H2-Ea-ps cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2-Ea-ps
Entrez Gene ID	100504404
Full Name	histocompatibility 2, class II antigen E alpha, pseudogene
Synonyms	AI323765,E-alpha-f,H-2Ea,H2-Ea,I-Ealpha,Ia-3,Ia3,MHC-H2-Ea
General protein information	Preferred Names histocompatibility 2, class II antigen E alpha, pseudogene Names histocompatibility 2, class II antigen E alpha H-2 class II histocompatibility antigen, E-D alpha chain H-2 class II histocompatibility antigen, E-K alpha chain H-2 class II histocompatibility antigen, E-U alpha chain H2-IE-alpha I-E alpha MHC class II MHC class II H2-E alpha chain MHC class II alpha chain MHC class II antigen E alpha MHC class II antigen IEk-alpha MHC class II protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 B1\|17 17.98 cM
Summary	This locus belongs to the class II major histocompatibility complex (MHC) family of genes, which encode immune response (Ia) antigens that function in the T-cell-dependent immune response. This family member has multiple haplotypes, some of which result in the production of an E-alpha subunit that combines with an E-beta subunit to form a functional E complex at the cell surface. Other haplotypes, including that of the reference genome allele, contain mutations and they thus represent polymorphic pseudogenes that do not produce functional products. These mutations include frameshifting indels, nonsense mutations, and deletions of larger regions. The reference genome haplotype contains a deletion at the 5' end of the gene, including the core promoter region and the transcription start site, and therefore no transcripts result from this haplotype. [provided by RefSeq, Aug 2011].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010381.3	NP_034511.3	histocompatibility 2, class II antigen E alpha precursor
XM_017317737.1	XP_017173226.1	histocompatibility 2, class II antigen E alpha isoform X1
NM_010381.2	NP_034511.2	histocompatibility 2, class II antigen E alpha precursor
XM_017317737.2	XP_017173226.1	histocompatibility 2, class II antigen E alpha isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PATR-DRA	NP_001127811.1
Gallus gallus (chicken)	BLA	NP_001231990.1
Bos taurus (cattle)	BOLA-DRA	NP_001012695.1
Mus musculus (house mouse)	H2-Ea-ps	XP_003688998.1
Rattus norvegicus (Norway rat)	RT1-Da	NP_001008847.1
Homo sapiens (human)	HLA-DRA	NP_061984.2
	MAMU-DRA	NP_001127770.1
Canis lupus familiaris (dog)	DLA-DRA	NP_001011723.1

Gene Ontology
Bibliography

Related articles in PubMed

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H, Stuart JM, Gu W
BMC immunology17(1)25(2016 08)

Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb.
Subramanian S, Yim YS, Liu K, Tus K, Zhou XJ, Wakeland EK
Journal of immunology (Baltimore, Md. : 1950)175(2)1062-72(2005 Jul)

Detection of a new cerebral malaria susceptibility locus, using CBA mice.
Ohno T, Nishimura M
Immunogenetics56(9)675-8(2004 Dec)

Inactivation of E alpha and E beta expression in inbred and wild mice by multiple distinct mutations, some of which predate speciation within Mus species.
Tacchini-Cottier F, Mayer WE, Begovich AB, Jones PP
International immunology7(9)1459-71(1995 Sep)

The complete nucleotide sequence of the I-E alpha d immune response gene.
Hyldig-Nielsen JJ, Schenning L, Hammerling U, Widmark E, Heldin E, Lind P, Servenius B, Lund T, Flavell R, Lee JS, Trowsdale J, Schreier PH, Zablitzky F, Larhammar D, Peterson PA, Rask L
Nucleic acids research11(15)5055-71(1983 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A computational method for mapping phenotypic traits was used to map an allele-specific, YY1 binding element regulating H2-Ealpha gene expression to the first intron of the H2-Ealpha gene.
Title: In silico genetics: identification of a functional element regulating H2-Ealpha gene expression.

The following H2-Ea-ps gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2-Ea-ps cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu21880	NM_010381.2 Latest version!	Mus musculus histocompatibility 2, class II antigen E alpha, pseudogene (H2-Ea-ps), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu90625	NM_010381.3 Latest version!	Mus musculus histocompatibility 2, class II antigen E alpha (H2-Ea), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu54259	XM_017317737.2 Latest version!	Mus musculus histocompatibility 2, class II antigen E alpha, pseudogene (H2-Ea-ps), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu54259	XM_017317737.1	Mus musculus histocompatibility 2, class II antigen E alpha, pseudogene (H2-Ea-ps), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2-Ea-ps ( NM_010381.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034511.2 Mus musculus histocompatibility 2, class II antigen E alpha, pseudogene (H2-Ea-ps), mRNA.

