RUSC2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RUSC2
Entrez Gene ID	9853
Full Name	RUN and SH3 domain containing 2
Synonyms	Iporin,MRT61
General protein information	Preferred Names RUN and SH3 domain containing 2 Names iporin RUN and SH3 domain-containing protein 2 interacting protein of Rab1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p13.3
Summary	This gene encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein GM130. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2012].
Disorder MIM:	611053
Disorder Html:	Mental retardation, autosomal recessive 61, 617773 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_014806.5	NP_055621.2	iporin isoform 1
NM_001135999.1	NP_001129471.1	iporin isoform 1
NM_014806.4	NP_055621.1	iporin isoform 1
NM_001330740.1	NP_001317669.1	iporin isoform 2
NM_001330740.2	NP_001317669.1	iporin isoform 2

Pathways from BioSystems

Homologies

	RUSC2	XP_002800131.1
Mus musculus (house mouse)	Rusc2	NP_001032798.1
Gallus gallus (chicken)	RUSC2	XP_003643016.1
Danio rerio (zebrafish)	rusc2	XP_005165247.1
Homo sapiens (human)	RUSC2	NP_001129471.1
Pan troglodytes (chimpanzee)	RUSC2	XP_520556.3
Canis lupus familiaris (dog)	RUSC2	XP_538715.3
Rattus norvegicus (Norway rat)	Rusc2	XP_003749975.1
Bos taurus (cattle)	RUSC2	NP_001075896.1
Xenopus tropicalis (tropical clawed frog)	rusc2	XP_002940237.2

Gene Ontology
Bibliography

Related articles in PubMed

Loss-of-function mutation in RUSC2 causes intellectual disability and secondary microcephaly.
Alwadei AH, Benini R, Mahmoud A, Alasmari A, Kamsteeg EJ, Alfadhel M
Developmental medicine and child neurology58(12)1317-1322(2016 Dec)

EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.
Duan B, Cui J, Sun S, Zheng J, Zhang Y, Ye B, Chen Y, Deng W, Du J, Zhu Y, Chen Y, Gu L
Cancer letters379(1)70-83(2016 08)

Copy number alterations and neoplasia-specific mutations in MELK, PDCD1LG2, TLN1, and PAX5 at 9p in different neoplasias.
Sarhadi VK, Lahti L, Scheinin I, Ellonen P, Kettunen E, Serra M, Scotlandi K, Picci P, Knuutila S
Genes, chromosomes & cancer53(7)579-88(2014 Jul)

Genome-wide investigation of the Rab binding activity of RUN domains: development of a novel tool that specifically traps GTP-Rab35.
Fukuda M, Kobayashi H, Ishibashi K, Ohbayashi N
Cell structure and function36(2)155-70(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

three patients with inherited homozygous nonsense mutations identified in RUSC2 on whole-exome sequencing. All three patients had central hypotonia, microcephaly, and moderate to severe intellectual disability
Title: Loss-of-function mutation in RUSC2 causes intellectual disability and secondary microcephaly.

Short-term EGF stimulation if of lung tumor cells can increase the interaction between RUSC2 and GIT2, prolonged stimulation leads to a decrease of their interaction through activating Rab35.
Title: EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.

conclude that Iporin might function as a link between the targeting of ER derived vesicles, triggered by the rab1 GTPase and a signaling pathway regulated by molecules containing SH3 and/or poly-proline regions
Title: Identification and characterization of Iporin as a novel interaction partner for rab1.

The following RUSC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RUSC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu42885	NM_001330740.2 Latest version!	Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu107240	NM_014806.5 Latest version!	Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$811.30 $1159.00
OHu21992	NM_001135999.1 Latest version!	Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$384.30 $549.00
OHu21992	NM_014806.4 Latest version!	Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$384.30 $549.00
View Old Accession Versions >>
OHu42885	NM_001330740.1	Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RUSC2 ( NM_001330740.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001317669.1 Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu42885
Clone ID Related Accession (Same CDS sequence)	NM_001330740.1 , NM_001330740.2
Accession Version	NM_001330740.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1917bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-05
Organism	Homo sapiens(human)
Product	iporin isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL133476.17. On Sep 1, 2016 this sequence version replaced XM_006716896.2. Transcript Variant: This variant (4) differs in the 5' UTR, lacks a large portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.213775.1, SRR1803617.78785.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCACCA GGCCCAGTAA TGCCAACCAC CTATCCCCTC AAGCCCTCAA GTGGCGGGAA 
TACAGGAGGA AGAACCCACT AGGGCCACCT GGTTTGTCAG GGAGCCTAGA CCGAAGATCA 
CAAGAAGCTC GGCTGGCCCG AAGAAACCCT ATCTTTGAGT TCCCTGGCTC CCTCAGTGCT 
GCCAGCCATC TGAACTGCCG GCTGAATGGC CAAGCAGTGA AGCCGTTACC ACTGACCTGC 
CCTGACTTCC AGGACCCCTT TTCCTTGACG GAGAAGCCTC CAGCTGAGTT TTGTCTGTCC 
CCAGATGGCA GCTCAGAGGC CATTTCCATT GACCTGCTTC AGAAAAAAGG GCTGGTAAAA 
GCTGTTAACA TCGCTGTGGA CCTCATTGTG GCTCATTTTG GCACAAGCCG GGATCCCGGG 
GTGAAGGCAA AGCTGGGAAA CAGTTCTGTG AGCCCCAATG TGGGCCACCT GGTTCTGAAG 
TACTTGTGCC CTGCCGTCCG CGCCGTGCTG GAGGATGGGC TCAAGGCCTT TGTACTGGAC 
GTCATCATCG GGCAGCGTAA GAACATGCCA TGGAGTGTGG TTGAGGCTTC CACACAGCTA 
GGCCCATCCA CCAAGGTCCT GCATGGCCTC TACAACAAAG TCAGCCAATT CCCAGAGCTC 
ACCAGTCATA CCATGCGCTT CAACGCCTTC ATCCTCGGCC TGCTCAACAT CCGGTCCCTG 
GAGTTCTGGT TTAATCACCT CTATAACCAC GAAGACATCA TCCAGACCCA CTACCAGCCC 
TGGGGCTTCC TGAGTGCAGC TCATACCGTG TGTCCCGGCC TCTTTGAAGA GCTGCTGCTG 
CTGCTACAGC CCCTGGCCCT GCTGCCCTTC AGCCTCGACT TGCTGTTCCA GCACCGGCTG 
CTGCAAAGTG GGCAGCAGCA GCGGCAGCAC AAGGAACTGC TGCGGGTGTC CCAGGACCTG 
CTGCTGTCTG CCCACTCCAC GCTGCAGCTG GCCCGGGCCC GGGGCCAGGA GGGCCCTGGA 
GACGTGGACA GGGCAGCCCA AGGGGAGCGG GTGAAGGGTG TGGGTGCCTC AGAAGGTGGA 
GAAGAGGAAG AGGAAGAAGA GGAGACAGAA GAGGTGGCAG AGGCAGCCGG GGGCTCAGGG 
CGTGCCAGGT GGGCCCGAGG TGGGCAGGCC GGCTGGTGGT ACCAGCTCAT GCAGAGCTCC 
CAGGTCTACA TCGATGGCTC CATTGAGGGT TCCAGGTTCC CTCGTGGTAG CAGCAACAGC 
AGCAGCGAGA AAAAGAAAGG GGCAGGAGGT GGGGGACCTC CCCAGGCTCC ACCACCCCGA 
GAGGGAGTAG TGGAGGGGGC TGAGGCCTGC CCTGCCTCTG AGGAGGCCCT GGGCCGGGAA 
AGGGGCTGGC CCTTCTGGAT GGGGAGCCCC CCTGACTCTG TGCTGGCCGA GCTGAGGCGC 
AGTCGGGAGA GGGAAGGGCC CGCTGCCTCG CCAGCAGAAA ATGAGGAAGG GGCCTCAGAG 
CCTTCACCTG GAGGCATCAA GTGGGGACAC CTCTTTGGCT CCCGAAAAGC CCAGCGGGAG 
GCCCGGCCCA CAAATAGGCT CCCCTCGGAC TGGCTGAGCC TGGACAAGTC CATGTTCCAA 
CTAGTGGCGC AGACAGTGGG TTCCCGCCGG GAGCCAGAGC CCAAGGAGAG CCTGCAGGAG 
CCACACTCCC CAGCCCTGCC CTCCAGTCCT CCGTGTGAGG TGCAGGCACT GTGCCACCAC 
CTGGCCACCG GCCCTGGACA GCTGAGCTTC CACAAAGGAG ACATCCTACG AGTGCTGGGG 
CGAGCTGGAG GAGACTGGCT GCGCTGCAGC CGTGGCCCCG ACTCTGGCCT GGTGCCCCTG 
GCCTACGTGA CATTGACCCC AACTCCAAGT CCAACCCCTG GAAGCAGCCA AAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001317669.1
CDS	961..2877
Translation	MATRPSNANHLSPQALKWREYRRKNPLGPPGLSGSLDRRSQEARLARRNPIFEFPGSLSAASHLNCRLNGQAVKPLPLTCPDFQDPFSLTEKPPAEFCLSPDGSSEAISIDLLQKKGLVKAVNIAVDLIVAHFGTSRDPGVKAKLGNSSVSPNVGHLVLKYLCPAVRAVLEDGLKAFVLDVIIGQRKNMPWSVVEASTQLGPSTKVLHGLYNKVSQFPELTSHTMRFNAFILGLLNIRSLEFWFNHLYNHEDIIQTHYQPWGFLSAAHTVCPGLFEELLLLLQPLALLPFSLDLLFQHRLLQSGQQQRQHKELLRVSQDLLLSAHSTLQLARARGQEGPGDVDRAAQGERVKGVGASEGGEEEEEEEETEEVAEAAGGSGRARWARGGQAGWWYQLMQSSQVYIDGSIEGSRFPRGSSNSSSEKKKGAGGGGPPQAPPPREGVVEGAEACPASEEALGRERGWPFWMGSPPDSVLAELRRSREREGPAASPAENEEGASEPSPGGIKWGHLFGSRKAQREARPTNRLPSDWLSLDKSMFQLVAQTVGSRREPEPKESLQEPHSPALPSSPPCEVQALCHHLATGPGQLSFHKGDILRVLGRAGGDWLRCSRGPDSGLVPLAYVTLTPTPSPTPGSSQN

Target ORF information:

RefSeq Version	NM_001330740.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001330740.1

ORF Insert Sequence:

