TOMM70 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TOMM70
Entrez Gene ID	9868
Full Name	translocase of outer mitochondrial membrane 70
Synonyms	TOMM70A,Tom70
General protein information	Preferred Names translocase of outer mitochondrial membrane 70 Names mitochondrial import receptor subunit TOM70 mitochondrial precursor proteins import receptor translocase of outer membrane 70 kDa subunit translocase of outer mitochondrial membrane 70 homolog A translocase of outer mitochondrial membrane protein 70
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q12.2
Summary	This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. [provided by RefSeq, Oct 2011].
Disorder MIM:	606081

mRNA and Protein(s)

mRNA	Protein	Name
NM_014820.4	NP_055635.3	mitochondrial import receptor subunit TOM70
NM_014820.5	NP_055635.3	mitochondrial import receptor subunit TOM70

Pathways from BioSystems

Homologies

	TOMM70A	XP_001092332.1
Danio rerio (zebrafish)	tomm70a	NP_956296.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009497	XP_310198.4
Schizosaccharomyces pombe (fission yeast)	tom70	NP_593767.1
Magnaporthe oryzae (rice blast fungus)	MGG_00979	XP_003717970.1
Mus musculus (house mouse)	Tomm70a	NP_613065.2
Rattus norvegicus (Norway rat)	Tomm70a	NP_997684.1
Gallus gallus (chicken)	TOMM70A	XP_416605.2
Drosophila melanogaster (fruit fly)	Tom70	NP_609536.1
Xenopus tropicalis (tropical clawed frog)	tomm70a	NP_001096527.1
Pan troglodytes (chimpanzee)	TOMM70A	XP_526255.2
Canis lupus familiaris (dog)	TOMM70A	XP_535719.3
Bos taurus (cattle)	TOMM70A	NP_001068796.1
Eremothecium gossypii	AGOS_ABR131W	NP_983078.1
Homo sapiens (human)	TOMM70A	NP_055635.3
Saccharomyces cerevisiae (baker's yeast)	TOM70	NP_014278.3
Kluyveromyces lactis	KLLA0F24046g	XP_456151.1
Neurospora crassa	NCU04245	XP_961236.1

Gene Ontology
Bibliography

Related articles in PubMed

Tom70 mediates Sendai virus-induced apoptosis on mitochondria.
Wei B, Cui Y, Huang Y, Liu H, Li L, Li M, Ruan KC, Zhou Q, Wang C
Journal of virology89(7)3804-18(2015 Apr)

Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy.
Li J, Qi M, Li C, Shi D, Zhang D, Xie D, Yuan T, Feng J, Liu Y, Liang D, Xu X, Chen J, Xu L, Zhang H, Ye J, Lv F, Huang J, Peng L, Chen YH
Cell research24(8)977-93(2014 Aug)

Cytoplasmic ribosomal protein S3 (rpS3) plays a pivotal role in mitochondrial DNA damage surveillance.
Kim Y, Kim HD, Kim J
Biochimica et biophysica acta1833(12)2943-2952(2013 Dec)

The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance.
Bertolin G, Ferrando-Miguel R, Jacoupy M, Traver S, Grenier K, Greene AW, Dauphin A, Waharte F, Bayot A, Salamero J, Lomb?s A, Bulteau AL, Fon EA, Brice A, Corti O
Autophagy9(11)1801-17(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Collectively, this study characterizes a novel protein complex, Tom70/Hsp90/IRF3/Bax, that is important for Sendai virus-induced apoptosis.
Title: Tom70 mediates Sendai virus-induced apoptosis on mitochondria.

Tom70 acts as a molecular switch that orchestrates hypertrophic stresses and mitochondrial responses to determine pathological cardiac hypertrophy.
Title: Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy.

Blockade of mitochondrial protein import triggers the recruitment of PARK2, by PINK1, to the TOMM machinery.
Title: The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance.

PINK1 is imported into mitochondria by a unique pathway that is independent of the TOM core complex but crucially depends on the import receptor Tom70
Title: Tom70 is essential for PINK1 import into mitochondria.

The hepatitis C virus NS3/4A protein induced Tom70 expression.
Title: Translocase of outer mitochondrial membrane 70 induces interferon response and is impaired by hepatitis C virus NS3.

