Pot1a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pot1a
Entrez Gene ID	101185
Full Name	protection of telomeres 1A
Synonyms	1500031H18Rik,AI851169,Pot1
General protein information	Preferred Names protection of telomeres 1A Names protection of telomeres protein 1 POT1-like telomere end-binding protein mPot1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 A3.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_133931.5	NP_598692.1	protection of telomeres protein 1
XM_006504955.2	XP_006505018.1	protection of telomeres protein 1 isoform X1
XM_006504956.2	XP_006505019.1	protection of telomeres protein 1 isoform X1
NM_133931.4	NP_598692.1	protection of telomeres protein 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	POT1	NP_996875.1
Xenopus tropicalis (tropical clawed frog)	pot1	NP_998876.1
Homo sapiens (human)	POT1	NP_056265.2
Pan troglodytes (chimpanzee)	POT1	XP_003951172.1
Mus musculus (house mouse)	Pot1a	NP_598692.1
Rattus norvegicus (Norway rat)	Pot1	NP_001019493.1
Danio rerio (zebrafish)	pot1	NP_001232889.1
	POT1	XP_002803507.1
Canis lupus familiaris (dog)	POT1	XP_005628493.1
Bos taurus (cattle)	POT1	XP_002686962.1

Gene Ontology
Bibliography

Related articles in PubMed

The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age.
Hosokawa K, MacArthur BD, Ikushima YM, Toyama H, Masuhiro Y, Hanazawa S, Suda T, Arai F
Nature communications8(1)804(2017 10)

Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis.
Gu P, Wang Y, Bisht KK, Wu L, Kukova L, Smith EM, Xiao Y, Bailey SM, Lei M, Nandakumar J, Chang S
Oncogene36(14)1939-1951(2017 Apr)

PHF11 promotes DSB resection, ATR signaling, and HR.
Gong Y, Handa N, Kowalczykowski SC, de Lange T
Genes & development31(1)46-58(2017 Jan)

Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease.
Ahmad T, Sundar IK, Tormos AM, Lerner CA, Gerloff J, Yao H, Rahman I
American journal of respiratory cell and molecular biology56(1)38-49(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Lung fibroblasts deficient in Sirt1 or treated with a selective Sirt1 inhibitor exhibit increased cellular senescence and decreased TPP1 levels, whereas Sirt1 overexpression and pharmacological activation protect against CS-induced TPP1 reduction and telomeric DNA damage.
Title: Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease.

proliferation of cancer cells lacking POT1 is enabled by the attenuation of the ATR kinase pathway.
Title: Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis.

demonstrated that cells expressing TIN2DeltaTPP1 instead of wild-type TIN2 phenocopy the POT1a,b knockout setting without showing additional phenotypes
Title: Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection.

The results of this study found telomere uncapping by Pot1a inactivation resulted in an Atm-dependent loss of cerebellar interneurons and granule neuron precursors in the mouse nervous system. The
Title: Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.

shelterin protein TIN2 can protect chromosome ends as a TRF2-tethered TIN2/TPP1/POT1 complex that lacks a physical connection to TRF1
Title: TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1.

