CDC5L cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDC5L
Entrez Gene ID	988
Full Name	cell division cycle 5 like
Synonyms	CDC5,CDC5-LIKE,CEF1,PCDC5RP,dJ319D22.1
General protein information	Preferred Names cell division cycle 5 like Names cell division cycle 5-like protein CDC5 cell division cycle 5-like Cdc5-related protein dJ319D22.1 (CDC5-like protein) pombe cdc5-related protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.1
Summary	The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008].
Disorder MIM:	602868

mRNA and Protein(s)

mRNA	Protein	Name
NM_001253.4	NP_001244.1	cell division cycle 5-like protein
NM_001253.3	NP_001244.1	cell division cycle 5-like protein

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002954	XP_311945.4
	CDC5L	XP_001100220.1
Gallus gallus (chicken)	CDC5L	XP_420058.4
Bos taurus (cattle)	CDC5L	NP_001070010.1
Rattus norvegicus (Norway rat)	Cdc5l	NP_445979.1
Xenopus tropicalis (tropical clawed frog)	cdc5l	NP_001008202.1
Mus musculus (house mouse)	Cdc5l	NP_690023.1
Danio rerio (zebrafish)	cdc5l	NP_957378.2
Drosophila melanogaster (fruit fly)	CG6905	NP_001163313.1
Caenorhabditis elegans (roundworm)	D1081.8	NP_492303.1
Schizosaccharomyces pombe (fission yeast)	cdc5	NP_593880.1
Magnaporthe oryzae (rice blast fungus)	MGG_01426	XP_003714375.1
Neurospora crassa	NCU06994	XP_962634.1
Homo sapiens (human)	CDC5L	NP_001244.1
Pan troglodytes (chimpanzee)	CDC5L	XP_518512.3
Canis lupus familiaris (dog)	CDC5L	XP_532156.3
Arabidopsis thaliana (thale cress)	CDC5	NP_172448.1
Oryza sativa (rice)	Os04g0348300	NP_001052521.2

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Prp19 Arrests Cell Cycle via Cdc5L in Hepatocellular Carcinoma Cells.
Huang R, Xue R, Qu D, Yin J, Shen XZ
International journal of molecular sciences18(4)(2017 Apr)

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Bertram K, Agafonov DE, Liu WT, Dybkov O, Will CL, Hartmuth K, Urlaub H, Kastner B, Stark H, L?hrmann R
Nature542(7641)318-323(2017 02)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study demonstrates that the levels of Prp19 and Cdc5L are overexpressed in hepatocellular carcinoma (HCC). Prp19 binds with Cdc5L and its downregulation results in reduction of Cdc5L. Mechanistic insights reveal that silencing Prp19 compromises translation activity of Cdc5L and facilitates lysosome-induced degradation of Cdc5L in HCC cells.
Title: Prp19 Arrests Cell Cycle via Cdc5L in Hepatocellular Carcinoma Cells.

Cdc5L was highly expressed in hepatocellular carcinoma. Overexpression of Cdc5L favors cell cycle progress of HCC cells, while downregulation of Cdc5L results in cell cycle arrest at G2/M phase and reduced cell proliferation of HCC cells.
Title: Expression and Clinical Role of Cdc5L as a Novel Cell Cycle Protein in Hepatocellular Carcinoma.

CDC5L might play an important role in glioma cell survival and disease progression.
Title: Expression of CDC5L is associated with tumor progression in gliomas.

The results show that CTNNBL1 enhances the association of CWC15 and CDC5L, both core Prp19 complex proteins and identify an overlap in the region of CDC5L that binds either CTNNBL1 or CWC15 suggesting the two proteins might exchange places in the complex.
Title: CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex.

Cdc5L is a key regulator of mitotic progression.
Title: Depletion of pre-mRNA splicing factor Cdc5L inhibits mitotic progression and triggers mitotic catastrophe.

The following CDC5L gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDC5L cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11466	NM_001253.4 Latest version!	Homo sapiens cell division cycle 5 like (CDC5L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu11466	NM_001253.3	Homo sapiens cell division cycle 5 like (CDC5L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDC5L ( NM_001253.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001244.1 Homo sapiens cell division cycle 5 like (CDC5L), mRNA.

Price & Availability↑

CloneID	OHu11466
Clone ID Related Accession (Same CDS sequence)	NM_001253.4 , NM_001253.3
Accession Version	NM_001253.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2409bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	cell division cycle 5-like protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC422730.1, BC001568.1 and AL133262.8. On Nov 23, 2018 this sequence version replaced NM_001253.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK128737.1, SRR1803611.250437.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371477.4/ ENSP00000360532.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCTCGAA TTATGATCAA GGGGGGCGTA TGGAGGAATA CCGAGGATGA AATTCTGAAA 
GCAGCGGTAA TGAAATATGG GAAAAATCAG TGGTCTAGGA TTGCCTCATT GCTGCATAGA 
AAATCAGCAA AGCAGTGCAA AGCCAGATGG TATGAATGGC TGGATCCAAG CATTAAGAAG 
ACAGAATGGT CCAGAGAAGA AGAGGAAAAA CTCTTGCACT TGGCCAAGTT GATGCCAACT 
CAGTGGAGGA CCATTGCTCC AATCATTGGA AGAACAGCGG CCCAGTGCTT AGAACACTAT 
GAATTTCTTC TGGATAAAGC TGCCCAAAGA GACAATGAAG AGGAAACAAC AGATGATCCA 
CGAAAACTTA AACCTGGAGA AATAGATCCA AATCCAGAAA CAAAACCAGC GCGGCCTGAT 
CCAATTGATA TGGATGAGGA TGAACTTGAG ATGCTTTCTG AAGCCAGAGC CCGCTTGGCT 
AATACTCAGG GAAAGAAGGC CAAGAGGAAA GCAAGAGAGA AACAATTGGA AGAAGCAAGA 
CGTCTTGCTG CCCTCCAAAA AAGAAGAGAA CTTCGAGCAG CTGGCATAGA AATTCAGAAG 
AAAAGAAAAA GGAAGAGAGG AGTTGATTAT AATGCCGAAA TCCCATTTGA AAAAAAGCCT 
GCCCTTGGTT TTTATGATAC TTCTGAGGAA AACTACCAAG CTCTTGACGC AGATTTCAGG 
AAATTAAGAC AACAGGATCT TGATGGGGAG CTAAGATCTG AAAAAGAAGG AAGAGATAGA 
AAAAAAGACA AACAGCATTT GAAAAGGAAA AAAGAATCTG ATTTACCATC AGCTATTCTT 
CAAACTAGTG GTGTTTCTGA ATTTACTAAA AAGAGAAGCA AACTAGTACT TCCTGCCCCT 
CAGATTTCAG ATGCAGAACT CCAGGAAGTT GTAAAAGTAG GCCAAGCGAG TGAAATTGCA 
CGTCAAACTG CCGAGGAATC TGGCATAACA AATTCTGCTT CCAGTACACT TTTGTCTGAG 
TACAATGTCA CCAACAACAG CGTTGCTCTT AGAACACCAC GAACACCAGC TTCCCAGGAC 
AGAATTCTGC AGGAAGCCCA GAACCTCATG GCCCTCACCA ATGTGGACAC CCCATTGAAA 
GGTGGACTTA ATACCCCATT GCATGAGAGT GACTTCTCAG GTGTAACTCC ACAGCGACAA 
GTTGTACAGA CTCCAAACAC AGTTCTCTCT ACTCCATTCA GGACTCCTTC TAATGGAGCT 
GAAGGGCTGA CTCCCCGGAG TGGAACAACT CCCAAACCAG TTATTAACTC TACTCCGGGT 
AGAACTCCTC TTCGAGACAA GTTAAACATT AATCCCGAGG ATGGAATGGC AGACTATAGT 
GATCCCTCTT ACGTGAAGCA GATGGAAAGA GAATCCCGAG AACATCTCCG TTTAGGGTTG 
TTGGGCCTTC CTGCCCCTAA GAATGATTTT GAAATTGTTC TACCAGAAAA TGCCGAGAAG 
GAGCTGGAAG AACGTGAAAT AGATGATACT TACATTGAAG ATGCTGCTGA TGTGGATGCT 
CGAAAGCAGG CCATACGAGA TGCAGAGCGT GTAAAGGAAA TGAAACGAAT GCATAAAGCT 
GTCCAGAAAG ATCTGCCAAG ACCATCAGAA GTAAATGAAA CTATTCTAAG ACCCTTAAAT 
GTAGAACCGC CTTTAACAGA TTTACAGAAA AGTGAAGAAC TAATCAAAAA AGAAATGATC 
ACAATGCTTC ATTATGACCT TCTACATCAC CCTTATGAAC CATCTGGAAA TAAAAAAGGC 
AAAACTGTAG GGTTTGGTAC CAATAATTCA GAGCACATTA CCTATCTGGA ACATAATCCT 
TATGAAAAGT TCTCCAAAGA AGAGCTGAAA AAGGCCCAGG ATGTTTTGGT GCAGGAGATG 
GAAGTGGTTA AACAAGGAAT GAGCCATGGA GAGCTCTCAA GTGAAGCTTA TAACCAGGTG 
TGGGAAGAAT GCTACAGTCA AGTTTTATAT CTTCCTGGGC AGAGCCGCTA CACACGGGCC 
AATCTGGCTA GTAAAAAGGA CAGAATTGAA TCACTTGAAA AGAGGCTCGA GATAAACAGG 
GGTCACATGA CGACAGAAGC CAAGAGGGCT GCAAAGATGG AAAAGAAGAT GAAAATTTTG 
CTTGGGGGTT ACCAGTCTCG TGCTATGGGG CTCATGAAAC AGTTGAATGA CTTATGGGAC 
CAAATTGAAC AGGCTCACTT GGAGTTACGC ACTTTTGAAG AACTCAAGAA ACATGAAGAT 
TCTGCTATTC CCCGGAGGCT AGAGTGTCTA AAAGAAGACG TTCAGCGACA ACAAGAAAGA 
GAAAAGGAAC TTCAACATAG ATATGCTGAT TTGCTGCTGG AGAAAGAGAC TTTAAAGTCA 
AAATTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001244.1
CDS	119..2527
Translation	MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKAAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSVALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVINSTPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKTVGFGTNNSEHITYLEHNPYEKFSKEELKKAQDVLVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPGQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQEREKELQHRYADLLLEKETLKSKF

Target ORF information:

RefSeq Version	NM_001253.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cell division cycle 5 like (CDC5L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001253.4

ORF Insert Sequence:

ATGCCTCGAA TTATGATCAA GGGGGGCGTA TGGAGGAATA CCGAGGATGA AATTCTGAAA 
GCAGCGGTAA TGAAATATGG GAAAAATCAG TGGTCTAGGA TTGCCTCATT GCTGCATAGA 
AAATCAGCAA AGCAGTGCAA AGCCAGATGG TATGAATGGC TGGATCCAAG CATTAAGAAG 
ACAGAATGGT CCAGAGAAGA AGAGGAAAAA CTCTTGCACT TGGCCAAGTT GATGCCAACT 
CAGTGGAGGA CCATTGCTCC AATCATTGGA AGAACAGCGG CCCAGTGCTT AGAACACTAT 
GAATTTCTTC TGGATAAAGC TGCCCAAAGA GACAATGAAG AGGAAACAAC AGATGATCCA 
CGAAAACTTA AACCTGGAGA AATAGATCCA AATCCAGAAA CAAAACCAGC GCGGCCTGAT 
CCAATTGATA TGGATGAGGA TGAACTTGAG ATGCTTTCTG AAGCCAGAGC CCGCTTGGCT 
AATACTCAGG GAAAGAAGGC CAAGAGGAAA GCAAGAGAGA AACAATTGGA AGAAGCAAGA 
CGTCTTGCTG CCCTCCAAAA AAGAAGAGAA CTTCGAGCAG CTGGCATAGA AATTCAGAAG 
AAAAGAAAAA GGAAGAGAGG AGTTGATTAT AATGCCGAAA TCCCATTTGA AAAAAAGCCT 
GCCCTTGGTT TTTATGATAC TTCTGAGGAA AACTACCAAG CTCTTGACGC AGATTTCAGG 
AAATTAAGAC AACAGGATCT TGATGGGGAG CTAAGATCTG AAAAAGAAGG AAGAGATAGA 
AAAAAAGACA AACAGCATTT GAAAAGGAAA AAAGAATCTG ATTTACCATC AGCTATTCTT 
CAAACTAGTG GTGTTTCTGA ATTTACTAAA AAGAGAAGCA AACTAGTACT TCCTGCCCCT 
CAGATTTCAG ATGCAGAACT CCAGGAAGTT GTAAAAGTAG GCCAAGCGAG TGAAATTGCA 
CGTCAAACTG CCGAGGAATC TGGCATAACA AATTCTGCTT CCAGTACACT TTTGTCTGAG 
TACAATGTCA CCAACAACAG CGTTGCTCTT AGAACACCAC GAACACCAGC TTCCCAGGAC 
AGAATTCTGC AGGAAGCCCA GAACCTCATG GCCCTCACCA ATGTGGACAC CCCATTGAAA 
GGTGGACTTA ATACCCCATT GCATGAGAGT GACTTCTCAG GTGTAACTCC ACAGCGACAA 
GTTGTACAGA CTCCAAACAC AGTTCTCTCT ACTCCATTCA GGACTCCTTC TAATGGAGCT 
GAAGGGCTGA CTCCCCGGAG TGGAACAACT CCCAAACCAG TTATTAACTC TACTCCGGGT 
AGAACTCCTC TTCGAGACAA GTTAAACATT AATCCCGAGG ATGGAATGGC AGACTATAGT 
GATCCCTCTT ACGTGAAGCA GATGGAAAGA GAATCCCGAG AACATCTCCG TTTAGGGTTG 
TTGGGCCTTC CTGCCCCTAA GAATGATTTT GAAATTGTTC TACCAGAAAA TGCCGAGAAG 
GAGCTGGAAG AACGTGAAAT AGATGATACT TACATTGAAG ATGCTGCTGA TGTGGATGCT 
CGAAAGCAGG CCATACGAGA TGCAGAGCGT GTAAAGGAAA TGAAACGAAT GCATAAAGCT 
GTCCAGAAAG ATCTGCCAAG ACCATCAGAA GTAAATGAAA CTATTCTAAG ACCCTTAAAT 
GTAGAACCGC CTTTAACAGA TTTACAGAAA AGTGAAGAAC TAATCAAAAA AGAAATGATC 
ACAATGCTTC ATTATGACCT TCTACATCAC CCTTATGAAC CATCTGGAAA TAAAAAAGGC 
AAAACTGTAG GGTTTGGTAC CAATAATTCA GAGCACATTA CCTATCTGGA ACATAATCCT 
TATGAAAAGT TCTCCAAAGA AGAGCTGAAA AAGGCCCAGG ATGTTTTGGT GCAGGAGATG 
GAAGTGGTTA AACAAGGAAT GAGCCATGGA GAGCTCTCAA GTGAAGCTTA TAACCAGGTG 
TGGGAAGAAT GCTACAGTCA AGTTTTATAT CTTCCTGGGC AGAGCCGCTA CACACGGGCC 
AATCTGGCTA GTAAAAAGGA CAGAATTGAA TCACTTGAAA AGAGGCTCGA GATAAACAGG 
GGTCACATGA CGACAGAAGC CAAGAGGGCT GCAAAGATGG AAAAGAAGAT GAAAATTTTG 
CTTGGGGGTT ACCAGTCTCG TGCTATGGGG CTCATGAAAC AGTTGAATGA CTTATGGGAC 
CAAATTGAAC AGGCTCACTT GGAGTTACGC ACTTTTGAAG AACTCAAGAA ACATGAAGAT 
TCTGCTATTC CCCGGAGGCT AGAGTGTCTA AAAGAAGACG TTCAGCGACA ACAAGAAAGA 
GAAAAGGAAC TTCAACATAG ATATGCTGAT TTGCTGCTGG AGAAAGAGAC TTTAAAGTCA 
AAATTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDC5L ( NM_001253.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001244.1 Homo sapiens cell division cycle 5 like (CDC5L), mRNA.

Price & Availability↑

CloneID	OHu11466
Clone ID Related Accession (Same CDS sequence)	NM_001253.4 , NM_001253.3
Accession Version	NM_001253.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2409bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-14
Organism	Homo sapiens(human)
Product	cell division cycle 5-like protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM829346.1, DC422730.1, BC001568.1 and AL133262.8. On Nov 10, 2011 this sequence version replaced NM_001253.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB007892.2, SRR1803611.250437.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTCGAA TTATGATCAA GGGGGGCGTA TGGAGGAATA CCGAGGATGA AATTCTGAAA 
GCAGCGGTAA TGAAATATGG GAAAAATCAG TGGTCTAGGA TTGCCTCATT GCTGCATAGA 
AAATCAGCAA AGCAGTGCAA AGCCAGATGG TATGAATGGC TGGATCCAAG CATTAAGAAG 
ACAGAATGGT CCAGAGAAGA AGAGGAAAAA CTCTTGCACT TGGCCAAGTT GATGCCAACT 
CAGTGGAGGA CCATTGCTCC AATCATTGGA AGAACAGCGG CCCAGTGCTT AGAACACTAT 
GAATTTCTTC TGGATAAAGC TGCCCAAAGA GACAATGAAG AGGAAACAAC AGATGATCCA 
CGAAAACTTA AACCTGGAGA AATAGATCCA AATCCAGAAA CAAAACCAGC GCGGCCTGAT 
CCAATTGATA TGGATGAGGA TGAACTTGAG ATGCTTTCTG AAGCCAGAGC CCGCTTGGCT 
AATACTCAGG GAAAGAAGGC CAAGAGGAAA GCAAGAGAGA AACAATTGGA AGAAGCAAGA 
CGTCTTGCTG CCCTCCAAAA AAGAAGAGAA CTTCGAGCAG CTGGCATAGA AATTCAGAAG 
AAAAGAAAAA GGAAGAGAGG AGTTGATTAT AATGCCGAAA TCCCATTTGA AAAAAAGCCT 
GCCCTTGGTT TTTATGATAC TTCTGAGGAA AACTACCAAG CTCTTGACGC AGATTTCAGG 
AAATTAAGAC AACAGGATCT TGATGGGGAG CTAAGATCTG AAAAAGAAGG AAGAGATAGA 
AAAAAAGACA AACAGCATTT GAAAAGGAAA AAAGAATCTG ATTTACCATC AGCTATTCTT 
CAAACTAGTG GTGTTTCTGA ATTTACTAAA AAGAGAAGCA AACTAGTACT TCCTGCCCCT 
CAGATTTCAG ATGCAGAACT CCAGGAAGTT GTAAAAGTAG GCCAAGCGAG TGAAATTGCA 
CGTCAAACTG CCGAGGAATC TGGCATAACA AATTCTGCTT CCAGTACACT TTTGTCTGAG 
TACAATGTCA CCAACAACAG CGTTGCTCTT AGAACACCAC GAACACCAGC TTCCCAGGAC 
AGAATTCTGC AGGAAGCCCA GAACCTCATG GCCCTCACCA ATGTGGACAC CCCATTGAAA 
