MAML1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAML1
Entrez Gene ID	9794
Full Name	mastermind like transcriptional coactivator 1
Synonyms	Mam-1,Mam1
General protein information	Preferred Names mastermind like transcriptional coactivator 1 Names mastermind-like protein 1 mastermind homolog mastermind-like 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q35.3
Summary	This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008].
Disorder MIM:	605424

mRNA and Protein(s)

mRNA	Protein	Name
NM_014757.5	NP_055572.1	mastermind-like protein 1
NM_014757.4	NP_055572.1	mastermind-like protein 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Maml1	NP_001100467.1
Homo sapiens (human)	MAML1	NP_055572.1
	MAML1	XP_001105097.2
Bos taurus (cattle)	MAML1	XP_005208449.1
Gallus gallus (chicken)	MAML1	XP_414607.4
Mus musculus (house mouse)	Maml1	NP_780543.2
Danio rerio (zebrafish)	LOC567335	XP_005157273.1
Pan troglodytes (chimpanzee)	MAML1	XP_527150.3
Canis lupus familiaris (dog)	MAML1	XP_005626406.1
Xenopus tropicalis (tropical clawed frog)	maml1	XP_002941844.2

Gene Ontology
Bibliography

Related articles in PubMed

MAML1 and TWIST1 co-overexpression promote invasion of head and neck squamous cell carcinoma.
Ardalan Khales S, Ebrahimi E, Jahanzad E, Ardalan Khales S, Forghanifard MM
Asia-Pacific journal of clinical oncology(2018 Jan)

Association of papillomavirus E6 proteins with either MAML1 or E6AP clusters E6 proteins by structure, function, and evolutionary relatedness.
Brimer N, Drews CM, Vande Pol SB
PLoS pathogens13(12)e1006781(2017 Dec)

Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription.
Jin K, Zhou W, Han X, Wang Z, Li B, Jeffries S, Tao W, Robbins DJ, Capobianco AJ
Cancer research77(16)4228-4237(2017 Aug)

Role of MAML1 and MEIS1 in Esophageal Squamous Cell Carcinoma Depth of Invasion.
Abbaszadegan MR, Moghbeli M
Pathology oncology research : POR(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Authors report that p300 and CBP acetylate Mastermind-like 1 (Maml1) on amino acid residues K188 and K189 to recruit NACK to the Notch1 ternary complex, which results in the recruitment of RNA polymerase II to initiate transcription.
Title: Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription.

Overexpression of Mastermind like1 was detected in 59% of tumor samples
Title: Contribution of MAML1 in esophageal squamous cell carcinoma tumorigenesis.

MAML1 may play an important role in tumor progression of Hepatocellular Carcinoma.
Title: Mastermind-like Transcriptional Coactivator 1 Overexpression Predicts Poor Prognosis in Human with Hepatocellular Carcinoma.

The transcriptional coregulator MAML1 affects DNA methylation and gene expression patterns in human embryonic kidney cells.
Title: The transcriptional coregulator MAML1 affects DNA methylation and gene expression patterns in human embryonic kidney cells.

Notch signaling was altered in almost half of the clear-cell renal cell carcinoma patients and copy number variances in MAML1 and KAT2B were predominant changes.
Title: Genetic alteration in notch pathway is associated with better prognosis in renal cell carcinoma.

The following MAML1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAML1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06660	NM_014757.5 Latest version!	Homo sapiens mastermind like transcriptional coactivator 1 (MAML1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$559.30 $799.00
View Old Accession Versions >>
OHu06660	NM_014757.4	Homo sapiens mastermind like transcriptional coactivator 1 (MAML1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$559.30 $799.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAML1 ( NM_014757.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055572.1 Homo sapiens mastermind like transcriptional coactivator 1 (MAML1), mRNA.

Price & Availability↑

CloneID	OHu06660
Clone ID Related Accession (Same CDS sequence)	NM_014757.5 , NM_014757.4
Accession Version	NM_014757.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3051bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	mastermind-like protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC113426.2, D83785.1, AF221759.1 and AA975821.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_014757.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D83785.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000292599.4/ ENSP00000292599.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGCTGC CCACCTGCCC CATGGCGGAG TTCGCGCTGC CGCGGCACAG CGCGGTCATG 
GAGCGCCTTC GCCGGCGCAT CGAGCTGTGC CGGCGCCACC ACAGCACCTG CGAGGCCCGC 
TACGAGGCCG TGTCGCCCGA GCGCCTGGAG CTGGAGCGCC AACACACCTT CGCCCTGCAC 
CAGCGCTGCA TCCAGGCCAA GGCCAAGCGC GCCGGGAAGC ACAGGCAGCC GCCCGCCGCC 
ACGGCCCCGG CGCCCGCCGC CCCGGCCCCG CGCCTGGACG CCGCTGACGG CCCCGAGCAC 
GGCCGCCCGG CCACGCATCT TCATGATACA GTTAAGAGGA ATCTTGACAG CGCCACTTCC 
CCTCAGAATG GCGATCAACA GAATGGCTAC GGGGACCTCT TTCCTGGGCA TAAGAAGACT 
CGCCGGGAGG CCCCTCTGGG AGTTGCCATC TCTTCCAATG GACTGCCTCC AGCCTCCCCC 
CTCGGTCAGT CTGACAAGCC TTCTGGAGCC GACGCCCTGC AGTCCAGTGG GAAGCACTCT 
CTGGGGCTAG ACTCTCTCAA CAAAAAGCGT CTGGCTGACT CCAGCCTTCA CTTGAATGGA 
GGCAGTAACC CCAGTGAGTC ATTTCCTCTG AGCCTGAATA AAGAACTGAA GCAGGAGCCT 
GTCGAAGACC TGCCTTGCAT GATCACTGGG ACTGTCGGCT CCATATCGCA AAGCAACCTC 
ATGCCAGACC TCAACCTTAA CGAGCAGGAG TGGAAGGAGC TCATCGAGGA GCTGAACAGG 
TCGGTGCCCG ATGAAGACAT GAAGGACCTG TTTAATGAGG ACTTCGAGGA GAAGAAGGAC 
CCAGAGTCTT CTGGCTCTGC CACACAAACC CCCTTGGCAC AGGACATTAA TATTAAGACG 
GAATTCTCTC CAGCAGCCTT TGAGCAAGAA CAGTTAGGCT CTCCACAAGT GAGGGCCGGG 
TCTGCAGGGC AGACCTTTCT GGGGCCTTCC TCTGCCCCTG TGAGTACAGA TTCCCCCAGC 
CTAGGGGGCT CCCAAACCTT ATTCCACACC TCTGGTCAGC CCCGGGCGGA CAATCCCAGT 
CCAAACCTGA TGCCGGCATC AGCCCAGGCC CAGAACGCAC AAAGAGCCCT TGCAGGTGTG 
GTATTGCCCA GTCAGGGCCC AGGAGGGGCC TCAGAGCTGT CCTCTGCCCA CCAGCTCCAG 
CAGATCGCTG CCAAGCAGAA GCGCGAGCAG ATGCTCCAGA ACCCACAGCA GGCCACCCCG 
GCACCAGCCC CGGGCCAGAT GTCCACATGG CAGCAGACGG GGCCCTCCCA CAGTTCCTTA 
GATGTCCCTT ACCCCATGGA GAAGCCTGCC AGCCCTTCCA GCTACAAGCA AGACTTCACT 
AACTCCAAAC TGCTCATGAT GCCTAGTGTG AATAAGAGTT CCCCTCGGCC CGGAGGCCCC 
TACCTCCAGC CCAGCCATGT GAACCTGCTG AGTCACCAGC CACCGAGTAA CTTGAATCAG 
AACTCCGCGA ATAACCAGGG GTCTGTGCTG GACTACGGCA ATACAAAACC CCTTTCTCAT 
TACAAAGCGG ACTGTGGGCA AGGCAGCCCG GGGTCTGGCC AGAGCAAGCC AGCCCTGATG 
GCTTATCTTC CCCAGCAGCT GTCCCATATA AGTCACGAGC AGAACTCCCT GTTTCTGATG 
AAGCCAAAGC CAGGAAATAT GCCTTTCCGA TCACTGGTTC CACCTGGCCA GGAGCAGAAC 
CCTTCCAGTG TCCCTGTGCA AGCCCAGGCT ACCAGTGTTG GGACCCAGCC GCCTGCCGTG 
TCCGTGGCCA GCTCCCACAA CAGCTCCCCC TATCTCAGCA GCCAGCAACA GGCCGCTGTA 
ATGAAGCAGC ATCAGTTGCT TTTGGACCAA CAGAAACAAA GGGAGCAGCA GCAAAAGCAT 
TTACAGCAAC AGCAGTTCCT TCAGAGGCAA CAGCACCTTC TCGCGGAACA GGAGAAGCAA 
CAGTTTCAGC GCCATCTGAC CCGCCCACCA CCCCAGTACC AAGACCCGAC ACAAGGCAGC 
TTCCCACAGC AGGTTGGACA GTTCACAGGG TCCTCTGCTG CCGTGCCCGG CATGAACACC 
TTGGGTCCAT CCAACTCCAG CTGTCCTCGA GTGTTCCCTC AGGCTGGGAA TCTGATGCCA 
ATGGGCCCTG GACATGCTTC AGTTTCCTCT CTCCCCACAA ACTCAGGCCA ACAGGACCGG 
GGTGTGGCTC AGTTCCCTGG CTCCCAAAAC ATGCCTCAGA GCAGCCTCTA TGGCATGGCT 
TCTGGCATAA CCCAGATAGT TGCCCAGCCC CCGCCACAGG CCACCAATGG ACATGCCCAC 
ATTCCACGGC AGACCAACGT GGGCCAGAAC ACCTCCGTCT CAGCTGCCTA TGGGCAGAAC 
TCTCTGGGAA GCTCTGGCCT CTCCCAGCAG CACAATAAGG GGACCCTGAA CCCTGGTTTA 
ACAAAGCCAC CGGTCCCAAG GGTGTCACCA GCCATGGGAG GCCAGAATTC CTCCTGGCAG 
CATCAGGGAA TGCCGAACCT CAGTGGCCAG ACCCCAGGGA ACAGCAACGT GAGTCCCTTC 
ACTGCAGCCT CCAGTTTCCA CATGCAGCAG CAGGCCCACC TGAAAATGTC TAGCCCGCAA 
TTCTCCCAGG CAGTGCCCAA CAGGCCCATG GCTCCCATGA GCTCAGCAGC TGCCGTGGGG 
TCCTTGCTAC CCCCAGTGAG TGCACAGCAG AGGACCAGCG CCCCTGCCCC AGCACCACCC 
CCAACAGCCC CTCAGCAGGG CTTGCCTGGC CTGAGCCCAG CAGGGCCTGA GCTGGGGGCC 
TTCAGCCAGA GCCCTGCCTC ACAGATGGGC GGTCGGGCGG GGCTGCACTG CACCCAGGCC 
TACCCTGTGC GGACCGCGGG CCAGGAGCTG CCTTTTGCCT ATAGCGGGCA GCCAGGTGGC 
AGTGGGCTCT CTAGTGTGGC TGGACACACC GATCTGATCG ACTCCCTGCT GAAGAACAGG 
ACTTCAGAGG AGTGGATGAG TGATTTGGAC GACCTGTTAG GGTCTCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055572.1
CDS	292..3342
Translation	MVLPTCPMAEFALPRHSAVMERLRRRIELCRRHHSTCEARYEAVSPERLELERQHTFALHQRCIQAKAKRAGKHRQPPAATAPAPAAPAPRLDAADGPEHGRPATHLHDTVKRNLDSATSPQNGDQQNGYGDLFPGHKKTRREAPLGVAISSNGLPPASPLGQSDKPSGADALQSSGKHSLGLDSLNKKRLADSSLHLNGGSNPSESFPLSLNKELKQEPVEDLPCMITGTVGSISQSNLMPDLNLNEQEWKELIEELNRSVPDEDMKDLFNEDFEEKKDPESSGSATQTPLAQDINIKTEFSPAAFEQEQLGSPQVRAGSAGQTFLGPSSAPVSTDSPSLGGSQTLFHTSGQPRADNPSPNLMPASAQAQNAQRALAGVVLPSQGPGGASELSSAHQLQQIAAKQKREQMLQNPQQATPAPAPGQMSTWQQTGPSHSSLDVPYPMEKPASPSSYKQDFTNSKLLMMPSVNKSSPRPGGPYLQPSHVNLLSHQPPSNLNQNSANNQGSVLDYGNTKPLSHYKADCGQGSPGSGQSKPALMAYLPQQLSHISHEQNSLFLMKPKPGNMPFRSLVPPGQEQNPSSVPVQAQATSVGTQPPAVSVASSHNSSPYLSSQQQAAVMKQHQLLLDQQKQREQQQKHLQQQQFLQRQQHLLAEQEKQQFQRHLTRPPPQYQDPTQGSFPQQVGQFTGSSAAVPGMNTLGPSNSSCPRVFPQAGNLMPMGPGHASVSSLPTNSGQQDRGVAQFPGSQNMPQSSLYGMASGITQIVAQPPPQATNGHAHIPRQTNVGQNTSVSAAYGQNSLGSSGLSQQHNKGTLNPGLTKPPVPRVSPAMGGQNSSWQHQGMPNLSGQTPGNSNVSPFTAASSFHMQQQAHLKMSSPQFSQAVPNRPMAPMSSAAAVGSLLPPVSAQQRTSAPAPAPPPTAPQQGLPGLSPAGPELGAFSQSPASQMGGRAGLHCTQAYPVRTAGQELPFAYSGQPGGSGLSSVAGHTDLIDSLLKNRTSEEWMSDLDDLLGSQ

