CD79A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CD79A
Entrez Gene ID	973
Full Name	CD79a molecule
Synonyms	IGA,MB-1
General protein information	Preferred Names CD79a molecule Names B-cell antigen receptor complex-associated protein alpha chain CD79a antigen (immunoglobulin-associated alpha) CD79a molecule, immunoglobulin-associated alpha MB-1 membrane glycoprotein ig-alpha membrane-bound immunoglobulin-associated protein surface IgM-associated protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.2
Summary	The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Disorder MIM:	112205
Disorder Html:	Agammaglobulinemia 3, 613501 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001783.3	NP_001774.1	B-cell antigen receptor complex-associated protein alpha chain isoform 1 precursor
NM_021601.3	NP_067612.1	B-cell antigen receptor complex-associated protein alpha chain isoform 2 precursor
NM_001783.4	NP_001774.1	B-cell antigen receptor complex-associated protein alpha chain isoform 1 precursor
NM_021601.4	NP_067612.1	B-cell antigen receptor complex-associated protein alpha chain isoform 2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CD79A	XP_001152742.1
Rattus norvegicus (Norway rat)	LOC100913063	XP_006228599.1
Xenopus tropicalis (tropical clawed frog)	LOC100485353	XP_002941973.1
Homo sapiens (human)	CD79A	NP_001774.1
Danio rerio (zebrafish)	cd79a	XP_001339223.1
Canis lupus familiaris (dog)	CD79A	XP_541597.2
Bos taurus (cattle)	CD79A	NP_776691.2
Mus musculus (house mouse)	Cd79a	NP_031681.2

Gene Ontology
Bibliography

Related articles in PubMed

MYD88, CD79B, and CARD11 gene mutations in CD5-positive diffuse large B-cell lymphoma.
Takeuchi T, Yamaguchi M, Kobayashi K, Miyazaki K, Tawara I, Imai H, Ono R, Nosaka T, Tanaka K, Katayama N
Cancer123(7)1166-1173(2017 Apr)

Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma.
Nagel D, Bognar M, Eitelhuber AC, Kutzner K, Vincendeau M, Krappmann D
Oncotarget6(39)42232-42(2015 Dec)

The assessment of sIgA, histatin-5, and lactoperoxidase levels in saliva of adolescents with dental caries.
Gornowicz A, Tokajuk G, Bielawska A, Maciorkowska E, Jab?o?ski R, W?jcicka A, Bielawski K
Medical science monitor : international medical journal of experimental and clinical research201095-100(2014 Jun)

Tyrosine phosphorylation within the intrinsically disordered cytosolic domains of the B-cell receptor: an NMR-based structural analysis.
Rosenl?w J, Isaksson L, Mayzel M, Lengqvist J, Orekhov VY
PloS one9(4)e96199(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The incidence of MYD88 and CD79B mutations in patients with CD5(+) DLBCL is lower than that in patients with DLBCL-SS, suggesting that CD5(+) DLBCL is not the same disease as DLBCL-SS in terms of gene mutation status.
Title: MYD88, CD79B, and CARD11 gene mutations in CD5-positive diffuse large B-cell lymphoma.

Data show that Bruton tyrosine kinase (BTK)inhibitor Ibrutinib augments MALT lymphoma associated translocation protein (MALT1) inhibition by S-Mepazine in CD79 antigen mutant activated B cell-subtype (ABC) of diffuse large B cell lymphoma (DLBCL).
Title: Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma.

High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase.
Title: The assessment of sIgA, histatin-5, and lactoperoxidase levels in saliva of adolescents with dental caries.

Phosphorylation of CD79a causes a decrease in helical propensity in the C-terminal region, for CD79b, the opposite was observed and phosphorylation resulted in an increase of helical propensity in the C-terminal part.
Title: Tyrosine phosphorylation within the intrinsically disordered cytosolic domains of the B-cell receptor: an NMR-based structural analysis.

CD79a plays a functional role in the tumor promoting effects of myeloid cells, and may represent a novel target for cancer therapy.
Title: Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects.