The following TOMM70 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TOMM70 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09660	NM_014820.5 Latest version!	Homo sapiens translocase of outer mitochondrial membrane 70 (TOMM70), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu09660	NM_014820.4	Homo sapiens translocase of outer mitochondrial membrane 70 (TOMM70), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TOMM70 ( NM_014820.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055635.3 Homo sapiens translocase of outer mitochondrial membrane 70 (TOMM70), mRNA.

Price & Availability↑

CloneID	OHu09660
Clone ID Related Accession (Same CDS sequence)	NM_014820.4 , NM_014820.5
Accession Version	NM_014820.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1827bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	mitochondrial import receptor subunit TOM70
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC065555.1, AB018262.1 and AW044465.1. On Oct 26, 2011 this sequence version replaced NM_014820.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC065555.1, SRR1660807.102626.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCCT CTAAACCTGT GGAGGCAGCG GTGGTCGCAG CCGCTGTACC GAGCTCCGGG 
AGTGGGGTGG GCGGCGGCGG GACTGCGGGC CCGGGCACGG GGGGGCTGCC GCGATGGCAG 
CTGGCTCTGG CGGTCGGGGC ACCCCTGCTG CTGGGCGCGG GTGCCATATA CCTGTGGAGT 
CGGCAGCAAC GGCGCCGGGA GGCCAGAGGC CGGGGCGACG CCAGCGGCCT GAAGCGCAAC 
AGCGAACGGA AGACCCCGGA GGGCAGGGCC AGTCCGGCCC CGGGCAGCGG ACACCCTGAA 
GGTCCCGGTG CTCACTTGGA CATGAACTCT CTTGATAGAG CCCAAGCAGC CAAGAATAAA 
GGCAATAAAT ATTTTAAAGC AGGAAAATAT GAACAAGCTA TTCAGTGCTA TACTGAGGCT 
ATTAGCTTGT GCCCTACAGA GAAGAATGTT GACCTTTCTA CATTTTATCA AAACAGAGCT 
GCTGCCTTTG AACAGTTGCA AAAATGGAAA GAAGTGGCAC AAGACTGTAC AAAAGCTGTT 
GAACTTAATC CCAAATATGT GAAAGCTCTC TTTAGACGTG CAAAAGCCCA TGAGAAGCTA 
GACAATAAGA AGGAATGTTT AGAAGATGTC ACTGCTGTGT GTATATTAGA AGGGTTCCAA 
AATCAACAAA GCATGCTGTT AGCCGATAAA GTTCTTAAAC TCCTTGGAAA AGAGAAAGCC 
AAAGAAAAAT ATAAGAATCG TGAACCTCTG ATGCCATCTC CACAGTTTAT CAAATCTTAC 
TTCAGTTCTT TCACGGATGA TATCATTTCC CAGCCCATGC TTAAAGGAGA GAAATCTGAT 
GAAGATAAAG ACAAGGAAGG GGAGGCTTTA GAAGTGAAAG AAAATTCTGG ATACTTAAAG 
GCCAAACAGT ATATGGAAGA AGAAAACTAC GATAAAATCA TAAGTGAATG CTCAAAAGAA 
ATAGATGCTG AAGGCAAATA CATGGCAGAA GCATTGCTAC TACGAGCTAC CTTCTACCTG 
CTTATTGGCA ATGCCAATGC AGCCAAACCA GATTTAGATA AAGTCATCAG TTTGAAAGAA 
GCTAATGTGA AGCTTCGAGC AAATGCTCTC ATCAAAAGAG GCAGCATGTA CATGCAACAG 
CAGCAGCCTT TGCTGTCCAC TCAAGATTTT AACATGGCTG CTGACATCGA TCCTCAGAAT 
GCAGATGTTT ATCACCACCG AGGACAGCTG AAAATACTCC TTGATCAAGT TGAAGAAGCA 
GTGGCAGATT TTGATGAATG TATTAGGTTA AGACCTGAGT CTGCTCTGGC ACAAGCACAG 
AAATGTTTTG CATTGTACCG CCAGGCATAT ACGGGAAACA ACTCTTCACA AATCCAAGCA 
GCTATGAAAG GTTTTGAAGA GGTCATAAAG AAATTTCCAA GGTGTGCCGA AGGCTATGCA 
CTATACGCCC AGGCATTAAC AGATCAACAA CAGTTTGGTA AAGCTGATGA AATGTATGAT 
AAATGTATTG ATTTGGAACC AGATAATGCT ACAACATATG TTCATAAAGG TTTACTTCAA 
CTTCAGTGGA AGCAAGATCT GGATAGAGGT TTGGAACTTA TCAGCAAGGC TATTGAAATT 
GACAATAAAT GTGATTTTGC CTATGAAACC ATGGGAACTA TTGAAGTACA AAGAGGAAAC 
ATGGAGAAAG CCATTGACAT GTTCAACAAA GCTATTAACC TGGCCAAATC GGAAATGGAG 
ATGGCCCATC TGTATTCACT TTGCGATGCC GCCCATGCCC AGACAGAAGT TGCAAAGAAA 
TACGGATTAA AACCACCAAC ATTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055635.3
CDS	450..2276
Translation	MAASKPVEAAVVAAAVPSSGSGVGGGGTAGPGTGGLPRWQLALAVGAPLLLGAGAIYLWSRQQRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKKYGLKPPTL

Target ORF information:

RefSeq Version	NM_014820.4
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of outer mitochondrial membrane 70 (TOMM70), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014820.4

ORF Insert Sequence:

ATGGCCGCCT CTAAACCTGT GGAGGCAGCG GTGGTCGCAG CCGCTGTACC GAGCTCCGGG 
AGTGGGGTGG GCGGCGGCGG GACTGCGGGC CCGGGCACGG GGGGGCTGCC GCGATGGCAG 
CTGGCTCTGG CGGTCGGGGC ACCCCTGCTG CTGGGCGCGG GTGCCATATA CCTGTGGAGT 
CGGCAGCAAC GGCGCCGGGA GGCCAGAGGC CGGGGCGACG CCAGCGGCCT GAAGCGCAAC 
AGCGAACGGA AGACCCCGGA GGGCAGGGCC AGTCCGGCCC CGGGCAGCGG ACACCCTGAA 
GGTCCCGGTG CTCACTTGGA CATGAACTCT CTTGATAGAG CCCAAGCAGC CAAGAATAAA 
GGCAATAAAT ATTTTAAAGC AGGAAAATAT GAACAAGCTA TTCAGTGCTA TACTGAGGCT 
ATTAGCTTGT GCCCTACAGA GAAGAATGTT GACCTTTCTA CATTTTATCA AAACAGAGCT 
GCTGCCTTTG AACAGTTGCA AAAATGGAAA GAAGTGGCAC AAGACTGTAC AAAAGCTGTT 
GAACTTAATC CCAAATATGT GAAAGCTCTC TTTAGACGTG CAAAAGCCCA TGAGAAGCTA 
GACAATAAGA AGGAATGTTT AGAAGATGTC ACTGCTGTGT GTATATTAGA AGGGTTCCAA 
AATCAACAAA GCATGCTGTT AGCCGATAAA GTTCTTAAAC TCCTTGGAAA AGAGAAAGCC 
AAAGAAAAAT ATAAGAATCG TGAACCTCTG ATGCCATCTC CACAGTTTAT CAAATCTTAC 
TTCAGTTCTT TCACGGATGA TATCATTTCC CAGCCCATGC TTAAAGGAGA GAAATCTGAT 
GAAGATAAAG ACAAGGAAGG GGAGGCTTTA GAAGTGAAAG AAAATTCTGG ATACTTAAAG 
GCCAAACAGT ATATGGAAGA AGAAAACTAC GATAAAATCA TAAGTGAATG CTCAAAAGAA 
ATAGATGCTG AAGGCAAATA CATGGCAGAA GCATTGCTAC TACGAGCTAC CTTCTACCTG 
CTTATTGGCA ATGCCAATGC AGCCAAACCA GATTTAGATA AAGTCATCAG TTTGAAAGAA 
GCTAATGTGA AGCTTCGAGC AAATGCTCTC ATCAAAAGAG GCAGCATGTA CATGCAACAG 
CAGCAGCCTT TGCTGTCCAC TCAAGATTTT AACATGGCTG CTGACATCGA TCCTCAGAAT 
GCAGATGTTT ATCACCACCG AGGACAGCTG AAAATACTCC TTGATCAAGT TGAAGAAGCA 
GTGGCAGATT TTGATGAATG TATTAGGTTA AGACCTGAGT CTGCTCTGGC ACAAGCACAG 
AAATGTTTTG CATTGTACCG CCAGGCATAT ACGGGAAACA ACTCTTCACA AATCCAAGCA 
GCTATGAAAG GTTTTGAAGA GGTCATAAAG AAATTTCCAA GGTGTGCCGA AGGCTATGCA 
CTATACGCCC AGGCATTAAC AGATCAACAA CAGTTTGGTA AAGCTGATGA AATGTATGAT 
AAATGTATTG ATTTGGAACC AGATAATGCT ACAACATATG TTCATAAAGG TTTACTTCAA 
CTTCAGTGGA AGCAAGATCT GGATAGAGGT TTGGAACTTA TCAGCAAGGC TATTGAAATT 
GACAATAAAT GTGATTTTGC CTATGAAACC ATGGGAACTA TTGAAGTACA AAGAGGAAAC 
ATGGAGAAAG CCATTGACAT GTTCAACAAA GCTATTAACC TGGCCAAATC GGAAATGGAG 
ATGGCCCATC TGTATTCACT TTGCGATGCC GCCCATGCCC AGACAGAAGT TGCAAAGAAA 
TACGGATTAA AACCACCAAC ATTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOMM70 ( NM_014820.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055635.3 Homo sapiens translocase of outer mitochondrial membrane 70 (TOMM70), mRNA.

