Cd276 cDNA ORF clone, Mus musculus(house mouse)

Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function.
Lee YH, Martin-Orozco N, Zheng P, Li J, Zhang P, Tan H, Park HJ, Jeong M, Chang SH, Kim BS, Xiong W, Zang W, Guo L, Liu Y, Dong ZJ, Overwijk WW, Hwu P, Yi Q, Kwak L, Yang Z, Mak TW, Li W, Radvanyi LG, Ni L, Liu D, Dong C
Cell research27(8)1034-1045(2017 Aug)

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.
Seaman S, Zhu Z, Saha S, Zhang XM, Yang MY, Hilton MB, Morris K, Szot C, Morris H, Swing DA, Tessarollo L, Smith SW, Degrado S, Borkin D, Jain N, Scheiermann J, Feng Y, Wang Y, Li J, Welsch D, DeCrescenzo G, Chaudhary A, Zudaire E, Klarmann KD, Keller JR, Dimitrov DS, St Croix B
Cancer cell31(4)501-515.e8(2017 Apr)

B7-H3 Augments Inflammatory Responses and Exacerbates Brain Damage via Amplifying NF-?B p65 and MAPK p38 Activation during Experimental Pneumococcal Meningitis.
Chen X, Li Y, Blankson S, Liu M, Huang D, Redmond HP, Huang J, Wang JH, Wang J
PloS one12(1)e0171146(2017)

B7-H3 participates in the development of Asthma by augmentation of the inflammatory response independent of TLR2 pathway.
Gu W, Zhang X, Yan Y, Wang Y, Huang L, Wang M, Shao X, Chen Z, Ji W
Scientific reports740398(2017 Jan)

B7H3 ameliorates LPS-induced acute lung injury via attenuation of neutrophil migration and infiltration.
Li Y, Huang J, Foley NM, Xu Y, Li YP, Pan J, Redmond HP, Wang JH, Wang J
Scientific reports631284(2016 Aug)

CD276 is broadly expressed by tumor cells and tumor vasculature but Is dispensable for tumor growth.
Title: Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.

blockage of NF-kappaB p65 and/or MAPK p38 with their specific inhibitors strongly attenuated B7-H3-amplified inflammatory response with significantly reduced proinflammatory cytokine and chemokine production, and markedly ameliorated B7-H3-exacerbated disruption of blood-brain barrier and severity of disease status in S. pneumoniae-infected mice.
Title: B7-H3 Augments Inflammatory Responses and Exacerbates Brain Damage via Amplifying NF-?B p65 and MAPK p38 Activation during Experimental Pneumococcal Meningitis.

this study shows that B7-H3 participates in the development of acute pancreatitis
Title: Anti-B7-H3 monoclonal antibody ameliorates the damage of acute experimental pancreatitis by attenuating the inflammatory response.

Data show that B7-H3 protein is over-expressed in cerulein-induced acute pancreatitis, and anti-B7-H3 monoclonal antibody can attenuate the inflammation and alleviate the injury of pancreas and lung tissues.
Title: [B7-H3 monoclonal antibody attenuates the inflammation and tissue injury in mice with cerulein-induced acute pancreatitis].

Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer
Title: Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer.