GINS1 cDNA ORF clone, Homo sapiens(human)

The following GINS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GINS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu17259 NM_021067.5
Latest version!
Homo sapiens GINS complex subunit 1 (GINS1), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK
$49.50-$69.30
$99.00
OHu52846 XM_017028162.1
Latest version!
Homo sapiens GINS complex subunit 1 (GINS1), transcript variant X2, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $69.30
$99.00
View Old Accession Versions >>
OHu17259 NM_021067.3 Homo sapiens GINS complex subunit 1 (Psf1 homolog) (GINS1), mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK
$49.50-$69.30
$99.00
OHu17259 NM_021067.4 Homo sapiens GINS complex subunit 1 (GINS1), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK
$49.50-$69.30
$99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

  • Reference Sequences (Refseq)
    CloneID OHu17259
    Clone ID Related Accession (Same CDS sequence) NM_021067.3 , NM_021067.5 , NM_021067.4
    Accession Version NM_021067.3 Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 591bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2015-03-14
    Organism Homo sapiens(Human)
    Product DNA replication complex GINS protein PSF1
    Comment

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGTTCTGCG AAAAAGCCAT GGAACTGATC CGCGAGCTGC ATCGCGCGCC CGAAGGGCAA 
    CTGCCTGCCT TCAACGAGGA TGGACTCAGA CAAGTTCTGG AGGAGATGAA AGCTTTGTAT
    GAACAAAACC AGTCTGATGT GAATGAAGCA AAGTCAGGTG GACGAAGTGA TTTGATACCA
    ACTATCAAAT TTCGACACTG TTCTCTGTTA AGAAATCGAC GCTGCACTGT AGCATACCTG
    TATGACCGCT TGCTTCGGAT CAGAGCACTC AGATGGGAAT ATGGTAGCGT CTTGCCAAAT
    GCATTACGAT TTCACATGGC TGCTGAAGAA ATGGAGTGGT TTAATAATTA TAAAAGATCT
    CTTGCTACTT ATATGAGGTC ACTGGGAGGA GATGAAGGTT TGGACATTAC ACAGGATATG
    AAACCACCAA AAAGCCTATA TATTGAAGTC CGGTGTCTAA AAGACTATGG AGAATTTGAA
    GTTGATGATG GCACTTCAGT CCTATTAAAA AAAAATAGCC AGCACTTTTT ACCTCGATGG
    AAATGTGAGC AGCTGATCAG ACAAGGAGTC CTGGAGCACA TCCTGTCATG A

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_066545.3
    Translation

    Target ORF information:

    RefSeq Version NM_021067.3
    Organism Homo sapiens(Human)
    Definition Homo sapiens GINS complex subunit 1 (Psf1 homolog) (GINS1), mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_021067.3

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGTTCTGCG AAAAAGCCAT GGAACTGATC CGCGAGCTGC ATCGCGCGCC CGAAGGGCAA 
    CTGCCTGCCT TCAACGAGGA TGGACTCAGA CAAGTTCTGG AGGAGATGAA AGCTTTGTAT
    GAACAAAACC AGTCTGATGT GAATGAAGCA AAGTCAGGTG GACGAAGTGA TTTGATACCA
    ACTATCAAAT TTCGACACTG TTCTCTGTTA AGAAATCGAC GCTGCACTGT AGCATACCTG
    TATGACCGCT TGCTTCGGAT CAGAGCACTC AGATGGGAAT ATGGTAGCGT CTTGCCAAAT
    GCATTACGAT TTCACATGGC TGCTGAAGAA ATGGAGTGGT TTAATAATTA TAAAAGATCT
    CTTGCTACTT ATATGAGGTC ACTGGGAGGA GATGAAGGTT TGGACATTAC ACAGGATATG
    AAACCACCAA AAAGCCTATA TATTGAAGTC CGGTGTCTAA AAGACTATGG AGAATTTGAA
    GTTGATGATG GCACTTCAGT CCTATTAAAA AAAAATAGCC AGCACTTTTT ACCTCGATGG
    AAATGTGAGC AGCTGATCAG ACAAGGAGTC CTGGAGCACA TCCTGTCATG A

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    CloneID OHu17259
    Clone ID Related Accession (Same CDS sequence) NM_021067.3 , NM_021067.5 , NM_021067.4
    Accession Version NM_021067.5 Latest version! Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 591bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2019-08-05
    Organism Homo sapiens(human)
    Product DNA replication complex GINS protein PSF1
    Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL353812.13, BP290581.1, D80008.1 and AL031672.13. On Nov 22, 2018 this sequence version replaced NM_021067.4. Transcript Variant: This variant (1) encodes the supported protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.232497.1, SRR1803613.141268.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262460.5/ ENSP00000262460.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGTTCTGCG AAAAAGCCAT GGAACTGATC CGCGAGCTGC ATCGCGCGCC CGAAGGGCAA 
    CTGCCTGCCT TCAACGAGGA TGGACTCAGA CAAGTTCTGG AGGAGATGAA AGCTTTGTAT
    GAACAAAACC AGTCTGATGT GAATGAAGCA AAGTCAGGTG GACGAAGTGA TTTGATACCA
    ACTATCAAAT TTCGACACTG TTCTCTGTTA AGAAATCGAC GCTGCACTGT AGCATACCTG
    TATGACCGCT TGCTTCGGAT CAGAGCACTC AGATGGGAAT ATGGTAGCGT CTTGCCAAAT
    GCATTACGAT TTCACATGGC TGCTGAAGAA ATGGAGTGGT TTAATAATTA TAAAAGATCT
    CTTGCTACTT ATATGAGGTC ACTGGGAGGA GATGAAGGTT TGGACATTAC ACAGGATATG
    AAACCACCAA AAAGCCTATA TATTGAAGTC CGGTGTCTAA AAGACTATGG AGAATTTGAA
    GTTGATGATG GCACTTCAGT CCTATTAAAA AAAAATAGCC AGCACTTTTT ACCTCGATGG
    AAATGTGAGC AGCTGATCAG ACAAGGAGTC CTGGAGCACA TCCTGTCATG A

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_066545.3
    CDS149..739
    Translation

    Target ORF information:

    RefSeq Version NM_021067.5
    Organism Homo sapiens(human)
    Definition Homo sapiens GINS complex subunit 1 (GINS1), transcript variant 1, mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_021067.5

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGTTCTGCG AAAAAGCCAT GGAACTGATC CGCGAGCTGC ATCGCGCGCC CGAAGGGCAA 
    CTGCCTGCCT TCAACGAGGA TGGACTCAGA CAAGTTCTGG AGGAGATGAA AGCTTTGTAT
    GAACAAAACC AGTCTGATGT GAATGAAGCA AAGTCAGGTG GACGAAGTGA TTTGATACCA
    ACTATCAAAT TTCGACACTG TTCTCTGTTA AGAAATCGAC GCTGCACTGT AGCATACCTG
    TATGACCGCT TGCTTCGGAT CAGAGCACTC AGATGGGAAT ATGGTAGCGT CTTGCCAAAT
    GCATTACGAT TTCACATGGC TGCTGAAGAA ATGGAGTGGT TTAATAATTA TAAAAGATCT
    CTTGCTACTT ATATGAGGTC ACTGGGAGGA GATGAAGGTT TGGACATTAC ACAGGATATG
    AAACCACCAA AAAGCCTATA TATTGAAGTC CGGTGTCTAA AAGACTATGG AGAATTTGAA
    GTTGATGATG GCACTTCAGT CCTATTAAAA AAAAATAGCC AGCACTTTTT ACCTCGATGG
    AAATGTGAGC AGCTGATCAG ACAAGGAGTC CTGGAGCACA TCCTGTCATG A

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    CloneID OHu17259
    Clone ID Related Accession (Same CDS sequence) NM_021067.3 , NM_021067.5 , NM_021067.4
    Accession Version NM_021067.4 Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 591bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2017-09-17
    Organism Homo sapiens(human)
    Product DNA replication complex GINS protein PSF1
    Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP290581.1, D80008.1 and AL031672.13. On Jan 2, 2016 this sequence version replaced NM_021067.3. Transcript Variant: This variant (1) encodes the supported protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: D80008.1, SRR1803613.141268.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGTTCTGCG AAAAAGCCAT GGAACTGATC CGCGAGCTGC ATCGCGCGCC CGAAGGGCAA 
    CTGCCTGCCT TCAACGAGGA TGGACTCAGA CAAGTTCTGG AGGAGATGAA AGCTTTGTAT
    GAACAAAACC AGTCTGATGT GAATGAAGCA AAGTCAGGTG GACGAAGTGA TTTGATACCA
    ACTATCAAAT TTCGACACTG TTCTCTGTTA AGAAATCGAC GCTGCACTGT AGCATACCTG
    TATGACCGCT TGCTTCGGAT CAGAGCACTC AGATGGGAAT ATGGTAGCGT CTTGCCAAAT
    GCATTACGAT TTCACATGGC TGCTGAAGAA ATGGAGTGGT TTAATAATTA TAAAAGATCT
    CTTGCTACTT ATATGAGGTC ACTGGGAGGA GATGAAGGTT TGGACATTAC ACAGGATATG
    AAACCACCAA AAAGCCTATA TATTGAAGTC CGGTGTCTAA AAGACTATGG AGAATTTGAA
    GTTGATGATG GCACTTCAGT CCTATTAAAA AAAAATAGCC AGCACTTTTT ACCTCGATGG
    AAATGTGAGC AGCTGATCAG ACAAGGAGTC CTGGAGCACA TCCTGTCATG A