ATGGCCACCA GGCCCAGTAA TGCCAACCAC CTATCCCCTC AAGCCCTCAA GTGGCGGGAA 
TACAGGAGGA AGAACCCACT AGGGCCACCT GGTTTGTCAG GGAGCCTAGA CCGAAGATCA 
CAAGAAGCTC GGCTGGCCCG AAGAAACCCT ATCTTTGAGT TCCCTGGCTC CCTCAGTGCT 
GCCAGCCATC TGAACTGCCG GCTGAATGGC CAAGCAGTGA AGCCGTTACC ACTGACCTGC 
CCTGACTTCC AGGACCCCTT TTCCTTGACG GAGAAGCCTC CAGCTGAGTT TTGTCTGTCC 
CCAGATGGCA GCTCAGAGGC CATTTCCATT GACCTGCTTC AGAAAAAAGG GCTGGTAAAA 
GCTGTTAACA TCGCTGTGGA CCTCATTGTG GCTCATTTTG GCACAAGCCG GGATCCCGGG 
GTGAAGGCAA AGCTGGGAAA CAGTTCTGTG AGCCCCAATG TGGGCCACCT GGTTCTGAAG 
TACTTGTGCC CTGCCGTCCG CGCCGTGCTG GAGGATGGGC TCAAGGCCTT TGTACTGGAC 
GTCATCATCG GGCAGCGTAA GAACATGCCA TGGAGTGTGG TTGAGGCTTC CACACAGCTA 
GGCCCATCCA CCAAGGTCCT GCATGGCCTC TACAACAAAG TCAGCCAATT CCCAGAGCTC 
ACCAGTCATA CCATGCGCTT CAACGCCTTC ATCCTCGGCC TGCTCAACAT CCGGTCCCTG 
GAGTTCTGGT TTAATCACCT CTATAACCAC GAAGACATCA TCCAGACCCA CTACCAGCCC 
TGGGGCTTCC TGAGTGCAGC TCATACCGTG TGTCCCGGCC TCTTTGAAGA GCTGCTGCTG 
CTGCTACAGC CCCTGGCCCT GCTGCCCTTC AGCCTCGACT TGCTGTTCCA GCACCGGCTG 
CTGCAAAGTG GGCAGCAGCA GCGGCAGCAC AAGGAACTGC TGCGGGTGTC CCAGGACCTG 
CTGCTGTCTG CCCACTCCAC GCTGCAGCTG GCCCGGGCCC GGGGCCAGGA GGGCCCTGGA 
GACGTGGACA GGGCAGCCCA AGGGGAGCGG GTGAAGGGTG TGGGTGCCTC AGAAGGTGGA 
GAAGAGGAAG AGGAAGAAGA GGAGACAGAA GAGGTGGCAG AGGCAGCCGG GGGCTCAGGG 
CGTGCCAGGT GGGCCCGAGG TGGGCAGGCC GGCTGGTGGT ACCAGCTCAT GCAGAGCTCC 
CAGGTCTACA TCGATGGCTC CATTGAGGGT TCCAGGTTCC CTCGTGGTAG CAGCAACAGC 
AGCAGCGAGA AAAAGAAAGG GGCAGGAGGT GGGGGACCTC CCCAGGCTCC ACCACCCCGA 
GAGGGAGTAG TGGAGGGGGC TGAGGCCTGC CCTGCCTCTG AGGAGGCCCT GGGCCGGGAA 
AGGGGCTGGC CCTTCTGGAT GGGGAGCCCC CCTGACTCTG TGCTGGCCGA GCTGAGGCGC 
AGTCGGGAGA GGGAAGGGCC CGCTGCCTCG CCAGCAGAAA ATGAGGAAGG GGCCTCAGAG 
CCTTCACCTG GAGGCATCAA GTGGGGACAC CTCTTTGGCT CCCGAAAAGC CCAGCGGGAG 
GCCCGGCCCA CAAATAGGCT CCCCTCGGAC TGGCTGAGCC TGGACAAGTC CATGTTCCAA 
CTAGTGGCGC AGACAGTGGG TTCCCGCCGG GAGCCAGAGC CCAAGGAGAG CCTGCAGGAG 
CCACACTCCC CAGCCCTGCC CTCCAGTCCT CCGTGTGAGG TGCAGGCACT GTGCCACCAC 
CTGGCCACCG GCCCTGGACA GCTGAGCTTC CACAAAGGAG ACATCCTACG AGTGCTGGGG 
CGAGCTGGAG GAGACTGGCT GCGCTGCAGC CGTGGCCCCG ACTCTGGCCT GGTGCCCCTG 
GCCTACGTGA CATTGACCCC AACTCCAAGT CCAACCCCTG GAAGCAGCCA AAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RUSC2 ( NM_001330740.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001317669.1 Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu42885
Clone ID Related Accession (Same CDS sequence)	NM_001330740.1 , NM_001330740.2
Accession Version	NM_001330740.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1917bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	iporin isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL133476.17. On May 31, 2019 this sequence version replaced NM_001330740.1. Transcript Variant: This variant (4) differs in the 5' UTR, lacks a large portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.213775.1, SRR1803617.78785.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCACCA GGCCCAGTAA TGCCAACCAC CTATCCCCTC AAGCCCTCAA GTGGCGGGAA 
TACAGGAGGA AGAACCCACT AGGGCCACCT GGTTTGTCAG GGAGCCTAGA CCGAAGATCA 
CAAGAAGCTC GGCTGGCCCG AAGAAACCCT ATCTTTGAGT TCCCTGGCTC CCTCAGTGCT 
GCCAGCCATC TGAACTGCCG GCTGAATGGC CAAGCAGTGA AGCCGTTACC ACTGACCTGC 
CCTGACTTCC AGGACCCCTT TTCCTTGACG GAGAAGCCTC CAGCTGAGTT TTGTCTGTCC 
CCAGATGGCA GCTCAGAGGC CATTTCCATT GACCTGCTTC AGAAAAAAGG GCTGGTAAAA 
GCTGTTAACA TCGCTGTGGA CCTCATTGTG GCTCATTTTG GCACAAGCCG GGATCCCGGG 
GTGAAGGCAA AGCTGGGAAA CAGTTCTGTG AGCCCCAATG TGGGCCACCT GGTTCTGAAG 
TACTTGTGCC CTGCCGTCCG CGCCGTGCTG GAGGATGGGC TCAAGGCCTT TGTACTGGAC 
GTCATCATCG GGCAGCGTAA GAACATGCCA TGGAGTGTGG TTGAGGCTTC CACACAGCTA 
GGCCCATCCA CCAAGGTCCT GCATGGCCTC TACAACAAAG TCAGCCAATT CCCAGAGCTC 
ACCAGTCATA CCATGCGCTT CAACGCCTTC ATCCTCGGCC TGCTCAACAT CCGGTCCCTG 
GAGTTCTGGT TTAATCACCT CTATAACCAC GAAGACATCA TCCAGACCCA CTACCAGCCC 
TGGGGCTTCC TGAGTGCAGC TCATACCGTG TGTCCCGGCC TCTTTGAAGA GCTGCTGCTG 
CTGCTACAGC CCCTGGCCCT GCTGCCCTTC AGCCTCGACT TGCTGTTCCA GCACCGGCTG 
CTGCAAAGTG GGCAGCAGCA GCGGCAGCAC AAGGAACTGC TGCGGGTGTC CCAGGACCTG 
CTGCTGTCTG CCCACTCCAC GCTGCAGCTG GCCCGGGCCC GGGGCCAGGA GGGCCCTGGA 
GACGTGGACA GGGCAGCCCA AGGGGAGCGG GTGAAGGGTG TGGGTGCCTC AGAAGGTGGA 
GAAGAGGAAG AGGAAGAAGA GGAGACAGAA GAGGTGGCAG AGGCAGCCGG GGGCTCAGGG 
CGTGCCAGGT GGGCCCGAGG TGGGCAGGCC GGCTGGTGGT ACCAGCTCAT GCAGAGCTCC 
CAGGTCTACA TCGATGGCTC CATTGAGGGT TCCAGGTTCC CTCGTGGTAG CAGCAACAGC 
AGCAGCGAGA AAAAGAAAGG GGCAGGAGGT GGGGGACCTC CCCAGGCTCC ACCACCCCGA 
GAGGGAGTAG TGGAGGGGGC TGAGGCCTGC CCTGCCTCTG AGGAGGCCCT GGGCCGGGAA 
AGGGGCTGGC CCTTCTGGAT GGGGAGCCCC CCTGACTCTG TGCTGGCCGA GCTGAGGCGC 
AGTCGGGAGA GGGAAGGGCC CGCTGCCTCG CCAGCAGAAA ATGAGGAAGG GGCCTCAGAG 
CCTTCACCTG GAGGCATCAA GTGGGGACAC CTCTTTGGCT CCCGAAAAGC CCAGCGGGAG 
GCCCGGCCCA CAAATAGGCT CCCCTCGGAC TGGCTGAGCC TGGACAAGTC CATGTTCCAA 
CTAGTGGCGC AGACAGTGGG TTCCCGCCGG GAGCCAGAGC CCAAGGAGAG CCTGCAGGAG 
CCACACTCCC CAGCCCTGCC CTCCAGTCCT CCGTGTGAGG TGCAGGCACT GTGCCACCAC 
CTGGCCACCG GCCCTGGACA GCTGAGCTTC CACAAAGGAG ACATCCTACG AGTGCTGGGG 
CGAGCTGGAG GAGACTGGCT GCGCTGCAGC CGTGGCCCCG ACTCTGGCCT GGTGCCCCTG 
GCCTACGTGA CATTGACCCC AACTCCAAGT CCAACCCCTG GAAGCAGCCA AAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001317669.1
CDS	683..2599
Translation	MATRPSNANHLSPQALKWREYRRKNPLGPPGLSGSLDRRSQEARLARRNPIFEFPGSLSAASHLNCRLNGQAVKPLPLTCPDFQDPFSLTEKPPAEFCLSPDGSSEAISIDLLQKKGLVKAVNIAVDLIVAHFGTSRDPGVKAKLGNSSVSPNVGHLVLKYLCPAVRAVLEDGLKAFVLDVIIGQRKNMPWSVVEASTQLGPSTKVLHGLYNKVSQFPELTSHTMRFNAFILGLLNIRSLEFWFNHLYNHEDIIQTHYQPWGFLSAAHTVCPGLFEELLLLLQPLALLPFSLDLLFQHRLLQSGQQQRQHKELLRVSQDLLLSAHSTLQLARARGQEGPGDVDRAAQGERVKGVGASEGGEEEEEEEETEEVAEAAGGSGRARWARGGQAGWWYQLMQSSQVYIDGSIEGSRFPRGSSNSSSEKKKGAGGGGPPQAPPPREGVVEGAEACPASEEALGRERGWPFWMGSPPDSVLAELRRSREREGPAASPAENEEGASEPSPGGIKWGHLFGSRKAQREARPTNRLPSDWLSLDKSMFQLVAQTVGSRREPEPKESLQEPHSPALPSSPPCEVQALCHHLATGPGQLSFHKGDILRVLGRAGGDWLRCSRGPDSGLVPLAYVTLTPTPSPTPGSSQN

Target ORF information:

RefSeq Version	NM_001330740.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001330740.2

ORF Insert Sequence:

ATGGCCACCA GGCCCAGTAA TGCCAACCAC CTATCCCCTC AAGCCCTCAA GTGGCGGGAA 
TACAGGAGGA AGAACCCACT AGGGCCACCT GGTTTGTCAG GGAGCCTAGA CCGAAGATCA 
CAAGAAGCTC GGCTGGCCCG AAGAAACCCT ATCTTTGAGT TCCCTGGCTC CCTCAGTGCT 
GCCAGCCATC TGAACTGCCG GCTGAATGGC CAAGCAGTGA AGCCGTTACC ACTGACCTGC 
CCTGACTTCC AGGACCCCTT TTCCTTGACG GAGAAGCCTC CAGCTGAGTT TTGTCTGTCC 
CCAGATGGCA GCTCAGAGGC CATTTCCATT GACCTGCTTC AGAAAAAAGG GCTGGTAAAA 
GCTGTTAACA TCGCTGTGGA CCTCATTGTG GCTCATTTTG GCACAAGCCG GGATCCCGGG 
GTGAAGGCAA AGCTGGGAAA CAGTTCTGTG AGCCCCAATG TGGGCCACCT GGTTCTGAAG 
TACTTGTGCC CTGCCGTCCG CGCCGTGCTG GAGGATGGGC TCAAGGCCTT TGTACTGGAC 
GTCATCATCG GGCAGCGTAA GAACATGCCA TGGAGTGTGG TTGAGGCTTC CACACAGCTA 
GGCCCATCCA CCAAGGTCCT GCATGGCCTC TACAACAAAG TCAGCCAATT CCCAGAGCTC 
ACCAGTCATA CCATGCGCTT CAACGCCTTC ATCCTCGGCC TGCTCAACAT CCGGTCCCTG 
GAGTTCTGGT TTAATCACCT CTATAACCAC GAAGACATCA TCCAGACCCA CTACCAGCCC 
TGGGGCTTCC TGAGTGCAGC TCATACCGTG TGTCCCGGCC TCTTTGAAGA GCTGCTGCTG 
CTGCTACAGC CCCTGGCCCT GCTGCCCTTC AGCCTCGACT TGCTGTTCCA GCACCGGCTG 
CTGCAAAGTG GGCAGCAGCA GCGGCAGCAC AAGGAACTGC TGCGGGTGTC CCAGGACCTG 
CTGCTGTCTG CCCACTCCAC GCTGCAGCTG GCCCGGGCCC GGGGCCAGGA GGGCCCTGGA 
GACGTGGACA GGGCAGCCCA AGGGGAGCGG GTGAAGGGTG TGGGTGCCTC AGAAGGTGGA 
GAAGAGGAAG AGGAAGAAGA GGAGACAGAA GAGGTGGCAG AGGCAGCCGG GGGCTCAGGG 
CGTGCCAGGT GGGCCCGAGG TGGGCAGGCC GGCTGGTGGT ACCAGCTCAT GCAGAGCTCC 
CAGGTCTACA TCGATGGCTC CATTGAGGGT TCCAGGTTCC CTCGTGGTAG CAGCAACAGC 
AGCAGCGAGA AAAAGAAAGG GGCAGGAGGT GGGGGACCTC CCCAGGCTCC ACCACCCCGA 
GAGGGAGTAG TGGAGGGGGC TGAGGCCTGC CCTGCCTCTG AGGAGGCCCT GGGCCGGGAA 
AGGGGCTGGC CCTTCTGGAT GGGGAGCCCC CCTGACTCTG TGCTGGCCGA GCTGAGGCGC 
AGTCGGGAGA GGGAAGGGCC CGCTGCCTCG CCAGCAGAAA ATGAGGAAGG GGCCTCAGAG 
CCTTCACCTG GAGGCATCAA GTGGGGACAC CTCTTTGGCT CCCGAAAAGC CCAGCGGGAG 
GCCCGGCCCA CAAATAGGCT CCCCTCGGAC TGGCTGAGCC TGGACAAGTC CATGTTCCAA 
CTAGTGGCGC AGACAGTGGG TTCCCGCCGG GAGCCAGAGC CCAAGGAGAG CCTGCAGGAG 
CCACACTCCC CAGCCCTGCC CTCCAGTCCT CCGTGTGAGG TGCAGGCACT GTGCCACCAC 
CTGGCCACCG GCCCTGGACA GCTGAGCTTC CACAAAGGAG ACATCCTACG AGTGCTGGGG 
CGAGCTGGAG GAGACTGGCT GCGCTGCAGC CGTGGCCCCG ACTCTGGCCT GGTGCCCCTG 
GCCTACGTGA CATTGACCCC AACTCCAAGT CCAACCCCTG GAAGCAGCCA AAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RUSC2 ( NM_014806.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055621.2 Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu107240
Clone ID Related Accession (Same CDS sequence)	NM_014806.5
Accession Version	NM_014806.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4551bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	iporin isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL133476.17. On Nov 23, 2018 this sequence version replaced NM_014806.4. Transcript Variant: This variant (2) contains an alternate 5' terminal exon and thus differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AB002373.2, SRR1803611.150051.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361226.8/ ENSP00000355177.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATAGTC CCCCAAAGCT GACTGGAGAG ACCCTCATCG TTCATCACAT CCCCCTGGTG 
CACTGCCAAG TCCCAGACAG GCAGTGCTGT GGAGGGGCAG GTGGAGGTGG TGGGAGCACA 
AGACCTAATC CCTTCTGCCC ACCTGAGCTG GGCATCACCC AGCCCGATCA AGACCTAGGA 
CAAGCTGACT CCCTGCTATT CAGCAGCCTG CACTCTACTC CAGGAGGAAC TGCACGGTCT 
ATAGACAGCA CCAAGAGTAG GAGTCGGGAT GGAAGAGGCC CTGGAGCCCC CAAACGACAC 
AACCCCTTCT TGCTGCAGGA GGGTGTGGGT GAGCCAGGAC TTGGTGACCT GTATGATGAC 
AGCATTGGTG ACAGTGCCAC CCAGCAGTCC TTCCACCTGC ATGGCACTGG CCAGCCCAAC 
TTTCATCTAT CCTCTTTCCA GCTGCCACCA TCTGGCCCCA GAGTGGGCAG GCCATGGGGG 
ACAACACGCA GTCGGGCTGG AGTGGTGGAA GGGCAGGAAC AGGAGCCAGT GATGACCTTG 
GATACTCAGC AGTGCGGCAC CAGCCACTGC TGCCGGCCAG AGCTGGAAGC AGAGACTATG 
GAGCTGGATG AGTGTGGGGG ACCTGGTGGG AGTGGCAGTG GGGGTGGAGC CAGCGATACC 
TCTGGCTTTT CCTTTGACCA GGAATGGAAG CTCAGTTCAG ATGAATCCCC AAGGAACCCT 
GGATGCTCCG GCTCAGGGGA CCAGCACTGC CGCTGCAGTA GCACATCCAG TCAGTCCGAG 
GCAGCTGACC AGTCCATGGG CTATGTGAGC GACTCCTCCT GCAACAGTTC AGATGGTGTG 
CTGGTCACCT TCAGCACCCT CTACAACAAG ATGCATGGCA CCCCCCGTGC CAATCTCAAC 
TCTGCCCCAC AGTCCTGCAG CGACTCTTCC TTCTGCAGCC ACTCAGACCC TGGCGCCTTC 
TATCTGGATC TGCAGCCCTC CCCATTTGAG TCTAAGATGT CTTATGAGTC CCATCACCCT 
GAAAGTGGAG GAAGGGAAGG GGGCTATGGT TGCCCTCATG CCTCTTCTCC TGAGCTTGAT 
GCCAACTGCA ACTCCTACCG CCCACACTGT GAGCCGTGCC CAGCAGTGGC TGACCTCACA 
GCCTGCTTCC AAAGCCAGGC CCGTCTTGTT GTGGCCACAC AAAATTACTA TAAACTTGTC 
ACCTGTGACC TATCTTCCCA ATCATCCCCA AGCCCTGCTG GCTCTTCCAT CACTAGCTGC 
TCTGAGGAAC ACACCAAGAT AAGTCCCCCA CCAGGCCCTG GCCCAGACCC AGGCCCCAGC 
CAGCCCTCTG AGTATTACCT ATTCCAGAAG CCAGAAGTCC AGCCAGAGGA ACAAGAAGCA 
GTGAGTTCCT CCACCCAAGC AGCAGCTGCT GTGGGCCCCA CTGTGCTTGA GGGACAAGTA 
TACACGAATA CTTCACCCCC CAACCTCAGC ACTGGACGTC AGCGCTCCCG CAGCTATGAT 
CGCAGCCTGC AGCGCAGCCC TCCTGTCCGC CTGGGCTCGC TGGAACGTAT GTTGAGTTGC 
CCAGTGCGCT TGAGTGAGGG CCCTGCAGCC ATGGCCGGGC CTGGCTCCCC ACCCAGGAGG 
GTCACCTCCT TTGCCGAGCT GGCCAAGGGC CGGAAGAAAA CTGGAGGCTC TGGCTCGCCC 
CCACTTCGTG TGAGTGTTGG GGACTCCTCC CAGGAGTTCT CACCCATCCA AGAAGCCCAG 
CAAGATCGGG GGGCCCCACT GGATGAGGGC ACTTGCTGTA GCCATAGCCT GCCACCCATG 
CCTTTGGGGC CAGGCATGGA CCTACTTGGC CCAGACCCAA GTCCACCCTG GTCCACCCAG 
GTCTGTCAGG GACCCCACTC CAGTGAGATG CCTCCTGCTG GCCTCAGAGC TACTGGGCAA 
GGCCCCCTGG CTCAGCTGAT GGATCCAGGG CCTGCTCTCC CAGGGAGCCC AGCCAACAGC 
CATACCCAGA GGGATGCAAG AGCTAGAGCT GACGGGGGTG GCACCGAGAG CCGACCAGTC 
CTTCGCTACA GCAAGGAACA GAGGCCAACC ACACTGCCCA TCCAGCCCTT CGTGTTCCAG 
CACCACTTCC CCAAGCAGCT GGCCAAGGCC CGGGCCCTCC ACAGCCTTTC CCAGCTCTAC 
AGCCTCTCAG GCTGCAGCCG TACACAGCAG CCTGCCCCAC TGGCTGCCCC TGCTGCTCAA 
GTCTCAGTCC CAGCTCCCTC AGGGGAACCG CAGGCATCCA CTCCCCGAGC CACTGGCAGA 
GGTGCCAGGA AAGCTGGGTC TGAGCCAGAG ACCTCTCGGC CATCGCCCCT GGGCAGCTAC 
TCCCCCATCC GGAGTGTTGG CCCCTTTGGG CCCAGCACTG ACTCTTCTGC CTCCACTTCG 
TGCTCCCCTC CCCCAGAGCA GCCCACAGCC ACAGAAAGCC TGCCCCCATG GAGCCACTCC 
TGTCCTTCTG CTGTCCGGCC TGCCACCTCC CAGCAGCCGC AGAAGGAGGA TCAGAAGATA 
CTGACCTTGA CTGAGTACCG GCTCCATGGA ACAGGAAGCT TGCCGCCTCT GGGCTCCTGG 
CGATCTGGCC TCAGCCGAGC AGAGAGCCTG GCCCGGGGAG GTGGTGAGGG CAGCATGGCC 
ACCAGGCCCA GTAATGCCAA CCACCTATCC CCTCAAGCCC TCAAGTGGCG GGAATACAGG 
AGGAAGAACC CACTAGGGCC ACCTGGTTTG TCAGGGAGCC TAGACCGAAG ATCACAAGAA 
GCTCGGCTGG CCCGAAGAAA CCCTATCTTT GAGTTCCCTG GCTCCCTCAG TGCTGCCAGC 
CATCTGAACT GCCGGCTGAA TGGCCAAGCA GTGAAGCCGT TACCACTGAC CTGCCCTGAC 
TTCCAGGACC CCTTTTCCTT GACGGAGAAG CCTCCAGCTG AGTTTTGTCT GTCCCCAGAT 
GGCAGCTCAG AGGCCATTTC CATTGACCTG CTTCAGAAAA AAGGGCTGGT AAAAGCTGTT 
AACATCGCTG TGGACCTCAT TGTGGCTCAT TTTGGCACAA GCCGGGATCC CGGGGTGAAG 
GCAAAGCTGG GAAACAGTTC TGTGAGCCCC AATGTGGGCC ACCTGGTTCT GAAGTACTTG 
TGCCCTGCCG TCCGCGCCGT GCTGGAGGAT GGGCTCAAGG CCTTTGTACT GGACGTCATC 
ATCGGGCAGC GTAAGAACAT GCCATGGAGT GTGGTTGAGG CTTCCACACA GCTAGGCCCA 
TCCACCAAGG TCCTGCATGG CCTCTACAAC AAAGTCAGCC AATTCCCAGA GCTCACCAGT 
CATACCATGC GCTTCAACGC CTTCATCCTC GGCCTGCTCA ACATCCGGTC CCTGGAGTTC 
TGGTTTAATC ACCTCTATAA CCACGAAGAC ATCATCCAGA CCCACTACCA GCCCTGGGGC 
TTCCTGAGTG CAGCTCATAC CGTGTGTCCC GGCCTCTTTG AAGAGCTGCT GCTGCTGCTA 
CAGCCCCTGG CCCTGCTGCC CTTCAGCCTC GACTTGCTGT TCCAGCACCG GCTGCTGCAA 
AGTGGGCAGC AGCAGCGGCA GCACAAGGAA CTGCTGCGGG TGTCCCAGGA CCTGCTGCTG 
TCTGCCCACT CCACGCTGCA GCTGGCCCGG GCCCGGGGCC AGGAGGGCCC TGGAGACGTG 
GACAGGGCAG CCCAAGGGGA GCGGGTGAAG GGTGTGGGTG CCTCAGAAGG TGGAGAAGAG 
GAAGAGGAAG AAGAGGAGAC AGAAGAGGTG GCAGAGGCAG CCGGGGGCTC AGGGCGTGCC 
AGGTGGGCCC GAGGTGGGCA GGCCGGCTGG TGGTACCAGC TCATGCAGAG CTCCCAGGTC 
TACATCGATG GCTCCATTGA GGGTTCCAGG TTCCCTCGTG GTAGCAGCAA CAGCAGCAGC 
GAGAAAAAGA AAGGGGCAGG AGGTGGGGGA CCTCCCCAGG CTCCACCACC CCGAGAGGGA 
GTAGTGGAGG GGGCTGAGGC CTGCCCTGCC TCTGAGGAGG CCCTGGGCCG GGAAAGGGGC 
TGGCCCTTCT GGATGGGGAG CCCCCCTGAC TCTGTGCTGG CCGAGCTGAG GCGCAGTCGG 
GAGAGGGAAG GGCCCGCTGC CTCGCCAGCA GAAAATGAGG AAGGGGCCTC AGAGCCTTCA 
CCTGGAGGCA TCAAGTGGGG ACACCTCTTT GGCTCCCGAA AAGCCCAGCG GGAGGCCCGG 
CCCACAAATA GGCTCCCCTC GGACTGGCTG AGCCTGGACA AGTCCATGTT CCAACTAGTG 
GCGCAGACAG TGGGTTCCCG CCGGGAGCCA GAGCCCAAGG AGAGCCTGCA GGAGCCACAC 
TCCCCAGCCC TGCCCTCCAG TCCTCCGTGT GAGGTGCAGG CACTGTGCCA CCACCTGGCC 
ACCGGCCCTG GACAGCTGAG CTTCCACAAA GGAGACATCC TACGAGTGCT GGGGCGAGCT 
GGAGGAGACT GGCTGCGCTG CAGCCGTGGC CCCGACTCTG GCCTGGTGCC CCTGGCCTAC 
GTGACATTGA CCCCAACTCC AAGTCCAACC CCTGGAAGCA GCCAAAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055621.2
CDS	155..4705
Translation	MDSPPKLTGETLIVHHIPLVHCQVPDRQCCGGAGGGGGSTRPNPFCPPELGITQPDQDLGQADSLLFSSLHSTPGGTARSIDSTKSRSRDGRGPGAPKRHNPFLLQEGVGEPGLGDLYDDSIGDSATQQSFHLHGTGQPNFHLSSFQLPPSGPRVGRPWGTTRSRAGVVEGQEQEPVMTLDTQQCGTSHCCRPELEAETMELDECGGPGGSGSGGGASDTSGFSFDQEWKLSSDESPRNPGCSGSGDQHCRCSSTSSQSEAADQSMGYVSDSSCNSSDGVLVTFSTLYNKMHGTPRANLNSAPQSCSDSSFCSHSDPGAFYLDLQPSPFESKMSYESHHPESGGREGGYGCPHASSPELDANCNSYRPHCEPCPAVADLTACFQSQARLVVATQNYYKLVTCDLSSQSSPSPAGSSITSCSEEHTKISPPPGPGPDPGPSQPSEYYLFQKPEVQPEEQEAVSSSTQAAAAVGPTVLEGQVYTNTSPPNLSTGRQRSRSYDRSLQRSPPVRLGSLERMLSCPVRLSEGPAAMAGPGSPPRRVTSFAELAKGRKKTGGSGSPPLRVSVGDSSQEFSPIQEAQQDRGAPLDEGTCCSHSLPPMPLGPGMDLLGPDPSPPWSTQVCQGPHSSEMPPAGLRATGQGPLAQLMDPGPALPGSPANSHTQRDARARADGGGTESRPVLRYSKEQRPTTLPIQPFVFQHHFPKQLAKARALHSLSQLYSLSGCSRTQQPAPLAAPAAQVSVPAPSGEPQASTPRATGRGARKAGSEPETSRPSPLGSYSPIRSVGPFGPSTDSSASTSCSPPPEQPTATESLPPWSHSCPSAVRPATSQQPQKEDQKILTLTEYRLHGTGSLPPLGSWRSGLSRAESLARGGGEGSMATRPSNANHLSPQALKWREYRRKNPLGPPGLSGSLDRRSQEARLARRNPIFEFPGSLSAASHLNCRLNGQAVKPLPLTCPDFQDPFSLTEKPPAEFCLSPDGSSEAISIDLLQKKGLVKAVNIAVDLIVAHFGTSRDPGVKAKLGNSSVSPNVGHLVLKYLCPAVRAVLEDGLKAFVLDVIIGQRKNMPWSVVEASTQLGPSTKVLHGLYNKVSQFPELTSHTMRFNAFILGLLNIRSLEFWFNHLYNHEDIIQTHYQPWGFLSAAHTVCPGLFEELLLLLQPLALLPFSLDLLFQHRLLQSGQQQRQHKELLRVSQDLLLSAHSTLQLARARGQEGPGDVDRAAQGERVKGVGASEGGEEEEEEEETEEVAEAAGGSGRARWARGGQAGWWYQLMQSSQVYIDGSIEGSRFPRGSSNSSSEKKKGAGGGGPPQAPPPREGVVEGAEACPASEEALGRERGWPFWMGSPPDSVLAELRRSREREGPAASPAENEEGASEPSPGGIKWGHLFGSRKAQREARPTNRLPSDWLSLDKSMFQLVAQTVGSRREPEPKESLQEPHSPALPSSPPCEVQALCHHLATGPGQLSFHKGDILRVLGRAGGDWLRCSRGPDSGLVPLAYVTLTPTPSPTPGSSQN

Target ORF information:

RefSeq Version	NM_014806.5
Organism	Homo sapiens(human)
Definition	Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014806.5

ORF Insert Sequence:

ATGGATAGTC CCCCAAAGCT GACTGGAGAG ACCCTCATCG TTCATCACAT CCCCCTGGTG 
CACTGCCAAG TCCCAGACAG GCAGTGCTGT GGAGGGGCAG GTGGAGGTGG TGGGAGCACA 
AGACCTAATC CCTTCTGCCC ACCTGAGCTG GGCATCACCC AGCCCGATCA AGACCTAGGA 
CAAGCTGACT CCCTGCTATT CAGCAGCCTG CACTCTACTC CAGGAGGAAC TGCACGGTCT 
ATAGACAGCA CCAAGAGTAG GAGTCGGGAT GGAAGAGGCC CTGGAGCCCC CAAACGACAC 
AACCCCTTCT TGCTGCAGGA GGGTGTGGGT GAGCCAGGAC TTGGTGACCT GTATGATGAC 
AGCATTGGTG ACAGTGCCAC CCAGCAGTCC TTCCACCTGC ATGGCACTGG CCAGCCCAAC 
TTTCATCTAT CCTCTTTCCA GCTGCCACCA TCTGGCCCCA GAGTGGGCAG GCCATGGGGG 
ACAACACGCA GTCGGGCTGG AGTGGTGGAA GGGCAGGAAC AGGAGCCAGT GATGACCTTG 
GATACTCAGC AGTGCGGCAC CAGCCACTGC TGCCGGCCAG AGCTGGAAGC AGAGACTATG 
GAGCTGGATG AGTGTGGGGG ACCTGGTGGG AGTGGCAGTG GGGGTGGAGC CAGCGATACC 
TCTGGCTTTT CCTTTGACCA GGAATGGAAG CTCAGTTCAG ATGAATCCCC AAGGAACCCT 
GGATGCTCCG GCTCAGGGGA CCAGCACTGC CGCTGCAGTA GCACATCCAG TCAGTCCGAG 
GCAGCTGACC AGTCCATGGG CTATGTGAGC GACTCCTCCT GCAACAGTTC AGATGGTGTG 
CTGGTCACCT TCAGCACCCT CTACAACAAG ATGCATGGCA CCCCCCGTGC CAATCTCAAC 
TCTGCCCCAC AGTCCTGCAG CGACTCTTCC TTCTGCAGCC ACTCAGACCC TGGCGCCTTC 
TATCTGGATC TGCAGCCCTC CCCATTTGAG TCTAAGATGT CTTATGAGTC CCATCACCCT 
GAAAGTGGAG GAAGGGAAGG GGGCTATGGT TGCCCTCATG CCTCTTCTCC TGAGCTTGAT 
GCCAACTGCA ACTCCTACCG CCCACACTGT GAGCCGTGCC CAGCAGTGGC TGACCTCACA 
GCCTGCTTCC AAAGCCAGGC CCGTCTTGTT GTGGCCACAC AAAATTACTA TAAACTTGTC 
ACCTGTGACC TATCTTCCCA ATCATCCCCA AGCCCTGCTG GCTCTTCCAT CACTAGCTGC 
TCTGAGGAAC ACACCAAGAT AAGTCCCCCA CCAGGCCCTG GCCCAGACCC AGGCCCCAGC 
CAGCCCTCTG AGTATTACCT ATTCCAGAAG CCAGAAGTCC AGCCAGAGGA ACAAGAAGCA 
GTGAGTTCCT CCACCCAAGC AGCAGCTGCT GTGGGCCCCA CTGTGCTTGA GGGACAAGTA 
TACACGAATA CTTCACCCCC CAACCTCAGC ACTGGACGTC AGCGCTCCCG CAGCTATGAT 
CGCAGCCTGC AGCGCAGCCC TCCTGTCCGC CTGGGCTCGC TGGAACGTAT GTTGAGTTGC 
CCAGTGCGCT TGAGTGAGGG CCCTGCAGCC ATGGCCGGGC CTGGCTCCCC ACCCAGGAGG 
GTCACCTCCT TTGCCGAGCT GGCCAAGGGC CGGAAGAAAA CTGGAGGCTC TGGCTCGCCC 
CCACTTCGTG TGAGTGTTGG GGACTCCTCC CAGGAGTTCT CACCCATCCA AGAAGCCCAG 
CAAGATCGGG GGGCCCCACT GGATGAGGGC ACTTGCTGTA GCCATAGCCT GCCACCCATG 
CCTTTGGGGC CAGGCATGGA CCTACTTGGC CCAGACCCAA GTCCACCCTG GTCCACCCAG 
GTCTGTCAGG GACCCCACTC CAGTGAGATG CCTCCTGCTG GCCTCAGAGC TACTGGGCAA 
GGCCCCCTGG CTCAGCTGAT GGATCCAGGG CCTGCTCTCC CAGGGAGCCC AGCCAACAGC 
CATACCCAGA GGGATGCAAG AGCTAGAGCT GACGGGGGTG GCACCGAGAG CCGACCAGTC 
CTTCGCTACA GCAAGGAACA GAGGCCAACC ACACTGCCCA TCCAGCCCTT CGTGTTCCAG 
CACCACTTCC CCAAGCAGCT GGCCAAGGCC CGGGCCCTCC ACAGCCTTTC CCAGCTCTAC 
AGCCTCTCAG GCTGCAGCCG TACACAGCAG CCTGCCCCAC TGGCTGCCCC TGCTGCTCAA 
GTCTCAGTCC CAGCTCCCTC AGGGGAACCG CAGGCATCCA CTCCCCGAGC CACTGGCAGA 
GGTGCCAGGA AAGCTGGGTC TGAGCCAGAG ACCTCTCGGC CATCGCCCCT GGGCAGCTAC 
TCCCCCATCC GGAGTGTTGG CCCCTTTGGG CCCAGCACTG ACTCTTCTGC CTCCACTTCG 
TGCTCCCCTC CCCCAGAGCA GCCCACAGCC ACAGAAAGCC TGCCCCCATG GAGCCACTCC 
TGTCCTTCTG CTGTCCGGCC TGCCACCTCC CAGCAGCCGC AGAAGGAGGA TCAGAAGATA 
CTGACCTTGA CTGAGTACCG GCTCCATGGA ACAGGAAGCT TGCCGCCTCT GGGCTCCTGG 
CGATCTGGCC TCAGCCGAGC AGAGAGCCTG GCCCGGGGAG GTGGTGAGGG CAGCATGGCC 
ACCAGGCCCA GTAATGCCAA CCACCTATCC CCTCAAGCCC TCAAGTGGCG GGAATACAGG 
AGGAAGAACC CACTAGGGCC ACCTGGTTTG TCAGGGAGCC TAGACCGAAG ATCACAAGAA 
GCTCGGCTGG CCCGAAGAAA CCCTATCTTT GAGTTCCCTG GCTCCCTCAG TGCTGCCAGC 
CATCTGAACT GCCGGCTGAA TGGCCAAGCA GTGAAGCCGT TACCACTGAC CTGCCCTGAC 
TTCCAGGACC CCTTTTCCTT GACGGAGAAG CCTCCAGCTG AGTTTTGTCT GTCCCCAGAT 
GGCAGCTCAG AGGCCATTTC CATTGACCTG CTTCAGAAAA AAGGGCTGGT AAAAGCTGTT 
AACATCGCTG TGGACCTCAT TGTGGCTCAT TTTGGCACAA GCCGGGATCC CGGGGTGAAG 
GCAAAGCTGG GAAACAGTTC TGTGAGCCCC AATGTGGGCC ACCTGGTTCT GAAGTACTTG 
TGCCCTGCCG TCCGCGCCGT GCTGGAGGAT GGGCTCAAGG CCTTTGTACT GGACGTCATC 
ATCGGGCAGC GTAAGAACAT GCCATGGAGT GTGGTTGAGG CTTCCACACA GCTAGGCCCA 
TCCACCAAGG TCCTGCATGG CCTCTACAAC AAAGTCAGCC AATTCCCAGA GCTCACCAGT 
CATACCATGC GCTTCAACGC CTTCATCCTC GGCCTGCTCA ACATCCGGTC CCTGGAGTTC 
TGGTTTAATC ACCTCTATAA CCACGAAGAC ATCATCCAGA CCCACTACCA GCCCTGGGGC 
TTCCTGAGTG CAGCTCATAC CGTGTGTCCC GGCCTCTTTG AAGAGCTGCT GCTGCTGCTA 
CAGCCCCTGG CCCTGCTGCC CTTCAGCCTC GACTTGCTGT TCCAGCACCG GCTGCTGCAA 
AGTGGGCAGC AGCAGCGGCA GCACAAGGAA CTGCTGCGGG TGTCCCAGGA CCTGCTGCTG 
TCTGCCCACT CCACGCTGCA GCTGGCCCGG GCCCGGGGCC AGGAGGGCCC TGGAGACGTG 
GACAGGGCAG CCCAAGGGGA GCGGGTGAAG GGTGTGGGTG CCTCAGAAGG TGGAGAAGAG 
GAAGAGGAAG AAGAGGAGAC AGAAGAGGTG GCAGAGGCAG CCGGGGGCTC AGGGCGTGCC 
AGGTGGGCCC GAGGTGGGCA GGCCGGCTGG TGGTACCAGC TCATGCAGAG CTCCCAGGTC 
TACATCGATG GCTCCATTGA GGGTTCCAGG TTCCCTCGTG GTAGCAGCAA CAGCAGCAGC 
GAGAAAAAGA AAGGGGCAGG AGGTGGGGGA CCTCCCCAGG CTCCACCACC CCGAGAGGGA 
GTAGTGGAGG GGGCTGAGGC CTGCCCTGCC TCTGAGGAGG CCCTGGGCCG GGAAAGGGGC 
TGGCCCTTCT GGATGGGGAG CCCCCCTGAC TCTGTGCTGG CCGAGCTGAG GCGCAGTCGG 
GAGAGGGAAG GGCCCGCTGC CTCGCCAGCA GAAAATGAGG AAGGGGCCTC AGAGCCTTCA 
CCTGGAGGCA TCAAGTGGGG ACACCTCTTT GGCTCCCGAA AAGCCCAGCG GGAGGCCCGG 
CCCACAAATA GGCTCCCCTC GGACTGGCTG AGCCTGGACA AGTCCATGTT CCAACTAGTG 
GCGCAGACAG TGGGTTCCCG CCGGGAGCCA GAGCCCAAGG AGAGCCTGCA GGAGCCACAC 
TCCCCAGCCC TGCCCTCCAG TCCTCCGTGT GAGGTGCAGG CACTGTGCCA CCACCTGGCC 
ACCGGCCCTG GACAGCTGAG CTTCCACAAA GGAGACATCC TACGAGTGCT GGGGCGAGCT 
GGAGGAGACT GGCTGCGCTG CAGCCGTGGC CCCGACTCTG GCCTGGTGCC CCTGGCCTAC 
GTGACATTGA CCCCAACTCC AAGTCCAACC CCTGGAAGCA GCCAAAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RUSC2 ( NM_001135999.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001129471.1 Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript variant 1, mRNA.

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CloneID	OHu21992
Clone ID Related Accession (Same CDS sequence)	NM_001135999.1 , NM_014806.4
Accession Version	NM_001135999.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4551bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Homo sapiens(human)
Product	iporin isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA185385.1, AL133476.17, BC146654.1 and AI818507.1. Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein (isoform 1). ##Evidence-Data-START## Transcript exon combination :: SRR1803613.60888.1, BC146654.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATAGTC CCCCAAAGCT GACTGGAGAG ACCCTCATCG TTCATCACAT CCCCCTGGTG 
CACTGCCAAG TCCCAGACAG GCAGTGCTGT GGAGGGGCAG GTGGAGGTGG TGGGAGCACA 
AGACCTAATC CCTTCTGCCC ACCTGAGCTG GGCATCACCC AGCCCGATCA AGACCTAGGA 
CAAGCTGACT CCCTGCTATT CAGCAGCCTG CACTCTGCTC CAGGAGGAAC TGCACGGTCT 
ATAGACAGCA CCAAGAGTAG GAGTCGGGAT GGAAGAGGCC CTGGAGCCCC CAAACGACAC 
AACCCCTTCT TGCTGCAGGA GGGTGTGGGT GAGCCAGGAC TTGGTGACCT GTATGATGAC 
AGCATTGGTG ACAGTGCCAC CCAGCAGTCC TTCCACCTGC ATGGCACTGG CCAGCCCAAC 
TTTCATCTAT CCTCTTTCCA GCTGCCACCA TCTGGCCCCA GAGTGGGCAG GCCATGGGGG 
ACAACACGCA GTCGGGCTGG AGTGGTGGAA GGGCAGGAAC AGGAGCCAGT GATGACCTTG 
GATACTCAGC AGTGCGGCAC CAGCCACTGC TGCCGGCCAG AGCTGGAAGC AGAGACTATG 
GAGCTGGATG AGTGTGGGGG ACCTGGTGGG AGTGGCAGTG GGGGTGGAGC CAGCGATACC 
TCTGGCTTTT CCTTTGACCA GGAATGGAAG CTCAGTTCAG ATGAATCCCC AAGGAACCCT 
GGATGCTCCG GCTCAGGGGA CCAGCACTGC CGCTGCAGTA GCACATCCAG TCAGTCCGAG 
GCAGCTGACC AGTCCATGGG CTATGTGAGC GACTCCTCCT GCAACAGTTC AGATGGTGTG 
CTGGTCACCT TCAGCACCCT CTACAACAAG ATGCATGGCA CCCCCCGTGC CAATCTCAAC 
TCTGCCCCAC AGTCCTGCAG CGACTCTTCC TTCTGCAGCC ACTCAGACCC TGGCGCCTTC 
TATCTGGATC TGCAGCCCTC CCCATTTGAG TCTAAGATGT CTTATGAGTC CCATCACCCT 
GAAAGTGGAG GAAGGGAAGG GGGCTATGGT TGCCCTCATG CCTCTTCTCC TGAGCTTGAT 
GCCAACTGCA ACTCCTACCG CCCACACTGT GAGCCGTGCC CAGCAGTGGC TGACCTCACA 
GCCTGCTTCC AAAGCCAGGC CCGTCTTGTT GTGGCCACAC AAAATTACTA TAAACTTGTC 
ACCTGTGACC TATCTTCCCA ATCATCCCCA AGCCCTGCTG GCTCTTCCAT CACTAGCTGC 
TCTGAGGAAC ACACCAAGAT AAGTCCCCCA CCAGGCCCTG GCCCAGACCC AGGCCCCAGC 
CAGCCCTCTG AGTATTACCT ATTCCAGAAG CCAGAAGTCC AGCCAGAGGA ACAAGAAGCA 
GTGAGTTCCT CCACCCAAGC AGCAGCTGCT GTGGGCCCCA CTGTGCTTGA GGGACAAGTA 
TACACGAATA CTTCACCCCC CAACCTCAGC ACTGGACGTC AGCGCTCCCG CAGCTATGAT 
CGCAGCCTGC AGCGCAGCCC TCCTGTCCGC CTGGGCTCGC TGGAACGTAT GTTGAGTTGC 
CCAGTGCGCT TGAGTGAGGG CCCTGCAGCC ATGGCCGGGC CTGGCTCCCC ACCCAGGAGG 
GTCACCTCCT TTGCCGAGCT GGCCAAGGGC CGGAAGAAAA CTGGAGGCTC TGGCTCGCCC 
CCACTTCGTG TGAGTGTTGG GGACTCCTCC CAGGAGTTCT CACCCATCCA AGAAGCCCAG 
CAAGATCGGG GGGCCCCACT GGATGAGGGC ACTTGCTGTA GCCATAGCCT GCCACCCATG 
CCTTTGGGGC CAGGCATGGA CCTACTTGGC CCAGACCCAA GTCCACCCTG GTCCACCCAG 
GTCTGTCAGG GACCCCACTC CAGTGAGATG CCTCCTGCTG GCCTCAGAGC TACTGGGCAA 
GGCCCCCTGG CTCAGCTGAT GGATCCAGGG CCTGCTCTCC CAGGGAGCCC AGCCAACAGC 
CATACCCAGA GGGATGCAAG AGCTAGAGCT GACGGGGGTG GCACCGAGAG CCGACCAGTC 
CTTCGCTACA GCAAGGAACA GAGGCCAACC ACACTGCCCA TCCAGCCCTT CGTGTTCCAG 
CACCACTTCC CCAAGCAGCT GGCCAAGGCC CGGGCCCTCC ACAGCCTTTC CCAGCTCTAC 
AGCCTCTCAG GCTGCAGCCG TACACAGCAG CCTGCCCCAC TGGCTGCCCC TGCTGCTCAA 
GTCTCAGTCC CAGCTCCCTC AGGGGAACCG CAGGCATCCA CTCCCCGAGC CACTGGCAGA 
GGTGCCAGGA AAGCTGGGTC TGAGCCAGAG ACCTCTCGGC CATCGCCCCT GGGCAGCTAC 
TCCCCCATCC GGAGTGTTGG CCCCTTTGGG CCCAGCACTG ACTCTTCTGC CTCCACTTCG 
TGCTCCCCTC CCCCAGAGCA GCCCACAGCC ACAGAAAGCC TGCCCCCATG GAGCCACTCC 
TGTCCTTCTG CTGTCCGGCC TGCCACCTCC CAGCAGCCGC AGAAGGAGGA TCAGAAGATA 
CTGACCTTGA CTGAGTACCG GCTCCATGGA ACAGGAAGCT TGCCGCCTCT GGGCTCCTGG 
CGATCTGGCC TCAGCCGAGC AGAGAGCCTG GCCCGGGGAG GTGGTGAGGG CAGCATGGCC 
ACCAGGCCCA GTAATGCCAA CCACCTATCC CCTCAAGCCC TCAAGTGGCG GGAATACAGG 
AGGAAGAACC CACTAGGGCC ACCTGGTTTG TCAGGGAGCC TAGACCGAAG ATCACAAGAA 
GCTCGGCTGG CCCGAAGAAA CCCTATCTTT GAGTTCCCTG GCTCCCTCAG TGCTGCCAGC 
CATCTGAACT GCCGGCTGAA TGGCCAAGCA GTGAAGCCGT TACCACTGAC CTGCCCTGAC 
TTCCAGGACC CCTTTTCCTT GACGGAGAAG CCTCCAGCTG AGTTTTGTCT GTCCCCAGAT 
GGCAGCTCAG AGGCCATTTC CATTGACCTG CTTCAGAAAA AAGGGCTGGT AAAAGCTGTT 
AACATCGCTG TGGACCTCAT TGTGGCTCAT TTTGGCACAA GCCGGGATCC CGGGGTGAAG 
GCAAAGCTGG GAAACAGTTC TGTGAGCCCC AATGTGGGCC ACCTGGTTCT GAAGTACTTG 
TGCCCTGCCG TCCGCGCCGT GCTGGAGGAT GGGCTCAAGG CCTTTGTACT GGACGTCATC 
ATCGGGCAGC GTAAGAACAT GCCATGGAGT GTGGTTGAGG CTTCCACACA GCTAGGCCCA 
TCCACCAAGG TCCTGCATGG CCTCTACAAC AAAGTCAGCC AATTCCCAGA GCTCACCAGT 
CATACCATGC GCTTCAACGC CTTCATCCTC GGCCTGCTCA ACATCCGGTC CCTGGAGTTC 
TGGTTTAATC ACCTCTATAA CCACGAAGAC ATCATCCAGA CCCACTACCA GCCCTGGGGC 
TTCCTGAGTG CAGCTCATAC CGTGTGTCCC GGCCTCTTTG AAGAGCTGCT GCTGCTGCTA 
CAGCCCCTGG CCCTGCTGCC CTTCAGCCTC GACTTGCTGT TCCAGCACCG GCTGCTGCAA 
AGTGGGCAGC AGCAGCGGCA GCACAAGGAA CTGCTGCGGG TGTCCCAGGA CCTGCTGCTG 
TCTGCCCACT CCACGCTGCA GCTGGCCCGG GCCCGGGGCC AGGAGGGCCC TGGAGACGTG 
GACAGGGCAG CCCAAGGGGA GCGGGTGAAG GGTGTGGGTG CCTCAGAAGG TGGAGAAGAG 
GAAGAGGAAG AAGAGGAGAC AGAAGAGGTG GCAGAGGCAG CCGGGGGCTC AGGGCGTGCC 
AGGTGGGCCC GAGGTGGGCA GGCCGGCTGG TGGTACCAGC TCATGCAGAG CTCCCAGGTC 
TACATCGATG GCTCCATTGA GGGTTCCAGG TTCCCTCGTG GTAGCAGCAA CAGCAGCAGC 
GAGAAAAAGA AAGGGGCAGG AGGTGGGGGA CCTCCCCAGG CTCCACCACC CCGAGAGGGA 
GTAGTGGAGG GGGCTGAGGC CTGCCCTGCC TCTGAGGAGG CCCTGGGCCG GGAAAGGGGC 
TGGCCCTTCT GGATGGGGAG CCCCCCTGAC TCTGTGCTGG CCGAGCTGAG GCGCAGTCGG 
GAGAGGGAAG GGCCCGCTGC CTCGCCAGCA GAAAATGAGG AAGGGGCCTC AGAGCCTTCA 
CCTGGAGGCA TCAAGTGGGG ACACCTCTTT GGCTCCCGAA AAGCCCAGCG GGAGGCCCGG 
CCCACAAATA GGCTCCCCTC GGACTGGCTG AGCCTGGACA AGTCCATGTT CCAACTAGTG 
GCGCAGACAG TGGGTTCCCG CCGGGAGCCA GAGCCCAAGG AGAGCCTGCA GGAGCCACAC 
TCCCCAGCCC TGCCCTCCAG TCCTCCGTGT GAGGTGCAGG CACTGTGCCA CCACCTGGCC 
ACCGGCCCTG GACAGCTGAG CTTCCACAAA GGAGACATCC TACGAGTGCT GGGGCGAGCT 
GGAGGAGACT GGCTGCGCTG CAGCCGTGGC CCCGACTCTG GCCTGGTGCC CCTGGCCTAC 
GTGACATTGA CCCCAACTCC AAGTCCAACC CCTGGAAGCA GCCAAAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129471.1
CDS	570..5120
Translation	MDSPPKLTGETLIVHHIPLVHCQVPDRQCCGGAGGGGGSTRPNPFCPPELGITQPDQDLGQADSLLFSSLHSAPGGTARSIDSTKSRSRDGRGPGAPKRHNPFLLQEGVGEPGLGDLYDDSIGDSATQQSFHLHGTGQPNFHLSSFQLPPSGPRVGRPWGTTRSRAGVVEGQEQEPVMTLDTQQCGTSHCCRPELEAETMELDECGGPGGSGSGGGASDTSGFSFDQEWKLSSDESPRNPGCSGSGDQHCRCSSTSSQSEAADQSMGYVSDSSCNSSDGVLVTFSTLYNKMHGTPRANLNSAPQSCSDSSFCSHSDPGAFYLDLQPSPFESKMSYESHHPESGGREGGYGCPHASSPELDANCNSYRPHCEPCPAVADLTACFQSQARLVVATQNYYKLVTCDLSSQSSPSPAGSSITSCSEEHTKISPPPGPGPDPGPSQPSEYYLFQKPEVQPEEQEAVSSSTQAAAAVGPTVLEGQVYTNTSPPNLSTGRQRSRSYDRSLQRSPPVRLGSLERMLSCPVRLSEGPAAMAGPGSPPRRVTSFAELAKGRKKTGGSGSPPLRVSVGDSSQEFSPIQEAQQDRGAPLDEGTCCSHSLPPMPLGPGMDLLGPDPSPPWSTQVCQGPHSSEMPPAGLRATGQGPLAQLMDPGPALPGSPANSHTQRDARARADGGGTESRPVLRYSKEQRPTTLPIQPFVFQHHFPKQLAKARALHSLSQLYSLSGCSRTQQPAPLAAPAAQVSVPAPSGEPQASTPRATGRGARKAGSEPETSRPSPLGSYSPIRSVGPFGPSTDSSASTSCSPPPEQPTATESLPPWSHSCPSAVRPATSQQPQKEDQKILTLTEYRLHGTGSLPPLGSWRSGLSRAESLARGGGEGSMATRPSNANHLSPQALKWREYRRKNPLGPPGLSGSLDRRSQEARLARRNPIFEFPGSLSAASHLNCRLNGQAVKPLPLTCPDFQDPFSLTEKPPAEFCLSPDGSSEAISIDLLQKKGLVKAVNIAVDLIVAHFGTSRDPGVKAKLGNSSVSPNVGHLVLKYLCPAVRAVLEDGLKAFVLDVIIGQRKNMPWSVVEASTQLGPSTKVLHGLYNKVSQFPELTSHTMRFNAFILGLLNIRSLEFWFNHLYNHEDIIQTHYQPWGFLSAAHTVCPGLFEELLLLLQPLALLPFSLDLLFQHRLLQSGQQQRQHKELLRVSQDLLLSAHSTLQLARARGQEGPGDVDRAAQGERVKGVGASEGGEEEEEEEETEEVAEAAGGSGRARWARGGQAGWWYQLMQSSQVYIDGSIEGSRFPRGSSNSSSEKKKGAGGGGPPQAPPPREGVVEGAEACPASEEALGRERGWPFWMGSPPDSVLAELRRSREREGPAASPAENEEGASEPSPGGIKWGHLFGSRKAQREARPTNRLPSDWLSLDKSMFQLVAQTVGSRREPEPKESLQEPHSPALPSSPPCEVQALCHHLATGPGQLSFHKGDILRVLGRAGGDWLRCSRGPDSGLVPLAYVTLTPTPSPTPGSSQN