Target ORF information:

RefSeq Version	NM_014757.5
Organism	Homo sapiens(human)
Definition	Homo sapiens mastermind like transcriptional coactivator 1 (MAML1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014757.5

ORF Insert Sequence:

ATGGTGCTGC CCACCTGCCC CATGGCGGAG TTCGCGCTGC CGCGGCACAG CGCGGTCATG 
GAGCGCCTTC GCCGGCGCAT CGAGCTGTGC CGGCGCCACC ACAGCACCTG CGAGGCCCGC 
TACGAGGCCG TGTCGCCCGA GCGCCTGGAG CTGGAGCGCC AACACACCTT CGCCCTGCAC 
CAGCGCTGCA TCCAGGCCAA GGCCAAGCGC GCCGGGAAGC ACAGGCAGCC GCCCGCCGCC 
ACGGCCCCGG CGCCCGCCGC CCCGGCCCCG CGCCTGGACG CCGCTGACGG CCCCGAGCAC 
GGCCGCCCGG CCACGCATCT TCATGATACA GTTAAGAGGA ATCTTGACAG CGCCACTTCC 
CCTCAGAATG GCGATCAACA GAATGGCTAC GGGGACCTCT TTCCTGGGCA TAAGAAGACT 
CGCCGGGAGG CCCCTCTGGG AGTTGCCATC TCTTCCAATG GACTGCCTCC AGCCTCCCCC 
CTCGGTCAGT CTGACAAGCC TTCTGGAGCC GACGCCCTGC AGTCCAGTGG GAAGCACTCT 
CTGGGGCTAG ACTCTCTCAA CAAAAAGCGT CTGGCTGACT CCAGCCTTCA CTTGAATGGA 
GGCAGTAACC CCAGTGAGTC ATTTCCTCTG AGCCTGAATA AAGAACTGAA GCAGGAGCCT 
GTCGAAGACC TGCCTTGCAT GATCACTGGG ACTGTCGGCT CCATATCGCA AAGCAACCTC 
ATGCCAGACC TCAACCTTAA CGAGCAGGAG TGGAAGGAGC TCATCGAGGA GCTGAACAGG 
TCGGTGCCCG ATGAAGACAT GAAGGACCTG TTTAATGAGG ACTTCGAGGA GAAGAAGGAC 
CCAGAGTCTT CTGGCTCTGC CACACAAACC CCCTTGGCAC AGGACATTAA TATTAAGACG 
GAATTCTCTC CAGCAGCCTT TGAGCAAGAA CAGTTAGGCT CTCCACAAGT GAGGGCCGGG 
TCTGCAGGGC AGACCTTTCT GGGGCCTTCC TCTGCCCCTG TGAGTACAGA TTCCCCCAGC 
CTAGGGGGCT CCCAAACCTT ATTCCACACC TCTGGTCAGC CCCGGGCGGA CAATCCCAGT 
CCAAACCTGA TGCCGGCATC AGCCCAGGCC CAGAACGCAC AAAGAGCCCT TGCAGGTGTG 
GTATTGCCCA GTCAGGGCCC AGGAGGGGCC TCAGAGCTGT CCTCTGCCCA CCAGCTCCAG 
CAGATCGCTG CCAAGCAGAA GCGCGAGCAG ATGCTCCAGA ACCCACAGCA GGCCACCCCG 
GCACCAGCCC CGGGCCAGAT GTCCACATGG CAGCAGACGG GGCCCTCCCA CAGTTCCTTA 
GATGTCCCTT ACCCCATGGA GAAGCCTGCC AGCCCTTCCA GCTACAAGCA AGACTTCACT 
AACTCCAAAC TGCTCATGAT GCCTAGTGTG AATAAGAGTT CCCCTCGGCC CGGAGGCCCC 
TACCTCCAGC CCAGCCATGT GAACCTGCTG AGTCACCAGC CACCGAGTAA CTTGAATCAG 
AACTCCGCGA ATAACCAGGG GTCTGTGCTG GACTACGGCA ATACAAAACC CCTTTCTCAT 
TACAAAGCGG ACTGTGGGCA AGGCAGCCCG GGGTCTGGCC AGAGCAAGCC AGCCCTGATG 
GCTTATCTTC CCCAGCAGCT GTCCCATATA AGTCACGAGC AGAACTCCCT GTTTCTGATG 
AAGCCAAAGC CAGGAAATAT GCCTTTCCGA TCACTGGTTC CACCTGGCCA GGAGCAGAAC 
CCTTCCAGTG TCCCTGTGCA AGCCCAGGCT ACCAGTGTTG GGACCCAGCC GCCTGCCGTG 
TCCGTGGCCA GCTCCCACAA CAGCTCCCCC TATCTCAGCA GCCAGCAACA GGCCGCTGTA 
ATGAAGCAGC ATCAGTTGCT TTTGGACCAA CAGAAACAAA GGGAGCAGCA GCAAAAGCAT 
TTACAGCAAC AGCAGTTCCT TCAGAGGCAA CAGCACCTTC TCGCGGAACA GGAGAAGCAA 
CAGTTTCAGC GCCATCTGAC CCGCCCACCA CCCCAGTACC AAGACCCGAC ACAAGGCAGC 
TTCCCACAGC AGGTTGGACA GTTCACAGGG TCCTCTGCTG CCGTGCCCGG CATGAACACC 
TTGGGTCCAT CCAACTCCAG CTGTCCTCGA GTGTTCCCTC AGGCTGGGAA TCTGATGCCA 
ATGGGCCCTG GACATGCTTC AGTTTCCTCT CTCCCCACAA ACTCAGGCCA ACAGGACCGG 
GGTGTGGCTC AGTTCCCTGG CTCCCAAAAC ATGCCTCAGA GCAGCCTCTA TGGCATGGCT 
TCTGGCATAA CCCAGATAGT TGCCCAGCCC CCGCCACAGG CCACCAATGG ACATGCCCAC 
ATTCCACGGC AGACCAACGT GGGCCAGAAC ACCTCCGTCT CAGCTGCCTA TGGGCAGAAC 
TCTCTGGGAA GCTCTGGCCT CTCCCAGCAG CACAATAAGG GGACCCTGAA CCCTGGTTTA 
ACAAAGCCAC CGGTCCCAAG GGTGTCACCA GCCATGGGAG GCCAGAATTC CTCCTGGCAG 
CATCAGGGAA TGCCGAACCT CAGTGGCCAG ACCCCAGGGA ACAGCAACGT GAGTCCCTTC 
ACTGCAGCCT CCAGTTTCCA CATGCAGCAG CAGGCCCACC TGAAAATGTC TAGCCCGCAA 
TTCTCCCAGG CAGTGCCCAA CAGGCCCATG GCTCCCATGA GCTCAGCAGC TGCCGTGGGG 
TCCTTGCTAC CCCCAGTGAG TGCACAGCAG AGGACCAGCG CCCCTGCCCC AGCACCACCC 
CCAACAGCCC CTCAGCAGGG CTTGCCTGGC CTGAGCCCAG CAGGGCCTGA GCTGGGGGCC 
TTCAGCCAGA GCCCTGCCTC ACAGATGGGC GGTCGGGCGG GGCTGCACTG CACCCAGGCC 
TACCCTGTGC GGACCGCGGG CCAGGAGCTG CCTTTTGCCT ATAGCGGGCA GCCAGGTGGC 
AGTGGGCTCT CTAGTGTGGC TGGACACACC GATCTGATCG ACTCCCTGCT GAAGAACAGG 
ACTTCAGAGG AGTGGATGAG TGATTTGGAC GACCTGTTAG GGTCTCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAML1 ( NM_014757.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055572.1 Homo sapiens mastermind like transcriptional coactivator 1 (MAML1), mRNA.