The following CD79A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD79A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23017	NM_001783.4 Latest version!	Homo sapiens CD79a molecule (CD79A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu12357	NM_021601.4 Latest version!	Homo sapiens CD79a molecule (CD79A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu23017	NM_001783.3	Homo sapiens CD79a molecule (CD79A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu12357	NM_021601.3	Homo sapiens CD79a molecule (CD79A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CD79A ( NM_001783.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001774.1 Homo sapiens CD79a molecule (CD79A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23017
Clone ID Related Accession (Same CDS sequence)	NM_001783.3 , NM_001783.4
Accession Version	NM_001783.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 681bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	B-cell antigen receptor complex-associated protein alpha chain isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC243967.3. This sequence is a reference standard in the RefSeqGene project. On Mar 22, 2006 this sequence version replaced NM_001783.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223371.1, SRR1163658.242894.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTGGGG GTCCAGGAGT CCTCCAAGCT CTGCCTGCCA CCATCTTCCT CCTCTTCCTG 
CTGTCTGCTG TCTACCTGGG CCCTGGGTGC CAGGCCCTGT GGATGCACAA GGTCCCAGCA 
TCATTGATGG TGAGCCTGGG GGAAGACGCC CACTTCCAAT GCCCGCACAA TAGCAGCAAC 
AACGCCAACG TCACCTGGTG GCGCGTCCTC CATGGCAACT ACACGTGGCC CCCTGAGTTC 
TTGGGCCCGG GCGAGGACCC CAATGGTACG CTGATCATCC AGAATGTGAA CAAGAGCCAT 
GGGGGCATAT ACGTGTGCCG GGTCCAGGAG GGCAACGAGT CATACCAGCA GTCCTGCGGC 
ACCTACCTCC GCGTGCGCCA GCCGCCCCCC AGGCCCTTCC TGGACATGGG GGAGGGCACC 
AAGAACCGAA TCATCACAGC CGAGGGGATC ATCCTCCTGT TCTGCGCGGT GGTGCCTGGG 
ACGCTGCTGC TGTTCAGGAA ACGATGGCAG AACGAGAAGC TCGGGTTGGA TGCCGGGGAT 
GAATATGAAG ATGAAAACCT TTATGAAGGC CTGAACCTGG ACGACTGCTC CATGTATGAG 
GACATCTCCC GGGGCCTCCA GGGCACCTAC CAGGATGTGG GCAGCCTCAA CATAGGAGAT 
GTCCAGCTGG AGAAGCCGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001774.1
CDS	186..866
Translation	MPGGPGVLQALPATIFLLFLLSAVYLGPGCQALWMHKVPASLMVSLGEDAHFQCPHNSSNNANVTWWRVLHGNYTWPPEFLGPGEDPNGTLIIQNVNKSHGGIYVCRVQEGNESYQQSCGTYLRVRQPPPRPFLDMGEGTKNRIITAEGIILLFCAVVPGTLLLFRKRWQNEKLGLDAGDEYEDENLYEGLNLDDCSMYEDISRGLQGTYQDVGSLNIGDVQLEKP

Target ORF information:

RefSeq Version	NM_001783.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CD79a molecule (CD79A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001783.3

ORF Insert Sequence:

ATGCCTGGGG GTCCAGGAGT CCTCCAAGCT CTGCCTGCCA CCATCTTCCT CCTCTTCCTG 
CTGTCTGCTG TCTACCTGGG CCCTGGGTGC CAGGCCCTGT GGATGCACAA GGTCCCAGCA 
TCATTGATGG TGAGCCTGGG GGAAGACGCC CACTTCCAAT GCCCGCACAA TAGCAGCAAC 
AACGCCAACG TCACCTGGTG GCGCGTCCTC CATGGCAACT ACACGTGGCC CCCTGAGTTC 
TTGGGCCCGG GCGAGGACCC CAATGGTACG CTGATCATCC AGAATGTGAA CAAGAGCCAT 
GGGGGCATAT ACGTGTGCCG GGTCCAGGAG GGCAACGAGT CATACCAGCA GTCCTGCGGC 
ACCTACCTCC GCGTGCGCCA GCCGCCCCCC AGGCCCTTCC TGGACATGGG GGAGGGCACC 
AAGAACCGAA TCATCACAGC CGAGGGGATC ATCCTCCTGT TCTGCGCGGT GGTGCCTGGG 
ACGCTGCTGC TGTTCAGGAA ACGATGGCAG AACGAGAAGC TCGGGTTGGA TGCCGGGGAT 
GAATATGAAG ATGAAAACCT TTATGAAGGC CTGAACCTGG ACGACTGCTC CATGTATGAG 
GACATCTCCC GGGGCCTCCA GGGCACCTAC CAGGATGTGG GCAGCCTCAA CATAGGAGAT 
GTCCAGCTGG AGAAGCCGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD79A ( NM_001783.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001774.1 Homo sapiens CD79a molecule (CD79A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23017
Clone ID Related Accession (Same CDS sequence)	NM_001783.3 , NM_001783.4
Accession Version	NM_001783.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 681bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	B-cell antigen receptor complex-associated protein alpha chain isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC243967.3. On Aug 31, 2019 this sequence version replaced NM_001783.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223371.1, AL559990.3 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTGGGG GTCCAGGAGT CCTCCAAGCT CTGCCTGCCA CCATCTTCCT CCTCTTCCTG 
CTGTCTGCTG TCTACCTGGG CCCTGGGTGC CAGGCCCTGT GGATGCACAA GGTCCCAGCA 
TCATTGATGG TGAGCCTGGG GGAAGACGCC CACTTCCAAT GCCCGCACAA TAGCAGCAAC 
AACGCCAACG TCACCTGGTG GCGCGTCCTC CATGGCAACT ACACGTGGCC CCCTGAGTTC 
TTGGGCCCGG GCGAGGACCC CAATGGTACG CTGATCATCC AGAATGTGAA CAAGAGCCAT 
GGGGGCATAT ACGTGTGCCG GGTCCAGGAG GGCAACGAGT CATACCAGCA GTCCTGCGGC 
ACCTACCTCC GCGTGCGCCA GCCGCCCCCC AGGCCCTTCC TGGACATGGG GGAGGGCACC 
AAGAACCGAA TCATCACAGC CGAGGGGATC ATCCTCCTGT TCTGCGCGGT GGTGCCTGGG 
ACGCTGCTGC TGTTCAGGAA ACGATGGCAG AACGAGAAGC TCGGGTTGGA TGCCGGGGAT 
GAATATGAAG ATGAAAACCT TTATGAAGGC CTGAACCTGG ACGACTGCTC CATGTATGAG 
GACATCTCCC GGGGCCTCCA GGGCACCTAC CAGGATGTGG GCAGCCTCAA CATAGGAGAT 
GTCCAGCTGG AGAAGCCGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001774.1
CDS	27..707
Translation	MPGGPGVLQALPATIFLLFLLSAVYLGPGCQALWMHKVPASLMVSLGEDAHFQCPHNSSNNANVTWWRVLHGNYTWPPEFLGPGEDPNGTLIIQNVNKSHGGIYVCRVQEGNESYQQSCGTYLRVRQPPPRPFLDMGEGTKNRIITAEGIILLFCAVVPGTLLLFRKRWQNEKLGLDAGDEYEDENLYEGLNLDDCSMYEDISRGLQGTYQDVGSLNIGDVQLEKP

Target ORF information:

RefSeq Version	NM_001783.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CD79a molecule (CD79A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001783.4

ORF Insert Sequence:

ATGCCTGGGG GTCCAGGAGT CCTCCAAGCT CTGCCTGCCA CCATCTTCCT CCTCTTCCTG 
CTGTCTGCTG TCTACCTGGG CCCTGGGTGC CAGGCCCTGT GGATGCACAA GGTCCCAGCA 
TCATTGATGG TGAGCCTGGG GGAAGACGCC CACTTCCAAT GCCCGCACAA TAGCAGCAAC 
AACGCCAACG TCACCTGGTG GCGCGTCCTC CATGGCAACT ACACGTGGCC CCCTGAGTTC 
TTGGGCCCGG GCGAGGACCC CAATGGTACG CTGATCATCC AGAATGTGAA CAAGAGCCAT 
GGGGGCATAT ACGTGTGCCG GGTCCAGGAG GGCAACGAGT CATACCAGCA GTCCTGCGGC 
ACCTACCTCC GCGTGCGCCA GCCGCCCCCC AGGCCCTTCC TGGACATGGG GGAGGGCACC 
AAGAACCGAA TCATCACAGC CGAGGGGATC ATCCTCCTGT TCTGCGCGGT GGTGCCTGGG 
ACGCTGCTGC TGTTCAGGAA ACGATGGCAG AACGAGAAGC TCGGGTTGGA TGCCGGGGAT 
GAATATGAAG ATGAAAACCT TTATGAAGGC CTGAACCTGG ACGACTGCTC CATGTATGAG 
GACATCTCCC GGGGCCTCCA GGGCACCTAC CAGGATGTGG GCAGCCTCAA CATAGGAGAT 
GTCCAGCTGG AGAAGCCGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD79A ( NM_021601.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_067612.1 Homo sapiens CD79a molecule (CD79A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12357
Clone ID Related Accession (Same CDS sequence)	NM_021601.3 , NM_021601.4
Accession Version	NM_021601.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	B-cell antigen receptor complex-associated protein alpha chain isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC243967.3 and X83540.1. On Mar 22, 2006 this sequence version replaced NM_021601.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.316548.1, SRR1163658.459018.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTGGGG GTCCAGGAGT CCTCCAAGCT CTGCCTGCCA CCATCTTCCT CCTCTTCCTG 
CTGTCTGCTG TCTACCTGGG CCCTGGGTGC CAGGCCCTGT GGATGCACAA GGTCCCAGCA 
TCATTGATGG TGAGCCTGGG GGAAGACGCC CACTTCCAAT GCCCGCACAA TAGCAGCAAC 
AACGCCAACG TCACCTGGTG GCGCGTCCTC CATGGCAACT ACACGTGGCC CCCTGAGTTC 
TTGGGCCCGG GCGAGGACCC CAATGAGCCG CCCCCCAGGC CCTTCCTGGA CATGGGGGAG 
GGCACCAAGA ACCGAATCAT CACAGCCGAG GGGATCATCC TCCTGTTCTG CGCGGTGGTG 
CCTGGGACGC TGCTGCTGTT CAGGAAACGA TGGCAGAACG AGAAGCTCGG GTTGGATGCC 
GGGGATGAAT ATGAAGATGA AAACCTTTAT GAAGGCCTGA ACCTGGACGA CTGCTCCATG 
TATGAGGACA TCTCCCGGGG CCTCCAGGGC ACCTACCAGG ATGTGGGCAG CCTCAACATA 
GGAGATGTCC AGCTGGAGAA GCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067612.1
CDS	186..752
Translation	MPGGPGVLQALPATIFLLFLLSAVYLGPGCQALWMHKVPASLMVSLGEDAHFQCPHNSSNNANVTWWRVLHGNYTWPPEFLGPGEDPNEPPPRPFLDMGEGTKNRIITAEGIILLFCAVVPGTLLLFRKRWQNEKLGLDAGDEYEDENLYEGLNLDDCSMYEDISRGLQGTYQDVGSLNIGDVQLEKP

Target ORF information:

RefSeq Version	NM_021601.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CD79a molecule (CD79A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021601.3

ORF Insert Sequence:

ATGCCTGGGG GTCCAGGAGT CCTCCAAGCT CTGCCTGCCA CCATCTTCCT CCTCTTCCTG 
CTGTCTGCTG TCTACCTGGG CCCTGGGTGC CAGGCCCTGT GGATGCACAA GGTCCCAGCA 
TCATTGATGG TGAGCCTGGG GGAAGACGCC CACTTCCAAT GCCCGCACAA TAGCAGCAAC 
AACGCCAACG TCACCTGGTG GCGCGTCCTC CATGGCAACT ACACGTGGCC CCCTGAGTTC 
TTGGGCCCGG GCGAGGACCC CAATGAGCCG CCCCCCAGGC CCTTCCTGGA CATGGGGGAG 
GGCACCAAGA ACCGAATCAT CACAGCCGAG GGGATCATCC TCCTGTTCTG CGCGGTGGTG 
CCTGGGACGC TGCTGCTGTT CAGGAAACGA TGGCAGAACG AGAAGCTCGG GTTGGATGCC 
GGGGATGAAT ATGAAGATGA AAACCTTTAT GAAGGCCTGA ACCTGGACGA CTGCTCCATG 
TATGAGGACA TCTCCCGGGG CCTCCAGGGC ACCTACCAGG ATGTGGGCAG CCTCAACATA 
GGAGATGTCC AGCTGGAGAA GCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD79A ( NM_021601.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_067612.1 Homo sapiens CD79a molecule (CD79A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12357
Clone ID Related Accession (Same CDS sequence)	NM_021601.3 , NM_021601.4
Accession Version	NM_021601.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-12
Organism	Homo sapiens(human)
Product	B-cell antigen receptor complex-associated protein alpha chain isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC243967.3 and X83540.1. On Jun 2, 2019 this sequence version replaced NM_021601.3. Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.136145.1, SRR1163657.245347.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTGGGG GTCCAGGAGT CCTCCAAGCT CTGCCTGCCA CCATCTTCCT CCTCTTCCTG 
CTGTCTGCTG TCTACCTGGG CCCTGGGTGC CAGGCCCTGT GGATGCACAA GGTCCCAGCA 
TCATTGATGG TGAGCCTGGG GGAAGACGCC CACTTCCAAT GCCCGCACAA TAGCAGCAAC 
AACGCCAACG TCACCTGGTG GCGCGTCCTC CATGGCAACT ACACGTGGCC CCCTGAGTTC 
TTGGGCCCGG GCGAGGACCC CAATGAGCCG CCCCCCAGGC CCTTCCTGGA CATGGGGGAG 
GGCACCAAGA ACCGAATCAT CACAGCCGAG GGGATCATCC TCCTGTTCTG CGCGGTGGTG 
CCTGGGACGC TGCTGCTGTT CAGGAAACGA TGGCAGAACG AGAAGCTCGG GTTGGATGCC 
GGGGATGAAT ATGAAGATGA AAACCTTTAT GAAGGCCTGA ACCTGGACGA CTGCTCCATG 
TATGAGGACA TCTCCCGGGG CCTCCAGGGC ACCTACCAGG ATGTGGGCAG CCTCAACATA 
GGAGATGTCC AGCTGGAGAA GCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067612.1
CDS	27..593
Translation	MPGGPGVLQALPATIFLLFLLSAVYLGPGCQALWMHKVPASLMVSLGEDAHFQCPHNSSNNANVTWWRVLHGNYTWPPEFLGPGEDPNEPPPRPFLDMGEGTKNRIITAEGIILLFCAVVPGTLLLFRKRWQNEKLGLDAGDEYEDENLYEGLNLDDCSMYEDISRGLQGTYQDVGSLNIGDVQLEKP