Target ORF information:

RefSeq Version	NM_001135999.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135999.1

ORF Insert Sequence:

ATGGATAGTC CCCCAAAGCT GACTGGAGAG ACCCTCATCG TTCATCACAT CCCCCTGGTG 
CACTGCCAAG TCCCAGACAG GCAGTGCTGT GGAGGGGCAG GTGGAGGTGG TGGGAGCACA 
AGACCTAATC CCTTCTGCCC ACCTGAGCTG GGCATCACCC AGCCCGATCA AGACCTAGGA 
CAAGCTGACT CCCTGCTATT CAGCAGCCTG CACTCTGCTC CAGGAGGAAC TGCACGGTCT 
ATAGACAGCA CCAAGAGTAG GAGTCGGGAT GGAAGAGGCC CTGGAGCCCC CAAACGACAC 
AACCCCTTCT TGCTGCAGGA GGGTGTGGGT GAGCCAGGAC TTGGTGACCT GTATGATGAC 
AGCATTGGTG ACAGTGCCAC CCAGCAGTCC TTCCACCTGC ATGGCACTGG CCAGCCCAAC 
TTTCATCTAT CCTCTTTCCA GCTGCCACCA TCTGGCCCCA GAGTGGGCAG GCCATGGGGG 
ACAACACGCA GTCGGGCTGG AGTGGTGGAA GGGCAGGAAC AGGAGCCAGT GATGACCTTG 
GATACTCAGC AGTGCGGCAC CAGCCACTGC TGCCGGCCAG AGCTGGAAGC AGAGACTATG 
GAGCTGGATG AGTGTGGGGG ACCTGGTGGG AGTGGCAGTG GGGGTGGAGC CAGCGATACC 
TCTGGCTTTT CCTTTGACCA GGAATGGAAG CTCAGTTCAG ATGAATCCCC AAGGAACCCT 
GGATGCTCCG GCTCAGGGGA CCAGCACTGC CGCTGCAGTA GCACATCCAG TCAGTCCGAG 
GCAGCTGACC AGTCCATGGG CTATGTGAGC GACTCCTCCT GCAACAGTTC AGATGGTGTG 
CTGGTCACCT TCAGCACCCT CTACAACAAG ATGCATGGCA CCCCCCGTGC CAATCTCAAC 
TCTGCCCCAC AGTCCTGCAG CGACTCTTCC TTCTGCAGCC ACTCAGACCC TGGCGCCTTC 
TATCTGGATC TGCAGCCCTC CCCATTTGAG TCTAAGATGT CTTATGAGTC CCATCACCCT 
GAAAGTGGAG GAAGGGAAGG GGGCTATGGT TGCCCTCATG CCTCTTCTCC TGAGCTTGAT 
GCCAACTGCA ACTCCTACCG CCCACACTGT GAGCCGTGCC CAGCAGTGGC TGACCTCACA 
GCCTGCTTCC AAAGCCAGGC CCGTCTTGTT GTGGCCACAC AAAATTACTA TAAACTTGTC 
ACCTGTGACC TATCTTCCCA ATCATCCCCA AGCCCTGCTG GCTCTTCCAT CACTAGCTGC 
TCTGAGGAAC ACACCAAGAT AAGTCCCCCA CCAGGCCCTG GCCCAGACCC AGGCCCCAGC 
CAGCCCTCTG AGTATTACCT ATTCCAGAAG CCAGAAGTCC AGCCAGAGGA ACAAGAAGCA 
GTGAGTTCCT CCACCCAAGC AGCAGCTGCT GTGGGCCCCA CTGTGCTTGA GGGACAAGTA 
TACACGAATA CTTCACCCCC CAACCTCAGC ACTGGACGTC AGCGCTCCCG CAGCTATGAT 
CGCAGCCTGC AGCGCAGCCC TCCTGTCCGC CTGGGCTCGC TGGAACGTAT GTTGAGTTGC 
CCAGTGCGCT TGAGTGAGGG CCCTGCAGCC ATGGCCGGGC CTGGCTCCCC ACCCAGGAGG 
GTCACCTCCT TTGCCGAGCT GGCCAAGGGC CGGAAGAAAA CTGGAGGCTC TGGCTCGCCC 
CCACTTCGTG TGAGTGTTGG GGACTCCTCC CAGGAGTTCT CACCCATCCA AGAAGCCCAG 
CAAGATCGGG GGGCCCCACT GGATGAGGGC ACTTGCTGTA GCCATAGCCT GCCACCCATG 
CCTTTGGGGC CAGGCATGGA CCTACTTGGC CCAGACCCAA GTCCACCCTG GTCCACCCAG 
GTCTGTCAGG GACCCCACTC CAGTGAGATG CCTCCTGCTG GCCTCAGAGC TACTGGGCAA 
GGCCCCCTGG CTCAGCTGAT GGATCCAGGG CCTGCTCTCC CAGGGAGCCC AGCCAACAGC 
CATACCCAGA GGGATGCAAG AGCTAGAGCT GACGGGGGTG GCACCGAGAG CCGACCAGTC 
CTTCGCTACA GCAAGGAACA GAGGCCAACC ACACTGCCCA TCCAGCCCTT CGTGTTCCAG 
CACCACTTCC CCAAGCAGCT GGCCAAGGCC CGGGCCCTCC ACAGCCTTTC CCAGCTCTAC 
AGCCTCTCAG GCTGCAGCCG TACACAGCAG CCTGCCCCAC TGGCTGCCCC TGCTGCTCAA 
GTCTCAGTCC CAGCTCCCTC AGGGGAACCG CAGGCATCCA CTCCCCGAGC CACTGGCAGA 
GGTGCCAGGA AAGCTGGGTC TGAGCCAGAG ACCTCTCGGC CATCGCCCCT GGGCAGCTAC 
TCCCCCATCC GGAGTGTTGG CCCCTTTGGG CCCAGCACTG ACTCTTCTGC CTCCACTTCG 
TGCTCCCCTC CCCCAGAGCA GCCCACAGCC ACAGAAAGCC TGCCCCCATG GAGCCACTCC 
TGTCCTTCTG CTGTCCGGCC TGCCACCTCC CAGCAGCCGC AGAAGGAGGA TCAGAAGATA 
CTGACCTTGA CTGAGTACCG GCTCCATGGA ACAGGAAGCT TGCCGCCTCT GGGCTCCTGG 
CGATCTGGCC TCAGCCGAGC AGAGAGCCTG GCCCGGGGAG GTGGTGAGGG CAGCATGGCC 
ACCAGGCCCA GTAATGCCAA CCACCTATCC CCTCAAGCCC TCAAGTGGCG GGAATACAGG 
AGGAAGAACC CACTAGGGCC ACCTGGTTTG TCAGGGAGCC TAGACCGAAG ATCACAAGAA 
GCTCGGCTGG CCCGAAGAAA CCCTATCTTT GAGTTCCCTG GCTCCCTCAG TGCTGCCAGC 
CATCTGAACT GCCGGCTGAA TGGCCAAGCA GTGAAGCCGT TACCACTGAC CTGCCCTGAC 
TTCCAGGACC CCTTTTCCTT GACGGAGAAG CCTCCAGCTG AGTTTTGTCT GTCCCCAGAT 
GGCAGCTCAG AGGCCATTTC CATTGACCTG CTTCAGAAAA AAGGGCTGGT AAAAGCTGTT 
AACATCGCTG TGGACCTCAT TGTGGCTCAT TTTGGCACAA GCCGGGATCC CGGGGTGAAG 
GCAAAGCTGG GAAACAGTTC TGTGAGCCCC AATGTGGGCC ACCTGGTTCT GAAGTACTTG 
TGCCCTGCCG TCCGCGCCGT GCTGGAGGAT GGGCTCAAGG CCTTTGTACT GGACGTCATC 
ATCGGGCAGC GTAAGAACAT GCCATGGAGT GTGGTTGAGG CTTCCACACA GCTAGGCCCA 
TCCACCAAGG TCCTGCATGG CCTCTACAAC AAAGTCAGCC AATTCCCAGA GCTCACCAGT 
CATACCATGC GCTTCAACGC CTTCATCCTC GGCCTGCTCA ACATCCGGTC CCTGGAGTTC 
TGGTTTAATC ACCTCTATAA CCACGAAGAC ATCATCCAGA CCCACTACCA GCCCTGGGGC 
TTCCTGAGTG CAGCTCATAC CGTGTGTCCC GGCCTCTTTG AAGAGCTGCT GCTGCTGCTA 
CAGCCCCTGG CCCTGCTGCC CTTCAGCCTC GACTTGCTGT TCCAGCACCG GCTGCTGCAA 
AGTGGGCAGC AGCAGCGGCA GCACAAGGAA CTGCTGCGGG TGTCCCAGGA CCTGCTGCTG 
TCTGCCCACT CCACGCTGCA GCTGGCCCGG GCCCGGGGCC AGGAGGGCCC TGGAGACGTG 
GACAGGGCAG CCCAAGGGGA GCGGGTGAAG GGTGTGGGTG CCTCAGAAGG TGGAGAAGAG 
GAAGAGGAAG AAGAGGAGAC AGAAGAGGTG GCAGAGGCAG CCGGGGGCTC AGGGCGTGCC 
AGGTGGGCCC GAGGTGGGCA GGCCGGCTGG TGGTACCAGC TCATGCAGAG CTCCCAGGTC 
TACATCGATG GCTCCATTGA GGGTTCCAGG TTCCCTCGTG GTAGCAGCAA CAGCAGCAGC 
GAGAAAAAGA AAGGGGCAGG AGGTGGGGGA CCTCCCCAGG CTCCACCACC CCGAGAGGGA 
GTAGTGGAGG GGGCTGAGGC CTGCCCTGCC TCTGAGGAGG CCCTGGGCCG GGAAAGGGGC 
TGGCCCTTCT GGATGGGGAG CCCCCCTGAC TCTGTGCTGG CCGAGCTGAG GCGCAGTCGG 
GAGAGGGAAG GGCCCGCTGC CTCGCCAGCA GAAAATGAGG AAGGGGCCTC AGAGCCTTCA 
CCTGGAGGCA TCAAGTGGGG ACACCTCTTT GGCTCCCGAA AAGCCCAGCG GGAGGCCCGG 
CCCACAAATA GGCTCCCCTC GGACTGGCTG AGCCTGGACA AGTCCATGTT CCAACTAGTG 
GCGCAGACAG TGGGTTCCCG CCGGGAGCCA GAGCCCAAGG AGAGCCTGCA GGAGCCACAC 
TCCCCAGCCC TGCCCTCCAG TCCTCCGTGT GAGGTGCAGG CACTGTGCCA CCACCTGGCC 
ACCGGCCCTG GACAGCTGAG CTTCCACAAA GGAGACATCC TACGAGTGCT GGGGCGAGCT 
GGAGGAGACT GGCTGCGCTG CAGCCGTGGC CCCGACTCTG GCCTGGTGCC CCTGGCCTAC 
GTGACATTGA CCCCAACTCC AAGTCCAACC CCTGGAAGCA GCCAAAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RUSC2 ( NM_014806.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055621.1 Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript variant 2, mRNA.