Price & Availability↑

CloneID	OMu21880
Clone ID Related Accession (Same CDS sequence)	NM_010381.2
Accession Version	NM_010381.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Mus musculus(house mouse)
Product	histocompatibility 2, class II antigen E alpha precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U13648.1. On or before Aug 26, 2011 this sequence version replaced XM_003085149.1, NM_010381.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC106107.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849384 [ECO:0000350] ##Evidence-Data-END##

ATGGCCACAA TTGGAGCCCT GCTGTTAAGA TTTTTCTTCA TTGCTGTTCT GATGAGCTCC 
CAGAAGTCAT GGGCTATCAA AGAGGAACAC ACCATCATCC AGGCGGAGTT CTATCTTTTA 
CCAGACAAAC GTGGAGAGTT TATGTTTGAC TTTGACGGCG ATGAGATTTT CCATGTAGAC 
ATTGAAAAGT CAGAGACCAT CTGGAGACTT GAAGAATTTG CAAAGTTTGC CAGCTTTGAG 
GCTCAGGGTG CACTGGCTAA TATAGCTGTG GACAAAGCTA ACCTGGATGT CATGAAAGAG 
CGTTCCAACA ACACTCCAGA TGCCAACGTG GCCCCAGAGG TGACTGTACT CTCCAGAAGC 
CCTGTGAACC TGGGAGAGCC CAACATCCTC ATCTGTTTCA TTGACAAGTT CTCCCCTCCA 
GTGGTCAATG TCACCTGGTT CCGGAATGGA CGGCCTGTCA CCGAAGGCGT GTCAGAGACA 
GTGTTTCTCC CGAGGGACGA TCACCTCTTC CGCAAATTCC ACTATCTGAC CTTCCTGCCC 
TCCACAGATG ATTTCTATGA CTGTGAGGTG GATCACTGGG GTTTGGAGGA GCCTCTGCGG 
AAGCACTGGG AGTTTGAAGA GAAAACCCTC CTCCCAGAAA CTACAGAGAA TGTCGTGTGT 
GCTCTTGGGT TGTTTGTGGG TCTGGTGGGC ATCGTTGTGG GGATTATCCT CATCATGAAG 
GGTATTAAAA AACGCAATGT TGTAGAACGC CGACAAGGAG CCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034511.2
CDS	25..792
Translation	MATIGALLLRFFFIAVLMSSQKSWAIKEEHTIIQAEFYLLPDKRGEFMFDFDGDEIFHVDIEKSETIWRLEEFAKFASFEAQGALANIAVDKANLDVMKERSNNTPDANVAPEVTVLSRSPVNLGEPNILICFIDKFSPPVVNVTWFRNGRPVTEGVSETVFLPRDDHLFRKFHYLTFLPSTDDFYDCEVDHWGLEEPLRKHWEFEEKTLLPETTENVVCALGLFVGLVGIVVGIILIMKGIKKRNVVERRQGAL

Target ORF information:

RefSeq Version	NM_010381.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus histocompatibility 2, class II antigen E alpha, pseudogene (H2-Ea-ps), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010381.2

ORF Insert Sequence:

