HERPUD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HERPUD1
Entrez Gene ID	9709
Full Name	homocysteine inducible ER protein with ubiquitin like domain 1
Synonyms	HERP,Mif1,SUP
General protein information	Preferred Names homocysteine inducible ER protein with ubiquitin like domain 1 Names homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein MMS-inducible homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 methyl methanesulfonate (MMF)-inducible fragment protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q13
Summary	The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013].
Disorder MIM:	608070

mRNA and Protein(s)

mRNA	Protein	Name
NM_014685.3	NP_055500.1	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 1
NM_001272103.1	NP_001259032.1	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 4
NM_014685.4	NP_055500.1	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 1
NM_001010989.3	NP_001010989.1	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 2
NM_001272103.2	NP_001259032.1	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 4
NM_001010989.2	NP_001010989.1	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Herpud1	NP_071726.1
	HERPUD1	XP_001095112.2
Bos taurus (cattle)	HERPUD1	NP_001095735.1
Canis lupus familiaris (dog)	HERPUD1	XP_851041.1
Rattus norvegicus (Norway rat)	Herpud1	NP_445975.1
Homo sapiens (human)	HERPUD1	NP_055500.1
Pan troglodytes (chimpanzee)	HERPUD1	XP_001141795.2
Gallus gallus (chicken)	HERPUD1	XP_414010.3
Danio rerio (zebrafish)	herpud1	NP_001020708.1
Xenopus tropicalis (tropical clawed frog)	herpud1	NP_998846.1

Gene Ontology
Bibliography

Related articles in PubMed

The endoplasmic reticulum-residing chaperone BiP is short-lived and metabolized through N-terminal arginylation.
Shim SM, Choi HR, Sung KW, Lee YJ, Kim ST, Kim D, Mun SR, Hwang J, Cha-Molstad H, Ciechanover A, Kim BY, Kwon YT
Science signaling11(511)(2018 Jan)

HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress.
Ge M, Luo Z, Qiao Z, Zhou Y, Cheng X, Geng Q, Cai Y, Wan P, Xiong Y, Liu F, Wu K, Liu Y, Wu J
Journal of immunology (Baltimore, Md. : 1950)199(9)3280-3292(2017 Nov)

HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model.
Schr?rs B, L?bcke S, Lennerz V, Fatho M, Bicker A, W?lfel C, Derigs P, Hankeln T, Schadendorf D, Paschen A, W?lfel T
Oncotarget8(17)28312-28327(2017 Apr)

MiR-9-3p augments apoptosis induced by H2O2 through down regulation of Herpud1 in glioma.
Yang L, Mu Y, Cui H, Liang Y, Su X
PloS one12(4)e0174839(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HERP plays an important role in the regulation of host innate immunity in response to ER stress during the infection of RNA viruses.
Title: HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress.

results indicated that low expression of miR-9-3p results in a high level of Herpud1, which may protect against apoptosis in glioma
Title: MiR-9-3p augments apoptosis induced by H2O2 through down regulation of Herpud1 in glioma.

The authors found that the CREB3/Herp pathway limited the increase in cytosolic Ca2+ concentration and apoptosis early in poliovirus infection and this may reduce the extent of poliovirus-induced damage to the central nervous system during poliomyelitis.
Title: The CREB3-Herp signalling module limits the cytosolic calcium concentration increase and apoptosis induced by poliovirus.

Thus, our findings indicated that NQO1 could stabilize Herp protein expression via indirect regulation of synoviolin.
Title: NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of homocysteine-induced endoplasmic reticulum protein.

HERPUD1 SNPs are highly associated with polypoidal choroidal vasculopathy.
Title: Evidence of a novel gene HERPUD1 in polypoidal choroidal vasculopathy.