Price & Availability↑

CloneID	OHu06660
Clone ID Related Accession (Same CDS sequence)	NM_014757.5 , NM_014757.4
Accession Version	NM_014757.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3051bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	mastermind-like protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D83785.1, AF221759.1 and AA975821.1. This sequence is a reference standard in the RefSeqGene project. On Oct 2, 2008 this sequence version replaced NM_014757.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D83785.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGCTGC CCACCTGCCC CATGGCGGAG TTCGCGCTGC CGCGGCACAG CGCGGTCATG 
GAGCGCCTTC GCCGGCGCAT CGAGCTGTGC CGGCGCCACC ACAGCACCTG CGAGGCCCGC 
TACGAGGCCG TGTCGCCCGA GCGCCTGGAG CTGGAGCGCC AACACACCTT CGCCCTGCAC 
CAGCGCTGCA TCCAGGCCAA GGCCAAGCGC GCCGGGAAGC ACAGGCAGCC GCCCGCCGCC 
ACGGCCCCGG CGCCCGCCGC CCCGGCCCCG CGCCTGGACG CCGCTGACGG CCCCGAGCAC 
GGCCGCCCGG CCACGCATCT TCATGATACA GTTAAGAGGA ATCTTGACAG CGCCACTTCC 
CCTCAGAATG GCGATCAACA GAATGGCTAC GGGGACCTCT TTCCTGGGCA TAAGAAGACT 
CGCCGGGAGG CCCCTCTGGG AGTTGCCATC TCTTCCAATG GACTGCCTCC AGCCTCCCCC 
CTCGGTCAGT CTGACAAGCC TTCTGGAGCC GACGCCCTGC AGTCCAGTGG GAAGCACTCT 
CTGGGGCTAG ACTCTCTCAA CAAAAAGCGT CTGGCTGACT CCAGCCTTCA CTTGAATGGA 
GGCAGTAACC CCAGTGAGTC ATTTCCTCTG AGCCTGAATA AAGAACTGAA GCAGGAGCCT 
GTCGAAGACC TGCCTTGCAT GATCACTGGG ACTGTCGGCT CCATATCGCA AAGCAACCTC 
ATGCCAGACC TCAACCTTAA CGAGCAGGAG TGGAAGGAGC TCATCGAGGA GCTGAACAGG 
TCGGTGCCCG ATGAAGACAT GAAGGACCTG TTTAATGAGG ACTTCGAGGA GAAGAAGGAC 
CCAGAGTCTT CTGGCTCTGC CACACAAACC CCCTTGGCAC AGGACATTAA TATTAAGACG 
GAATTCTCTC CAGCAGCCTT TGAGCAAGAA CAGTTAGGCT CTCCACAAGT GAGGGCCGGG 
TCTGCAGGGC AGACCTTTCT GGGGCCTTCC TCTGCCCCTG TGAGTACAGA TTCCCCCAGC 
CTAGGGGGCT CCCAAACCTT ATTCCACACC TCTGGTCAGC CCCGGGCGGA CAATCCCAGT 
CCAAACCTGA TGCCGGCATC AGCCCAGGCC CAGAACGCAC AAAGAGCCCT TGCAGGTGTG 
GTATTGCCCA GTCAGGGCCC AGGAGGGGCC TCAGAGCTGT CCTCTGCCCA CCAGCTCCAG 
CAGATCGCTG CCAAGCAGAA GCGCGAGCAG ATGCTCCAGA ACCCACAGCA GGCCACCCCG 
GCACCAGCCC CGGGCCAGAT GTCCACATGG CAGCAGACGG GGCCCTCCCA CAGTTCCTTA 
GATGTCCCTT ACCCCATGGA GAAGCCTGCC AGCCCTTCCA GCTACAAGCA AGACTTCACT 
AACTCCAAAC TGCTCATGAT GCCTAGTGTG AATAAGAGTT CCCCTCGGCC CGGAGGCCCC 
TACCTCCAGC CCAGCCATGT GAACCTGCTG AGTCACCAGC CACCGAGTAA CTTGAATCAG 
AACTCCGCGA ATAACCAGGG GTCTGTGCTG GACTACGGCA ATACAAAACC CCTTTCTCAT 
TACAAAGCGG ACTGTGGGCA AGGCAGCCCG GGGTCTGGCC AGAGCAAGCC AGCCCTGATG 
GCTTATCTTC CCCAGCAGCT GTCCCATATA AGTCACGAGC AGAACTCCCT GTTTCTGATG 
AAGCCAAAGC CAGGAAATAT GCCTTTCCGA TCACTGGTTC CACCTGGCCA GGAGCAGAAC 