ATGGCCACAA TTGGAGCCCT GCTGTTAAGA TTTTTCTTCA TTGCTGTTCT GATGAGCTCC 
CAGAAGTCAT GGGCTATCAA AGAGGAACAC ACCATCATCC AGGCGGAGTT CTATCTTTTA 
CCAGACAAAC GTGGAGAGTT TATGTTTGAC TTTGACGGCG ATGAGATTTT CCATGTAGAC 
ATTGAAAAGT CAGAGACCAT CTGGAGACTT GAAGAATTTG CAAAGTTTGC CAGCTTTGAG 
GCTCAGGGTG CACTGGCTAA TATAGCTGTG GACAAAGCTA ACCTGGATGT CATGAAAGAG 
CGTTCCAACA ACACTCCAGA TGCCAACGTG GCCCCAGAGG TGACTGTACT CTCCAGAAGC 
CCTGTGAACC TGGGAGAGCC CAACATCCTC ATCTGTTTCA TTGACAAGTT CTCCCCTCCA 
GTGGTCAATG TCACCTGGTT CCGGAATGGA CGGCCTGTCA CCGAAGGCGT GTCAGAGACA 
GTGTTTCTCC CGAGGGACGA TCACCTCTTC CGCAAATTCC ACTATCTGAC CTTCCTGCCC 
TCCACAGATG ATTTCTATGA CTGTGAGGTG GATCACTGGG GTTTGGAGGA GCCTCTGCGG 
AAGCACTGGG AGTTTGAAGA GAAAACCCTC CTCCCAGAAA CTACAGAGAA TGTCGTGTGT 
GCTCTTGGGT TGTTTGTGGG TCTGGTGGGC ATCGTTGTGG GGATTATCCT CATCATGAAG 
GGTATTAAAA AACGCAATGT TGTAGAACGC CGACAAGGAG CCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2-Ea-ps ( XM_017317737.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017173226.1 Mus musculus histocompatibility 2, class II antigen E alpha, pseudogene (H2-Ea-ps), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu54259
Clone ID Related Accession (Same CDS sequence)	XM_017317737.1 , XM_017317737.2
Accession Version	XM_017317737.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	histocompatibility 2, class II antigen E alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 17% of CDS bases ##RefSeq-Attributes-END##

ATGATCCTGT TAGTGATCTG GGGGTTGATA TCAGATGCCT TACTTAGCCC CTGGCATGAT 
CGGACCATCA GCAGTCAGGA GGATGACGGC CCTCTTTGTT GTGTTACTAT GTTGAAGATT 
CACCAAGGCA CTAATTCAGC CCCAGAGGAA CACACCATCA TCCAGGCGGA GTTCTATCTT 
TTACCAGACA AACGTGGAGA GTTTATGTTT GACTTTGACG GCGATGAGAT TTTCCATGTA 
GACATTGAAA AGTCAGAGAC CATCTGGAGA CTTGAAGAAT TTGCAAAGTT TGCCAGCTTT 
GAGGCTCAGG GTGCACTGGC TAATATAGCT GTGGACAAAG CTAACCTGGA TGTCATGAAA 
GAGCGTTCCA ACAACACTCC AGATGCCAAC GTGGCCCCAG AGGTGACTGT ACTCTCCAGA 
AGCCCTGTGA ACCTGGGAGA GCCCAACATC CTCATCTGTT TCATTGACAA GTTCTCCCCT 
CCAGTCGTCA ATGTCACCTG GCTCCGGAAT GGACGGCCTG TCACCGAAGG CGTGTCAGAG 
ACAGTGTTTC TCCCGAGGGA CGATCACCTC TTCCGCAAAT TCCACTTTCT GACCTTCCTG 
CCCTCCACAG ATGATTTCTA TGACTGTGAG GTGGATCACT GGGGTTTGGA GGAGCCTCTG 
CGGAAGCACT GGGAGTTTGA AGAGAAAACC CTCCTCCCAG AAACTAAAGA GAATGTCGTG 
TGTGCTCTTG GGTTGTTTGT GGGTCTGGTG GGCATCGTTG TGGGGATTAT CCTCATCATG 
AAGGGTATTA AAAAACGCAA TGTTGTAGAA CGCCGACAAG GAGCCCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017173226.1
CDS	1..831
Translation	MILLVIWGLISDALLSPWHDRTISSQEDDGPLCCVTMLKIHQGTNSAPEEHTIIQAEFYLLPDKRGEFMFDFDGDEIFHVDIEKSETIWRLEEFAKFASFEAQGALANIAVDKANLDVMKERSNNTPDANVAPEVTVLSRSPVNLGEPNILICFIDKFSPPVVNVTWLRNGRPVTEGVSETVFLPRDDHLFRKFHFLTFLPSTDDFYDCEVDHWGLEEPLRKHWEFEEKTLLPETKENVVCALGLFVGLVGIVVGIILIMKGIKKRNVVERRQGAL

Target ORF information:

RefSeq Version	XM_017317737.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus histocompatibility 2, class II antigen E alpha, pseudogene (H2-Ea-ps), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017317737.1

ORF Insert Sequence:

ATGATCCTGT TAGTGATCTG GGGGTTGATA TCAGATGCCT TACTTAGCCC CTGGCATGAT 
CGGACCATCA GCAGTCAGGA GGATGACGGC CCTCTTTGTT GTGTTACTAT GTTGAAGATT 
CACCAAGGCA CTAATTCAGC CCCAGAGGAA CACACCATCA TCCAGGCGGA GTTCTATCTT 
TTACCAGACA AACGTGGAGA GTTTATGTTT GACTTTGACG GCGATGAGAT TTTCCATGTA 
GACATTGAAA AGTCAGAGAC CATCTGGAGA CTTGAAGAAT TTGCAAAGTT TGCCAGCTTT 
GAGGCTCAGG GTGCACTGGC TAATATAGCT GTGGACAAAG CTAACCTGGA TGTCATGAAA 
GAGCGTTCCA ACAACACTCC AGATGCCAAC GTGGCCCCAG AGGTGACTGT ACTCTCCAGA 
AGCCCTGTGA ACCTGGGAGA GCCCAACATC CTCATCTGTT TCATTGACAA GTTCTCCCCT 
CCAGTCGTCA ATGTCACCTG GCTCCGGAAT GGACGGCCTG TCACCGAAGG CGTGTCAGAG 
ACAGTGTTTC TCCCGAGGGA CGATCACCTC TTCCGCAAAT TCCACTTTCT GACCTTCCTG 
CCCTCCACAG ATGATTTCTA TGACTGTGAG GTGGATCACT GGGGTTTGGA GGAGCCTCTG 
CGGAAGCACT GGGAGTTTGA AGAGAAAACC CTCCTCCCAG AAACTAAAGA GAATGTCGTG 
TGTGCTCTTG GGTTGTTTGT GGGTCTGGTG GGCATCGTTG TGGGGATTAT CCTCATCATG 
AAGGGTATTA AAAAACGCAA TGTTGTAGAA CGCCGACAAG GAGCCCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2-Ea-ps ( NM_010381.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034511.3 Mus musculus histocompatibility 2, class II antigen E alpha (H2-Ea), mRNA.

Price & Availability↑

CloneID	OMu90625
Clone ID Related Accession (Same CDS sequence)	NM_010381.3
Accession Version	NM_010381.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Mus musculus(house mouse)
Product	histocompatibility 2, class II antigen E alpha precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC106107.1. On Sep 5, 2019 this sequence version replaced NM_010381.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC106107.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849384 [ECO:0000350] ##Evidence-Data-END##

ATGGCCACAA TTGGAGCCCT GGTGTTAAGA TTTTTCTTCA TTGCTGTTCT GATGAGCTCC 
CAGAAGTCAT GGGCTATCAA AGAGGAACAC ACCATCATCC AGGCGGAGTT CTATCTTTTA 
CCAGACAAAC GTGGAGAGTT TATGTTTGAC TTTGACGGCG ATGAGATTTT CCATGTAGAC 
ATTGAAAAGT CAGAGACCAT CTGGAGACTT GAAGAATTTG CAAAGTTTGC CAGCTTTGAG 
GCTCAGGGTG CACTGGCTAA TATAGCTGTG GACAAAGCTA ACCTGGATGT CATGAAAGAG 
CGTTCCAACA ACACTCCAGA TGCCAACGTG GCCCCAGAGG TGACTGTACT CTCCAGAAGC 
CCTGTGAACC TGGGAGAGCC CAACATCCTC ATCTGTTTCA TTGACAAGTT CTCCCCTCCA 
GTGGTCAATG TCACCTGGCT CCGGAATGGA CGGCCTGTCA CCGAAGGCGT GTCAGAGACA 
GTGTTTCTCC CGAGGGACGA TCACCTCTTC CGCAAATTCC ACTATCTGAC CTTCCTGCCC 
TCCACAGATG ATTTCTATGA CTGTGAGGTG GATCACTGGG GTTTGGAGGA GCCCCTGCGG 
AAGCACTGGG AGTTTGAAGA GAAAACCCTC CTCCCAGAAA CTAAAGAGAA TGTCGTGTGT 
GCTCTTGGGT TGTTTGTGGG TCTGGTGGGC ATCGTTGTGG GGATTATCCT CATCATGAAG 
GGTATTAAAA AACGCAATGT TGTAGAACGC CGACAAGGAG CCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034511.3
CDS	30..797
Translation	MATIGALVLRFFFIAVLMSSQKSWAIKEEHTIIQAEFYLLPDKRGEFMFDFDGDEIFHVDIEKSETIWRLEEFAKFASFEAQGALANIAVDKANLDVMKERSNNTPDANVAPEVTVLSRSPVNLGEPNILICFIDKFSPPVVNVTWLRNGRPVTEGVSETVFLPRDDHLFRKFHYLTFLPSTDDFYDCEVDHWGLEEPLRKHWEFEEKTLLPETKENVVCALGLFVGLVGIVVGIILIMKGIKKRNVVERRQGAL