GGTGGACTTA ATACCCCATT GCATGAGAGT GACTTCTCAG GTGTAACTCC ACAGCGACAA 
GTTGTACAGA CTCCAAACAC AGTTCTCTCT ACTCCATTCA GGACTCCTTC TAATGGAGCT 
GAAGGGCTGA CTCCCCGGAG TGGAACAACT CCCAAACCAG TTATTAACTC TACTCCGGGT 
AGAACTCCTC TTCGAGACAA GTTAAACATT AATCCCGAGG ATGGAATGGC AGACTATAGT 
GATCCCTCTT ACGTGAAGCA GATGGAAAGA GAATCCCGAG AACATCTCCG TTTAGGGTTG 
TTGGGCCTTC CTGCCCCTAA GAATGATTTT GAAATTGTTC TACCAGAAAA TGCCGAGAAG 
GAGCTGGAAG AACGTGAAAT AGATGATACT TACATTGAAG ATGCTGCTGA TGTGGATGCT 
CGAAAGCAGG CCATACGAGA TGCAGAGCGT GTAAAGGAAA TGAAACGAAT GCATAAAGCT 
GTCCAGAAAG ATCTGCCAAG ACCATCAGAA GTAAATGAAA CTATTCTAAG ACCCTTAAAT 
GTAGAACCGC CTTTAACAGA TTTACAGAAA AGTGAAGAAC TAATCAAAAA AGAAATGATC 
ACAATGCTTC ATTATGACCT TCTACATCAC CCTTATGAAC CATCTGGAAA TAAAAAAGGC 
AAAACTGTAG GGTTTGGTAC CAATAATTCA GAGCACATTA CCTATCTGGA ACATAATCCT 
TATGAAAAGT TCTCCAAAGA AGAGCTGAAA AAGGCCCAGG ATGTTTTGGT GCAGGAGATG 
GAAGTGGTTA AACAAGGAAT GAGCCATGGA GAGCTCTCAA GTGAAGCTTA TAACCAGGTG 
TGGGAAGAAT GCTACAGTCA AGTTTTATAT CTTCCTGGGC AGAGCCGCTA CACACGGGCC 
AATCTGGCTA GTAAAAAGGA CAGAATTGAA TCACTTGAAA AGAGGCTCGA GATAAACAGG 
GGTCACATGA CGACAGAAGC CAAGAGGGCT GCAAAGATGG AAAAGAAGAT GAAAATTTTG 
CTTGGGGGTT ACCAGTCTCG TGCTATGGGG CTCATGAAAC AGTTGAATGA CTTATGGGAC 
CAAATTGAAC AGGCTCACTT GGAGTTACGC ACTTTTGAAG AACTCAAGAA ACATGAAGAT 
TCTGCTATTC CCCGGAGGCT AGAGTGTCTA AAAGAAGACG TTCAGCGACA ACAAGAAAGA 
GAAAAGGAAC TTCAACATAG ATATGCTGAT TTGCTGCTGG AGAAAGAGAC TTTAAAGTCA 
AAATTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001244.1
CDS	311..2719
Translation	MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKAAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSVALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVINSTPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKTVGFGTNNSEHITYLEHNPYEKFSKEELKKAQDVLVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPGQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQEREKELQHRYADLLLEKETLKSKF