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_066545.3
    CDS139..729
    Translation

    Target ORF information:

    RefSeq Version NM_021067.4
    Organism Homo sapiens(human)
    Definition Homo sapiens GINS complex subunit 1 (GINS1), transcript variant 1, mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_021067.4

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGTTCTGCG AAAAAGCCAT GGAACTGATC CGCGAGCTGC ATCGCGCGCC CGAAGGGCAA 
    CTGCCTGCCT TCAACGAGGA TGGACTCAGA CAAGTTCTGG AGGAGATGAA AGCTTTGTAT
    GAACAAAACC AGTCTGATGT GAATGAAGCA AAGTCAGGTG GACGAAGTGA TTTGATACCA
    ACTATCAAAT TTCGACACTG TTCTCTGTTA AGAAATCGAC GCTGCACTGT AGCATACCTG
    TATGACCGCT TGCTTCGGAT CAGAGCACTC AGATGGGAAT ATGGTAGCGT CTTGCCAAAT
    GCATTACGAT TTCACATGGC TGCTGAAGAA ATGGAGTGGT TTAATAATTA TAAAAGATCT
    CTTGCTACTT ATATGAGGTC ACTGGGAGGA GATGAAGGTT TGGACATTAC ACAGGATATG
    AAACCACCAA AAAGCCTATA TATTGAAGTC CGGTGTCTAA AAGACTATGG AGAATTTGAA
    GTTGATGATG GCACTTCAGT CCTATTAAAA AAAAATAGCC AGCACTTTTT ACCTCGATGG
    AAATGTGAGC AGCTGATCAG ACAAGGAGTC CTGGAGCACA TCCTGTCATG A

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    CloneID OHu52846
    Clone ID Related Accession (Same CDS sequence) XM_017028162.1
    Accession Version XM_017028162.1 Latest version! Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 486bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2019-12-05
    Organism Homo sapiens(human)
    Product DNA replication complex GINS protein PSF1 isoform X1
    Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

    1
    61
    121
    181
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    301
    361
    421
    481
    ATGAAAGCTT TGTATGAACA AAACCAGTCT GATGTGAATG AAGCAAAGTC AGGTGGACGA 
    AGTGATTTGA TACCAACTAT CAAATTTCGA CACTGTTCTC TGTTAAGAAA TCGACGCTGC
    ACTGTAGCAT ACCTGTATGA CCGCTTGCTT CGGATCAGAG CACTCAGATG GGAATATGGT
    AGCGTCTTGC CAAATGCATT ACGATTTCAC ATGGCTGCTG AAGAAATGGA GTGGTTTAAT
    AATTATAAAA GATCTCTTGC TACTTATATG AGGTCACTGG GAGGAGATGA AGGTTTGGAC
    ATTACACAGG ATATGAAACC ACCAAAAAGC CTATATATTG AAGTCCGGTG TCTAAAAGAC
    TATGGAGAAT TTGAAGTTGA TGATGGCACT TCAGTCCTAT TAAAAAAAAA TAGCCAGCAC
    TTTTTACCTC GATGGAAATG TGAGCAGCTG ATCAGACAAG GAGTCCTGGA GCACATCCTG
    TCATGA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq XP_016883651.1
    CDS201..686
    Translation

    Target ORF information:

    RefSeq Version XM_017028162.1
    Organism Homo sapiens(human)
    Definition Homo sapiens GINS complex subunit 1 (GINS1), transcript variant X2, mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    XM_017028162.1

