CD69 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CD69
Entrez Gene ID	969
Full Name	CD69 molecule
Synonyms	AIM,BL-AC/P26,CLEC2C,EA1,GP32/28,MLR-3
General protein information	Preferred Names CD69 molecule Names early activation antigen CD69 C-type lectin domain family 2, member C CD69 antigen (p60, early T-cell activation antigen) activation inducer molecule (AIM/CD69) early T-cell activation antigen p60 early lymphocyte activation antigen leukocyte surface antigen Leu-23
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.31
Summary	This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011].
Disorder MIM:	107273

mRNA and Protein(s)

mRNA	Protein	Name
NM_001781.2	NP_001772.1	early activation antigen CD69

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CD69	XP_520732.2
Bos taurus (cattle)	CD69	NP_776439.1
Gallus gallus (chicken)	LOC100859673	XP_003643265.2
Gallus gallus (chicken)	LOC769354	XP_001231743.2
Gallus gallus (chicken)	LOC100858840	XP_003643254.2
Gallus gallus (chicken)	LOC101748375	XP_004950008.1
Gallus gallus (chicken)	LOC100857536	XP_003643395.1
Gallus gallus (chicken)	Y-LEC1	NP_001026644.1
Gallus gallus (chicken)	LOC100859310	XP_003643259.1
Gallus gallus (chicken)	LOC101751702	XP_004949996.1
Gallus gallus (chicken)	LOC776458	XP_004950983.1
Rattus norvegicus (Norway rat)	Cd69	NP_599154.1
Gallus gallus (chicken)	LOC426336	XP_423996.4
Gallus gallus (chicken)	CD69	XP_004950954.1
Gallus gallus (chicken)	LOC768352	XP_001231207.3
Gallus gallus (chicken)	LOC100858620	XP_003643754.2
Gallus gallus (chicken)	LOC776463	XP_004950985.1
Gallus gallus (chicken)	LOC100857569	XP_003643943.2
Homo sapiens (human)	CD69	NP_001772.1
Canis lupus familiaris (dog)	CD69	XP_534892.4
Gallus gallus (chicken)	LOC100858282	XP_003643700.1
Gallus gallus (chicken)	TCLEC2B	XP_001232736.3
Gallus gallus (chicken)	LOC100859736	XP_003643266.2
Gallus gallus (chicken)	LOC101750977	XP_004949993.1
Gallus gallus (chicken)	LOC100857879	XP_003643544.1
	CD69	XP_001114683.1
Mus musculus (house mouse)	Cd69	NP_001028294.1
Gallus gallus (chicken)	LOC101751163	XP_004937449.1
Gallus gallus (chicken)	17.5	NP_990760.2
Gallus gallus (chicken)	LOC425783	NP_001264787.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors.
L?pez-Cabrera M, Santis AG, Fern?ndez-Ruiz E, Blacher R, Esch F, S?nchez-Mateos P, S?nchez-Madrid F
The Journal of experimental medicine178(2)537-47(1993 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AIM expression in the kidney was associated with urinary protein and decline in kidney function.
Title: Association of apoptosis inhibitor of macrophage (AIM) expression with urinary protein and kidney dysfunction.

In vitro functional assays showed that CD69(+) Treg cells exerted an important suppressive effect on the activation of T effector cells
Title: Levels of regulatory T cells CD69(+)NKG2D(+)IL-10(+) are increased in patients with autoimmune thyroid disorders.

Higher CD69 expression were less sensitive to bendamustine and is associated with chronic lymphocytic leukemia.
Title: CD69 expression potentially predicts response to bendamustine and its modulation by ibrutinib or idelalisib enhances cytotoxic effect in chronic lymphocytic leukemia.

results demonstrate the functional and mechanistic interplays between CD69 and S100A8/S100A9 in supporting Treg-cell differentiation
Title: Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation.

Elevated expression of CD69 and CD161 on NK cells can be considered as immunological risk markers in RSA and IVF failure.
Title: Increase of CD69, CD161 and CD94 on NK cells in women with recurrent spontaneous abortion and in vitro fertilization failure.