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CloneID	OHu21992
Clone ID Related Accession (Same CDS sequence)	NM_001135999.1 , NM_014806.4
Accession Version	NM_014806.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4551bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-01
Organism	Homo sapiens(human)
Product	iporin isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY019160.1, BC150211.1, AL133476.17 and AI818507.1. On Sep 1, 2016 this sequence version replaced NM_014806.3. Transcript Variant: This variant (2) contains an alternate 5' terminal exon and thus differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AB002373.2, SRR1803611.150051.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATAGTC CCCCAAAGCT GACTGGAGAG ACCCTCATCG TTCATCACAT CCCCCTGGTG 
CACTGCCAAG TCCCAGACAG GCAGTGCTGT GGAGGGGCAG GTGGAGGTGG TGGGAGCACA 
AGACCTAATC CCTTCTGCCC ACCTGAGCTG GGCATCACCC AGCCCGATCA AGACCTAGGA 
CAAGCTGACT CCCTGCTATT CAGCAGCCTG CACTCTGCTC CAGGAGGAAC TGCACGGTCT 
ATAGACAGCA CCAAGAGTAG GAGTCGGGAT GGAAGAGGCC CTGGAGCCCC CAAACGACAC 
AACCCCTTCT TGCTGCAGGA GGGTGTGGGT GAGCCAGGAC TTGGTGACCT GTATGATGAC 
AGCATTGGTG ACAGTGCCAC CCAGCAGTCC TTCCACCTGC ATGGCACTGG CCAGCCCAAC 
TTTCATCTAT CCTCTTTCCA GCTGCCACCA TCTGGCCCCA GAGTGGGCAG GCCATGGGGG 
ACAACACGCA GTCGGGCTGG AGTGGTGGAA GGGCAGGAAC AGGAGCCAGT GATGACCTTG 
GATACTCAGC AGTGCGGCAC CAGCCACTGC TGCCGGCCAG AGCTGGAAGC AGAGACTATG 
GAGCTGGATG AGTGTGGGGG ACCTGGTGGG AGTGGCAGTG GGGGTGGAGC CAGCGATACC 
TCTGGCTTTT CCTTTGACCA GGAATGGAAG CTCAGTTCAG ATGAATCCCC AAGGAACCCT 
GGATGCTCCG GCTCAGGGGA CCAGCACTGC CGCTGCAGTA GCACATCCAG TCAGTCCGAG 
GCAGCTGACC AGTCCATGGG CTATGTGAGC GACTCCTCCT GCAACAGTTC AGATGGTGTG 
CTGGTCACCT TCAGCACCCT CTACAACAAG ATGCATGGCA CCCCCCGTGC CAATCTCAAC 
TCTGCCCCAC AGTCCTGCAG CGACTCTTCC TTCTGCAGCC ACTCAGACCC TGGCGCCTTC 
TATCTGGATC TGCAGCCCTC CCCATTTGAG TCTAAGATGT CTTATGAGTC CCATCACCCT 
GAAAGTGGAG GAAGGGAAGG GGGCTATGGT TGCCCTCATG CCTCTTCTCC TGAGCTTGAT 
GCCAACTGCA ACTCCTACCG CCCACACTGT GAGCCGTGCC CAGCAGTGGC TGACCTCACA 
GCCTGCTTCC AAAGCCAGGC CCGTCTTGTT GTGGCCACAC AAAATTACTA TAAACTTGTC 
ACCTGTGACC TATCTTCCCA ATCATCCCCA AGCCCTGCTG GCTCTTCCAT CACTAGCTGC 
TCTGAGGAAC ACACCAAGAT AAGTCCCCCA CCAGGCCCTG GCCCAGACCC AGGCCCCAGC 
CAGCCCTCTG AGTATTACCT ATTCCAGAAG CCAGAAGTCC AGCCAGAGGA ACAAGAAGCA 
GTGAGTTCCT CCACCCAAGC AGCAGCTGCT GTGGGCCCCA CTGTGCTTGA GGGACAAGTA 
TACACGAATA CTTCACCCCC CAACCTCAGC ACTGGACGTC AGCGCTCCCG CAGCTATGAT 
CGCAGCCTGC AGCGCAGCCC TCCTGTCCGC CTGGGCTCGC TGGAACGTAT GTTGAGTTGC 
CCAGTGCGCT TGAGTGAGGG CCCTGCAGCC ATGGCCGGGC CTGGCTCCCC ACCCAGGAGG 
GTCACCTCCT TTGCCGAGCT GGCCAAGGGC CGGAAGAAAA CTGGAGGCTC TGGCTCGCCC 
CCACTTCGTG TGAGTGTTGG GGACTCCTCC CAGGAGTTCT CACCCATCCA AGAAGCCCAG 
CAAGATCGGG GGGCCCCACT GGATGAGGGC ACTTGCTGTA GCCATAGCCT GCCACCCATG 
CCTTTGGGGC CAGGCATGGA CCTACTTGGC CCAGACCCAA GTCCACCCTG GTCCACCCAG 
GTCTGTCAGG GACCCCACTC CAGTGAGATG CCTCCTGCTG GCCTCAGAGC TACTGGGCAA 
GGCCCCCTGG CTCAGCTGAT GGATCCAGGG CCTGCTCTCC CAGGGAGCCC AGCCAACAGC 
CATACCCAGA GGGATGCAAG AGCTAGAGCT GACGGGGGTG GCACCGAGAG CCGACCAGTC 
CTTCGCTACA GCAAGGAACA GAGGCCAACC ACACTGCCCA TCCAGCCCTT CGTGTTCCAG 
CACCACTTCC CCAAGCAGCT GGCCAAGGCC CGGGCCCTCC ACAGCCTTTC CCAGCTCTAC 
AGCCTCTCAG GCTGCAGCCG TACACAGCAG CCTGCCCCAC TGGCTGCCCC TGCTGCTCAA 
GTCTCAGTCC CAGCTCCCTC AGGGGAACCG CAGGCATCCA CTCCCCGAGC CACTGGCAGA 
GGTGCCAGGA AAGCTGGGTC TGAGCCAGAG ACCTCTCGGC CATCGCCCCT GGGCAGCTAC 
TCCCCCATCC GGAGTGTTGG CCCCTTTGGG CCCAGCACTG ACTCTTCTGC CTCCACTTCG 
TGCTCCCCTC CCCCAGAGCA GCCCACAGCC ACAGAAAGCC TGCCCCCATG GAGCCACTCC 
TGTCCTTCTG CTGTCCGGCC TGCCACCTCC CAGCAGCCGC AGAAGGAGGA TCAGAAGATA 
CTGACCTTGA CTGAGTACCG GCTCCATGGA ACAGGAAGCT TGCCGCCTCT GGGCTCCTGG 
CGATCTGGCC TCAGCCGAGC AGAGAGCCTG GCCCGGGGAG GTGGTGAGGG CAGCATGGCC 
ACCAGGCCCA GTAATGCCAA CCACCTATCC CCTCAAGCCC TCAAGTGGCG GGAATACAGG 
AGGAAGAACC CACTAGGGCC ACCTGGTTTG TCAGGGAGCC TAGACCGAAG ATCACAAGAA 
GCTCGGCTGG CCCGAAGAAA CCCTATCTTT GAGTTCCCTG GCTCCCTCAG TGCTGCCAGC 
CATCTGAACT GCCGGCTGAA TGGCCAAGCA GTGAAGCCGT TACCACTGAC CTGCCCTGAC 
TTCCAGGACC CCTTTTCCTT GACGGAGAAG CCTCCAGCTG AGTTTTGTCT GTCCCCAGAT 
GGCAGCTCAG AGGCCATTTC CATTGACCTG CTTCAGAAAA AAGGGCTGGT AAAAGCTGTT 
AACATCGCTG TGGACCTCAT TGTGGCTCAT TTTGGCACAA GCCGGGATCC CGGGGTGAAG 
GCAAAGCTGG GAAACAGTTC TGTGAGCCCC AATGTGGGCC ACCTGGTTCT GAAGTACTTG 
TGCCCTGCCG TCCGCGCCGT GCTGGAGGAT GGGCTCAAGG CCTTTGTACT GGACGTCATC 
ATCGGGCAGC GTAAGAACAT GCCATGGAGT GTGGTTGAGG CTTCCACACA GCTAGGCCCA 
TCCACCAAGG TCCTGCATGG CCTCTACAAC AAAGTCAGCC AATTCCCAGA GCTCACCAGT 
CATACCATGC GCTTCAACGC CTTCATCCTC GGCCTGCTCA ACATCCGGTC CCTGGAGTTC 
TGGTTTAATC ACCTCTATAA CCACGAAGAC ATCATCCAGA CCCACTACCA GCCCTGGGGC 
TTCCTGAGTG CAGCTCATAC CGTGTGTCCC GGCCTCTTTG AAGAGCTGCT GCTGCTGCTA 
CAGCCCCTGG CCCTGCTGCC CTTCAGCCTC GACTTGCTGT TCCAGCACCG GCTGCTGCAA 
AGTGGGCAGC AGCAGCGGCA GCACAAGGAA CTGCTGCGGG TGTCCCAGGA CCTGCTGCTG 
TCTGCCCACT CCACGCTGCA GCTGGCCCGG GCCCGGGGCC AGGAGGGCCC TGGAGACGTG 
GACAGGGCAG CCCAAGGGGA GCGGGTGAAG GGTGTGGGTG CCTCAGAAGG TGGAGAAGAG 
GAAGAGGAAG AAGAGGAGAC AGAAGAGGTG GCAGAGGCAG CCGGGGGCTC AGGGCGTGCC 
AGGTGGGCCC GAGGTGGGCA GGCCGGCTGG TGGTACCAGC TCATGCAGAG CTCCCAGGTC 
TACATCGATG GCTCCATTGA GGGTTCCAGG TTCCCTCGTG GTAGCAGCAA CAGCAGCAGC 
GAGAAAAAGA AAGGGGCAGG AGGTGGGGGA CCTCCCCAGG CTCCACCACC CCGAGAGGGA 
GTAGTGGAGG GGGCTGAGGC CTGCCCTGCC TCTGAGGAGG CCCTGGGCCG GGAAAGGGGC 
TGGCCCTTCT GGATGGGGAG CCCCCCTGAC TCTGTGCTGG CCGAGCTGAG GCGCAGTCGG 
GAGAGGGAAG GGCCCGCTGC CTCGCCAGCA GAAAATGAGG AAGGGGCCTC AGAGCCTTCA 
CCTGGAGGCA TCAAGTGGGG ACACCTCTTT GGCTCCCGAA AAGCCCAGCG GGAGGCCCGG 
CCCACAAATA GGCTCCCCTC GGACTGGCTG AGCCTGGACA AGTCCATGTT CCAACTAGTG 
GCGCAGACAG TGGGTTCCCG CCGGGAGCCA GAGCCCAAGG AGAGCCTGCA GGAGCCACAC 
TCCCCAGCCC TGCCCTCCAG TCCTCCGTGT GAGGTGCAGG CACTGTGCCA CCACCTGGCC 
ACCGGCCCTG GACAGCTGAG CTTCCACAAA GGAGACATCC TACGAGTGCT GGGGCGAGCT 
GGAGGAGACT GGCTGCGCTG CAGCCGTGGC CCCGACTCTG GCCTGGTGCC CCTGGCCTAC 
GTGACATTGA CCCCAACTCC AAGTCCAACC CCTGGAAGCA GCCAAAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055621.1
CDS	433..4983
Translation	MDSPPKLTGETLIVHHIPLVHCQVPDRQCCGGAGGGGGSTRPNPFCPPELGITQPDQDLGQADSLLFSSLHSAPGGTARSIDSTKSRSRDGRGPGAPKRHNPFLLQEGVGEPGLGDLYDDSIGDSATQQSFHLHGTGQPNFHLSSFQLPPSGPRVGRPWGTTRSRAGVVEGQEQEPVMTLDTQQCGTSHCCRPELEAETMELDECGGPGGSGSGGGASDTSGFSFDQEWKLSSDESPRNPGCSGSGDQHCRCSSTSSQSEAADQSMGYVSDSSCNSSDGVLVTFSTLYNKMHGTPRANLNSAPQSCSDSSFCSHSDPGAFYLDLQPSPFESKMSYESHHPESGGREGGYGCPHASSPELDANCNSYRPHCEPCPAVADLTACFQSQARLVVATQNYYKLVTCDLSSQSSPSPAGSSITSCSEEHTKISPPPGPGPDPGPSQPSEYYLFQKPEVQPEEQEAVSSSTQAAAAVGPTVLEGQVYTNTSPPNLSTGRQRSRSYDRSLQRSPPVRLGSLERMLSCPVRLSEGPAAMAGPGSPPRRVTSFAELAKGRKKTGGSGSPPLRVSVGDSSQEFSPIQEAQQDRGAPLDEGTCCSHSLPPMPLGPGMDLLGPDPSPPWSTQVCQGPHSSEMPPAGLRATGQGPLAQLMDPGPALPGSPANSHTQRDARARADGGGTESRPVLRYSKEQRPTTLPIQPFVFQHHFPKQLAKARALHSLSQLYSLSGCSRTQQPAPLAAPAAQVSVPAPSGEPQASTPRATGRGARKAGSEPETSRPSPLGSYSPIRSVGPFGPSTDSSASTSCSPPPEQPTATESLPPWSHSCPSAVRPATSQQPQKEDQKILTLTEYRLHGTGSLPPLGSWRSGLSRAESLARGGGEGSMATRPSNANHLSPQALKWREYRRKNPLGPPGLSGSLDRRSQEARLARRNPIFEFPGSLSAASHLNCRLNGQAVKPLPLTCPDFQDPFSLTEKPPAEFCLSPDGSSEAISIDLLQKKGLVKAVNIAVDLIVAHFGTSRDPGVKAKLGNSSVSPNVGHLVLKYLCPAVRAVLEDGLKAFVLDVIIGQRKNMPWSVVEASTQLGPSTKVLHGLYNKVSQFPELTSHTMRFNAFILGLLNIRSLEFWFNHLYNHEDIIQTHYQPWGFLSAAHTVCPGLFEELLLLLQPLALLPFSLDLLFQHRLLQSGQQQRQHKELLRVSQDLLLSAHSTLQLARARGQEGPGDVDRAAQGERVKGVGASEGGEEEEEEEETEEVAEAAGGSGRARWARGGQAGWWYQLMQSSQVYIDGSIEGSRFPRGSSNSSSEKKKGAGGGGPPQAPPPREGVVEGAEACPASEEALGRERGWPFWMGSPPDSVLAELRRSREREGPAASPAENEEGASEPSPGGIKWGHLFGSRKAQREARPTNRLPSDWLSLDKSMFQLVAQTVGSRREPEPKESLQEPHSPALPSSPPCEVQALCHHLATGPGQLSFHKGDILRVLGRAGGDWLRCSRGPDSGLVPLAYVTLTPTPSPTPGSSQN