The following Pot1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pot1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu36497	XM_006504956.2 Latest version!	Mus musculus protection of telomeres 1A (Pot1a), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu36497	XM_006504955.2 Latest version!	Mus musculus protection of telomeres 1A (Pot1a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu22194	NM_133931.5 Latest version!	Mus musculus protection of telomeres 1A (Pot1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$377.30 $539.00
View Old Accession Versions >>
OMu22194	NM_133931.4	Mus musculus protection of telomeres 1A (Pot1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$377.30 $539.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pot1a ( XM_006504955.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006505018.1 Mus musculus protection of telomeres 1A (Pot1a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu36497
Clone ID Related Accession (Same CDS sequence)	XM_006504955.2 , XM_006504956.2
Accession Version	XM_006504955.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1746bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	protection of telomeres protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006504955.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCTTTA GTGGAAACTA TGAAGCCCTC CCCATCATTT ATAAAGTTGG AGACATTGTT 
CGCTTCCACA GGCTGAAGAT CCAAGTGTAT AAAAATGAGC TTCAGGGAAT CAACTGCTCT 
GGCTTCGCCT CTTTGACATT TGAAGGGACT GTAGGGATGC CTGTCACAGC ACGCACTTCC 
AGCAAAGTTT TTAGCTTCAC TCCTCAGGAC CAAAAAATGG TAGAAGCTTT GCGGGTTTGG 
GCATCCAAGC ACATCTCGGC GTCTTCAACT TTAGTGCAGC TGTGCGATGC GCAGCCCATG 
CAGTATTACG ACCTGACCTG TCAGCTCCTG GGTAAAGCAC AAGTGGATTC CACAGCATTT 
CTTCTAAAGG TATGGGATGG AACCCAGACT GTGCTTCCCT CCTGGAGAGT CTCCACACAA 
GATCTAACTT TTGAAGGTGA CTTGAGTCAC ATCGAACGGC TACAGAGTCT GGTGGTAGAC 
ATTCTAGTCT ACGATAACCA CGTTCAAGTG GCGAGATCCA TCGAGGTTGG ATGCTTTCTA 
AGACTCTATA GCCTCCATAC AAAACTTCAG CCTGGAAATT CAGAAACCAG CAGTTCTGAA 
TCATTAAGGC TGGAGTTCCA TCTCCACGGA GGGACCAGTT ATGGTCGGGG CATTAGGGTT 
TTGCCAGATA CAAGCCCTTG TGTGGATCAG CTGAAAAAAG CTTTAGAAGG TGCAAATTTG 
CCAGTCACTG AGACCTCAAC TGGTATCTGT CAATCAGAAA ATGGGGACAG CTCTGCACTA 
TCAAACTCAG GATCAGGTGC AGTATCACCT TATGAAGAAG AACGATGTCA ACAAGTCTCT 
GCTACAATAC TTACCAATCA CCAACATTTA GAGAAAACAC CACTGTGTGC CATCTTGACG 
CAAAAAGCTC CTCAACAATA TCGAGTCCGC GCCAAACTGA GATCCTATTT GCCCAGGAGA 
CTTTCCCAGT CTGTTAAACT TCTCTGTCCT AAATGTCATT CAGTACAAGA AGTTCCACAT 
GGGGACAGTT TGGATAAAAT TTTGCAAGAT GCTGCAACTG AAGCTCCAGA CATCAAGCTG 
AAAGCGACAT CATTGTATTA TTCAAAAGTC TGGACCACTG AAGACCAGGG CGGACGGCAG 
GTCGCTGTTC ATTTTGTGAA AAATAATGGC ATTCTCCCTG CTTCAAGTGA ATGTCTAATT 
TTGATAGAAG GAGGAAGGCT CTGCGAAGTC TCTAAACTGT CCAGCAAGTT CCACAGTGTG 
ATGCCTGTGC GGTCCGGCCC TGAGAGCCTG GAGCTCCTTA CCCTTTCAGC CCCGTTCCTC 
ATACAGGGAA AGGTGCATCA CTATGGATGT AAACAGTGCT CAAGCTTGAA ACCTATACAA 
AATCTAAACT CCCGTTTTCA TAAAGGACCG TGGACTCCTT CCTCTGTGGC AGAAGCCCTG 
GGCGTTGTGC CGCTGCAGTA TGTGTTTGTT ATGGTTTTCA CTCTGGATGA CGGGACAGGG 
GTGTTGGAAG CTTACCTCAA GGATTCTGAA CACTTTTTCA AGATCCCAGC ATCTGAAGTC 
CTCACTGATG ACGACCTTCA GAGAAGTCTA GAAACGATCA TGGATATGAT ATGTCCCCCA 
GGAATAAAAG TTGATGCATA CCCATGGCTA GAGTGCCTCC TCAAGTCCTA CAATGTCACC 
ATCGGAACAG AGCGACGAAT TTGCTACCAG ATTTTTGATA CTACAGTTGC AGAAAATGTT 
GTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006505018.1
CDS	566..2311
Translation	MLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINCSGFASLTFEGTVGMPVTARTSSKVFSFTPQDQKMVEALRVWASKHISASSTLVQLCDAQPMQYYDLTCQLLGKAQVDSTAFLLKVWDGTQTVLPSWRVSTQDLTFEGDLSHIERLQSLVVDILVYDNHVQVARSIEVGCFLRLYSLHTKLQPGNSETSSSESLRLEFHLHGGTSYGRGIRVLPDTSPCVDQLKKALEGANLPVTETSTGICQSENGDSSALSNSGSGAVSPYEEERCQQVSATILTNHQHLEKTPLCAILTQKAPQQYRVRAKLRSYLPRRLSQSVKLLCPKCHSVQEVPHGDSLDKILQDAATEAPDIKLKATSLYYSKVWTTEDQGGRQVAVHFVKNNGILPASSECLILIEGGRLCEVSKLSSKFHSVMPVRSGPESLELLTLSAPFLIQGKVHHYGCKQCSSLKPIQNLNSRFHKGPWTPSSVAEALGVVPLQYVFVMVFTLDDGTGVLEAYLKDSEHFFKIPASEVLTDDDLQRSLETIMDMICPPGIKVDAYPWLECLLKSYNVTIGTERRICYQIFDTTVAENVV

Target ORF information:

RefSeq Version	XM_006504955.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus protection of telomeres 1A (Pot1a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006504955.2

ORF Insert Sequence:

ATGCTCTTTA GTGGAAACTA TGAAGCCCTC CCCATCATTT ATAAAGTTGG AGACATTGTT 
CGCTTCCACA GGCTGAAGAT CCAAGTGTAT AAAAATGAGC TTCAGGGAAT CAACTGCTCT 
GGCTTCGCCT CTTTGACATT TGAAGGGACT GTAGGGATGC CTGTCACAGC ACGCACTTCC 
AGCAAAGTTT TTAGCTTCAC TCCTCAGGAC CAAAAAATGG TAGAAGCTTT GCGGGTTTGG 
GCATCCAAGC ACATCTCGGC GTCTTCAACT TTAGTGCAGC TGTGCGATGC GCAGCCCATG 
CAGTATTACG ACCTGACCTG TCAGCTCCTG GGTAAAGCAC AAGTGGATTC CACAGCATTT 
CTTCTAAAGG TATGGGATGG AACCCAGACT GTGCTTCCCT CCTGGAGAGT CTCCACACAA 
GATCTAACTT TTGAAGGTGA CTTGAGTCAC ATCGAACGGC TACAGAGTCT GGTGGTAGAC 
ATTCTAGTCT ACGATAACCA CGTTCAAGTG GCGAGATCCA TCGAGGTTGG ATGCTTTCTA 
AGACTCTATA GCCTCCATAC AAAACTTCAG CCTGGAAATT CAGAAACCAG CAGTTCTGAA 
TCATTAAGGC TGGAGTTCCA TCTCCACGGA GGGACCAGTT ATGGTCGGGG CATTAGGGTT 
TTGCCAGATA CAAGCCCTTG TGTGGATCAG CTGAAAAAAG CTTTAGAAGG TGCAAATTTG 
CCAGTCACTG AGACCTCAAC TGGTATCTGT CAATCAGAAA ATGGGGACAG CTCTGCACTA 
TCAAACTCAG GATCAGGTGC AGTATCACCT TATGAAGAAG AACGATGTCA ACAAGTCTCT 
GCTACAATAC TTACCAATCA CCAACATTTA GAGAAAACAC CACTGTGTGC CATCTTGACG 
CAAAAAGCTC CTCAACAATA TCGAGTCCGC GCCAAACTGA GATCCTATTT GCCCAGGAGA 
CTTTCCCAGT CTGTTAAACT TCTCTGTCCT AAATGTCATT CAGTACAAGA AGTTCCACAT 
GGGGACAGTT TGGATAAAAT TTTGCAAGAT GCTGCAACTG AAGCTCCAGA CATCAAGCTG 
AAAGCGACAT CATTGTATTA TTCAAAAGTC TGGACCACTG AAGACCAGGG CGGACGGCAG 
GTCGCTGTTC ATTTTGTGAA AAATAATGGC ATTCTCCCTG CTTCAAGTGA ATGTCTAATT 
TTGATAGAAG GAGGAAGGCT CTGCGAAGTC TCTAAACTGT CCAGCAAGTT CCACAGTGTG 
ATGCCTGTGC GGTCCGGCCC TGAGAGCCTG GAGCTCCTTA CCCTTTCAGC CCCGTTCCTC 
ATACAGGGAA AGGTGCATCA CTATGGATGT AAACAGTGCT CAAGCTTGAA ACCTATACAA 
AATCTAAACT CCCGTTTTCA TAAAGGACCG TGGACTCCTT CCTCTGTGGC AGAAGCCCTG 
GGCGTTGTGC CGCTGCAGTA TGTGTTTGTT ATGGTTTTCA CTCTGGATGA CGGGACAGGG 
GTGTTGGAAG CTTACCTCAA GGATTCTGAA CACTTTTTCA AGATCCCAGC ATCTGAAGTC 
CTCACTGATG ACGACCTTCA GAGAAGTCTA GAAACGATCA TGGATATGAT ATGTCCCCCA 
GGAATAAAAG TTGATGCATA CCCATGGCTA GAGTGCCTCC TCAAGTCCTA CAATGTCACC 
ATCGGAACAG AGCGACGAAT TTGCTACCAG ATTTTTGATA CTACAGTTGC AGAAAATGTT 
GTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pot1a ( XM_006504956.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006505019.1 Mus musculus protection of telomeres 1A (Pot1a), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu36497
Clone ID Related Accession (Same CDS sequence)	XM_006504955.2 , XM_006504956.2
Accession Version	XM_006504956.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1746bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	protection of telomeres protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006504956.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCTTTA GTGGAAACTA TGAAGCCCTC CCCATCATTT ATAAAGTTGG AGACATTGTT 
CGCTTCCACA GGCTGAAGAT CCAAGTGTAT AAAAATGAGC TTCAGGGAAT CAACTGCTCT 
GGCTTCGCCT CTTTGACATT TGAAGGGACT GTAGGGATGC CTGTCACAGC ACGCACTTCC 
AGCAAAGTTT TTAGCTTCAC TCCTCAGGAC CAAAAAATGG TAGAAGCTTT GCGGGTTTGG 
GCATCCAAGC ACATCTCGGC GTCTTCAACT TTAGTGCAGC TGTGCGATGC GCAGCCCATG 
CAGTATTACG ACCTGACCTG TCAGCTCCTG GGTAAAGCAC AAGTGGATTC CACAGCATTT 
CTTCTAAAGG TATGGGATGG AACCCAGACT GTGCTTCCCT CCTGGAGAGT CTCCACACAA 
GATCTAACTT TTGAAGGTGA CTTGAGTCAC ATCGAACGGC TACAGAGTCT GGTGGTAGAC 
ATTCTAGTCT ACGATAACCA CGTTCAAGTG GCGAGATCCA TCGAGGTTGG ATGCTTTCTA 
AGACTCTATA GCCTCCATAC AAAACTTCAG CCTGGAAATT CAGAAACCAG CAGTTCTGAA 
TCATTAAGGC TGGAGTTCCA TCTCCACGGA GGGACCAGTT ATGGTCGGGG CATTAGGGTT 
TTGCCAGATA CAAGCCCTTG TGTGGATCAG CTGAAAAAAG CTTTAGAAGG TGCAAATTTG 
CCAGTCACTG AGACCTCAAC TGGTATCTGT CAATCAGAAA ATGGGGACAG CTCTGCACTA 
TCAAACTCAG GATCAGGTGC AGTATCACCT TATGAAGAAG AACGATGTCA ACAAGTCTCT 
GCTACAATAC TTACCAATCA CCAACATTTA GAGAAAACAC CACTGTGTGC CATCTTGACG 
CAAAAAGCTC CTCAACAATA TCGAGTCCGC GCCAAACTGA GATCCTATTT GCCCAGGAGA 
CTTTCCCAGT CTGTTAAACT TCTCTGTCCT AAATGTCATT CAGTACAAGA AGTTCCACAT 
GGGGACAGTT TGGATAAAAT TTTGCAAGAT GCTGCAACTG AAGCTCCAGA CATCAAGCTG 
AAAGCGACAT CATTGTATTA TTCAAAAGTC TGGACCACTG AAGACCAGGG CGGACGGCAG 
GTCGCTGTTC ATTTTGTGAA AAATAATGGC ATTCTCCCTG CTTCAAGTGA ATGTCTAATT 
TTGATAGAAG GAGGAAGGCT CTGCGAAGTC TCTAAACTGT CCAGCAAGTT CCACAGTGTG 
ATGCCTGTGC GGTCCGGCCC TGAGAGCCTG GAGCTCCTTA CCCTTTCAGC CCCGTTCCTC 
ATACAGGGAA AGGTGCATCA CTATGGATGT AAACAGTGCT CAAGCTTGAA ACCTATACAA 
AATCTAAACT CCCGTTTTCA TAAAGGACCG TGGACTCCTT CCTCTGTGGC AGAAGCCCTG 
GGCGTTGTGC CGCTGCAGTA TGTGTTTGTT ATGGTTTTCA CTCTGGATGA CGGGACAGGG 
GTGTTGGAAG CTTACCTCAA GGATTCTGAA CACTTTTTCA AGATCCCAGC ATCTGAAGTC 
CTCACTGATG ACGACCTTCA GAGAAGTCTA GAAACGATCA TGGATATGAT ATGTCCCCCA 
GGAATAAAAG TTGATGCATA CCCATGGCTA GAGTGCCTCC TCAAGTCCTA CAATGTCACC 
ATCGGAACAG AGCGACGAAT TTGCTACCAG ATTTTTGATA CTACAGTTGC AGAAAATGTT 
GTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006505019.1
CDS	339..2084
Translation	MLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINCSGFASLTFEGTVGMPVTARTSSKVFSFTPQDQKMVEALRVWASKHISASSTLVQLCDAQPMQYYDLTCQLLGKAQVDSTAFLLKVWDGTQTVLPSWRVSTQDLTFEGDLSHIERLQSLVVDILVYDNHVQVARSIEVGCFLRLYSLHTKLQPGNSETSSSESLRLEFHLHGGTSYGRGIRVLPDTSPCVDQLKKALEGANLPVTETSTGICQSENGDSSALSNSGSGAVSPYEEERCQQVSATILTNHQHLEKTPLCAILTQKAPQQYRVRAKLRSYLPRRLSQSVKLLCPKCHSVQEVPHGDSLDKILQDAATEAPDIKLKATSLYYSKVWTTEDQGGRQVAVHFVKNNGILPASSECLILIEGGRLCEVSKLSSKFHSVMPVRSGPESLELLTLSAPFLIQGKVHHYGCKQCSSLKPIQNLNSRFHKGPWTPSSVAEALGVVPLQYVFVMVFTLDDGTGVLEAYLKDSEHFFKIPASEVLTDDDLQRSLETIMDMICPPGIKVDAYPWLECLLKSYNVTIGTERRICYQIFDTTVAENVV