CCTTCCAGTG TCCCTGTGCA AGCCCAGGCT ACCAGTGTTG GGACCCAGCC GCCTGCCGTG 
TCCGTGGCCA GCTCCCACAA CAGCTCCCCC TATCTCAGCA GCCAGCAACA GGCCGCTGTA 
ATGAAGCAGC ATCAGTTGCT TTTGGACCAA CAGAAACAAA GGGAGCAGCA GCAAAAGCAT 
TTACAGCAAC AGCAGTTCCT TCAGAGGCAA CAGCACCTTC TCGCGGAACA GGAGAAGCAA 
CAGTTTCAGC GCCATCTGAC CCGCCCACCA CCCCAGTACC AAGACCCGAC ACAAGGCAGC 
TTCCCACAGC AGGTTGGACA GTTCACAGGG TCCTCTGCTG CCGTGCCCGG CATGAACACC 
TTGGGTCCAT CCAACTCCAG CTGTCCTCGA GTGTTCCCTC AGGCTGGGAA TCTGATGCCA 
ATGGGCCCTG GACATGCTTC AGTTTCCTCT CTCCCCACAA ACTCAGGCCA ACAGGACCGG 
GGTGTGGCTC AGTTCCCTGG CTCCCAAAAC ATGCCTCAGA GCAGCCTCTA TGGCATGGCT 
TCTGGCATAA CCCAGATAGT TGCCCAGCCC CCGCCACAGG CCACCAATGG ACATGCCCAC 
ATTCCACGGC AGACCAACGT GGGCCAGAAC ACCTCCGTCT CAGCTGCCTA TGGGCAGAAC 
TCTCTGGGAA GCTCTGGCCT CTCCCAGCAG CACAATAAGG GGACCCTGAA CCCTGGTTTA 
ACAAAGCCAC CGGTCCCAAG GGTGTCACCA GCCATGGGAG GCCAGAATTC CTCCTGGCAG 
CATCAGGGAA TGCCGAACCT CAGTGGCCAG ACCCCAGGGA ACAGCAACGT GAGTCCCTTC 
ACTGCAGCCT CCAGTTTCCA CATGCAGCAG CAGGCCCACC TGAAAATGTC TAGCCCGCAA 
TTCTCCCAGG CAGTGCCCAA CAGGCCCATG GCTCCCATGA GCTCAGCAGC TGCCGTGGGG 
TCCTTGCTAC CCCCAGTGAG TGCACAGCAG AGGACCAGCG CCCCTGCCCC AGCACCACCC 
CCAACAGCCC CTCAGCAGGG CTTGCCTGGC CTGAGCCCAG CAGGGCCTGA GCTGGGGGCC 
TTCAGCCAGA GCCCTGCCTC ACAGATGGGC GGTCGGGCGG GGCTGCACTG CACCCAGGCC 
TACCCTGTGC GGACCGCGGG CCAGGAGCTG CCTTTTGCCT ATAGCGGGCA GCCAGGTGGC 
AGTGGGCTCT CTAGTGTGGC TGGACACACC GATCTGATCG ACTCCCTGCT GAAGAACAGG 
ACTTCAGAGG AGTGGATGAG TGATTTGGAC GACCTGTTAG GGTCTCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055572.1
CDS	264..3314
Translation	MVLPTCPMAEFALPRHSAVMERLRRRIELCRRHHSTCEARYEAVSPERLELERQHTFALHQRCIQAKAKRAGKHRQPPAATAPAPAAPAPRLDAADGPEHGRPATHLHDTVKRNLDSATSPQNGDQQNGYGDLFPGHKKTRREAPLGVAISSNGLPPASPLGQSDKPSGADALQSSGKHSLGLDSLNKKRLADSSLHLNGGSNPSESFPLSLNKELKQEPVEDLPCMITGTVGSISQSNLMPDLNLNEQEWKELIEELNRSVPDEDMKDLFNEDFEEKKDPESSGSATQTPLAQDINIKTEFSPAAFEQEQLGSPQVRAGSAGQTFLGPSSAPVSTDSPSLGGSQTLFHTSGQPRADNPSPNLMPASAQAQNAQRALAGVVLPSQGPGGASELSSAHQLQQIAAKQKREQMLQNPQQATPAPAPGQMSTWQQTGPSHSSLDVPYPMEKPASPSSYKQDFTNSKLLMMPSVNKSSPRPGGPYLQPSHVNLLSHQPPSNLNQNSANNQGSVLDYGNTKPLSHYKADCGQGSPGSGQSKPALMAYLPQQLSHISHEQNSLFLMKPKPGNMPFRSLVPPGQEQNPSSVPVQAQATSVGTQPPAVSVASSHNSSPYLSSQQQAAVMKQHQLLLDQQKQREQQQKHLQQQQFLQRQQHLLAEQEKQQFQRHLTRPPPQYQDPTQGSFPQQVGQFTGSSAAVPGMNTLGPSNSSCPRVFPQAGNLMPMGPGHASVSSLPTNSGQQDRGVAQFPGSQNMPQSSLYGMASGITQIVAQPPPQATNGHAHIPRQTNVGQNTSVSAAYGQNSLGSSGLSQQHNKGTLNPGLTKPPVPRVSPAMGGQNSSWQHQGMPNLSGQTPGNSNVSPFTAASSFHMQQQAHLKMSSPQFSQAVPNRPMAPMSSAAAVGSLLPPVSAQQRTSAPAPAPPPTAPQQGLPGLSPAGPELGAFSQSPASQMGGRAGLHCTQAYPVRTAGQELPFAYSGQPGGSGLSSVAGHTDLIDSLLKNRTSEEWMSDLDDLLGSQ