The following CD69 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD69 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu23374	NM_001781.2 Latest version!	Homo sapiens CD69 molecule (CD69), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CD69 ( NM_001781.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001772.1 Homo sapiens CD69 molecule (CD69), mRNA.

Price & Availability↑

CloneID	OHu23374
Clone ID Related Accession (Same CDS sequence)	NM_001781.2
Accession Version	NM_001781.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	early activation antigen CD69
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z22576.1 and AC007068.17. On Jan 27, 2009 this sequence version replaced NM_001781.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC007037.1, Z22576.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000228434.7/ ENSP00000228434.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCTCTG AAAATTGTTT CGTAGCAGAG AACAGCTCTT TGCATCCGGA GAGTGGACAA 
GAAAATGATG CCACCAGTCC CCATTTCTCA ACACGTCATG AAGGGTCCTT CCAAGTTCCT 
GTCCTGTGTG CTGTAATGAA TGTGGTCTTC ATCACCATTT TAATCATAGC TCTCATTGCC 
TTATCAGTGG GCCAATACAA TTGTCCAGGC CAATACACAT TCTCAATGCC ATCAGACAGC 
CATGTTTCTT CATGCTCTGA GGACTGGGTT GGCTACCAGA GGAAATGCTA CTTTATTTCT 
ACTGTGAAGA GGAGCTGGAC TTCAGCCCAA AATGCTTGTT CTGAACATGG TGCTACTCTT 
GCTGTCATTG ATTCTGAAAA GGACATGAAC TTTCTAAAAC GATACGCAGG TAGAGAGGAA 
CACTGGGTTG GACTGAAAAA GGAACCTGGT CACCCATGGA AGTGGTCAAA TGGCAAAGAA 
TTTAACAACT GGTTCAACGT TACAGGGTCT GACAAGTGTG TTTTTCTGAA AAACACAGAG 
GTCAGCAGCA TGGAATGTGA GAAGAATTTA TACTGGATAT GTAACAAACC TTACAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001772.1
CDS	82..681
Translation	MSSENCFVAENSSLHPESGQENDATSPHFSTRHEGSFQVPVLCAVMNVVFITILIIALIALSVGQYNCPGQYTFSMPSDSHVSSCSEDWVGYQRKCYFISTVKRSWTSAQNACSEHGATLAVIDSEKDMNFLKRYAGREEHWVGLKKEPGHPWKWSNGKEFNNWFNVTGSDKCVFLKNTEVSSMECEKNLYWICNKPYK

Target ORF information:

RefSeq Version	NM_001781.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CD69 molecule (CD69), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001781.2

ORF Insert Sequence:

ATGAGCTCTG AAAATTGTTT CGTAGCAGAG AACAGCTCTT TGCATCCGGA GAGTGGACAA 
GAAAATGATG CCACCAGTCC CCATTTCTCA ACACGTCATG AAGGGTCCTT CCAAGTTCCT 
GTCCTGTGTG CTGTAATGAA TGTGGTCTTC ATCACCATTT TAATCATAGC TCTCATTGCC 
TTATCAGTGG GCCAATACAA TTGTCCAGGC CAATACACAT TCTCAATGCC ATCAGACAGC 
CATGTTTCTT CATGCTCTGA GGACTGGGTT GGCTACCAGA GGAAATGCTA CTTTATTTCT 
ACTGTGAAGA GGAGCTGGAC TTCAGCCCAA AATGCTTGTT CTGAACATGG TGCTACTCTT 
GCTGTCATTG ATTCTGAAAA GGACATGAAC TTTCTAAAAC GATACGCAGG TAGAGAGGAA 
CACTGGGTTG GACTGAAAAA GGAACCTGGT CACCCATGGA AGTGGTCAAA TGGCAAAGAA 
TTTAACAACT GGTTCAACGT TACAGGGTCT GACAAGTGTG TTTTTCTGAA AAACACAGAG 
GTCAGCAGCA TGGAATGTGA GAAGAATTTA TACTGGATAT GTAACAAACC TTACAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors.
The Journal of experimental medicine178(2)537-47(1993 Aug)
L?pez-Cabrera M,Santis AG,Fern?ndez-Ruiz E,Blacher R,Esch F,S?nchez-Mateos P,S?nchez-Madrid F

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CD69 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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