Target ORF information:

RefSeq Version	NM_010381.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus histocompatibility 2, class II antigen E alpha (H2-Ea), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010381.3

ORF Insert Sequence:

ATGGCCACAA TTGGAGCCCT GGTGTTAAGA TTTTTCTTCA TTGCTGTTCT GATGAGCTCC 
CAGAAGTCAT GGGCTATCAA AGAGGAACAC ACCATCATCC AGGCGGAGTT CTATCTTTTA 
CCAGACAAAC GTGGAGAGTT TATGTTTGAC TTTGACGGCG ATGAGATTTT CCATGTAGAC 
ATTGAAAAGT CAGAGACCAT CTGGAGACTT GAAGAATTTG CAAAGTTTGC CAGCTTTGAG 
GCTCAGGGTG CACTGGCTAA TATAGCTGTG GACAAAGCTA ACCTGGATGT CATGAAAGAG 
CGTTCCAACA ACACTCCAGA TGCCAACGTG GCCCCAGAGG TGACTGTACT CTCCAGAAGC 
CCTGTGAACC TGGGAGAGCC CAACATCCTC ATCTGTTTCA TTGACAAGTT CTCCCCTCCA 
GTGGTCAATG TCACCTGGCT CCGGAATGGA CGGCCTGTCA CCGAAGGCGT GTCAGAGACA 
GTGTTTCTCC CGAGGGACGA TCACCTCTTC CGCAAATTCC ACTATCTGAC CTTCCTGCCC 
TCCACAGATG ATTTCTATGA CTGTGAGGTG GATCACTGGG GTTTGGAGGA GCCCCTGCGG 
AAGCACTGGG AGTTTGAAGA GAAAACCCTC CTCCCAGAAA CTAAAGAGAA TGTCGTGTGT 
GCTCTTGGGT TGTTTGTGGG TCTGGTGGGC ATCGTTGTGG GGATTATCCT CATCATGAAG 
GGTATTAAAA AACGCAATGT TGTAGAACGC CGACAAGGAG CCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2-Ea-ps ( XM_017317737.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017173226.1 Mus musculus histocompatibility 2, class II antigen E alpha, pseudogene (H2-Ea-ps), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu54259
Clone ID Related Accession (Same CDS sequence)	XM_017317737.1 , XM_017317737.2
Accession Version	XM_017317737.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	histocompatibility 2, class II antigen E alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017317737.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 17% of CDS bases ##RefSeq-Attributes-END##

ATGATCCTGT TAGTGATCTG GGGGTTGATA TCAGATGCCT TACTTAGCCC CTGGCATGAT 
CGGACCATCA GCAGTCAGGA GGATGACGGC CCTCTTTGTT GTGTTACTAT GTTGAAGATT 
CACCAAGGCA CTAATTCAGC CCCAGAGGAA CACACCATCA TCCAGGCGGA GTTCTATCTT 
TTACCAGACA AACGTGGAGA GTTTATGTTT GACTTTGACG GCGATGAGAT TTTCCATGTA 
GACATTGAAA AGTCAGAGAC CATCTGGAGA CTTGAAGAAT TTGCAAAGTT TGCCAGCTTT 
GAGGCTCAGG GTGCACTGGC TAATATAGCT GTGGACAAAG CTAACCTGGA TGTCATGAAA 
GAGCGTTCCA ACAACACTCC AGATGCCAAC GTGGCCCCAG AGGTGACTGT ACTCTCCAGA 
AGCCCTGTGA ACCTGGGAGA GCCCAACATC CTCATCTGTT TCATTGACAA GTTCTCCCCT 
CCAGTCGTCA ATGTCACCTG GCTCCGGAAT GGACGGCCTG TCACCGAAGG CGTGTCAGAG 
ACAGTGTTTC TCCCGAGGGA CGATCACCTC TTCCGCAAAT TCCACTTTCT GACCTTCCTG 
CCCTCCACAG ATGATTTCTA TGACTGTGAG GTGGATCACT GGGGTTTGGA GGAGCCTCTG 
CGGAAGCACT GGGAGTTTGA AGAGAAAACC CTCCTCCCAG AAACTAAAGA GAATGTCGTG 
TGTGCTCTTG GGTTGTTTGT GGGTCTGGTG GGCATCGTTG TGGGGATTAT CCTCATCATG 
AAGGGTATTA AAAAACGCAA TGTTGTAGAA CGCCGACAAG GAGCCCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017173226.1
CDS	1..831
Translation	MILLVIWGLISDALLSPWHDRTISSQEDDGPLCCVTMLKIHQGTNSAPEEHTIIQAEFYLLPDKRGEFMFDFDGDEIFHVDIEKSETIWRLEEFAKFASFEAQGALANIAVDKANLDVMKERSNNTPDANVAPEVTVLSRSPVNLGEPNILICFIDKFSPPVVNVTWLRNGRPVTEGVSETVFLPRDDHLFRKFHFLTFLPSTDDFYDCEVDHWGLEEPLRKHWEFEEKTLLPETKENVVCALGLFVGLVGIVVGIILIMKGIKKRNVVERRQGAL

