CCS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCS
Entrez Gene ID	9973
Full Name	copper chaperone for superoxide dismutase
General protein information	Preferred Names copper chaperone for superoxide dismutase Names copper chaperone for superoxide dismutase superoxide dismutase copper chaperone
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.2
Summary	Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008].
Disorder MIM:	603864

mRNA and Protein(s)

mRNA	Protein	Name
NM_005125.1	NP_005116.1	copper chaperone for superoxide dismutase
NM_005125.2	NP_005116.1	copper chaperone for superoxide dismutase

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ccs	NP_445877.1
Danio rerio (zebrafish)	ccs	NP_001191151.1
	CCS	XP_001118002.2
Canis lupus familiaris (dog)	CCS	NP_001181899.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007026	XP_308747.4
Homo sapiens (human)	CCS	NP_005116.1
Rattus norvegicus (Norway rat)	LOC100911589	XP_003749080.1
Drosophila melanogaster (fruit fly)	CCS	NP_001163108.1
Saccharomyces cerevisiae (baker's yeast)	CCS1	NP_013752.1
Magnaporthe oryzae (rice blast fungus)	MGG_05281	XP_003712840.1
Arabidopsis thaliana (thale cress)	CCS	NP_563910.2
Oryza sativa (rice)	Os04g0573200	NP_001053613.1
Mus musculus (house mouse)	Ccs	NP_058588.1
Neurospora crassa	NCU07851	XP_963112.2
Xenopus tropicalis (tropical clawed frog)	ccs	NP_001011020.1
Pan troglodytes (chimpanzee)	CCS	NP_001167001.1
Kluyveromyces lactis	KLLA0F26917g	XP_456277.1

Gene Ontology
Bibliography

Related articles in PubMed

A molecular chaperone activity of CCS restores the maturation of SOD1 fALS mutants.
Luchinat E, Barbieri L, Banci L
Scientific reports7(1)17433(2017 Dec)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Extended functional repertoire for human copper chaperones.
Matson Dzebo M, Ari?z C, Wittung-Stafshede P
Biomolecular concepts7(1)29-39(2016 Feb)

Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro.
Petzoldt S, Kahra D, Kovermann M, Dingeldein AP, Niemiec MS, ?d?n J, Wittung-Stafshede P
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine28(3)577-85(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In addition to Atox1, the human cytoplasm also contains Cu chaperones for loading of superoxide dismutase 1 (i.e. CCS) and cytochrome c oxidase in mitochondria (i.e. Cox17). [review]
Title: Extended functional repertoire for human copper chaperones.

Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro
Title: Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro.

Coexpression of hCCS in the presence of copper restores the correct maturation of the SOD1 mutants and prevents the formation of the unstructured species, confirming that hCCS also acts as a molecular chaperone.
Title: In-cell NMR reveals potential precursor of toxic species from SOD1 fALS mutants.

CCS mRNA and protein levels in the serum are not correlated with inflammatory processes.
Title: CCS mRNA transcripts and serum CCS protein as copper marker in adults suffering inflammatory processes.

CTR1 silencing increased the protein levels of copper chaperone ATOX1 and copper chaperone for superoxide dismutase 1 (CCS-1), but decreased copper chaperone for cytochrome c oxidase (COX17).
Title: Changes in copper concentrations affect the protein levels but not the mRNA levels of copper chaperones in human umbilical vein endothelial cells.

The following CCS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17840	NM_005125.2 Latest version!	Homo sapiens copper chaperone for superoxide dismutase (CCS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu17840	NM_005125.1	Homo sapiens copper chaperone for superoxide dismutase (CCS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCS ( NM_005125.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_005116.1 Homo sapiens copper chaperone for superoxide dismutase (CCS), mRNA.

