GDF3 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GDF3
Entrez Gene ID	9573
Full Name	growth differentiation factor 3
Synonyms	KFS3,MCOP7,MCOPCB6
General protein information	Preferred Names growth differentiation factor 3 Names growth/differentiation factor 3
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 12 Map Location: 12p13.31
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role ocular and skeletal development. Mutations in this gene are associated with microphthalmia, coloboma, and skeletal abnormalities in human patients. [provided by RefSeq, Aug 2016].
Disorder MIM:	606522
Disorder Html:	Klippel-Feil syndrome 3, autosomal dominant, 613702 (3); Microphthalmia with coloboma 6, 613703 (3); Microphthalmia, isolated 7, 613704 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_020634.2	NP_065685.1	growth/differentiation factor 3 preproprotein
NM_020634.3	NP_065685.1	growth/differentiation factor 3 preproprotein
NM_020634.1	NP_065685.1	growth/differentiation factor 3 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gdf3	NP_032134.2
Danio rerio (zebrafish)	dvr1	NP_571023.1
Bos taurus (cattle)	GDF3	XP_002687893.1
Xenopus tropicalis (tropical clawed frog)	gdf1	NP_001016819.1
	GDF3	XP_001112644.1
Gallus gallus (chicken)	GDF3	NP_990542.1
Xenopus tropicalis (tropical clawed frog)	gdf3	NP_001007905.1
Pan troglodytes (chimpanzee)	GDF3	XP_508988.2
Canis lupus familiaris (dog)	GDF3	XP_534896.1
Rattus norvegicus (Norway rat)	Gdf3	NP_001103141.1
Homo sapiens (human)	GDF3	NP_065685.1

Gene Ontology
Bibliography

Related articles in PubMed

Growth and Differentiation Factor 3 Is Transcriptionally Regulated by OCT4 in Human Embryonic Carcinoma Cells.
Han MH, Park SW, Do HJ, Chung HJ, Song H, Kim JH, Kim NH, Park KH, Kim JH
Biological & pharmaceutical bulletin39(11)1802-1808(2016)

A novel variation of GDF3 in Chinese Han children with a broad phenotypic spectrum of non-syndromic CHDs.
Xiao J, Kang G, Wang J, Li T, Chen J, Wang J, Li W, Wang B
Cardiology in the young25(7)1263-7(2015 Oct)

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
Del-Aguila JL, Beitelshees AL, Cooper-Dehoff RM, Chapman AB, Gums JG, Bailey K, Gong Y, Turner ST, Johnson JA, Boerwinkle E
The pharmacogenomics journal14(1)35-40(2014 Feb)

Regulation of human growth and differentiation factor 3 gene expression by NANOG in human embryonic carcinoma NCCIT cells.
Park SW, Lim HY, Do HJ, Sung B, Huh SH, Uhm SJ, Song H, Chung HJ, Kim JH, Kim NH, Kim JH
FEBS letters586(19)3529-35(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

OCT4 plays a role as a transcriptional activator for GDF3 transcription in pluripotent human embryonic carcinoma NCCIT cells and contributes to the understanding of the molecular networks of stem cell regulators in germ cell-derived pluripotency and tumorigenesis.
Title: Growth and Differentiation Factor 3 Is Transcriptionally Regulated by OCT4 in Human Embryonic Carcinoma Cells.

The results expand the spectrum of mutations associated with CHDs and first suggest the potentially disease-related GDF3 gene variant in the pathogenesis of CHDs.
Title: A novel variation of GDF3 in Chinese Han children with a broad phenotypic spectrum of non-syndromic CHDs.

first evidence that NANOG is a transcriptional activator of the expression of the oncogenic growth factor GDF3 in embryonic carcinoma cells
Title: Regulation of human growth and differentiation factor 3 gene expression by NANOG in human embryonic carcinoma NCCIT cells.

GDF3 expression level was significantly down-regulated in breast cancer tissues compared to the surrounding nontumorous tissues.
Title: GDF3 inhibits the growth of breast cancer cells and promotes the apoptosis induced by Taxol.

Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells.
Title: Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells.

The following GDF3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GDF3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18012	NM_020634.3 Latest version!	Homo sapiens growth differentiation factor 3 (GDF3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu18012	NM_020634.2	Homo sapiens growth differentiation factor 3 (GDF3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu18012	NM_020634.1	Homo sapiens growth differentiation factor 3 (GDF3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GDF3 ( NM_020634.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_065685.1 Homo sapiens growth differentiation factor 3 (GDF3), mRNA.