Target ORF information:

RefSeq Version	XM_006504956.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus protection of telomeres 1A (Pot1a), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006504956.2

ORF Insert Sequence:

ATGCTCTTTA GTGGAAACTA TGAAGCCCTC CCCATCATTT ATAAAGTTGG AGACATTGTT 
CGCTTCCACA GGCTGAAGAT CCAAGTGTAT AAAAATGAGC TTCAGGGAAT CAACTGCTCT 
GGCTTCGCCT CTTTGACATT TGAAGGGACT GTAGGGATGC CTGTCACAGC ACGCACTTCC 
AGCAAAGTTT TTAGCTTCAC TCCTCAGGAC CAAAAAATGG TAGAAGCTTT GCGGGTTTGG 
GCATCCAAGC ACATCTCGGC GTCTTCAACT TTAGTGCAGC TGTGCGATGC GCAGCCCATG 
CAGTATTACG ACCTGACCTG TCAGCTCCTG GGTAAAGCAC AAGTGGATTC CACAGCATTT 
CTTCTAAAGG TATGGGATGG AACCCAGACT GTGCTTCCCT CCTGGAGAGT CTCCACACAA 
GATCTAACTT TTGAAGGTGA CTTGAGTCAC ATCGAACGGC TACAGAGTCT GGTGGTAGAC 
ATTCTAGTCT ACGATAACCA CGTTCAAGTG GCGAGATCCA TCGAGGTTGG ATGCTTTCTA 
AGACTCTATA GCCTCCATAC AAAACTTCAG CCTGGAAATT CAGAAACCAG CAGTTCTGAA 
TCATTAAGGC TGGAGTTCCA TCTCCACGGA GGGACCAGTT ATGGTCGGGG CATTAGGGTT 
TTGCCAGATA CAAGCCCTTG TGTGGATCAG CTGAAAAAAG CTTTAGAAGG TGCAAATTTG 
CCAGTCACTG AGACCTCAAC TGGTATCTGT CAATCAGAAA ATGGGGACAG CTCTGCACTA 
TCAAACTCAG GATCAGGTGC AGTATCACCT TATGAAGAAG AACGATGTCA ACAAGTCTCT 
GCTACAATAC TTACCAATCA CCAACATTTA GAGAAAACAC CACTGTGTGC CATCTTGACG 
CAAAAAGCTC CTCAACAATA TCGAGTCCGC GCCAAACTGA GATCCTATTT GCCCAGGAGA 
CTTTCCCAGT CTGTTAAACT TCTCTGTCCT AAATGTCATT CAGTACAAGA AGTTCCACAT 
GGGGACAGTT TGGATAAAAT TTTGCAAGAT GCTGCAACTG AAGCTCCAGA CATCAAGCTG 
AAAGCGACAT CATTGTATTA TTCAAAAGTC TGGACCACTG AAGACCAGGG CGGACGGCAG 
GTCGCTGTTC ATTTTGTGAA AAATAATGGC ATTCTCCCTG CTTCAAGTGA ATGTCTAATT 
TTGATAGAAG GAGGAAGGCT CTGCGAAGTC TCTAAACTGT CCAGCAAGTT CCACAGTGTG 
ATGCCTGTGC GGTCCGGCCC TGAGAGCCTG GAGCTCCTTA CCCTTTCAGC CCCGTTCCTC 
ATACAGGGAA AGGTGCATCA CTATGGATGT AAACAGTGCT CAAGCTTGAA ACCTATACAA 
AATCTAAACT CCCGTTTTCA TAAAGGACCG TGGACTCCTT CCTCTGTGGC AGAAGCCCTG 
GGCGTTGTGC CGCTGCAGTA TGTGTTTGTT ATGGTTTTCA CTCTGGATGA CGGGACAGGG 
GTGTTGGAAG CTTACCTCAA GGATTCTGAA CACTTTTTCA AGATCCCAGC ATCTGAAGTC 
CTCACTGATG ACGACCTTCA GAGAAGTCTA GAAACGATCA TGGATATGAT ATGTCCCCCA 
GGAATAAAAG TTGATGCATA CCCATGGCTA GAGTGCCTCC TCAAGTCCTA CAATGTCACC 
ATCGGAACAG AGCGACGAAT TTGCTACCAG ATTTTTGATA CTACAGTTGC AGAAAATGTT 
GTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pot1a ( NM_133931.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598692.1 Mus musculus protection of telomeres 1A (Pot1a), mRNA.