Price & Availability↑

CloneID	OHu17840
Clone ID Related Accession (Same CDS sequence)	NM_005125.1 , NM_005125.2
Accession Version	NM_005125.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	copper chaperone for superoxide dismutase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF002210.1. This sequence is a reference standard in the RefSeqGene project. On Mar 4, 2006 this sequence version replaced XM_938909.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF002210.1, SRR1163655.337609.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCGG ATTCGGGGAA CCAGGGGACC CTCTGCACGT TGGAGTTCGC GGTGCAGATG 
ACCTGTCAGA GCTGTGTGGA CGCGGTGCGC AAATCCCTGC AAGGGGTGGC AGGTGTCCAG 
GATGTGGAGG TGCACTTGGA GGACCAGATG GTCTTGGTAC ACACCACTCT ACCCAGCCAG 
GAGGTGCAGG CTCTCCTGGA AGGCACGGGG CGGCAGGCGG TACTCAAGGG CATGGGCAGC 
GGCCAGTTGC AGAATCTGGG GGCAGCAGTG GCCATCCTGG GGGGGCCTGG CACCGTGCAG 
GGGGTGGTGC GCTTCCTACA GCTGACCCCT GAGCGCTGCC TCATCGAGGG AACTATTGAC 
GGCCTGGAGC CTGGGCTGCA TGGACTCCAC GTCCATCAGT ACGGGGACCT TACAAACAAC 
TGCAACAGCT GTGGGAATCA CTTTAACCCT GATGGAGCAT CTCATGGGGG CCCCCAGGAC 
TCTGACCGGC ACCGCGGAGA CCTGGGCAAT GTCCGTGCTG ATGCTGACGG CCGCGCCATC 
TTCAGAATGG AGGATGAGCA GCTGAAGGTG TGGGATGTGA TTGGCCGCAG CCTGATTATT 
GATGAGGGAG AAGATGACCT GGGCCGGGGA GGCCATCCCT TATCCAAGAT CACAGGGAAC 
TCCGGGGAGA GGTTGGCCTG TGGCATCATT GCACGCTCCG CTGGCCTTTT CCAGAACCCC 
AAGCAGATCT GCTCTTGCGA TGGCCTCACC ATCTGGGAGG AGCGAGGCCG GCCCATCGCT 
GGCAAGGGCC GAAAGGAGTC AGCGCAGCCC CCTGCCCACC TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005116.1
CDS	44..868
Translation	MASDSGNQGTLCTLEFAVQMTCQSCVDAVRKSLQGVAGVQDVEVHLEDQMVLVHTTLPSQEVQALLEGTGRQAVLKGMGSGQLQNLGAAVAILGGPGTVQGVVRFLQLTPERCLIEGTIDGLEPGLHGLHVHQYGDLTNNCNSCGNHFNPDGASHGGPQDSDRHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGKGRKESAQPPAHL

Target ORF information:

RefSeq Version	NM_005125.1
Organism	Homo sapiens(human)
Definition	Homo sapiens copper chaperone for superoxide dismutase (CCS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005125.1

ORF Insert Sequence:

ATGGCTTCGG ATTCGGGGAA CCAGGGGACC CTCTGCACGT TGGAGTTCGC GGTGCAGATG 
ACCTGTCAGA GCTGTGTGGA CGCGGTGCGC AAATCCCTGC AAGGGGTGGC AGGTGTCCAG 
GATGTGGAGG TGCACTTGGA GGACCAGATG GTCTTGGTAC ACACCACTCT ACCCAGCCAG 
GAGGTGCAGG CTCTCCTGGA AGGCACGGGG CGGCAGGCGG TACTCAAGGG CATGGGCAGC 
GGCCAGTTGC AGAATCTGGG GGCAGCAGTG GCCATCCTGG GGGGGCCTGG CACCGTGCAG 
GGGGTGGTGC GCTTCCTACA GCTGACCCCT GAGCGCTGCC TCATCGAGGG AACTATTGAC 
GGCCTGGAGC CTGGGCTGCA TGGACTCCAC GTCCATCAGT ACGGGGACCT TACAAACAAC 
TGCAACAGCT GTGGGAATCA CTTTAACCCT GATGGAGCAT CTCATGGGGG CCCCCAGGAC 
TCTGACCGGC ACCGCGGAGA CCTGGGCAAT GTCCGTGCTG ATGCTGACGG CCGCGCCATC 
TTCAGAATGG AGGATGAGCA GCTGAAGGTG TGGGATGTGA TTGGCCGCAG CCTGATTATT 
GATGAGGGAG AAGATGACCT GGGCCGGGGA GGCCATCCCT TATCCAAGAT CACAGGGAAC 
TCCGGGGAGA GGTTGGCCTG TGGCATCATT GCACGCTCCG CTGGCCTTTT CCAGAACCCC 
AAGCAGATCT GCTCTTGCGA TGGCCTCACC ATCTGGGAGG AGCGAGGCCG GCCCATCGCT 
GGCAAGGGCC GAAAGGAGTC AGCGCAGCCC CCTGCCCACC TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCS ( NM_005125.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005116.1 Homo sapiens copper chaperone for superoxide dismutase (CCS), mRNA.