Target ORF information:

RefSeq Version	NM_014757.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mastermind like transcriptional coactivator 1 (MAML1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014757.4

ORF Insert Sequence:

ATGGTGCTGC CCACCTGCCC CATGGCGGAG TTCGCGCTGC CGCGGCACAG CGCGGTCATG 
GAGCGCCTTC GCCGGCGCAT CGAGCTGTGC CGGCGCCACC ACAGCACCTG CGAGGCCCGC 
TACGAGGCCG TGTCGCCCGA GCGCCTGGAG CTGGAGCGCC AACACACCTT CGCCCTGCAC 
CAGCGCTGCA TCCAGGCCAA GGCCAAGCGC GCCGGGAAGC ACAGGCAGCC GCCCGCCGCC 
ACGGCCCCGG CGCCCGCCGC CCCGGCCCCG CGCCTGGACG CCGCTGACGG CCCCGAGCAC 
GGCCGCCCGG CCACGCATCT TCATGATACA GTTAAGAGGA ATCTTGACAG CGCCACTTCC 
CCTCAGAATG GCGATCAACA GAATGGCTAC GGGGACCTCT TTCCTGGGCA TAAGAAGACT 
CGCCGGGAGG CCCCTCTGGG AGTTGCCATC TCTTCCAATG GACTGCCTCC AGCCTCCCCC 
CTCGGTCAGT CTGACAAGCC TTCTGGAGCC GACGCCCTGC AGTCCAGTGG GAAGCACTCT 
CTGGGGCTAG ACTCTCTCAA CAAAAAGCGT CTGGCTGACT CCAGCCTTCA CTTGAATGGA 
GGCAGTAACC CCAGTGAGTC ATTTCCTCTG AGCCTGAATA AAGAACTGAA GCAGGAGCCT 
GTCGAAGACC TGCCTTGCAT GATCACTGGG ACTGTCGGCT CCATATCGCA AAGCAACCTC 
ATGCCAGACC TCAACCTTAA CGAGCAGGAG TGGAAGGAGC TCATCGAGGA GCTGAACAGG 
TCGGTGCCCG ATGAAGACAT GAAGGACCTG TTTAATGAGG ACTTCGAGGA GAAGAAGGAC 
CCAGAGTCTT CTGGCTCTGC CACACAAACC CCCTTGGCAC AGGACATTAA TATTAAGACG 
GAATTCTCTC CAGCAGCCTT TGAGCAAGAA CAGTTAGGCT CTCCACAAGT GAGGGCCGGG 
TCTGCAGGGC AGACCTTTCT GGGGCCTTCC TCTGCCCCTG TGAGTACAGA TTCCCCCAGC 
CTAGGGGGCT CCCAAACCTT ATTCCACACC TCTGGTCAGC CCCGGGCGGA CAATCCCAGT 
CCAAACCTGA TGCCGGCATC AGCCCAGGCC CAGAACGCAC AAAGAGCCCT TGCAGGTGTG 
GTATTGCCCA GTCAGGGCCC AGGAGGGGCC TCAGAGCTGT CCTCTGCCCA CCAGCTCCAG 
CAGATCGCTG CCAAGCAGAA GCGCGAGCAG ATGCTCCAGA ACCCACAGCA GGCCACCCCG 
GCACCAGCCC CGGGCCAGAT GTCCACATGG CAGCAGACGG GGCCCTCCCA CAGTTCCTTA 
GATGTCCCTT ACCCCATGGA GAAGCCTGCC AGCCCTTCCA GCTACAAGCA AGACTTCACT 
AACTCCAAAC TGCTCATGAT GCCTAGTGTG AATAAGAGTT CCCCTCGGCC CGGAGGCCCC 
TACCTCCAGC CCAGCCATGT GAACCTGCTG AGTCACCAGC CACCGAGTAA CTTGAATCAG 
AACTCCGCGA ATAACCAGGG GTCTGTGCTG GACTACGGCA ATACAAAACC CCTTTCTCAT 
TACAAAGCGG ACTGTGGGCA AGGCAGCCCG GGGTCTGGCC AGAGCAAGCC AGCCCTGATG 
GCTTATCTTC CCCAGCAGCT GTCCCATATA AGTCACGAGC AGAACTCCCT GTTTCTGATG 
AAGCCAAAGC CAGGAAATAT GCCTTTCCGA TCACTGGTTC CACCTGGCCA GGAGCAGAAC 
CCTTCCAGTG TCCCTGTGCA AGCCCAGGCT ACCAGTGTTG GGACCCAGCC GCCTGCCGTG 
TCCGTGGCCA GCTCCCACAA CAGCTCCCCC TATCTCAGCA GCCAGCAACA GGCCGCTGTA 