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGAAAGCTT TGTATGAACA AAACCAGTCT GATGTGAATG AAGCAAAGTC AGGTGGACGA 
    AGTGATTTGA TACCAACTAT CAAATTTCGA CACTGTTCTC TGTTAAGAAA TCGACGCTGC
    ACTGTAGCAT ACCTGTATGA CCGCTTGCTT CGGATCAGAG CACTCAGATG GGAATATGGT
    AGCGTCTTGC CAAATGCATT ACGATTTCAC ATGGCTGCTG AAGAAATGGA GTGGTTTAAT
    AATTATAAAA GATCTCTTGC TACTTATATG AGGTCACTGG GAGGAGATGA AGGTTTGGAC
    ATTACACAGG ATATGAAACC ACCAAAAAGC CTATATATTG AAGTCCGGTG TCTAAAAGAC
    TATGGAGAAT TTGAAGTTGA TGATGGCACT TCAGTCCTAT TAAAAAAAAA TAGCCAGCAC
    TTTTTACCTC GATGGAAATG TGAGCAGCTG ATCAGACAAG GAGTCCTGGA GCACATCCTG
    TCATGA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

  • PubMed

    Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency.
    The Journal of clinical investigation127(5)1991-2006(2017 May)
    Cottineau J,Kottemann MC,Lach FP,Kang YH,V?ly F,Deenick EK,Lazarov T,Gineau L,Wang Y,Farina A,Chansel M,Lorenzo L,Piperoglou C,Ma CS,Nitschke P,Belkadi A,Itan Y,Boisson B,Jabot-Hanin F,Picard C,Bustamante J,Eidenschenk C,Boucherit S,Aladjidi N,Lacombe D,Barat P,Qasim W,Hurst JA,Pollard AJ,Uhlig HH,Fieschi C,Michon J,Bermudez VP,Abel L,de Villartay JP,Geissmann F,Tangye SG,Hurwitz J,Vivier E,Casanova JL,Smogorzewska A,Jouanguy E


    New insights into the GINS complex explain the controversy between existing structural models.
    Scientific reports740188(2017 Jan)
    Carroni M,De March M,Medagli B,Krastanova I,Taylor IA,Amenitsch H,Araki H,Pisani FM,Patwardhan A,Onesti S


    Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
    Nature genetics43(11)1131-8(2011 Oct)
    Chambers JC,Zhang W,Sehmi J,Li X,Wass MN,Van der Harst P,Holm H,Sanna S,Kavousi M,Baumeister SE,Coin LJ,Deng G,Gieger C,Heard-Costa NL,Hottenga JJ,K?hnel B,Kumar V,Lagou V,Liang L,Luan J,Vidal PM,Mateo Leach I,O'Reilly PF,Peden JF,Rahmioglu N,Soininen P,Speliotes EK,Yuan X,Thorleifsson G,Alizadeh BZ,Atwood LD,Borecki IB,Brown MJ,Charoen P,Cucca F,Das D,de Geus EJ,Dixon AL,D?ring A,Ehret G,Eyjolfsson GI,Farrall M,Forouhi NG,Friedrich N,Goessling W,Gudbjartsson DF,Harris TB,Hartikainen AL,Heath S,Hirschfield GM,Hofman A,Homuth G,Hypp?nen E,Janssen HL,Johnson T,Kangas AJ,Kema IP,K?hn JP,Lai S,Lathrop M,Lerch MM,Li Y,Liang TJ,Lin JP,Loos RJ,Martin NG,Moffatt MF,Montgomery GW,Munroe PB,Musunuru K,Nakamura Y,O'Donnell CJ,Olafsson I,Penninx BW,Pouta A,Prins BP,Prokopenko I,Puls R,Ruokonen A,Savolainen MJ,Schlessinger D,Schouten JN,Seedorf U,Sen-Chowdhry S,Siminovitch KA,Smit JH,Spector TD,Tan W,Teslovich TM,Tukiainen T,Uitterlinden AG,Van der Klauw MM,Vasan RS,Wallace C,Wallaschofski H,Wichmann HE,Willemsen G,W?rtz P,Xu C,Yerges-Armstrong LM,,,,,,,,Abecasis GR,Ahmadi KR,Boomsma DI,Caulfield M,Cookson WO,van Duijn CM,Froguel P,Matsuda K,McCarthy MI,Meisinger C,Mooser V,Pietil?inen KH,Schumann G,Snieder H,Sternberg MJ,Stolk RP,Thomas HC,Thorsteinsdottir U,Uda M,Waeber G,Wareham NJ,Waterworth DM,Watkins H,Whitfield JB,Witteman JC,Wolffenbuttel BH,Fox CS,Ala-Korpela M,Stefansson K,Vollenweider P,V?lzke H,Schadt EE,Scott J,J?rvelin MR,Elliott P,Kooner JS