Target ORF information:

RefSeq Version	NM_021601.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CD79a molecule (CD79A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021601.4

ORF Insert Sequence:

ATGCCTGGGG GTCCAGGAGT CCTCCAAGCT CTGCCTGCCA CCATCTTCCT CCTCTTCCTG 
CTGTCTGCTG TCTACCTGGG CCCTGGGTGC CAGGCCCTGT GGATGCACAA GGTCCCAGCA 
TCATTGATGG TGAGCCTGGG GGAAGACGCC CACTTCCAAT GCCCGCACAA TAGCAGCAAC 
AACGCCAACG TCACCTGGTG GCGCGTCCTC CATGGCAACT ACACGTGGCC CCCTGAGTTC 
TTGGGCCCGG GCGAGGACCC CAATGAGCCG CCCCCCAGGC CCTTCCTGGA CATGGGGGAG 
GGCACCAAGA ACCGAATCAT CACAGCCGAG GGGATCATCC TCCTGTTCTG CGCGGTGGTG 
CCTGGGACGC TGCTGCTGTT CAGGAAACGA TGGCAGAACG AGAAGCTCGG GTTGGATGCC 
GGGGATGAAT ATGAAGATGA AAACCTTTAT GAAGGCCTGA ACCTGGACGA CTGCTCCATG 
TATGAGGACA TCTCCCGGGG CCTCCAGGGC ACCTACCAGG ATGTGGGCAG CCTCAACATA 
GGAGATGTCC AGCTGGAGAA GCCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MYD88, CD79B, and CARD11 gene mutations in CD5-positive diffuse large B-cell lymphoma.
Cancer123(7)1166-1173(2017 Apr)
Takeuchi T,Yamaguchi M,Kobayashi K,Miyazaki K,Tawara I,Imai H,Ono R,Nosaka T,Tanaka K,Katayama N

Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma.
Oncotarget6(39)42232-42(2015 Dec)
Nagel D,Bognar M,Eitelhuber AC,Kutzner K,Vincendeau M,Krappmann D

The assessment of sIgA, histatin-5, and lactoperoxidase levels in saliva of adolescents with dental caries.
Medical science monitor : international medical journal of experimental and clinical research201095-100(2014 Jun)
Gornowicz A,Tokajuk G,Bielawska A,Maciorkowska E,Jab?o?ski R,W?jcicka A,Bielawski K

Tyrosine phosphorylation within the intrinsically disordered cytosolic domains of the B-cell receptor: an NMR-based structural analysis.
PloS one9(4)e96199(2014)
Rosenl?w J,Isaksson L,Mayzel M,Lengqvist J,Orekhov VY

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CD79A cDNA ORF clone, Homo sapiens(human)

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