Price & Availability↑

CloneID	OMu22194
Clone ID Related Accession (Same CDS sequence)	NM_133931.5 , NM_133931.4
Accession Version	NM_133931.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1923bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Mus musculus(house mouse)
Product	protection of telomeres protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC158683.2 and AC153888.3. On May 29, 2018 this sequence version replaced NM_133931.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK036052.1, AK040864.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTTTGG TTTCAACAGC TCCCTATACA TATACACCCC TGAATCTACT CAAGGAAGGT 
ACAATTGCCA ATGTCTATGG TGTTGTGAAA TTCTTTAAGC CTCCGTATGT TAGCAAAGGA 
ACTGATTATT GCTCAGTTGT AACAATTGTG GACCAGACAA ATGTGAAGTT AACCTGTATG 
CTCTTTAGTG GAAACTATGA AGCCCTCCCC ATCATTTATA AAGTTGGAGA CATTGTTCGC 
TTCCACAGGC TGAAGATCCA AGTGTATAAA AATGAGCTTC AGGGAATCAA CTGCTCTGGC 
TTCGCCTCTT TGACATTTGA AGGGACTGTA GGGATGCCTG TCACAGCACG CACTTCCAGC 
AAAGTTTTTA GCTTCACTCC TCAGGACCAA AAAATGGTAG AAGCTTTGCG GGTTTGGGCA 
TCCAAGCACA TCTCGGCGTC TTCAACTTTA GTGCAGCTGT GCGATGCGCA GCCCATGCAG 
TATTACGACC TGACCTGTCA GCTCCTGGGT AAAGCACAAG TGGATTCCAC AGCATTTCTT 
CTAAAGGTAT GGGATGGAAC CCAGACTGTG CTTCCCTCCT GGAGAGTCTC CACACAAGAT 
CTAACTTTTG AAGGTGACTT GAGTCACATC GAACGGCTAC AGAGTCTGGT GGTAGACATT 
CTAGTCTACG ATAACCACGT TCAAGTGGCG AGATCCATCG AGGTTGGATG CTTTCTAAGA 
CTCTATAGCC TCCATACAAA ACTTCAGCCT GGAAATTCAG AAACCAGCAG TTCTGAATCA 
TTAAGGCTGG AGTTCCATCT CCACGGAGGG ACCAGTTATG GTCGGGGCAT TAGGGTTTTG 
CCAGATACAA GCCCTTGTGT GGATCAGCTG AAAAAAGCTT TAGAAGGTGC AAATTTGCCA 
GTCACTGAGA CCTCAACTGG TATCTGTCAA TCAGAAAATG GGGACAGCTC TGCACTATCA 
AACTCAGGAT CAGGTGCAGT ATCACCTTAT GAAGAAGAAC GATGTCAACA AGTCTCTGCT 
ACAATACTTA CCAATCACCA ACATTTAGAG AAAACACCAC TGTGTGCCAT CTTGACGCAA 
AAAGCTCCTC AACAATATCG AGTCCGCGCC AAACTGAGAT CCTATTTGCC CAGGAGACTT 
TCCCAGTCTG TTAAACTTCT CTGTCCTAAA TGTCATTCAG TACAAGAAGT TCCACATGGG 
GACAGTTTGG ATAAAATTTT GCAAGATGCT GCAACTGAAG CTCCAGACAT CAAGCTGAAA 
GCGACATCAT TGTATTATTC AAAAGTCTGG ACCACTGAAG ACCAGGGCGG ACGGCAGGTC 
GCTGTTCATT TTGTGAAAAA TAATGGCATT CTCCCTGCTT CAAGTGAATG TCTAATTTTG 
ATAGAAGGAG GAAGGCTCTG CGAAGTCTCT AAACTGTCCA GCAAGTTCCA CAGTGTGATG 
CCTGTGCGGT CCGGCCCTGA GAGCCTGGAG CTCCTTACCC TTTCAGCCCC GTTCCTCATA 
CAGGGAAAGG TGCATCACTA TGGATGTAAA CAGTGCTCAA GCTTGAAACC TATACAAAAT 
CTAAACTCCC GTTTTCATAA AGGACCGTGG ACTCCTTCCT CTGTGGCAGA AGCCCTGGGC 
GTTGTGCCGC TGCAGTATGT GTTTGTTATG GTTTTCACTC TGGATGACGG GACAGGGGTG 
TTGGAAGCTT ACCTCAAGGA TTCTGAACAC TTTTTCAAGA TCCCAGCATC TGAAGTCCTC 
ACTGATGACG ACCTTCAGAG AAGTCTAGAA ACGATCATGG ATATGATATG TCCCCCAGGA 
ATAAAAGTTG ATGCATACCC ATGGCTAGAG TGCCTCCTCA AGTCCTACAA TGTCACCATC 
GGAACAGAGC GACGAATTTG CTACCAGATT TTTGATACTA CAGTTGCAGA AAATGTTGTC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598692.1
CDS	377..2299
Translation	MSLVSTAPYTYTPLNLLKEGTIANVYGVVKFFKPPYVSKGTDYCSVVTIVDQTNVKLTCMLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINCSGFASLTFEGTVGMPVTARTSSKVFSFTPQDQKMVEALRVWASKHISASSTLVQLCDAQPMQYYDLTCQLLGKAQVDSTAFLLKVWDGTQTVLPSWRVSTQDLTFEGDLSHIERLQSLVVDILVYDNHVQVARSIEVGCFLRLYSLHTKLQPGNSETSSSESLRLEFHLHGGTSYGRGIRVLPDTSPCVDQLKKALEGANLPVTETSTGICQSENGDSSALSNSGSGAVSPYEEERCQQVSATILTNHQHLEKTPLCAILTQKAPQQYRVRAKLRSYLPRRLSQSVKLLCPKCHSVQEVPHGDSLDKILQDAATEAPDIKLKATSLYYSKVWTTEDQGGRQVAVHFVKNNGILPASSECLILIEGGRLCEVSKLSSKFHSVMPVRSGPESLELLTLSAPFLIQGKVHHYGCKQCSSLKPIQNLNSRFHKGPWTPSSVAEALGVVPLQYVFVMVFTLDDGTGVLEAYLKDSEHFFKIPASEVLTDDDLQRSLETIMDMICPPGIKVDAYPWLECLLKSYNVTIGTERRICYQIFDTTVAENVV