Price & Availability↑

CloneID	OHu09660
Clone ID Related Accession (Same CDS sequence)	NM_014820.4 , NM_014820.5
Accession Version	NM_014820.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1827bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	mitochondrial import receptor subunit TOM70
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC065555.1, AB018262.1, AW044465.1 and AC093003.11. On May 17, 2019 this sequence version replaced NM_014820.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB018262.1, SRR1660805.66750.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000284320.6/ ENSP00000284320.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCCT CTAAACCTGT GGAGGCAGCG GTGGTCGCAG CCGCTGTACC GAGCTCCGGG 
AGTGGGGTGG GCGGCGGCGG GACTGCGGGC CCGGGCACGG GGGGGCTGCC GCGATGGCAG 
CTGGCTCTGG CGGTCGGGGC ACCCCTGCTG CTGGGCGCGG GTGCCATATA CCTGTGGAGT 
CGGCAGCAAC GGCGCCGGGA GGCCAGAGGC CGGGGCGACG CCAGCGGCCT GAAGCGCAAC 
AGCGAACGGA AGACCCCGGA GGGCAGGGCC AGTCCGGCCC CGGGCAGCGG ACACCCTGAA 
GGTCCCGGTG CTCACTTGGA CATGAACTCT CTTGATAGAG CCCAAGCAGC CAAGAATAAA 
GGCAATAAAT ATTTTAAAGC AGGAAAATAT GAACAAGCTA TTCAGTGCTA TACTGAGGCT 
ATTAGCTTGT GCCCTACAGA GAAGAATGTT GACCTTTCTA CATTTTATCA AAACAGAGCT 
GCTGCCTTTG AACAGTTGCA AAAATGGAAA GAAGTGGCAC AAGACTGTAC AAAAGCTGTT 
GAACTTAATC CCAAATATGT GAAAGCTCTC TTTAGACGTG CAAAAGCCCA TGAGAAGCTA 
GACAATAAGA AGGAATGTTT AGAAGATGTC ACTGCTGTGT GTATATTAGA AGGGTTCCAA 
AATCAACAAA GCATGCTGTT AGCCGATAAA GTTCTTAAAC TCCTTGGAAA AGAGAAAGCC 
AAAGAAAAAT ATAAGAATCG TGAACCTCTG ATGCCATCTC CACAGTTTAT CAAATCTTAC 
TTCAGTTCTT TCACGGATGA TATCATTTCC CAGCCCATGC TTAAAGGAGA GAAATCTGAT 
GAAGATAAAG ACAAGGAAGG GGAGGCTTTA GAAGTGAAAG AAAATTCTGG ATACTTAAAG 
GCCAAACAGT ATATGGAAGA AGAAAACTAC GATAAAATCA TAAGTGAATG CTCAAAAGAA 
ATAGATGCTG AAGGCAAATA CATGGCAGAA GCATTGCTAC TACGAGCTAC CTTCTACCTG 
CTTATTGGCA ATGCCAATGC AGCCAAACCA GATTTAGATA AAGTCATCAG TTTGAAAGAA 
GCTAATGTGA AGCTTCGAGC AAATGCTCTC ATCAAAAGAG GCAGCATGTA CATGCAACAG 
CAGCAGCCTT TGCTGTCCAC TCAAGATTTT AACATGGCTG CTGACATCGA TCCTCAGAAT 
GCAGATGTTT ATCACCACCG AGGACAGCTG AAAATACTCC TTGATCAAGT TGAAGAAGCA 
GTGGCAGATT TTGATGAATG TATTAGGTTA AGACCTGAGT CTGCTCTGGC ACAAGCACAG 
AAATGTTTTG CATTGTACCG CCAGGCATAT ACGGGAAACA ACTCTTCACA AATCCAAGCA 
GCTATGAAAG GTTTTGAAGA GGTCATAAAG AAATTTCCAA GGTGTGCCGA AGGCTATGCA 
CTATACGCCC AGGCATTAAC AGATCAACAA CAGTTTGGTA AAGCTGATGA AATGTATGAT 
AAATGTATTG ATTTGGAACC AGATAATGCT ACAACATATG TTCATAAAGG TTTACTTCAA 
CTTCAGTGGA AGCAAGATCT GGATAGAGGT TTGGAACTTA TCAGCAAGGC TATTGAAATT 
GACAATAAAT GTGATTTTGC CTATGAAACC ATGGGAACTA TTGAAGTACA AAGAGGAAAC 
ATGGAGAAAG CCATTGACAT GTTCAACAAA GCTATTAACC TGGCCAAATC GGAAATGGAG 
ATGGCCCATC TGTATTCACT TTGCGATGCC GCCCATGCCC AGACAGAAGT TGCAAAGAAA 
TACGGATTAA AACCACCAAC ATTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055635.3
CDS	141..1967
Translation	MAASKPVEAAVVAAAVPSSGSGVGGGGTAGPGTGGLPRWQLALAVGAPLLLGAGAIYLWSRQQRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKKYGLKPPTL

Target ORF information:

RefSeq Version	NM_014820.5
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of outer mitochondrial membrane 70 (TOMM70), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014820.5

ORF Insert Sequence:

ATGGCCGCCT CTAAACCTGT GGAGGCAGCG GTGGTCGCAG CCGCTGTACC GAGCTCCGGG 
AGTGGGGTGG GCGGCGGCGG GACTGCGGGC CCGGGCACGG GGGGGCTGCC GCGATGGCAG 
CTGGCTCTGG CGGTCGGGGC ACCCCTGCTG CTGGGCGCGG GTGCCATATA CCTGTGGAGT 
CGGCAGCAAC GGCGCCGGGA GGCCAGAGGC CGGGGCGACG CCAGCGGCCT GAAGCGCAAC 
AGCGAACGGA AGACCCCGGA GGGCAGGGCC AGTCCGGCCC CGGGCAGCGG ACACCCTGAA 
GGTCCCGGTG CTCACTTGGA CATGAACTCT CTTGATAGAG CCCAAGCAGC CAAGAATAAA 
GGCAATAAAT ATTTTAAAGC AGGAAAATAT GAACAAGCTA TTCAGTGCTA TACTGAGGCT 
ATTAGCTTGT GCCCTACAGA GAAGAATGTT GACCTTTCTA CATTTTATCA AAACAGAGCT 
GCTGCCTTTG AACAGTTGCA AAAATGGAAA GAAGTGGCAC AAGACTGTAC AAAAGCTGTT 
GAACTTAATC CCAAATATGT GAAAGCTCTC TTTAGACGTG CAAAAGCCCA TGAGAAGCTA 
GACAATAAGA AGGAATGTTT AGAAGATGTC ACTGCTGTGT GTATATTAGA AGGGTTCCAA 
AATCAACAAA GCATGCTGTT AGCCGATAAA GTTCTTAAAC TCCTTGGAAA AGAGAAAGCC 
AAAGAAAAAT ATAAGAATCG TGAACCTCTG ATGCCATCTC CACAGTTTAT CAAATCTTAC 
TTCAGTTCTT TCACGGATGA TATCATTTCC CAGCCCATGC TTAAAGGAGA GAAATCTGAT 
GAAGATAAAG ACAAGGAAGG GGAGGCTTTA GAAGTGAAAG AAAATTCTGG ATACTTAAAG 
GCCAAACAGT ATATGGAAGA AGAAAACTAC GATAAAATCA TAAGTGAATG CTCAAAAGAA 
ATAGATGCTG AAGGCAAATA CATGGCAGAA GCATTGCTAC TACGAGCTAC CTTCTACCTG 
CTTATTGGCA ATGCCAATGC AGCCAAACCA GATTTAGATA AAGTCATCAG TTTGAAAGAA 
GCTAATGTGA AGCTTCGAGC AAATGCTCTC ATCAAAAGAG GCAGCATGTA CATGCAACAG 
CAGCAGCCTT TGCTGTCCAC TCAAGATTTT AACATGGCTG CTGACATCGA TCCTCAGAAT 
GCAGATGTTT ATCACCACCG AGGACAGCTG AAAATACTCC TTGATCAAGT TGAAGAAGCA 
GTGGCAGATT TTGATGAATG TATTAGGTTA AGACCTGAGT CTGCTCTGGC ACAAGCACAG 
AAATGTTTTG CATTGTACCG CCAGGCATAT ACGGGAAACA ACTCTTCACA AATCCAAGCA 
