CTATGGGCTG GGCCTTTGCA CTCTCTTCTA TGCTATGTGT ACCCCTCCAC 
CTCCTGGGCT GTCTCCTCAG GGCAAAAGGA ACCATGGCAG AGCGATGGCA GCACCTGACC 
CAGCCTATCT GGGGCCTCCA TCACTTGGAA TACAGAGCTC AGGATGCAGA TGTCAGGGGC 
CTGACCACCC TGACTCCCGT GTCCGAGAGC AGCAAGGTCG TCGTGGTGGA GAGTGTCATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc6a8 ( NM_001142809.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001136281.1 Mus musculus solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (Slc6a8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu22155
Clone ID Related Accession (Same CDS sequence)	NM_001142809.1
Accession Version	NM_001142809.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1908bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	sodium- and chloride-dependent creatine transporter 1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB245363.1, AF459435.1, AB077327.1 and BC029000.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 2. The resulting isoform (2) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB077327.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGAAAA AGAGCGCTGA AAACGGTATC TATAGCGTGT CTGGTGACGA GAAGAAGGGT 
CCTCTCATCG TGTCCGGGCC CGACGGTGCC CCAGCCAAGG GCGATGGCCC TGCGGGCCTG 
GGGGCGCCTG GCGGCCGCCT TGCAGTGCCA CCGCGAGAGA CTTGGACACG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCCTCGGTA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ATGTCCTGAT TGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CCTGGAAATC TCATTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTATTC AAAGGTCTGG GCTATGCCTC CATGGTGATT 
GTCTTCTACT GCAACACTTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CTACCACTTT GCCATGGGCT ACATGTGGCC ACACCTGGAA CACTCCTGAC 
TGTGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACATGT 
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTATTGAGG 
CTCTCCACGG GGCTGGAGGT TCCAGGAGCC CTCAACTGGG AGGTGACCTT GTGCCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTG TGGAAGGGGG TCAAGTCAAC AGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTCGTTG TGCTGCTGGT GCGAGGGGTG 
CTGCTGCCTG GAGCCCTGGA TGGTATCATC TACTATCTCA AGCCTGACTG GTCAAAGCTA 
GGGTCCCCTC AGGTATGGAT AGATGCTGGG ACCCAGATTT TCTTCTCTTA TGCCATAGGC 
CTGGGGGCCC TCACAGCCCT AGGCAGCTAC AATCGCTTCA ACAACAACTG CTACAAGGAT 
GCCATCATCC TGGCACTCAT CAACAGCGGG ACCAGCTTCT TTGCTGGCTT TGTGGTCTTC 
TCCATCCTGG GCTTCATGGC CACAGAGCAG GGTGTGCATA TCTCCAAGGT GGCAGAATCA 
GGGCCTGGTC TAGCCTTCAT TGCCTACCCA CGGGCTGTCA CACTGATGCC TGTGGCCCCA 
CTCTGGGCTG CCTTGTTCTT CTTCATGCTG CTGCTGCTCG GTCTGGACAG CCAGTTTGTA 
GGTGTGGAGG GCTTCATTAC CGGGCTCCTG GATCTCCTCC CGGCCTCCTA CTACTTCCGT 
TTCCAAAGGG AGATCTCCGT TGCTCTCTGC TGCGCCCTCT GCTTTGTCAT CGATCTCTCC 
ATGGTGACTG ATGGTGGAAT GTACGTCTTC CAGCTATTTG ACTACTACTC AGCTAGTGGC 
ACTACCCTGC TTTGGCAAGC CTTTTGGGAG TGTGTAGTTG TGGCTTGGGT TTATGGAGCT 
GACCGCTTCA TGGATGACAT TGCCTGTATG ATTGGGTACC GACCTTGCCC CTGGATGAAA 
TGGTGCTGGT CCTTCTTCAC CCCATTGGTC TGCATGGGCA TCTTCATCTT CAACATTGTG 
TACTACGAGC CACTGGTCTA CAACAACACC TACGTGTACC CATGGTGGGG TGAAGCTATG 
GGCTGGGCCT TTGCACTCTC TTCTATGCTA TGTGTACCCC TCCACCTCCT GGGCTGTCTC 
CTCAGGGCAA AAGGAACCAT GGCAGAGCGA TGGCAGCACC TGACCCAGCC TATCTGGGGC 
CTCCATCACT TGGAATACAG AGCTCAGGAT GCAGATGTCA GGGGCCTGAC CACCCTGACT 
CCCGTGTCCG AGAGCAGCAA GGTCGTCGTG GTGGAGAGTG TCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001136281.1
CDS	657..2564
Translation	MAKKSAENGIYSVSGDEKKGPLIVSGPDGAPAKGDGPAGLGAPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSTGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNIVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM

Target ORF information:

RefSeq Version	NM_001142809.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (Slc6a8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142809.1

ORF Insert Sequence:

ATGGCGAAAA AGAGCGCTGA AAACGGTATC TATAGCGTGT CTGGTGACGA GAAGAAGGGT 
CCTCTCATCG TGTCCGGGCC CGACGGTGCC CCAGCCAAGG GCGATGGCCC TGCGGGCCTG 
GGGGCGCCTG GCGGCCGCCT TGCAGTGCCA CCGCGAGAGA CTTGGACACG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCCTCGGTA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ATGTCCTGAT TGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CCTGGAAATC TCATTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTATTC AAAGGTCTGG GCTATGCCTC CATGGTGATT 
GTCTTCTACT GCAACACTTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CTACCACTTT GCCATGGGCT ACATGTGGCC ACACCTGGAA CACTCCTGAC 
TGTGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACATGT 
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTATTGAGG 
CTCTCCACGG GGCTGGAGGT TCCAGGAGCC CTCAACTGGG AGGTGACCTT GTGCCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTG TGGAAGGGGG TCAAGTCAAC AGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTCGTTG TGCTGCTGGT GCGAGGGGTG 
CTGCTGCCTG GAGCCCTGGA TGGTATCATC TACTATCTCA AGCCTGACTG GTCAAAGCTA 
GGGTCCCCTC AGGTATGGAT AGATGCTGGG ACCCAGATTT TCTTCTCTTA TGCCATAGGC 
CTGGGGGCCC TCACAGCCCT AGGCAGCTAC AATCGCTTCA ACAACAACTG CTACAAGGAT 
GCCATCATCC TGGCACTCAT CAACAGCGGG ACCAGCTTCT TTGCTGGCTT TGTGGTCTTC 
TCCATCCTGG GCTTCATGGC CACAGAGCAG GGTGTGCATA TCTCCAAGGT GGCAGAATCA 
GGGCCTGGTC TAGCCTTCAT TGCCTACCCA CGGGCTGTCA CACTGATGCC TGTGGCCCCA 
CTCTGGGCTG CCTTGTTCTT CTTCATGCTG CTGCTGCTCG GTCTGGACAG CCAGTTTGTA 
GGTGTGGAGG GCTTCATTAC CGGGCTCCTG GATCTCCTCC CGGCCTCCTA CTACTTCCGT 
TTCCAAAGGG AGATCTCCGT TGCTCTCTGC TGCGCCCTCT GCTTTGTCAT CGATCTCTCC 
ATGGTGACTG ATGGTGGAAT GTACGTCTTC CAGCTATTTG ACTACTACTC AGCTAGTGGC 
ACTACCCTGC TTTGGCAAGC CTTTTGGGAG TGTGTAGTTG TGGCTTGGGT TTATGGAGCT 
GACCGCTTCA TGGATGACAT TGCCTGTATG ATTGGGTACC GACCTTGCCC CTGGATGAAA 
TGGTGCTGGT CCTTCTTCAC CCCATTGGTC TGCATGGGCA TCTTCATCTT CAACATTGTG 
TACTACGAGC CACTGGTCTA CAACAACACC TACGTGTACC CATGGTGGGG TGAAGCTATG 
GGCTGGGCCT TTGCACTCTC TTCTATGCTA TGTGTACCCC TCCACCTCCT GGGCTGTCTC 
CTCAGGGCAA AAGGAACCAT GGCAGAGCGA TGGCAGCACC TGACCCAGCC TATCTGGGGC 
CTCCATCACT TGGAATACAG AGCTCAGGAT GCAGATGTCA GGGGCCTGAC CACCCTGACT 
CCCGTGTCCG AGAGCAGCAA GGTCGTCGTG GTGGAGAGTG TCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.
Nature cell biology18(12)1269-1280(2016 Dec)
Kaminski MM,Tosic J,Kresbach C,Engel H,Klockenbusch J,M?ller AL,Pichler R,Grahammer F,Kretz O,Huber TB,Walz G,Arnold SJ,Lienkamp SS

A mouse model for creatine transporter deficiency reveals early onset cognitive impairment and neuropathology associated with brain aging.
Human molecular genetics25(19)4186-4200(2016 10)
Baroncelli L,Molinaro A,Cacciante F,Alessandr? MG,Napoli D,Putignano E,Tola J,Leuzzi V,Cioni G,Pizzorusso T

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Slc6a8 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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