Target ORF information:

RefSeq Version	NM_001253.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cell division cycle 5 like (CDC5L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001253.3

ORF Insert Sequence:

ATGCCTCGAA TTATGATCAA GGGGGGCGTA TGGAGGAATA CCGAGGATGA AATTCTGAAA 
GCAGCGGTAA TGAAATATGG GAAAAATCAG TGGTCTAGGA TTGCCTCATT GCTGCATAGA 
AAATCAGCAA AGCAGTGCAA AGCCAGATGG TATGAATGGC TGGATCCAAG CATTAAGAAG 
ACAGAATGGT CCAGAGAAGA AGAGGAAAAA CTCTTGCACT TGGCCAAGTT GATGCCAACT 
CAGTGGAGGA CCATTGCTCC AATCATTGGA AGAACAGCGG CCCAGTGCTT AGAACACTAT 
GAATTTCTTC TGGATAAAGC TGCCCAAAGA GACAATGAAG AGGAAACAAC AGATGATCCA 
CGAAAACTTA AACCTGGAGA AATAGATCCA AATCCAGAAA CAAAACCAGC GCGGCCTGAT 
CCAATTGATA TGGATGAGGA TGAACTTGAG ATGCTTTCTG AAGCCAGAGC CCGCTTGGCT 
AATACTCAGG GAAAGAAGGC CAAGAGGAAA GCAAGAGAGA AACAATTGGA AGAAGCAAGA 
CGTCTTGCTG CCCTCCAAAA AAGAAGAGAA CTTCGAGCAG CTGGCATAGA AATTCAGAAG 
AAAAGAAAAA GGAAGAGAGG AGTTGATTAT AATGCCGAAA TCCCATTTGA AAAAAAGCCT 
GCCCTTGGTT TTTATGATAC TTCTGAGGAA AACTACCAAG CTCTTGACGC AGATTTCAGG 
AAATTAAGAC AACAGGATCT TGATGGGGAG CTAAGATCTG AAAAAGAAGG AAGAGATAGA 
AAAAAAGACA AACAGCATTT GAAAAGGAAA AAAGAATCTG ATTTACCATC AGCTATTCTT 
CAAACTAGTG GTGTTTCTGA ATTTACTAAA AAGAGAAGCA AACTAGTACT TCCTGCCCCT 
CAGATTTCAG ATGCAGAACT CCAGGAAGTT GTAAAAGTAG GCCAAGCGAG TGAAATTGCA 
CGTCAAACTG CCGAGGAATC TGGCATAACA AATTCTGCTT CCAGTACACT TTTGTCTGAG 
TACAATGTCA CCAACAACAG CGTTGCTCTT AGAACACCAC GAACACCAGC TTCCCAGGAC 
AGAATTCTGC AGGAAGCCCA GAACCTCATG GCCCTCACCA ATGTGGACAC CCCATTGAAA 
GGTGGACTTA ATACCCCATT GCATGAGAGT GACTTCTCAG GTGTAACTCC ACAGCGACAA 
GTTGTACAGA CTCCAAACAC AGTTCTCTCT ACTCCATTCA GGACTCCTTC TAATGGAGCT 
GAAGGGCTGA CTCCCCGGAG TGGAACAACT CCCAAACCAG TTATTAACTC TACTCCGGGT 
AGAACTCCTC TTCGAGACAA GTTAAACATT AATCCCGAGG ATGGAATGGC AGACTATAGT 
GATCCCTCTT ACGTGAAGCA GATGGAAAGA GAATCCCGAG AACATCTCCG TTTAGGGTTG 
TTGGGCCTTC CTGCCCCTAA GAATGATTTT GAAATTGTTC TACCAGAAAA TGCCGAGAAG 
GAGCTGGAAG AACGTGAAAT AGATGATACT TACATTGAAG ATGCTGCTGA TGTGGATGCT 
CGAAAGCAGG CCATACGAGA TGCAGAGCGT GTAAAGGAAA TGAAACGAAT GCATAAAGCT 
GTCCAGAAAG ATCTGCCAAG ACCATCAGAA GTAAATGAAA CTATTCTAAG ACCCTTAAAT 
GTAGAACCGC CTTTAACAGA TTTACAGAAA AGTGAAGAAC TAATCAAAAA AGAAATGATC 
ACAATGCTTC ATTATGACCT TCTACATCAC CCTTATGAAC CATCTGGAAA TAAAAAAGGC 
AAAACTGTAG GGTTTGGTAC CAATAATTCA GAGCACATTA CCTATCTGGA ACATAATCCT 
TATGAAAAGT TCTCCAAAGA AGAGCTGAAA AAGGCCCAGG ATGTTTTGGT GCAGGAGATG 
GAAGTGGTTA AACAAGGAAT GAGCCATGGA GAGCTCTCAA GTGAAGCTTA TAACCAGGTG 
TGGGAAGAAT GCTACAGTCA AGTTTTATAT CTTCCTGGGC AGAGCCGCTA CACACGGGCC 
AATCTGGCTA GTAAAAAGGA CAGAATTGAA TCACTTGAAA AGAGGCTCGA GATAAACAGG 
GGTCACATGA CGACAGAAGC CAAGAGGGCT GCAAAGATGG AAAAGAAGAT GAAAATTTTG 
CTTGGGGGTT ACCAGTCTCG TGCTATGGGG CTCATGAAAC AGTTGAATGA CTTATGGGAC 
CAAATTGAAC AGGCTCACTT GGAGTTACGC ACTTTTGAAG AACTCAAGAA ACATGAAGAT 
TCTGCTATTC CCCGGAGGCT AGAGTGTCTA AAAGAAGACG TTCAGCGACA ACAAGAAAGA 
GAAAAGGAAC TTCAACATAG ATATGCTGAT TTGCTGCTGG AGAAAGAGAC TTTAAAGTCA 
AAATTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Prp19 Arrests Cell Cycle via Cdc5L in Hepatocellular Carcinoma Cells.
International journal of molecular sciences18(4)(2017 Apr)
Huang R,Xue R,Qu D,Yin J,Shen XZ

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Nature542(7641)318-323(2017 02)
Bertram K,Agafonov DE,Liu WT,Dybkov O,Will CL,Hartmuth K,Urlaub H,Kastner B,Stark H,L?hrmann R

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CDC5L cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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