GCTATGAAAG GTTTTGAAGA GGTCATAAAG AAATTTCCAA GGTGTGCCGA AGGCTATGCA 
CTATACGCCC AGGCATTAAC AGATCAACAA CAGTTTGGTA AAGCTGATGA AATGTATGAT 
AAATGTATTG ATTTGGAACC AGATAATGCT ACAACATATG TTCATAAAGG TTTACTTCAA 
CTTCAGTGGA AGCAAGATCT GGATAGAGGT TTGGAACTTA TCAGCAAGGC TATTGAAATT 
GACAATAAAT GTGATTTTGC CTATGAAACC ATGGGAACTA TTGAAGTACA AAGAGGAAAC 
ATGGAGAAAG CCATTGACAT GTTCAACAAA GCTATTAACC TGGCCAAATC GGAAATGGAG 
ATGGCCCATC TGTATTCACT TTGCGATGCC GCCCATGCCC AGACAGAAGT TGCAAAGAAA 
TACGGATTAA AACCACCAAC ATTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tom70 mediates Sendai virus-induced apoptosis on mitochondria.
Journal of virology89(7)3804-18(2015 Apr)
Wei B,Cui Y,Huang Y,Liu H,Li L,Li M,Ruan KC,Zhou Q,Wang C

Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy.
Cell research24(8)977-93(2014 Aug)
Li J,Qi M,Li C,Shi D,Zhang D,Xie D,Yuan T,Feng J,Liu Y,Liang D,Xu X,Chen J,Xu L,Zhang H,Ye J,Lv F,Huang J,Peng L,Chen YH

Cytoplasmic ribosomal protein S3 (rpS3) plays a pivotal role in mitochondrial DNA damage surveillance.
Biochimica et biophysica acta1833(12)2943-2952(2013 Dec)
Kim Y,Kim HD,Kim J

The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance.
Autophagy9(11)1801-17(2013 Nov)
Bertolin G,Ferrando-Miguel R,Jacoupy M,Traver S,Grenier K,Greene AW,Dauphin A,Waharte F,Bayot A,Salamero J,Lomb?s A,Bulteau AL,Fon EA,Brice A,Corti O

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TOMM70 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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