Price & Availability↑

CloneID	OHu17840
Clone ID Related Accession (Same CDS sequence)	NM_005125.1 , NM_005125.2
Accession Version	NM_005125.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	copper chaperone for superoxide dismutase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP001157.4 and AF002210.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_005125.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.638477.1, SRR1163655.337609.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000533244.6/ ENSP00000436318.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTTCGG ATTCGGGGAA CCAGGGGACC CTCTGCACGT TGGAGTTCGC GGTGCAGATG 
ACCTGTCAGA GCTGTGTGGA CGCGGTGCGC AAATCCCTGC AAGGGGTGGC AGGTGTCCAG 
GATGTGGAGG TGCACTTGGA GGACCAGATG GTCTTGGTAC ACACCACTCT ACCCAGCCAG 
GAGGTGCAGG CTCTCCTGGA AGGCACGGGG CGGCAGGCGG TACTCAAGGG CATGGGCAGC 
GGCCAGTTGC AGAATCTGGG GGCAGCAGTG GCCATCCTGG GGGGGCCTGG CACCGTGCAG 
GGGGTGGTGC GCTTCCTACA GCTGACCCCT GAGCGCTGCC TCATCGAGGG AACTATTGAC 
GGCCTGGAGC CTGGGCTGCA TGGACTCCAC GTCCATCAGT ACGGGGACCT TACAAACAAC 
TGCAACAGCT GTGGGAATCA CTTTAACCCT GATGGAGCAT CTCATGGGGG CCCCCAGGAC 
TCTGACCGGC ACCGCGGAGA CCTGGGCAAT GTCCGTGCTG ATGCTGACGG CCGCGCCATC 
TTCAGAATGG AGGATGAGCA GCTGAAGGTG TGGGATGTGA TTGGCCGCAG CCTGATTATT 
GATGAGGGAG AAGATGACCT GGGCCGGGGA GGCCATCCCT TATCCAAGAT CACAGGGAAC 
TCCGGGGAGA GGTTGGCCTG TGGCATCATT GCACGCTCCG CTGGCCTTTT CCAGAACCCC 
AAGCAGATCT GCTCTTGCGA TGGCCTCACC ATCTGGGAGG AGCGAGGCCG GCCCATCGCT 
GGCAAGGGCC GAAAGGAGTC AGCGCAGCCC CCTGCCCACC TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005116.1
CDS	78..902
Translation	MASDSGNQGTLCTLEFAVQMTCQSCVDAVRKSLQGVAGVQDVEVHLEDQMVLVHTTLPSQEVQALLEGTGRQAVLKGMGSGQLQNLGAAVAILGGPGTVQGVVRFLQLTPERCLIEGTIDGLEPGLHGLHVHQYGDLTNNCNSCGNHFNPDGASHGGPQDSDRHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGKGRKESAQPPAHL

Target ORF information:

RefSeq Version	NM_005125.2
Organism	Homo sapiens(human)
Definition	Homo sapiens copper chaperone for superoxide dismutase (CCS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005125.2

ORF Insert Sequence:

ATGGCTTCGG ATTCGGGGAA CCAGGGGACC CTCTGCACGT TGGAGTTCGC GGTGCAGATG 
ACCTGTCAGA GCTGTGTGGA CGCGGTGCGC AAATCCCTGC AAGGGGTGGC AGGTGTCCAG 
GATGTGGAGG TGCACTTGGA GGACCAGATG GTCTTGGTAC ACACCACTCT ACCCAGCCAG 
GAGGTGCAGG CTCTCCTGGA AGGCACGGGG CGGCAGGCGG TACTCAAGGG CATGGGCAGC 
GGCCAGTTGC AGAATCTGGG GGCAGCAGTG GCCATCCTGG GGGGGCCTGG CACCGTGCAG 
GGGGTGGTGC GCTTCCTACA GCTGACCCCT GAGCGCTGCC TCATCGAGGG AACTATTGAC 
GGCCTGGAGC CTGGGCTGCA TGGACTCCAC GTCCATCAGT ACGGGGACCT TACAAACAAC 
TGCAACAGCT GTGGGAATCA CTTTAACCCT GATGGAGCAT CTCATGGGGG CCCCCAGGAC 
TCTGACCGGC ACCGCGGAGA CCTGGGCAAT GTCCGTGCTG ATGCTGACGG CCGCGCCATC 
TTCAGAATGG AGGATGAGCA GCTGAAGGTG TGGGATGTGA TTGGCCGCAG CCTGATTATT 
GATGAGGGAG AAGATGACCT GGGCCGGGGA GGCCATCCCT TATCCAAGAT CACAGGGAAC 
TCCGGGGAGA GGTTGGCCTG TGGCATCATT GCACGCTCCG CTGGCCTTTT CCAGAACCCC 
AAGCAGATCT GCTCTTGCGA TGGCCTCACC ATCTGGGAGG AGCGAGGCCG GCCCATCGCT 
GGCAAGGGCC GAAAGGAGTC AGCGCAGCCC CCTGCCCACC TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A molecular chaperone activity of CCS restores the maturation of SOD1 fALS mutants.
Scientific reports7(1)17433(2017 Dec)
Luchinat E,Barbieri L,Banci L

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Extended functional repertoire for human copper chaperones.
Biomolecular concepts7(1)29-39(2016 Feb)
Matson Dzebo M,Ari?z C,Wittung-Stafshede P

Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine28(3)577-85(2015 Jun)
Petzoldt S,Kahra D,Kovermann M,Dingeldein AP,Niemiec MS,?d?n J,Wittung-Stafshede P

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CCS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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