The following HERPUD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HERPUD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25201	NM_014685.4 Latest version!	Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu25178	NM_001272103.2 Latest version!	Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu25246	NM_001010989.3 Latest version!	Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu25201	NM_014685.3	Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu25178	NM_001272103.1	Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu25246	NM_001010989.2	Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HERPUD1 ( NM_014685.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055500.1 Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25201
Clone ID Related Accession (Same CDS sequence)	NM_014685.3 , NM_014685.4
Accession Version	NM_014685.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-02
Organism	Homo sapiens(human)
Product	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC012181.8, DA581153.1, AB034989.1 and AK223233.1. On Jan 15, 2013 this sequence version replaced NM_014685.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223233.1, SRR1660803.183737.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCCG AGACCGAACC CGAGCCCGTC ACGCTCCTGG TGAAGAGCCC CAACCAGCGC 
CACCGCGACT TGGAGCTGAG TGGCGACCGC GGCTGGAGTG TGGGCCACCT CAAGGCCCAC 
CTGAGCCGCG TCTACCCCGA GCGTCCGCGT CCAGAGGACC AGAGGTTAAT TTATTCTGGG 
AAGCTGTTGT TGGATCACCA ATGTCTCAGG GACTTGCTTC CAAAGCAGGA AAAACGGCAT 
GTTTTGCATC TGGTGTGCAA TGTGAAGAGT CCTTCAAAAA TGCCAGAAAT CAACGCCAAG 
GTGGCTGAAT CCACAGAGGA GCCTGCTGGT TCTAATCGGG GACAGTATCC TGAGGATTCC 
TCAAGTGATG GTTTAAGGCA AAGGGAAGTT CTTCGGAACC TTTCTTCCCC TGGATGGGAA 
AACATCTCAA GGCCTGAAGC TGCCCAGCAG GCATTCCAAG GCCTGGGTCC TGGTTTCTCC 
GGTTACACAC CCTATGGGTG GCTTCAGCTT TCCTGGTTCC AGCAGATATA TGCACGACAG 
TACTACATGC AATATTTAGC AGCCACTGCT GCATCAGGGG CTTTTGTTCC ACCACCAAGT 
GCACAAGAGA TACCTGTGGT CTCTGCACCT GCTCCAGCCC CTATTCACAA CCAGTTTCCA 
GCTGAAAACC AGCCTGCCAA TCAGAATGCT GCTCCTCAAG TGGTTGTTAA TCCTGGAGCC 
AATCAAAATT TGCGGATGAA TGCACAAGGT GGCCCTATTG TGGAAGAAGA TGATGAAATA 
AATCGAGATT GGTTGGATTG GACCTATTCA GCAGCTACAT TTTCTGTTTT TCTCAGTATC 
CTCTACTTCT ACTCCTCCCT GAGCAGATTC CTCATGGTCA TGGGGGCCAC CGTTGTTATG 
TACCTGCATC ACGTTGGGTG GTTTCCATTT AGACCGAGGC CGGTTCAGAA CTTCCCAAAT 
GATGGTCCTC CTCCTGACGT TGTAAATCAG GACCCCAACA ATAACTTACA GGAAGGCACT 
GATCCTGAAA CTGAAGACCC CAACCACCTC CCTCCAGACA GGGATGTACT AGATGGCGAG 
CAGACCAGCC CCTCCTTTAT GAGCACAGCA TGGCTTGTCT TCAAGACTTT CTTTGCCTCT 
CTTCTTCCAG AAGGCCCCCC AGCCATCGCA AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055500.1
CDS	156..1331
Translation	MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLRDLLPKQEKRHVLHLVCNVKSPSKMPEINAKVAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQGGPIVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNLQEGTDPETEDPNHLPPDRDVLDGEQTSPSFMSTAWLVFKTFFASLLPEGPPAIAN

Target ORF information:

RefSeq Version	NM_014685.3
Organism	Homo sapiens(human)
Definition	Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014685.3

ORF Insert Sequence:

ATGGAGTCCG AGACCGAACC CGAGCCCGTC ACGCTCCTGG TGAAGAGCCC CAACCAGCGC 
CACCGCGACT TGGAGCTGAG TGGCGACCGC GGCTGGAGTG TGGGCCACCT CAAGGCCCAC 
CTGAGCCGCG TCTACCCCGA GCGTCCGCGT CCAGAGGACC AGAGGTTAAT TTATTCTGGG 
AAGCTGTTGT TGGATCACCA ATGTCTCAGG GACTTGCTTC CAAAGCAGGA AAAACGGCAT 
GTTTTGCATC TGGTGTGCAA TGTGAAGAGT CCTTCAAAAA TGCCAGAAAT CAACGCCAAG 
GTGGCTGAAT CCACAGAGGA GCCTGCTGGT TCTAATCGGG GACAGTATCC TGAGGATTCC 
TCAAGTGATG GTTTAAGGCA AAGGGAAGTT CTTCGGAACC TTTCTTCCCC TGGATGGGAA 
AACATCTCAA GGCCTGAAGC TGCCCAGCAG GCATTCCAAG GCCTGGGTCC TGGTTTCTCC 
GGTTACACAC CCTATGGGTG GCTTCAGCTT TCCTGGTTCC AGCAGATATA TGCACGACAG 
TACTACATGC AATATTTAGC AGCCACTGCT GCATCAGGGG CTTTTGTTCC ACCACCAAGT 
GCACAAGAGA TACCTGTGGT CTCTGCACCT GCTCCAGCCC CTATTCACAA CCAGTTTCCA 
GCTGAAAACC AGCCTGCCAA TCAGAATGCT GCTCCTCAAG TGGTTGTTAA TCCTGGAGCC 
AATCAAAATT TGCGGATGAA TGCACAAGGT GGCCCTATTG TGGAAGAAGA TGATGAAATA 
AATCGAGATT GGTTGGATTG GACCTATTCA GCAGCTACAT TTTCTGTTTT TCTCAGTATC 
CTCTACTTCT ACTCCTCCCT GAGCAGATTC CTCATGGTCA TGGGGGCCAC CGTTGTTATG 
TACCTGCATC ACGTTGGGTG GTTTCCATTT AGACCGAGGC CGGTTCAGAA CTTCCCAAAT 
GATGGTCCTC CTCCTGACGT TGTAAATCAG GACCCCAACA ATAACTTACA GGAAGGCACT 
GATCCTGAAA CTGAAGACCC CAACCACCTC CCTCCAGACA GGGATGTACT AGATGGCGAG 
CAGACCAGCC CCTCCTTTAT GAGCACAGCA TGGCTTGTCT TCAAGACTTT CTTTGCCTCT 
CTTCTTCCAG AAGGCCCCCC AGCCATCGCA AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HERPUD1 ( NM_014685.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055500.1 Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25201
Clone ID Related Accession (Same CDS sequence)	NM_014685.3 , NM_014685.4
Accession Version	NM_014685.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA581153.1, AB034989.1, AK223233.1 and AC012181.8. On Nov 22, 2018 this sequence version replaced NM_014685.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.253426.1, SRR1803611.69902.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000439977.7/ ENSP00000409555.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGTCCG AGACCGAACC CGAGCCCGTC ACGCTCCTGG TGAAGAGCCC CAACCAGCGC 
CACCGCGACT TGGAGCTGAG TGGCGACCGC GGCTGGAGTG TGGGCCACCT CAAGGCCCAC 
CTGAGCCGCG TCTACCCCGA GCGTCCGCGT CCAGAGGACC AGAGGTTAAT TTATTCTGGG 
AAGCTGTTGT TGGATCACCA ATGTCTCAGG GACTTGCTTC CAAAGCAGGA AAAACGGCAT 
GTTTTGCATC TGGTGTGCAA TGTGAAGAGT CCTTCAAAAA TGCCAGAAAT CAACGCCAAG 
GTGGCTGAAT CCACAGAGGA GCCTGCTGGT TCTAATCGGG GACAGTATCC TGAGGATTCC 
TCAAGTGATG GTTTAAGGCA AAGGGAAGTT CTTCGGAACC TTTCTTCCCC TGGATGGGAA 
AACATCTCAA GGCCTGAAGC TGCCCAGCAG GCATTCCAAG GCCTGGGTCC TGGTTTCTCC 
GGTTACACAC CCTATGGGTG GCTTCAGCTT TCCTGGTTCC AGCAGATATA TGCACGACAG 
TACTACATGC AATATTTAGC AGCCACTGCT GCATCAGGGG CTTTTGTTCC ACCACCAAGT 
GCACAAGAGA TACCTGTGGT CTCTGCACCT GCTCCAGCCC CTATTCACAA CCAGTTTCCA 
GCTGAAAACC AGCCTGCCAA TCAGAATGCT GCTCCTCAAG TGGTTGTTAA TCCTGGAGCC 
AATCAAAATT TGCGGATGAA TGCACAAGGT GGCCCTATTG TGGAAGAAGA TGATGAAATA 
AATCGAGATT GGTTGGATTG GACCTATTCA GCAGCTACAT TTTCTGTTTT TCTCAGTATC 
CTCTACTTCT ACTCCTCCCT GAGCAGATTC CTCATGGTCA TGGGGGCCAC CGTTGTTATG 
TACCTGCATC ACGTTGGGTG GTTTCCATTT AGACCGAGGC CGGTTCAGAA CTTCCCAAAT 
GATGGTCCTC CTCCTGACGT TGTAAATCAG GACCCCAACA ATAACTTACA GGAAGGCACT 
GATCCTGAAA CTGAAGACCC CAACCACCTC CCTCCAGACA GGGATGTACT AGATGGCGAG 
CAGACCAGCC CCTCCTTTAT GAGCACAGCA TGGCTTGTCT TCAAGACTTT CTTTGCCTCT 
CTTCTTCCAG AAGGCCCCCC AGCCATCGCA AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055500.1
CDS	104..1279
Translation	MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLRDLLPKQEKRHVLHLVCNVKSPSKMPEINAKVAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQGGPIVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNLQEGTDPETEDPNHLPPDRDVLDGEQTSPSFMSTAWLVFKTFFASLLPEGPPAIAN

Target ORF information:

RefSeq Version	NM_014685.4
Organism	Homo sapiens(human)
Definition	Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014685.4

ORF Insert Sequence:

ATGGAGTCCG AGACCGAACC CGAGCCCGTC ACGCTCCTGG TGAAGAGCCC CAACCAGCGC 
CACCGCGACT TGGAGCTGAG TGGCGACCGC GGCTGGAGTG TGGGCCACCT CAAGGCCCAC 
CTGAGCCGCG TCTACCCCGA GCGTCCGCGT CCAGAGGACC AGAGGTTAAT TTATTCTGGG 
AAGCTGTTGT TGGATCACCA ATGTCTCAGG GACTTGCTTC CAAAGCAGGA AAAACGGCAT 
GTTTTGCATC TGGTGTGCAA TGTGAAGAGT CCTTCAAAAA TGCCAGAAAT CAACGCCAAG 
GTGGCTGAAT CCACAGAGGA GCCTGCTGGT TCTAATCGGG GACAGTATCC TGAGGATTCC 
TCAAGTGATG GTTTAAGGCA AAGGGAAGTT CTTCGGAACC TTTCTTCCCC TGGATGGGAA 
AACATCTCAA GGCCTGAAGC TGCCCAGCAG GCATTCCAAG GCCTGGGTCC TGGTTTCTCC 
GGTTACACAC CCTATGGGTG GCTTCAGCTT TCCTGGTTCC AGCAGATATA TGCACGACAG 
TACTACATGC AATATTTAGC AGCCACTGCT GCATCAGGGG CTTTTGTTCC ACCACCAAGT 
GCACAAGAGA TACCTGTGGT CTCTGCACCT GCTCCAGCCC CTATTCACAA CCAGTTTCCA 
GCTGAAAACC AGCCTGCCAA TCAGAATGCT GCTCCTCAAG TGGTTGTTAA TCCTGGAGCC 
AATCAAAATT TGCGGATGAA TGCACAAGGT GGCCCTATTG TGGAAGAAGA TGATGAAATA 
AATCGAGATT GGTTGGATTG GACCTATTCA GCAGCTACAT TTTCTGTTTT TCTCAGTATC 
CTCTACTTCT ACTCCTCCCT GAGCAGATTC CTCATGGTCA TGGGGGCCAC CGTTGTTATG 
TACCTGCATC ACGTTGGGTG GTTTCCATTT AGACCGAGGC CGGTTCAGAA CTTCCCAAAT 
GATGGTCCTC CTCCTGACGT TGTAAATCAG GACCCCAACA ATAACTTACA GGAAGGCACT 
GATCCTGAAA CTGAAGACCC CAACCACCTC CCTCCAGACA GGGATGTACT AGATGGCGAG 
CAGACCAGCC CCTCCTTTAT GAGCACAGCA TGGCTTGTCT TCAAGACTTT CTTTGCCTCT 
CTTCTTCCAG AAGGCCCCCC AGCCATCGCA AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HERPUD1 ( NM_001272103.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001259032.1 Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu25178
Clone ID Related Accession (Same CDS sequence)	NM_001272103.1 , NM_001272103.2
Accession Version	NM_001272103.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-12
Organism	Homo sapiens(human)
Product	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC012181.8, DA581153.1, DQ837586.1 and AF055001.1. Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ837586.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCCG AGACCGAACC CGAGCCCGTC ACGCTCCTGG TGAAGAGCCC CAACCAGCGC 
CACCGCGACT TGGAGCTGAG TGGCGACCGC GGCTGGAGTG TGGGCCACCT CAAGGCCCAC 
CTGAGCCGCG TCTACCCCGA GCGTCCGCGT CCAGAGGACC AGAGGTTAAT TTATTCTGGG 
AAGCTGTTGT TGGATCACCA ATGTCTCAGG GACTTGCTTC CAAAGCAGGA AAAACGGCAT 
GTTTTGCATC TGGTGTGCAA TGTGAAGAGT CCTTCAAAAA TGCCAGAAAT CAACGCCAAG 
GTGGCTGAAT CCACAGAGGA GCCTGCTGGT TCTAATCGGG GACAGTATCC TGAGGATTCC 
TCAAGTGATG GTTTAAGGCA AAGGGAAGTT CTTCGGAACC TTTCTTCCCC TGGATGGGAA 
AACATCTCAA GGCCTGAAGC TGCCCAGCAG GCATTCCAAG GCCTGGGTCC TGGTTTCTCC 
GGTTACACAC CCTATGGGTG GCTTCAGCTT TCCTGGTTCC AGCAGATATA TGCACGACAG 
TACTACATGC AATATTTAGC AGCCACTGCT GCATCAGGGG CTTTTGTTCC ACCACCAAGT 
GCACAAGAGA TACCTGTGGT CTCTGCACCT GCTCCAGCCC CTATTCACAA CCAGTTTCCA 
GCTGAAAACC AGCCTGCCAA TCAGAATGCT GCTCCTCAAG TGGTTGTTAA TCCTGGAGCC 
AATCAAAATT TGCGGATGAA TGCACAAGGC ATCACGTTGG GTGGTTTCCA TTTAGACCGA 
GGCCGGTTCA GAACTTCCCA AATGATGGTC CTCCTCCTGA CGTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001259032.1
CDS	156..983
Translation	MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLRDLLPKQEKRHVLHLVCNVKSPSKMPEINAKVAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQGITLGGFHLDRGRFRTSQMMVLLLTL

Target ORF information:

RefSeq Version	NM_001272103.1
Organism	Homo sapiens(human)
Definition	Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001272103.1

ORF Insert Sequence:

ATGGAGTCCG AGACCGAACC CGAGCCCGTC ACGCTCCTGG TGAAGAGCCC CAACCAGCGC 
CACCGCGACT TGGAGCTGAG TGGCGACCGC GGCTGGAGTG TGGGCCACCT CAAGGCCCAC 
CTGAGCCGCG TCTACCCCGA GCGTCCGCGT CCAGAGGACC AGAGGTTAAT TTATTCTGGG 
AAGCTGTTGT TGGATCACCA ATGTCTCAGG GACTTGCTTC CAAAGCAGGA AAAACGGCAT 
GTTTTGCATC TGGTGTGCAA TGTGAAGAGT CCTTCAAAAA TGCCAGAAAT CAACGCCAAG 
GTGGCTGAAT CCACAGAGGA GCCTGCTGGT TCTAATCGGG GACAGTATCC TGAGGATTCC 
TCAAGTGATG GTTTAAGGCA AAGGGAAGTT CTTCGGAACC TTTCTTCCCC TGGATGGGAA 
AACATCTCAA GGCCTGAAGC TGCCCAGCAG GCATTCCAAG GCCTGGGTCC TGGTTTCTCC 
GGTTACACAC CCTATGGGTG GCTTCAGCTT TCCTGGTTCC AGCAGATATA TGCACGACAG 
TACTACATGC AATATTTAGC AGCCACTGCT GCATCAGGGG CTTTTGTTCC ACCACCAAGT 
GCACAAGAGA TACCTGTGGT CTCTGCACCT GCTCCAGCCC CTATTCACAA CCAGTTTCCA 
GCTGAAAACC AGCCTGCCAA TCAGAATGCT GCTCCTCAAG TGGTTGTTAA TCCTGGAGCC 
AATCAAAATT TGCGGATGAA TGCACAAGGC ATCACGTTGG GTGGTTTCCA TTTAGACCGA 
GGCCGGTTCA GAACTTCCCA AATGATGGTC CTCCTCCTGA CGTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HERPUD1 ( NM_001272103.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001259032.1 Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 4, mRNA.

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CloneID	OHu25178
Clone ID Related Accession (Same CDS sequence)	NM_001272103.1 , NM_001272103.2
Accession Version	NM_001272103.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-06
Organism	Homo sapiens(human)
Product	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA581153.1, DQ837586.1, AF055001.1 and AC012181.8. On Jun 1, 2019 this sequence version replaced NM_001272103.1. Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.651178.1, DQ837586.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCCG AGACCGAACC CGAGCCCGTC ACGCTCCTGG TGAAGAGCCC CAACCAGCGC 
CACCGCGACT TGGAGCTGAG TGGCGACCGC GGCTGGAGTG TGGGCCACCT CAAGGCCCAC 
CTGAGCCGCG TCTACCCCGA GCGTCCGCGT CCAGAGGACC AGAGGTTAAT TTATTCTGGG 
AAGCTGTTGT TGGATCACCA ATGTCTCAGG GACTTGCTTC CAAAGCAGGA AAAACGGCAT 
GTTTTGCATC TGGTGTGCAA TGTGAAGAGT CCTTCAAAAA TGCCAGAAAT CAACGCCAAG 
GTGGCTGAAT CCACAGAGGA GCCTGCTGGT TCTAATCGGG GACAGTATCC TGAGGATTCC 
TCAAGTGATG GTTTAAGGCA AAGGGAAGTT CTTCGGAACC TTTCTTCCCC TGGATGGGAA 
AACATCTCAA GGCCTGAAGC TGCCCAGCAG GCATTCCAAG GCCTGGGTCC TGGTTTCTCC 
GGTTACACAC CCTATGGGTG GCTTCAGCTT TCCTGGTTCC AGCAGATATA TGCACGACAG 
TACTACATGC AATATTTAGC AGCCACTGCT GCATCAGGGG CTTTTGTTCC ACCACCAAGT 
GCACAAGAGA TACCTGTGGT CTCTGCACCT GCTCCAGCCC CTATTCACAA CCAGTTTCCA 
GCTGAAAACC AGCCTGCCAA TCAGAATGCT GCTCCTCAAG TGGTTGTTAA TCCTGGAGCC 
AATCAAAATT TGCGGATGAA TGCACAAGGC ATCACGTTGG GTGGTTTCCA TTTAGACCGA 
GGCCGGTTCA GAACTTCCCA AATGATGGTC CTCCTCCTGA CGTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001259032.1
CDS	104..931
Translation	MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLRDLLPKQEKRHVLHLVCNVKSPSKMPEINAKVAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQGITLGGFHLDRGRFRTSQMMVLLLTL

Target ORF information:

RefSeq Version	NM_001272103.2
Organism	Homo sapiens(human)
Definition	Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001272103.2

ORF Insert Sequence:

ATGGAGTCCG AGACCGAACC CGAGCCCGTC ACGCTCCTGG TGAAGAGCCC CAACCAGCGC 
CACCGCGACT TGGAGCTGAG TGGCGACCGC GGCTGGAGTG TGGGCCACCT CAAGGCCCAC 
CTGAGCCGCG TCTACCCCGA GCGTCCGCGT CCAGAGGACC AGAGGTTAAT TTATTCTGGG 
AAGCTGTTGT TGGATCACCA ATGTCTCAGG GACTTGCTTC CAAAGCAGGA AAAACGGCAT 
GTTTTGCATC TGGTGTGCAA TGTGAAGAGT CCTTCAAAAA TGCCAGAAAT CAACGCCAAG 
GTGGCTGAAT CCACAGAGGA GCCTGCTGGT TCTAATCGGG GACAGTATCC TGAGGATTCC 
TCAAGTGATG GTTTAAGGCA AAGGGAAGTT CTTCGGAACC TTTCTTCCCC TGGATGGGAA 
AACATCTCAA GGCCTGAAGC TGCCCAGCAG GCATTCCAAG GCCTGGGTCC TGGTTTCTCC 
GGTTACACAC CCTATGGGTG GCTTCAGCTT TCCTGGTTCC AGCAGATATA TGCACGACAG 
TACTACATGC AATATTTAGC AGCCACTGCT GCATCAGGGG CTTTTGTTCC ACCACCAAGT 
GCACAAGAGA TACCTGTGGT CTCTGCACCT GCTCCAGCCC CTATTCACAA CCAGTTTCCA 
GCTGAAAACC AGCCTGCCAA TCAGAATGCT GCTCCTCAAG TGGTTGTTAA TCCTGGAGCC 
AATCAAAATT TGCGGATGAA TGCACAAGGC ATCACGTTGG GTGGTTTCCA TTTAGACCGA 
GGCCGGTTCA GAACTTCCCA AATGATGGTC CTCCTCCTGA CGTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HERPUD1 ( NM_001010989.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001010989.1 Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 2, mRNA.

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CloneID	OHu25246
Clone ID Related Accession (Same CDS sequence)	NM_001010989.3 , NM_001010989.2
Accession Version	NM_001010989.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-06
Organism	Homo sapiens(human)
Product	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA581153.1, AF055003.1 and AC012181.8. On May 31, 2019 this sequence version replaced NM_001010989.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.243968.1, SRR1660809.203045.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCCG AGACCGAACC CGAGCCCGTC ACGCTCCTGG TGAAGAGCCC CAACCAGCGC 
CACCGCGACT TGGAGCTGAG TGGCGACCGC GGCTGGAGTG TGGGCCACCT CAAGGCCCAC 
CTGAGCCGCG TCTACCCCGA GCGTCCGCGT CCAGAGGACC AGAGGTTAAT TTATTCTGGG 
AAGCTGTTGT TGGATCACCA ATGTCTCAGG GACTTGCTTC CAAAGGAAAA ACGGCATGTT 
TTGCATCTGG TGTGCAATGT GAAGAGTCCT TCAAAAATGC CAGAAATCAA CGCCAAGGTG 
GCTGAATCCA CAGAGGAGCC TGCTGGTTCT AATCGGGGAC AGTATCCTGA GGATTCCTCA 
AGTGATGGTT TAAGGCAAAG GGAAGTTCTT CGGAACCTTT CTTCCCCTGG ATGGGAAAAC 
ATCTCAAGGC CTGAAGCTGC CCAGCAGGCA TTCCAAGGCC TGGGTCCTGG TTTCTCCGGT 
TACACACCCT ATGGGTGGCT TCAGCTTTCC TGGTTCCAGC AGATATATGC ACGACAGTAC 
TACATGCAAT ATTTAGCAGC CACTGCTGCA TCAGGGGCTT TTGTTCCACC ACCAAGTGCA 
CAAGAGATAC CTGTGGTCTC TGCACCTGCT CCAGCCCCTA TTCACAACCA GTTTCCAGCT 
GAAAACCAGC CTGCCAATCA GAATGCTGCT CCTCAAGTGG TTGTTAATCC TGGAGCCAAT 
CAAAATTTGC GGATGAATGC ACAAGGTGGC CCTATTGTGG AAGAAGATGA TGAAATAAAT 
CGAGATTGGT TGGATTGGAC CTATTCAGCA GCTACATTTT CTGTTTTTCT CAGTATCCTC 
TACTTCTACT CCTCCCTGAG CAGATTCCTC ATGGTCATGG GGGCCACCGT TGTTATGTAC 
CTGCATCACG TTGGGTGGTT TCCATTTAGA CCGAGGCCGG TTCAGAACTT CCCAAATGAT 
GGTCCTCCTC CTGACGTTGT AAATCAGGAC CCCAACAATA ACTTACAGGA AGGCACTGAT 
CCTGAAACTG AAGACCCCAA CCACCTCCCT CCAGACAGGG ATGTACTAGA TGGCGAGCAG 
ACCAGCCCCT CCTTTATGAG CACAGCATGG CTTGTCTTCA AGACTTTCTT TGCCTCTCTT 
CTTCCAGAAG GCCCCCCAGC CATCGCAAAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001010989.1
CDS	104..1276
Translation	MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLRDLLPKEKRHVLHLVCNVKSPSKMPEINAKVAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQGGPIVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNLQEGTDPETEDPNHLPPDRDVLDGEQTSPSFMSTAWLVFKTFFASLLPEGPPAIAN

Target ORF information:

RefSeq Version	NM_001010989.3
Organism	Homo sapiens(human)
Definition	Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001010989.3

ORF Insert Sequence:

ATGGAGTCCG AGACCGAACC CGAGCCCGTC ACGCTCCTGG TGAAGAGCCC CAACCAGCGC 
CACCGCGACT TGGAGCTGAG TGGCGACCGC GGCTGGAGTG TGGGCCACCT CAAGGCCCAC 
CTGAGCCGCG TCTACCCCGA GCGTCCGCGT CCAGAGGACC AGAGGTTAAT TTATTCTGGG 
AAGCTGTTGT TGGATCACCA ATGTCTCAGG GACTTGCTTC CAAAGGAAAA ACGGCATGTT 
TTGCATCTGG TGTGCAATGT GAAGAGTCCT TCAAAAATGC CAGAAATCAA CGCCAAGGTG 
GCTGAATCCA CAGAGGAGCC TGCTGGTTCT AATCGGGGAC AGTATCCTGA GGATTCCTCA 
AGTGATGGTT TAAGGCAAAG GGAAGTTCTT CGGAACCTTT CTTCCCCTGG ATGGGAAAAC 
ATCTCAAGGC CTGAAGCTGC CCAGCAGGCA TTCCAAGGCC TGGGTCCTGG TTTCTCCGGT 
TACACACCCT ATGGGTGGCT TCAGCTTTCC TGGTTCCAGC AGATATATGC ACGACAGTAC 
TACATGCAAT ATTTAGCAGC CACTGCTGCA TCAGGGGCTT TTGTTCCACC ACCAAGTGCA 
CAAGAGATAC CTGTGGTCTC TGCACCTGCT CCAGCCCCTA TTCACAACCA GTTTCCAGCT 
GAAAACCAGC CTGCCAATCA GAATGCTGCT CCTCAAGTGG TTGTTAATCC TGGAGCCAAT 
CAAAATTTGC GGATGAATGC ACAAGGTGGC CCTATTGTGG AAGAAGATGA TGAAATAAAT 
CGAGATTGGT TGGATTGGAC CTATTCAGCA GCTACATTTT CTGTTTTTCT CAGTATCCTC 
TACTTCTACT CCTCCCTGAG CAGATTCCTC ATGGTCATGG GGGCCACCGT TGTTATGTAC 
CTGCATCACG TTGGGTGGTT TCCATTTAGA CCGAGGCCGG TTCAGAACTT CCCAAATGAT 
GGTCCTCCTC CTGACGTTGT AAATCAGGAC CCCAACAATA ACTTACAGGA AGGCACTGAT 
CCTGAAACTG AAGACCCCAA CCACCTCCCT CCAGACAGGG ATGTACTAGA TGGCGAGCAG 
ACCAGCCCCT CCTTTATGAG CACAGCATGG CTTGTCTTCA AGACTTTCTT TGCCTCTCTT 
CTTCCAGAAG GCCCCCCAGC CATCGCAAAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HERPUD1 ( NM_001010989.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001010989.1 Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu25246
Clone ID Related Accession (Same CDS sequence)	NM_001010989.3 , NM_001010989.2
Accession Version	NM_001010989.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-12
Organism	Homo sapiens(human)
Product	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC012181.8, DA581153.1 and AF055003.1. On Jan 15, 2013 this sequence version replaced NM_001010989.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF055003.1, SRR1660805.243968.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCCG AGACCGAACC CGAGCCCGTC ACGCTCCTGG TGAAGAGCCC CAACCAGCGC 
CACCGCGACT TGGAGCTGAG TGGCGACCGC GGCTGGAGTG TGGGCCACCT CAAGGCCCAC 
CTGAGCCGCG TCTACCCCGA GCGTCCGCGT CCAGAGGACC AGAGGTTAAT TTATTCTGGG 
AAGCTGTTGT TGGATCACCA ATGTCTCAGG GACTTGCTTC CAAAGGAAAA ACGGCATGTT 
TTGCATCTGG TGTGCAATGT GAAGAGTCCT TCAAAAATGC CAGAAATCAA CGCCAAGGTG 
GCTGAATCCA CAGAGGAGCC TGCTGGTTCT AATCGGGGAC AGTATCCTGA GGATTCCTCA 
AGTGATGGTT TAAGGCAAAG GGAAGTTCTT CGGAACCTTT CTTCCCCTGG ATGGGAAAAC 
ATCTCAAGGC CTGAAGCTGC CCAGCAGGCA TTCCAAGGCC TGGGTCCTGG TTTCTCCGGT 
TACACACCCT ATGGGTGGCT TCAGCTTTCC TGGTTCCAGC AGATATATGC ACGACAGTAC 
TACATGCAAT ATTTAGCAGC CACTGCTGCA TCAGGGGCTT TTGTTCCACC ACCAAGTGCA 
CAAGAGATAC CTGTGGTCTC TGCACCTGCT CCAGCCCCTA TTCACAACCA GTTTCCAGCT 
GAAAACCAGC CTGCCAATCA GAATGCTGCT CCTCAAGTGG TTGTTAATCC TGGAGCCAAT 
CAAAATTTGC GGATGAATGC ACAAGGTGGC CCTATTGTGG AAGAAGATGA TGAAATAAAT 
CGAGATTGGT TGGATTGGAC CTATTCAGCA GCTACATTTT CTGTTTTTCT CAGTATCCTC 
TACTTCTACT CCTCCCTGAG CAGATTCCTC ATGGTCATGG GGGCCACCGT TGTTATGTAC 
CTGCATCACG TTGGGTGGTT TCCATTTAGA CCGAGGCCGG TTCAGAACTT CCCAAATGAT 
GGTCCTCCTC CTGACGTTGT AAATCAGGAC CCCAACAATA ACTTACAGGA AGGCACTGAT 
CCTGAAACTG AAGACCCCAA CCACCTCCCT CCAGACAGGG ATGTACTAGA TGGCGAGCAG 
ACCAGCCCCT CCTTTATGAG CACAGCATGG CTTGTCTTCA AGACTTTCTT TGCCTCTCTT 
CTTCCAGAAG GCCCCCCAGC CATCGCAAAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001010989.1
CDS	156..1328
Translation	MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLRDLLPKEKRHVLHLVCNVKSPSKMPEINAKVAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQGGPIVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNLQEGTDPETEDPNHLPPDRDVLDGEQTSPSFMSTAWLVFKTFFASLLPEGPPAIAN