Target ORF information:

RefSeq Version	NM_014806.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014806.4

ORF Insert Sequence:

ATGGATAGTC CCCCAAAGCT GACTGGAGAG ACCCTCATCG TTCATCACAT CCCCCTGGTG 
CACTGCCAAG TCCCAGACAG GCAGTGCTGT GGAGGGGCAG GTGGAGGTGG TGGGAGCACA 
AGACCTAATC CCTTCTGCCC ACCTGAGCTG GGCATCACCC AGCCCGATCA AGACCTAGGA 
CAAGCTGACT CCCTGCTATT CAGCAGCCTG CACTCTGCTC CAGGAGGAAC TGCACGGTCT 
ATAGACAGCA CCAAGAGTAG GAGTCGGGAT GGAAGAGGCC CTGGAGCCCC CAAACGACAC 
AACCCCTTCT TGCTGCAGGA GGGTGTGGGT GAGCCAGGAC TTGGTGACCT GTATGATGAC 
AGCATTGGTG ACAGTGCCAC CCAGCAGTCC TTCCACCTGC ATGGCACTGG CCAGCCCAAC 
TTTCATCTAT CCTCTTTCCA GCTGCCACCA TCTGGCCCCA GAGTGGGCAG GCCATGGGGG 
ACAACACGCA GTCGGGCTGG AGTGGTGGAA GGGCAGGAAC AGGAGCCAGT GATGACCTTG 
GATACTCAGC AGTGCGGCAC CAGCCACTGC TGCCGGCCAG AGCTGGAAGC AGAGACTATG 
GAGCTGGATG AGTGTGGGGG ACCTGGTGGG AGTGGCAGTG GGGGTGGAGC CAGCGATACC 
TCTGGCTTTT CCTTTGACCA GGAATGGAAG CTCAGTTCAG ATGAATCCCC AAGGAACCCT 
GGATGCTCCG GCTCAGGGGA CCAGCACTGC CGCTGCAGTA GCACATCCAG TCAGTCCGAG 
GCAGCTGACC AGTCCATGGG CTATGTGAGC GACTCCTCCT GCAACAGTTC AGATGGTGTG 
CTGGTCACCT TCAGCACCCT CTACAACAAG ATGCATGGCA CCCCCCGTGC CAATCTCAAC 
TCTGCCCCAC AGTCCTGCAG CGACTCTTCC TTCTGCAGCC ACTCAGACCC TGGCGCCTTC 
TATCTGGATC TGCAGCCCTC CCCATTTGAG TCTAAGATGT CTTATGAGTC CCATCACCCT 
GAAAGTGGAG GAAGGGAAGG GGGCTATGGT TGCCCTCATG CCTCTTCTCC TGAGCTTGAT 
GCCAACTGCA ACTCCTACCG CCCACACTGT GAGCCGTGCC CAGCAGTGGC TGACCTCACA 
GCCTGCTTCC AAAGCCAGGC CCGTCTTGTT GTGGCCACAC AAAATTACTA TAAACTTGTC 
ACCTGTGACC TATCTTCCCA ATCATCCCCA AGCCCTGCTG GCTCTTCCAT CACTAGCTGC 
TCTGAGGAAC ACACCAAGAT AAGTCCCCCA CCAGGCCCTG GCCCAGACCC AGGCCCCAGC 
CAGCCCTCTG AGTATTACCT ATTCCAGAAG CCAGAAGTCC AGCCAGAGGA ACAAGAAGCA 
GTGAGTTCCT CCACCCAAGC AGCAGCTGCT GTGGGCCCCA CTGTGCTTGA GGGACAAGTA 
TACACGAATA CTTCACCCCC CAACCTCAGC ACTGGACGTC AGCGCTCCCG CAGCTATGAT 
CGCAGCCTGC AGCGCAGCCC TCCTGTCCGC CTGGGCTCGC TGGAACGTAT GTTGAGTTGC 
CCAGTGCGCT TGAGTGAGGG CCCTGCAGCC ATGGCCGGGC CTGGCTCCCC ACCCAGGAGG 
GTCACCTCCT TTGCCGAGCT GGCCAAGGGC CGGAAGAAAA CTGGAGGCTC TGGCTCGCCC 
CCACTTCGTG TGAGTGTTGG GGACTCCTCC CAGGAGTTCT CACCCATCCA AGAAGCCCAG 
CAAGATCGGG GGGCCCCACT GGATGAGGGC ACTTGCTGTA GCCATAGCCT GCCACCCATG 
CCTTTGGGGC CAGGCATGGA CCTACTTGGC CCAGACCCAA GTCCACCCTG GTCCACCCAG 
GTCTGTCAGG GACCCCACTC CAGTGAGATG CCTCCTGCTG GCCTCAGAGC TACTGGGCAA 
GGCCCCCTGG CTCAGCTGAT GGATCCAGGG CCTGCTCTCC CAGGGAGCCC AGCCAACAGC 
CATACCCAGA GGGATGCAAG AGCTAGAGCT GACGGGGGTG GCACCGAGAG CCGACCAGTC 
CTTCGCTACA GCAAGGAACA GAGGCCAACC ACACTGCCCA TCCAGCCCTT CGTGTTCCAG 
CACCACTTCC CCAAGCAGCT GGCCAAGGCC CGGGCCCTCC ACAGCCTTTC CCAGCTCTAC 
AGCCTCTCAG GCTGCAGCCG TACACAGCAG CCTGCCCCAC TGGCTGCCCC TGCTGCTCAA 
GTCTCAGTCC CAGCTCCCTC AGGGGAACCG CAGGCATCCA CTCCCCGAGC CACTGGCAGA 
GGTGCCAGGA AAGCTGGGTC TGAGCCAGAG ACCTCTCGGC CATCGCCCCT GGGCAGCTAC 
TCCCCCATCC GGAGTGTTGG CCCCTTTGGG CCCAGCACTG ACTCTTCTGC CTCCACTTCG 
TGCTCCCCTC CCCCAGAGCA GCCCACAGCC ACAGAAAGCC TGCCCCCATG GAGCCACTCC 
TGTCCTTCTG CTGTCCGGCC TGCCACCTCC CAGCAGCCGC AGAAGGAGGA TCAGAAGATA 
CTGACCTTGA CTGAGTACCG GCTCCATGGA ACAGGAAGCT TGCCGCCTCT GGGCTCCTGG 
CGATCTGGCC TCAGCCGAGC AGAGAGCCTG GCCCGGGGAG GTGGTGAGGG CAGCATGGCC 
ACCAGGCCCA GTAATGCCAA CCACCTATCC CCTCAAGCCC TCAAGTGGCG GGAATACAGG 
AGGAAGAACC CACTAGGGCC ACCTGGTTTG TCAGGGAGCC TAGACCGAAG ATCACAAGAA 
GCTCGGCTGG CCCGAAGAAA CCCTATCTTT GAGTTCCCTG GCTCCCTCAG TGCTGCCAGC 
CATCTGAACT GCCGGCTGAA TGGCCAAGCA GTGAAGCCGT TACCACTGAC CTGCCCTGAC 
TTCCAGGACC CCTTTTCCTT GACGGAGAAG CCTCCAGCTG AGTTTTGTCT GTCCCCAGAT 
GGCAGCTCAG AGGCCATTTC CATTGACCTG CTTCAGAAAA AAGGGCTGGT AAAAGCTGTT 
AACATCGCTG TGGACCTCAT TGTGGCTCAT TTTGGCACAA GCCGGGATCC CGGGGTGAAG 
GCAAAGCTGG GAAACAGTTC TGTGAGCCCC AATGTGGGCC ACCTGGTTCT GAAGTACTTG 
TGCCCTGCCG TCCGCGCCGT GCTGGAGGAT GGGCTCAAGG CCTTTGTACT GGACGTCATC 
ATCGGGCAGC GTAAGAACAT GCCATGGAGT GTGGTTGAGG CTTCCACACA GCTAGGCCCA 
TCCACCAAGG TCCTGCATGG CCTCTACAAC AAAGTCAGCC AATTCCCAGA GCTCACCAGT 
CATACCATGC GCTTCAACGC CTTCATCCTC GGCCTGCTCA ACATCCGGTC CCTGGAGTTC 
TGGTTTAATC ACCTCTATAA CCACGAAGAC ATCATCCAGA CCCACTACCA GCCCTGGGGC 
TTCCTGAGTG CAGCTCATAC CGTGTGTCCC GGCCTCTTTG AAGAGCTGCT GCTGCTGCTA 
CAGCCCCTGG CCCTGCTGCC CTTCAGCCTC GACTTGCTGT TCCAGCACCG GCTGCTGCAA 
AGTGGGCAGC AGCAGCGGCA GCACAAGGAA CTGCTGCGGG TGTCCCAGGA CCTGCTGCTG 
TCTGCCCACT CCACGCTGCA GCTGGCCCGG GCCCGGGGCC AGGAGGGCCC TGGAGACGTG 
GACAGGGCAG CCCAAGGGGA GCGGGTGAAG GGTGTGGGTG CCTCAGAAGG TGGAGAAGAG 
GAAGAGGAAG AAGAGGAGAC AGAAGAGGTG GCAGAGGCAG CCGGGGGCTC AGGGCGTGCC 
AGGTGGGCCC GAGGTGGGCA GGCCGGCTGG TGGTACCAGC TCATGCAGAG CTCCCAGGTC 
TACATCGATG GCTCCATTGA GGGTTCCAGG TTCCCTCGTG GTAGCAGCAA CAGCAGCAGC 
GAGAAAAAGA AAGGGGCAGG AGGTGGGGGA CCTCCCCAGG CTCCACCACC CCGAGAGGGA 
GTAGTGGAGG GGGCTGAGGC CTGCCCTGCC TCTGAGGAGG CCCTGGGCCG GGAAAGGGGC 
TGGCCCTTCT GGATGGGGAG CCCCCCTGAC TCTGTGCTGG CCGAGCTGAG GCGCAGTCGG 
GAGAGGGAAG GGCCCGCTGC CTCGCCAGCA GAAAATGAGG AAGGGGCCTC AGAGCCTTCA 
CCTGGAGGCA TCAAGTGGGG ACACCTCTTT GGCTCCCGAA AAGCCCAGCG GGAGGCCCGG 
CCCACAAATA GGCTCCCCTC GGACTGGCTG AGCCTGGACA AGTCCATGTT CCAACTAGTG 
GCGCAGACAG TGGGTTCCCG CCGGGAGCCA GAGCCCAAGG AGAGCCTGCA GGAGCCACAC 
TCCCCAGCCC TGCCCTCCAG TCCTCCGTGT GAGGTGCAGG CACTGTGCCA CCACCTGGCC 
ACCGGCCCTG GACAGCTGAG CTTCCACAAA GGAGACATCC TACGAGTGCT GGGGCGAGCT 
GGAGGAGACT GGCTGCGCTG CAGCCGTGGC CCCGACTCTG GCCTGGTGCC CCTGGCCTAC 
GTGACATTGA CCCCAACTCC AAGTCCAACC CCTGGAAGCA GCCAAAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss-of-function mutation in RUSC2 causes intellectual disability and secondary microcephaly.
Developmental medicine and child neurology58(12)1317-1322(2016 Dec)
Alwadei AH,Benini R,Mahmoud A,Alasmari A,Kamsteeg EJ,Alfadhel M

EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.
Cancer letters379(1)70-83(2016 08)
Duan B,Cui J,Sun S,Zheng J,Zhang Y,Ye B,Chen Y,Deng W,Du J,Zhu Y,Chen Y,Gu L

Copy number alterations and neoplasia-specific mutations in MELK, PDCD1LG2, TLN1, and PAX5 at 9p in different neoplasias.
Genes, chromosomes & cancer53(7)579-88(2014 Jul)
Sarhadi VK,Lahti L,Scheinin I,Ellonen P,Kettunen E,Serra M,Scotlandi K,Picci P,Knuutila S

Genome-wide investigation of the Rab binding activity of RUN domains: development of a novel tool that specifically traps GTP-Rab35.
Cell structure and function36(2)155-70(2011)
Fukuda M,Kobayashi H,Ishibashi K,Ohbayashi N

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RUSC2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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