ATGAAGCAGC ATCAGTTGCT TTTGGACCAA CAGAAACAAA GGGAGCAGCA GCAAAAGCAT 
TTACAGCAAC AGCAGTTCCT TCAGAGGCAA CAGCACCTTC TCGCGGAACA GGAGAAGCAA 
CAGTTTCAGC GCCATCTGAC CCGCCCACCA CCCCAGTACC AAGACCCGAC ACAAGGCAGC 
TTCCCACAGC AGGTTGGACA GTTCACAGGG TCCTCTGCTG CCGTGCCCGG CATGAACACC 
TTGGGTCCAT CCAACTCCAG CTGTCCTCGA GTGTTCCCTC AGGCTGGGAA TCTGATGCCA 
ATGGGCCCTG GACATGCTTC AGTTTCCTCT CTCCCCACAA ACTCAGGCCA ACAGGACCGG 
GGTGTGGCTC AGTTCCCTGG CTCCCAAAAC ATGCCTCAGA GCAGCCTCTA TGGCATGGCT 
TCTGGCATAA CCCAGATAGT TGCCCAGCCC CCGCCACAGG CCACCAATGG ACATGCCCAC 
ATTCCACGGC AGACCAACGT GGGCCAGAAC ACCTCCGTCT CAGCTGCCTA TGGGCAGAAC 
TCTCTGGGAA GCTCTGGCCT CTCCCAGCAG CACAATAAGG GGACCCTGAA CCCTGGTTTA 
ACAAAGCCAC CGGTCCCAAG GGTGTCACCA GCCATGGGAG GCCAGAATTC CTCCTGGCAG 
CATCAGGGAA TGCCGAACCT CAGTGGCCAG ACCCCAGGGA ACAGCAACGT GAGTCCCTTC 
ACTGCAGCCT CCAGTTTCCA CATGCAGCAG CAGGCCCACC TGAAAATGTC TAGCCCGCAA 
TTCTCCCAGG CAGTGCCCAA CAGGCCCATG GCTCCCATGA GCTCAGCAGC TGCCGTGGGG 
TCCTTGCTAC CCCCAGTGAG TGCACAGCAG AGGACCAGCG CCCCTGCCCC AGCACCACCC 
CCAACAGCCC CTCAGCAGGG CTTGCCTGGC CTGAGCCCAG CAGGGCCTGA GCTGGGGGCC 
TTCAGCCAGA GCCCTGCCTC ACAGATGGGC GGTCGGGCGG GGCTGCACTG CACCCAGGCC 
TACCCTGTGC GGACCGCGGG CCAGGAGCTG CCTTTTGCCT ATAGCGGGCA GCCAGGTGGC 
AGTGGGCTCT CTAGTGTGGC TGGACACACC GATCTGATCG ACTCCCTGCT GAAGAACAGG 
ACTTCAGAGG AGTGGATGAG TGATTTGGAC GACCTGTTAG GGTCTCAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MAML1 and TWIST1 co-overexpression promote invasion of head and neck squamous cell carcinoma.
Asia-Pacific journal of clinical oncology(2018 Jan)
Ardalan Khales S,Ebrahimi E,Jahanzad E,Ardalan Khales S,Forghanifard MM

Association of papillomavirus E6 proteins with either MAML1 or E6AP clusters E6 proteins by structure, function, and evolutionary relatedness.
PLoS pathogens13(12)e1006781(2017 Dec)
Brimer N,Drews CM,Vande Pol SB

Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription.
Cancer research77(16)4228-4237(2017 Aug)
Jin K,Zhou W,Han X,Wang Z,Li B,Jeffries S,Tao W,Robbins DJ,Capobianco AJ

Role of MAML1 and MEIS1 in Esophageal Squamous Cell Carcinoma Depth of Invasion.
Pathology oncology research : POR(2017 May)
Abbaszadegan MR,Moghbeli M

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MAML1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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