Target ORF information:

RefSeq Version	NM_001010989.2
Organism	Homo sapiens(human)
Definition	Homo sapiens homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001010989.2

ORF Insert Sequence:

ATGGAGTCCG AGACCGAACC CGAGCCCGTC ACGCTCCTGG TGAAGAGCCC CAACCAGCGC 
CACCGCGACT TGGAGCTGAG TGGCGACCGC GGCTGGAGTG TGGGCCACCT CAAGGCCCAC 
CTGAGCCGCG TCTACCCCGA GCGTCCGCGT CCAGAGGACC AGAGGTTAAT TTATTCTGGG 
AAGCTGTTGT TGGATCACCA ATGTCTCAGG GACTTGCTTC CAAAGGAAAA ACGGCATGTT 
TTGCATCTGG TGTGCAATGT GAAGAGTCCT TCAAAAATGC CAGAAATCAA CGCCAAGGTG 
GCTGAATCCA CAGAGGAGCC TGCTGGTTCT AATCGGGGAC AGTATCCTGA GGATTCCTCA 
AGTGATGGTT TAAGGCAAAG GGAAGTTCTT CGGAACCTTT CTTCCCCTGG ATGGGAAAAC 
ATCTCAAGGC CTGAAGCTGC CCAGCAGGCA TTCCAAGGCC TGGGTCCTGG TTTCTCCGGT 
TACACACCCT ATGGGTGGCT TCAGCTTTCC TGGTTCCAGC AGATATATGC ACGACAGTAC 
TACATGCAAT ATTTAGCAGC CACTGCTGCA TCAGGGGCTT TTGTTCCACC ACCAAGTGCA 
CAAGAGATAC CTGTGGTCTC TGCACCTGCT CCAGCCCCTA TTCACAACCA GTTTCCAGCT 
GAAAACCAGC CTGCCAATCA GAATGCTGCT CCTCAAGTGG TTGTTAATCC TGGAGCCAAT 
CAAAATTTGC GGATGAATGC ACAAGGTGGC CCTATTGTGG AAGAAGATGA TGAAATAAAT 
CGAGATTGGT TGGATTGGAC CTATTCAGCA GCTACATTTT CTGTTTTTCT CAGTATCCTC 
TACTTCTACT CCTCCCTGAG CAGATTCCTC ATGGTCATGG GGGCCACCGT TGTTATGTAC 
CTGCATCACG TTGGGTGGTT TCCATTTAGA CCGAGGCCGG TTCAGAACTT CCCAAATGAT 
GGTCCTCCTC CTGACGTTGT AAATCAGGAC CCCAACAATA ACTTACAGGA AGGCACTGAT 
CCTGAAACTG AAGACCCCAA CCACCTCCCT CCAGACAGGG ATGTACTAGA TGGCGAGCAG 
ACCAGCCCCT CCTTTATGAG CACAGCATGG CTTGTCTTCA AGACTTTCTT TGCCTCTCTT 
CTTCCAGAAG GCCCCCCAGC CATCGCAAAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The endoplasmic reticulum-residing chaperone BiP is short-lived and metabolized through N-terminal arginylation.
Science signaling11(511)(2018 Jan)
Shim SM,Choi HR,Sung KW,Lee YJ,Kim ST,Kim D,Mun SR,Hwang J,Cha-Molstad H,Ciechanover A,Kim BY,Kwon YT

HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress.
Journal of immunology (Baltimore, Md. : 1950)199(9)3280-3292(2017 Nov)
Ge M,Luo Z,Qiao Z,Zhou Y,Cheng X,Geng Q,Cai Y,Wan P,Xiong Y,Liu F,Wu K,Liu Y,Wu J

HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model.
Oncotarget8(17)28312-28327(2017 Apr)
Schr?rs B,L?bcke S,Lennerz V,Fatho M,Bicker A,W?lfel C,Derigs P,Hankeln T,Schadendorf D,Paschen A,W?lfel T

MiR-9-3p augments apoptosis induced by H2O2 through down regulation of Herpud1 in glioma.
PloS one12(4)e0174839(2017)
Yang L,Mu Y,Cui H,Liang Y,Su X

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HERPUD1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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