Target ORF information:

RefSeq Version	XM_017317737.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus histocompatibility 2, class II antigen E alpha, pseudogene (H2-Ea-ps), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017317737.2

ORF Insert Sequence:

ATGATCCTGT TAGTGATCTG GGGGTTGATA TCAGATGCCT TACTTAGCCC CTGGCATGAT 
CGGACCATCA GCAGTCAGGA GGATGACGGC CCTCTTTGTT GTGTTACTAT GTTGAAGATT 
CACCAAGGCA CTAATTCAGC CCCAGAGGAA CACACCATCA TCCAGGCGGA GTTCTATCTT 
TTACCAGACA AACGTGGAGA GTTTATGTTT GACTTTGACG GCGATGAGAT TTTCCATGTA 
GACATTGAAA AGTCAGAGAC CATCTGGAGA CTTGAAGAAT TTGCAAAGTT TGCCAGCTTT 
GAGGCTCAGG GTGCACTGGC TAATATAGCT GTGGACAAAG CTAACCTGGA TGTCATGAAA 
GAGCGTTCCA ACAACACTCC AGATGCCAAC GTGGCCCCAG AGGTGACTGT ACTCTCCAGA 
AGCCCTGTGA ACCTGGGAGA GCCCAACATC CTCATCTGTT TCATTGACAA GTTCTCCCCT 
CCAGTCGTCA ATGTCACCTG GCTCCGGAAT GGACGGCCTG TCACCGAAGG CGTGTCAGAG 
ACAGTGTTTC TCCCGAGGGA CGATCACCTC TTCCGCAAAT TCCACTTTCT GACCTTCCTG 
CCCTCCACAG ATGATTTCTA TGACTGTGAG GTGGATCACT GGGGTTTGGA GGAGCCTCTG 
CGGAAGCACT GGGAGTTTGA AGAGAAAACC CTCCTCCCAG AAACTAAAGA GAATGTCGTG 
TGTGCTCTTG GGTTGTTTGT GGGTCTGGTG GGCATCGTTG TGGGGATTAT CCTCATCATG 
AAGGGTATTA AAAAACGCAA TGTTGTAGAA CGCCGACAAG GAGCCCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
BMC immunology17(1)25(2016 08)
Liu X,Jiao Y,Cao Y,Deng N,Ma Y,Hasty KA,Kang A,Chen H,Stuart JM,Gu W

Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb.
Journal of immunology (Baltimore, Md. : 1950)175(2)1062-72(2005 Jul)
Subramanian S,Yim YS,Liu K,Tus K,Zhou XJ,Wakeland EK

Detection of a new cerebral malaria susceptibility locus, using CBA mice.
Immunogenetics56(9)675-8(2004 Dec)
Ohno T,Nishimura M

Inactivation of E alpha and E beta expression in inbred and wild mice by multiple distinct mutations, some of which predate speciation within Mus species.
International immunology7(9)1459-71(1995 Sep)
Tacchini-Cottier F,Mayer WE,Begovich AB,Jones PP

The complete nucleotide sequence of the I-E alpha d immune response gene.
Nucleic acids research11(15)5055-71(1983 Aug)
Hyldig-Nielsen JJ,Schenning L,Hammerling U,Widmark E,Heldin E,Lind P,Servenius B,Lund T,Flavell R,Lee JS,Trowsdale J,Schreier PH,Zablitzky F,Larhammar D,Peterson PA,Rask L

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H2-Ea-ps cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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