Target ORF information:

RefSeq Version	NM_133931.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus protection of telomeres 1A (Pot1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133931.5

ORF Insert Sequence:

ATGTCTTTGG TTTCAACAGC TCCCTATACA TATACACCCC TGAATCTACT CAAGGAAGGT 
ACAATTGCCA ATGTCTATGG TGTTGTGAAA TTCTTTAAGC CTCCGTATGT TAGCAAAGGA 
ACTGATTATT GCTCAGTTGT AACAATTGTG GACCAGACAA ATGTGAAGTT AACCTGTATG 
CTCTTTAGTG GAAACTATGA AGCCCTCCCC ATCATTTATA AAGTTGGAGA CATTGTTCGC 
TTCCACAGGC TGAAGATCCA AGTGTATAAA AATGAGCTTC AGGGAATCAA CTGCTCTGGC 
TTCGCCTCTT TGACATTTGA AGGGACTGTA GGGATGCCTG TCACAGCACG CACTTCCAGC 
AAAGTTTTTA GCTTCACTCC TCAGGACCAA AAAATGGTAG AAGCTTTGCG GGTTTGGGCA 
TCCAAGCACA TCTCGGCGTC TTCAACTTTA GTGCAGCTGT GCGATGCGCA GCCCATGCAG 
TATTACGACC TGACCTGTCA GCTCCTGGGT AAAGCACAAG TGGATTCCAC AGCATTTCTT 
CTAAAGGTAT GGGATGGAAC CCAGACTGTG CTTCCCTCCT GGAGAGTCTC CACACAAGAT 
CTAACTTTTG AAGGTGACTT GAGTCACATC GAACGGCTAC AGAGTCTGGT GGTAGACATT 
CTAGTCTACG ATAACCACGT TCAAGTGGCG AGATCCATCG AGGTTGGATG CTTTCTAAGA 
CTCTATAGCC TCCATACAAA ACTTCAGCCT GGAAATTCAG AAACCAGCAG TTCTGAATCA 
TTAAGGCTGG AGTTCCATCT CCACGGAGGG ACCAGTTATG GTCGGGGCAT TAGGGTTTTG 
CCAGATACAA GCCCTTGTGT GGATCAGCTG AAAAAAGCTT TAGAAGGTGC AAATTTGCCA 
GTCACTGAGA CCTCAACTGG TATCTGTCAA TCAGAAAATG GGGACAGCTC TGCACTATCA 
AACTCAGGAT CAGGTGCAGT ATCACCTTAT GAAGAAGAAC GATGTCAACA AGTCTCTGCT 
ACAATACTTA CCAATCACCA ACATTTAGAG AAAACACCAC TGTGTGCCAT CTTGACGCAA 
AAAGCTCCTC AACAATATCG AGTCCGCGCC AAACTGAGAT CCTATTTGCC CAGGAGACTT 
TCCCAGTCTG TTAAACTTCT CTGTCCTAAA TGTCATTCAG TACAAGAAGT TCCACATGGG 
GACAGTTTGG ATAAAATTTT GCAAGATGCT GCAACTGAAG CTCCAGACAT CAAGCTGAAA 
GCGACATCAT TGTATTATTC AAAAGTCTGG ACCACTGAAG ACCAGGGCGG ACGGCAGGTC 
GCTGTTCATT TTGTGAAAAA TAATGGCATT CTCCCTGCTT CAAGTGAATG TCTAATTTTG 
ATAGAAGGAG GAAGGCTCTG CGAAGTCTCT AAACTGTCCA GCAAGTTCCA CAGTGTGATG 
CCTGTGCGGT CCGGCCCTGA GAGCCTGGAG CTCCTTACCC TTTCAGCCCC GTTCCTCATA 
CAGGGAAAGG TGCATCACTA TGGATGTAAA CAGTGCTCAA GCTTGAAACC TATACAAAAT 
CTAAACTCCC GTTTTCATAA AGGACCGTGG ACTCCTTCCT CTGTGGCAGA AGCCCTGGGC 
GTTGTGCCGC TGCAGTATGT GTTTGTTATG GTTTTCACTC TGGATGACGG GACAGGGGTG 
TTGGAAGCTT ACCTCAAGGA TTCTGAACAC TTTTTCAAGA TCCCAGCATC TGAAGTCCTC 
ACTGATGACG ACCTTCAGAG AAGTCTAGAA ACGATCATGG ATATGATATG TCCCCCAGGA 
ATAAAAGTTG ATGCATACCC ATGGCTAGAG TGCCTCCTCA AGTCCTACAA TGTCACCATC 
GGAACAGAGC GACGAATTTG CTACCAGATT TTTGATACTA CAGTTGCAGA AAATGTTGTC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pot1a ( NM_133931.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598692.1 Mus musculus protection of telomeres 1A (Pot1a), mRNA.

