Sco2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sco2
Entrez Gene ID	100126824
Full Name	SCO2 cytochrome c oxidase assembly protein
General protein information	Preferred Names SCO2 cytochrome c oxidase assembly protein Names protein SCO2 homolog, mitochondrial SCO cytochrome oxidase deficient homolog 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 E3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001111288.1	NP_001104758.1	protein SCO2 homolog, mitochondrial
NM_001111288.2	NP_001104758.1	protein SCO2 homolog, mitochondrial

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	LOC100497895	XP_002935088.1
Pan troglodytes (chimpanzee)	SCO2	XP_003953968.1
	LOC720679	XP_002798471.1
Mus musculus (house mouse)	Sco2	NP_001104758.1
Danio rerio (zebrafish)	sco2	NP_001038697.1
Bos taurus (cattle)	SCO2	NP_001098963.1
Gallus gallus (chicken)	SCO2	XP_003640374.1
Homo sapiens (human)	SCO2	NP_005129.2
Canis lupus familiaris (dog)	SCO2	XP_538308.4

Gene Ontology
Bibliography

Related articles in PubMed

Sco2 deficient mice develop increased adiposity and insulin resistance.
Hill S, Deepa SS, Sataranatarajan K, Premkumar P, Pulliam D, Liu Y, Soto VY, Fischer KE, Van Remmen H
Molecular and cellular endocrinology455103-114(2017 Nov)

SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells.
Du W, Amarachintha S, Wilson AF, Pang Q
Stem cells (Dayton, Ohio)34(4)960-71(2016 Apr)

Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
Ishimura A, Terashima M, Tange S, Suzuki T
Cell and tissue research363(3)723-33(2016 Mar)

Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.
Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pab?n MA, Konrad C, Polverino F, Siempos II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM
Nature medicine22(2)163-74(2016 Feb)

Cardiac deficiency of single cytochrome oxidase assembly factor scox induces p53-dependent apoptosis in a Drosophila cardiomyopathy model.
Mart?nez-Morentin L, Mart?nez L, Piloto S, Yang H, Schon EA, Garesse R, Bodmer R, Ocorr K, Cervera M, Arredondo JJ
Human molecular genetics24(13)3608-22(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that physical exercise attenuates age-related changes in mitochondrial COX biogenesis and p53 activity targeting SCO2 and mitochondria, and thereby induces antisenescent and protective effects in cardiac muscle.
Title: Physical exercise regulates p53 activity targeting SCO2 and increases mitochondrial COX biogenesis in cardiac muscle with age.

Results describe the tissue distribution of SCO1 and SCO2 in mouse and human tissues.
Title: Unexpected vascular enrichment of SCO1 over SCO2 in mammalian tissues: implications for human mitochondrial disease.

To understand the biological role of SCO2, mice harboring both a Sco2 knock-out (KO) allele and a Sco2 knock-in (KI) E129K allele, corresponding to the common E140K mutation in humans, were studied.
Title: Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2.

findings show that p53 modulates the balance between the utilization of respiratory and glycolytic pathways; identifed Synthesis of Cytochrome c Oxidase 2 (SCO2) as the downstream mediator of this effect
Title: p53 regulates mitochondrial respiration.

The following Sco2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sco2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu13003	NM_001111288.2 Latest version!	Mus musculus SCO2 cytochrome c oxidase assembly protein (Sco2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
View Old Accession Versions >>
OMu13003	NM_001111288.1	Mus musculus SCO2 cytochrome c oxidase assembly protein (Sco2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sco2 ( NM_001111288.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001104758.1 Mus musculus SCO2 cytochrome c oxidase assembly protein (Sco2), mRNA.