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CloneID	OMu22194
Clone ID Related Accession (Same CDS sequence)	NM_133931.5 , NM_133931.4
Accession Version	NM_133931.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1923bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-23
Organism	Mus musculus(house mouse)
Product	protection of telomeres protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC158683.2 and AC153888.3. On May 1, 2007 this sequence version replaced NM_133931.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK036052.1, AK040864.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGTCTTTGG TTTCAACAGC TCCCTATACA TATACACCCC TGAATCTACT CAAGGAAGGT 
ACAATTGCCA ATGTCTATGG TGTTGTGAAA TTCTTTAAGC CTCCGTATGT TAGCAAAGGA 
ACTGATTATT GCTCAGTTGT AACAATTGTG GACCAGACAA ATGTGAAGTT AACCTGTATG 
CTCTTTAGTG GAAACTATGA AGCCCTCCCC ATCATTTATA AAGTTGGAGA CATTGTTCGC 
TTCCACAGGC TGAAGATCCA AGTGTATAAA AATGAGCTTC AGGGAATCAA CTGCTCTGGC 
TTCGCCTCTT TGACATTTGA AGGGACTGTA GGGATGCCTG TCACAGCACG CACTTCCAGC 
AAAGTTTTTA GCTTCACTCC TCAGGACCAA AAAATGGTAG AAGCTTTGCG GGTTTGGGCA 
TCCAAGCACA TCTCGGCGTC TTCAACTTTA GTGCAGCTGT GCGATGCGCA GCCCATGCAG 
TATTACGACC TGACCTGTCA GCTCCTGGGT AAAGCACAAG TGGATTCCAC AGCATTTCTT 
CTAAAGGTAT GGGATGGAAC CCAGACTGTG CTTCCCTCCT GGAGAGTCTC CACACAAGAT 
CTAACTTTTG AAGGTGACTT GAGTCACATC GAACGGCTAC AGAGTCTGGT GGTAGACATT 
CTAGTCTACG ATAACCACGT TCAAGTGGCG AGATCCATCG AGGTTGGATG CTTTCTAAGA 
CTCTATAGCC TCCATACAAA ACTTCAGCCT GGAAATTCAG AAACCAGCAG TTCTGAATCA 
TTAAGGCTGG AGTTCCATCT CCACGGAGGG ACCAGTTATG GTCGGGGCAT TAGGGTTTTG 
CCAGATACAA GCCCTTGTGT GGATCAGCTG AAAAAAGCTT TAGAAGGTGC AAATTTGCCA 
GTCACTGAGA CCTCAACTGG TATCTGTCAA TCAGAAAATG GGGACAGCTC TGCACTATCA 
AACTCAGGAT CAGGTGCAGT ATCACCTTAT GAAGAAGAAC GATGTCAACA AGTCTCTGCT 
ACAATACTTA CCAATCACCA ACATTTAGAG AAAACACCAC TGTGTGCCAT CTTGACGCAA 
AAAGCTCCTC AACAATATCG AGTCCGCGCC AAACTGAGAT CCTATTTGCC CAGGAGACTT 
TCCCAGTCTG TTAAACTTCT CTGTCCTAAA TGTCATTCAG TACAAGAAGT TCCACATGGG 
GACAGTTTGG ATAAAATTTT GCAAGATGCT GCAACTGAAG CTCCAGACAT CAAGCTGAAA 
GCGACATCAT TGTATTATTC AAAAGTCTGG ACCACTGAAG ACCAGGGCGG ACGGCAGGTC 
GCTGTTCATT TTGTGAAAAA TAATGGCATT CTCCCTGCTT CAAGTGAATG TCTAATTTTG 
ATAGAAGGAG GAAGGCTCTG CGAAGTCTCT AAACTGTCCA GCAAGTTCCA CAGTGTGATG 
CCTGTGCGGT CCGGCCCTGA GAGCCTGGAG CTCCTTACCC TTTCAGCCCC GTTCCTCATA 
CAGGGAAAGG TGCATCACTA TGGATGTAAA CAGTGCTCAA GCTTGAAACC TATACAAAAT 
CTAAACTCCC GTTTTCATAA AGGACCGTGG ACTCCTTCCT CTGTGGCAGA AGCCCTGGGC 
GTTGTGCCGC TGCAGTATGT GTTTGTTATG GTTTTCACTC TGGATGACGG GACAGGGGTG 
TTGGAAGCTT ACCTCAAGGA TTCTGAACAC TTTTTCAAGA TCCCAGCATC TGAAGTCCTC 
ACTGATGACG ACCTTCAGAG AAGTCTAGAA ACGATCATGG ATATGATATG TCCCCCAGGA 
ATAAAAGTTG ATGCATACCC ATGGCTAGAG TGCCTCCTCA AGTCCTACAA TGTCACCATC 
GGAACAGAGC GACGAATTTG CTACCAGATT TTTGATACTA CAGTTGCAGA AAATGTTGTC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598692.1
CDS	385..2307
Translation	MSLVSTAPYTYTPLNLLKEGTIANVYGVVKFFKPPYVSKGTDYCSVVTIVDQTNVKLTCMLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINCSGFASLTFEGTVGMPVTARTSSKVFSFTPQDQKMVEALRVWASKHISASSTLVQLCDAQPMQYYDLTCQLLGKAQVDSTAFLLKVWDGTQTVLPSWRVSTQDLTFEGDLSHIERLQSLVVDILVYDNHVQVARSIEVGCFLRLYSLHTKLQPGNSETSSSESLRLEFHLHGGTSYGRGIRVLPDTSPCVDQLKKALEGANLPVTETSTGICQSENGDSSALSNSGSGAVSPYEEERCQQVSATILTNHQHLEKTPLCAILTQKAPQQYRVRAKLRSYLPRRLSQSVKLLCPKCHSVQEVPHGDSLDKILQDAATEAPDIKLKATSLYYSKVWTTEDQGGRQVAVHFVKNNGILPASSECLILIEGGRLCEVSKLSSKFHSVMPVRSGPESLELLTLSAPFLIQGKVHHYGCKQCSSLKPIQNLNSRFHKGPWTPSSVAEALGVVPLQYVFVMVFTLDDGTGVLEAYLKDSEHFFKIPASEVLTDDDLQRSLETIMDMICPPGIKVDAYPWLECLLKSYNVTIGTERRICYQIFDTTVAENVV