Price & Availability↑

CloneID	OMu13003
Clone ID Related Accession (Same CDS sequence)	NM_001111288.1 , NM_001111288.2
Accession Version	NM_001111288.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-29
Organism	Mus musculus(house mouse)
Product	protein SCO2 homolog, mitochondrial
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC019554.1. ##Evidence-Data-START## Transcript exon combination :: BC019554.1, SRR1660819.11955.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGCTACTGG CTCTAGGGCC CAAAGCTTGG CCCAAGCTCT CTCAGTTCAA ACCCCTCCTC 
AGGATCTCAG GAGGTGAAAC TCTGCATAGA AATTCCCGAC ACTGGGCAGG GCAGGGCCAG 
CGCCAAGGCC CTGGGCTAAG AACTAGACTG CTGATCACAG CCCTGTTTGG GGCTGGGCTA 
GGCTGGGCCT GGCTGGCCGC GAGGGCTGAG AAGGAACAGT GGCGCCAACA GCAGCGTACA 
GAGGCCCTGC GCCAGGCTGC TGTGGGCCAG GGTGACTTCA GCCTACTAGA CCACAAAGGC 
CAGCCTCGAT GCAAAGCCGA CTTCCGAGGC CAGTGGGTGC TGATGTACTT CGGTTTTACT 
CACTGCCCTG ATATTTGCCC CGATGAGCTG GAAAAGCTAG TGCAGGTGGT GCGGAAGCTA 
GAGGCGGAGC CTGACCTGCC CCTGGTGCAG CCTGTCTTCA TCACTGTGGA CCCAGAACGA 
GATGACGTGG CAGCCATGGC CCGCTATGTG CAAGAATTCC ACCCAAGACT GTTAGGTCTG 
ACCGGTTCTA CAGAACAGGT GGCCCATGCT AGTCGCAACT ACCGCGTATA CTACAGCGCT 
GGGCCTAAGG ATGAGGACCA GGACTACATT GTGGACCACT CCATTGCCAT CTATCTGCTC 
AACCCTGATG GTCTTTTCAC CGATTACTAT GGTCGCAGCA GGTCAGCAGA GCAGATCGTA 
GAGAGTATAC GTCGGCACAT AGCTGCCTTC CACAGTGTCT TGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001104758.1
CDS	333..1100
Translation	MLLALGPKAWPKLSQFKPLLRISGGETLHRNSRHWAGQGQRQGPGLRTRLLITALFGAGLGWAWLAARAEKEQWRQQQRTEALRQAAVGQGDFSLLDHKGQPRCKADFRGQWVLMYFGFTHCPDICPDELEKLVQVVRKLEAEPDLPLVQPVFITVDPERDDVAAMARYVQEFHPRLLGLTGSTEQVAHASRNYRVYYSAGPKDEDQDYIVDHSIAIYLLNPDGLFTDYYGRSRSAEQIVESIRRHIAAFHSVLP

Target ORF information:

RefSeq Version	NM_001111288.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SCO2 cytochrome c oxidase assembly protein (Sco2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001111288.1

ORF Insert Sequence:

ATGCTACTGG CTCTAGGGCC CAAAGCTTGG CCCAAGCTCT CTCAGTTCAA ACCCCTCCTC 
AGGATCTCAG GAGGTGAAAC TCTGCATAGA AATTCCCGAC ACTGGGCAGG GCAGGGCCAG 
CGCCAAGGCC CTGGGCTAAG AACTAGACTG CTGATCACAG CCCTGTTTGG GGCTGGGCTA 
GGCTGGGCCT GGCTGGCCGC GAGGGCTGAG AAGGAACAGT GGCGCCAACA GCAGCGTACA 
GAGGCCCTGC GCCAGGCTGC TGTGGGCCAG GGTGACTTCA GCCTACTAGA CCACAAAGGC 
CAGCCTCGAT GCAAAGCCGA CTTCCGAGGC CAGTGGGTGC TGATGTACTT CGGTTTTACT 
CACTGCCCTG ATATTTGCCC CGATGAGCTG GAAAAGCTAG TGCAGGTGGT GCGGAAGCTA 
GAGGCGGAGC CTGACCTGCC CCTGGTGCAG CCTGTCTTCA TCACTGTGGA CCCAGAACGA 
GATGACGTGG CAGCCATGGC CCGCTATGTG CAAGAATTCC ACCCAAGACT GTTAGGTCTG 
ACCGGTTCTA CAGAACAGGT GGCCCATGCT AGTCGCAACT ACCGCGTATA CTACAGCGCT 
GGGCCTAAGG ATGAGGACCA GGACTACATT GTGGACCACT CCATTGCCAT CTATCTGCTC 
AACCCTGATG GTCTTTTCAC CGATTACTAT GGTCGCAGCA GGTCAGCAGA GCAGATCGTA 
GAGAGTATAC GTCGGCACAT AGCTGCCTTC CACAGTGTCT TGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sco2 ( NM_001111288.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001104758.1 Mus musculus SCO2 cytochrome c oxidase assembly protein (Sco2), mRNA.