Target ORF information:

RefSeq Version	NM_133931.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus protection of telomeres 1A (Pot1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133931.4

ORF Insert Sequence:

ATGTCTTTGG TTTCAACAGC TCCCTATACA TATACACCCC TGAATCTACT CAAGGAAGGT 
ACAATTGCCA ATGTCTATGG TGTTGTGAAA TTCTTTAAGC CTCCGTATGT TAGCAAAGGA 
ACTGATTATT GCTCAGTTGT AACAATTGTG GACCAGACAA ATGTGAAGTT AACCTGTATG 
CTCTTTAGTG GAAACTATGA AGCCCTCCCC ATCATTTATA AAGTTGGAGA CATTGTTCGC 
TTCCACAGGC TGAAGATCCA AGTGTATAAA AATGAGCTTC AGGGAATCAA CTGCTCTGGC 
TTCGCCTCTT TGACATTTGA AGGGACTGTA GGGATGCCTG TCACAGCACG CACTTCCAGC 
AAAGTTTTTA GCTTCACTCC TCAGGACCAA AAAATGGTAG AAGCTTTGCG GGTTTGGGCA 
TCCAAGCACA TCTCGGCGTC TTCAACTTTA GTGCAGCTGT GCGATGCGCA GCCCATGCAG 
TATTACGACC TGACCTGTCA GCTCCTGGGT AAAGCACAAG TGGATTCCAC AGCATTTCTT 
CTAAAGGTAT GGGATGGAAC CCAGACTGTG CTTCCCTCCT GGAGAGTCTC CACACAAGAT 
CTAACTTTTG AAGGTGACTT GAGTCACATC GAACGGCTAC AGAGTCTGGT GGTAGACATT 
CTAGTCTACG ATAACCACGT TCAAGTGGCG AGATCCATCG AGGTTGGATG CTTTCTAAGA 
CTCTATAGCC TCCATACAAA ACTTCAGCCT GGAAATTCAG AAACCAGCAG TTCTGAATCA 
TTAAGGCTGG AGTTCCATCT CCACGGAGGG ACCAGTTATG GTCGGGGCAT TAGGGTTTTG 
CCAGATACAA GCCCTTGTGT GGATCAGCTG AAAAAAGCTT TAGAAGGTGC AAATTTGCCA 
GTCACTGAGA CCTCAACTGG TATCTGTCAA TCAGAAAATG GGGACAGCTC TGCACTATCA 
AACTCAGGAT CAGGTGCAGT ATCACCTTAT GAAGAAGAAC GATGTCAACA AGTCTCTGCT 
ACAATACTTA CCAATCACCA ACATTTAGAG AAAACACCAC TGTGTGCCAT CTTGACGCAA 
AAAGCTCCTC AACAATATCG AGTCCGCGCC AAACTGAGAT CCTATTTGCC CAGGAGACTT 
TCCCAGTCTG TTAAACTTCT CTGTCCTAAA TGTCATTCAG TACAAGAAGT TCCACATGGG 
GACAGTTTGG ATAAAATTTT GCAAGATGCT GCAACTGAAG CTCCAGACAT CAAGCTGAAA 
GCGACATCAT TGTATTATTC AAAAGTCTGG ACCACTGAAG ACCAGGGCGG ACGGCAGGTC 
GCTGTTCATT TTGTGAAAAA TAATGGCATT CTCCCTGCTT CAAGTGAATG TCTAATTTTG 
ATAGAAGGAG GAAGGCTCTG CGAAGTCTCT AAACTGTCCA GCAAGTTCCA CAGTGTGATG 
CCTGTGCGGT CCGGCCCTGA GAGCCTGGAG CTCCTTACCC TTTCAGCCCC GTTCCTCATA 
CAGGGAAAGG TGCATCACTA TGGATGTAAA CAGTGCTCAA GCTTGAAACC TATACAAAAT 
CTAAACTCCC GTTTTCATAA AGGACCGTGG ACTCCTTCCT CTGTGGCAGA AGCCCTGGGC 
GTTGTGCCGC TGCAGTATGT GTTTGTTATG GTTTTCACTC TGGATGACGG GACAGGGGTG 
TTGGAAGCTT ACCTCAAGGA TTCTGAACAC TTTTTCAAGA TCCCAGCATC TGAAGTCCTC 
ACTGATGACG ACCTTCAGAG AAGTCTAGAA ACGATCATGG ATATGATATG TCCCCCAGGA 
ATAAAAGTTG ATGCATACCC ATGGCTAGAG TGCCTCCTCA AGTCCTACAA TGTCACCATC 
GGAACAGAGC GACGAATTTG CTACCAGATT TTTGATACTA CAGTTGCAGA AAATGTTGTC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age.
Nature communications8(1)804(2017 10)
Hosokawa K,MacArthur BD,Ikushima YM,Toyama H,Masuhiro Y,Hanazawa S,Suda T,Arai F

Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis.
Oncogene36(14)1939-1951(2017 Apr)
Gu P,Wang Y,Bisht KK,Wu L,Kukova L,Smith EM,Xiao Y,Bailey SM,Lei M,Nandakumar J,Chang S

PHF11 promotes DSB resection, ATR signaling, and HR.
Genes & development31(1)46-58(2017 Jan)
Gong Y,Handa N,Kowalczykowski SC,de Lange T

Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease.
American journal of respiratory cell and molecular biology56(1)38-49(2017 Jan)
Ahmad T,Sundar IK,Tormos AM,Lerner CA,Gerloff J,Yao H,Rahman I

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Pot1a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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