Price & Availability↑

CloneID	OMu13003
Clone ID Related Accession (Same CDS sequence)	NM_001111288.1 , NM_001111288.2
Accession Version	NM_001111288.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-08
Organism	Mus musculus(house mouse)
Product	protein SCO2 homolog, mitochondrial
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC113976.13. On Jul 12, 2018 this sequence version replaced NM_001111288.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.11955.1, BC019554.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGCTACTGG CTCTAGGGCC CAAAGCTTGG CCCAAGCTCT CTCAGTTCAA ACCCCTCCTC 
AGGATCTCAG GAGGTGAAAC TCTGCATAGA AATTCCCGAC ACTGGGCAGG GCAGGGCCAG 
CGCCAAGGCC CTGGGCTAAG AACTAGACTG CTGATCACAG CCCTGTTTGG GGCTGGGCTA 
GGCTGGGCCT GGCTGGCCGC GAGGGCTGAG AAGGAACAGT GGCGCCAACA GCAGCGTACA 
GAGGCCCTGC GCCAGGCTGC TGTGGGCCAG GGTGACTTCA GCCTACTAGA CCACAAAGGC 
CAGCCTCGAT GCAAAGCCGA CTTCCGAGGC CAGTGGGTGC TGATGTACTT CGGTTTTACT 
CACTGCCCTG ATATTTGCCC CGATGAGCTG GAAAAGCTAG TGCAGGTGGT GCGGAAGCTA 
GAGGCGGAGC CTGACCTGCC CCTGGTGCAG CCTGTCTTCA TCACTGTGGA CCCAGAACGA 
GATGACGTGG CAGCCATGGC CCGCTATGTG CAAGAATTCC ACCCAAGACT GTTAGGTCTG 
ACCGGTTCTA CAGAACAGGT GGCCCATGCT AGTCGCAACT ACCGCGTATA CTACAGCGCT 
GGGCCTAAGG ATGAGGACCA GGACTACATT GTGGACCACT CCATTGCCAT CTATCTGCTC 
AACCCTGATG GTCTTTTCAC CGATTACTAT GGTCGCAGCA GGTCAGCAGA GCAGATCGTA 
GAGAGTATAC GTCGGCACAT AGCTGCCTTC CACAGTGTCT TGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001104758.1
CDS	406..1173
Translation	MLLALGPKAWPKLSQFKPLLRISGGETLHRNSRHWAGQGQRQGPGLRTRLLITALFGAGLGWAWLAARAEKEQWRQQQRTEALRQAAVGQGDFSLLDHKGQPRCKADFRGQWVLMYFGFTHCPDICPDELEKLVQVVRKLEAEPDLPLVQPVFITVDPERDDVAAMARYVQEFHPRLLGLTGSTEQVAHASRNYRVYYSAGPKDEDQDYIVDHSIAIYLLNPDGLFTDYYGRSRSAEQIVESIRRHIAAFHSVLP

Target ORF information:

RefSeq Version	NM_001111288.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus SCO2 cytochrome c oxidase assembly protein (Sco2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001111288.2

ORF Insert Sequence:

ATGCTACTGG CTCTAGGGCC CAAAGCTTGG CCCAAGCTCT CTCAGTTCAA ACCCCTCCTC 
AGGATCTCAG GAGGTGAAAC TCTGCATAGA AATTCCCGAC ACTGGGCAGG GCAGGGCCAG 
CGCCAAGGCC CTGGGCTAAG AACTAGACTG CTGATCACAG CCCTGTTTGG GGCTGGGCTA 
GGCTGGGCCT GGCTGGCCGC GAGGGCTGAG AAGGAACAGT GGCGCCAACA GCAGCGTACA 
GAGGCCCTGC GCCAGGCTGC TGTGGGCCAG GGTGACTTCA GCCTACTAGA CCACAAAGGC 
CAGCCTCGAT GCAAAGCCGA CTTCCGAGGC CAGTGGGTGC TGATGTACTT CGGTTTTACT 
CACTGCCCTG ATATTTGCCC CGATGAGCTG GAAAAGCTAG TGCAGGTGGT GCGGAAGCTA 
GAGGCGGAGC CTGACCTGCC CCTGGTGCAG CCTGTCTTCA TCACTGTGGA CCCAGAACGA 
GATGACGTGG CAGCCATGGC CCGCTATGTG CAAGAATTCC ACCCAAGACT GTTAGGTCTG 
ACCGGTTCTA CAGAACAGGT GGCCCATGCT AGTCGCAACT ACCGCGTATA CTACAGCGCT 
GGGCCTAAGG ATGAGGACCA GGACTACATT GTGGACCACT CCATTGCCAT CTATCTGCTC 
AACCCTGATG GTCTTTTCAC CGATTACTAT GGTCGCAGCA GGTCAGCAGA GCAGATCGTA 
GAGAGTATAC GTCGGCACAT AGCTGCCTTC CACAGTGTCT TGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sco2 deficient mice develop increased adiposity and insulin resistance.
Molecular and cellular endocrinology455103-114(2017 Nov)
Hill S,Deepa SS,Sataranatarajan K,Premkumar P,Pulliam D,Liu Y,Soto VY,Fischer KE,Van Remmen H

SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells.
Stem cells (Dayton, Ohio)34(4)960-71(2016 Apr)
Du W,Amarachintha S,Wilson AF,Pang Q

Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
Cell and tissue research363(3)723-33(2016 Mar)
Ishimura A,Terashima M,Tange S,Suzuki T

Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.
Nature medicine22(2)163-74(2016 Feb)
Cloonan SM,Glass K,Laucho-Contreras ME,Bhashyam AR,Cervo M,Pab?n MA,Konrad C,Polverino F,Siempos II,Perez E,Mizumura K,Ghosh MC,Parameswaran H,Williams NC,Rooney KT,Chen ZH,Goldklang MP,Yuan GC,Moore SC,Demeo DL,Rouault TA,D'Armiento JM,Schon EA,Manfredi G,Quackenbush J,Mahmood A,Silverman EK,Owen CA,Choi AM

Cardiac deficiency of single cytochrome oxidase assembly factor scox induces p53-dependent apoptosis in a Drosophila cardiomyopathy model.
Human molecular genetics24(13)3608-22(2015 Jul)
Mart?nez-Morentin L,Mart?nez L,Piloto S,Yang H,Schon EA,Garesse R,Bodmer R,Ocorr K,Cervera M,Arredondo JJ

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Sco2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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