Price & Availability↑

CloneID	OHu18012
Clone ID Related Accession (Same CDS sequence)	NM_020634.2 , NM_020634.3 , NM_020634.1
Accession Version	NM_020634.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	growth/differentiation factor 3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY358875.1, AF263538.1 and AA926805.1. This sequence is a reference standard in the RefSeqGene project. On Sep 1, 2016 this sequence version replaced NM_020634.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358875.1, BC030959.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCTTCGTT TCTTGCCAGA TTTGGCTTTC AGCTTCCTGT TAATTCTGGC TTTGGGCCAG 
GCAGTCCAAT TTCAAGAATA TGTCTTTCTC CAATTTCTGG GCTTAGATAA GGCGCCTTCA 
CCCCAGAAGT TCCAACCTGT GCCTTATATC TTGAAGAAAA TTTTCCAGGA TCGCGAGGCA 
GCAGCGACCA CTGGGGTCTC CCGAGACTTA TGCTACGTAA AGGAGCTGGG CGTCCGCGGG 
AATGTACTTC GCTTTCTCCC AGACCAAGGT TTCTTTCTTT ACCCAAAGAA AATTTCCCAA 
GCTTCCTCCT GCCTGCAGAA GCTCCTCTAC TTTAACCTGT CTGCCATCAA AGAAAGGGAA 
CAGTTGACAT TGGCCCAGCT GGGCCTGGAC TTGGGGCCCA ATTCTTACTA TAACCTGGGA 
CCAGAGCTGG AACTGGCTCT GTTCCTGGTT CAGGAGCCTC ATGTGTGGGG CCAGACCACC 
CCTAAGCCAG GTAAAATGTT TGTGTTGCGG TCAGTCCCAT GGCCACAAGG TGCTGTTCAC 
TTCAACCTGC TGGATGTAGC TAAGGATTGG AATGACAACC CCCGGAAAAA TTTCGGGTTA 
TTCCTGGAGA TACTGGTCAA AGAAGATAGA GACTCAGGGG TGAATTTTCA GCCTGAAGAC 
ACCTGTGCCA GACTAAGATG CTCCCTTCAT GCTTCCCTGC TGGTGGTGAC TCTCAACCCT 
GATCAGTGCC ACCCTTCTCG GAAAAGGAGA GCAGCCATCC CTGTCCCCAA GCTTTCTTGT 
AAGAACCTCT GCCACCGTCA CCAGCTATTC ATTAACTTCC GGGACCTGGG TTGGCACAAG 
TGGATCATTG CCCCCAAGGG GTTCATGGCA AATTACTGCC ATGGAGAGTG TCCCTTCTCA 
CTGACCATCT CTCTCAACAG CTCCAATTAT GCTTTCATGC AAGCCCTGAT GCATGCCGTT 
GACCCAGAGA TCCCCCAGGC TGTGTGTATC CCCACCAAGC TGTCTCCCAT TTCCATGCTC 
TACCAGGACA ATAATGACAA TGTCATTCTA CGACATTATG AAGACATGGT AGTCGATGAA 
TGTGGGTGTG GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065685.1
CDS	66..1160
Translation	MLRFLPDLAFSFLLILALGQAVQFQEYVFLQFLGLDKAPSPQKFQPVPYILKKIFQDREAAATTGVSRDLCYVKELGVRGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNLSAIKEREQLTLAQLGLDLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMFVLRSVPWPQGAVHFNLLDVAKDWNDNPRKNFGLFLEILVKEDRDSGVNFQPEDTCARLRCSLHASLLVVTLNPDQCHPSRKRRAAIPVPKLSCKNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGCG

Target ORF information:

RefSeq Version	NM_020634.2
Organism	Homo sapiens(human)
Definition	Homo sapiens growth differentiation factor 3 (GDF3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020634.2

ORF Insert Sequence:

ATGCTTCGTT TCTTGCCAGA TTTGGCTTTC AGCTTCCTGT TAATTCTGGC TTTGGGCCAG 
GCAGTCCAAT TTCAAGAATA TGTCTTTCTC CAATTTCTGG GCTTAGATAA GGCGCCTTCA 
CCCCAGAAGT TCCAACCTGT GCCTTATATC TTGAAGAAAA TTTTCCAGGA TCGCGAGGCA 
GCAGCGACCA CTGGGGTCTC CCGAGACTTA TGCTACGTAA AGGAGCTGGG CGTCCGCGGG 
AATGTACTTC GCTTTCTCCC AGACCAAGGT TTCTTTCTTT ACCCAAAGAA AATTTCCCAA 
GCTTCCTCCT GCCTGCAGAA GCTCCTCTAC TTTAACCTGT CTGCCATCAA AGAAAGGGAA 
CAGTTGACAT TGGCCCAGCT GGGCCTGGAC TTGGGGCCCA ATTCTTACTA TAACCTGGGA 
CCAGAGCTGG AACTGGCTCT GTTCCTGGTT CAGGAGCCTC ATGTGTGGGG CCAGACCACC 
CCTAAGCCAG GTAAAATGTT TGTGTTGCGG TCAGTCCCAT GGCCACAAGG TGCTGTTCAC 
TTCAACCTGC TGGATGTAGC TAAGGATTGG AATGACAACC CCCGGAAAAA TTTCGGGTTA 
TTCCTGGAGA TACTGGTCAA AGAAGATAGA GACTCAGGGG TGAATTTTCA GCCTGAAGAC 
ACCTGTGCCA GACTAAGATG CTCCCTTCAT GCTTCCCTGC TGGTGGTGAC TCTCAACCCT 
GATCAGTGCC ACCCTTCTCG GAAAAGGAGA GCAGCCATCC CTGTCCCCAA GCTTTCTTGT 
AAGAACCTCT GCCACCGTCA CCAGCTATTC ATTAACTTCC GGGACCTGGG TTGGCACAAG 
TGGATCATTG CCCCCAAGGG GTTCATGGCA AATTACTGCC ATGGAGAGTG TCCCTTCTCA 
CTGACCATCT CTCTCAACAG CTCCAATTAT GCTTTCATGC AAGCCCTGAT GCATGCCGTT 
GACCCAGAGA TCCCCCAGGC TGTGTGTATC CCCACCAAGC TGTCTCCCAT TTCCATGCTC 
TACCAGGACA ATAATGACAA TGTCATTCTA CGACATTATG AAGACATGGT AGTCGATGAA 
TGTGGGTGTG GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GDF3 ( NM_020634.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_065685.1 Homo sapiens growth differentiation factor 3 (GDF3), mRNA.

Price & Availability↑

CloneID	OHu18012
Clone ID Related Accession (Same CDS sequence)	NM_020634.2 , NM_020634.3 , NM_020634.1
Accession Version	NM_020634.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	growth/differentiation factor 3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY358875.1, AF263538.1 and AA926805.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_020634.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358875.1, BC030959.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000329913.4/ ENSP00000331745.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTTCGTT TCTTGCCAGA TTTGGCTTTC AGCTTCCTGT TAATTCTGGC TTTGGGCCAG 
GCAGTCCAAT TTCAAGAATA TGTCTTTCTC CAATTTCTGG GCTTAGATAA GGCGCCTTCA 
CCCCAGAAGT TCCAACCTGT GCCTTATATC TTGAAGAAAA TTTTCCAGGA TCGCGAGGCA 
GCAGCGACCA CTGGGGTCTC CCGAGACTTA TGCTACGTAA AGGAGCTGGG CGTCCGCGGG 
AATGTACTTC GCTTTCTCCC AGACCAAGGT TTCTTTCTTT ACCCAAAGAA AATTTCCCAA 
GCTTCCTCCT GCCTGCAGAA GCTCCTCTAC TTTAACCTGT CTGCCATCAA AGAAAGGGAA 
CAGTTGACAT TGGCCCAGCT GGGCCTGGAC TTGGGGCCCA ATTCTTACTA TAACCTGGGA 
CCAGAGCTGG AACTGGCTCT GTTCCTGGTT CAGGAGCCTC ATGTGTGGGG CCAGACCACC 
CCTAAGCCAG GTAAAATGTT TGTGTTGCGG TCAGTCCCAT GGCCACAAGG TGCTGTTCAC 
TTCAACCTGC TGGATGTAGC TAAGGATTGG AATGACAACC CCCGGAAAAA TTTCGGGTTA 
TTCCTGGAGA TACTGGTCAA AGAAGATAGA GACTCAGGGG TGAATTTTCA GCCTGAAGAC 
ACCTGTGCCA GACTAAGATG CTCCCTTCAT GCTTCCCTGC TGGTGGTGAC TCTCAACCCT 
GATCAGTGCC ACCCTTCTCG GAAAAGGAGA GCAGCCATCC CTGTCCCCAA GCTTTCTTGT 
AAGAACCTCT GCCACCGTCA CCAGCTATTC ATTAACTTCC GGGACCTGGG TTGGCACAAG 
TGGATCATTG CCCCCAAGGG GTTCATGGCA AATTACTGCC ATGGAGAGTG TCCCTTCTCA 
CTGACCATCT CTCTCAACAG CTCCAATTAT GCTTTCATGC AAGCCCTGAT GCATGCCGTT 
GACCCAGAGA TCCCCCAGGC TGTGTGTATC CCCACCAAGC TGTCTCCCAT TTCCATGCTC 
TACCAGGACA ATAATGACAA TGTCATTCTA CGACATTATG AAGACATGGT AGTCGATGAA 
TGTGGGTGTG GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065685.1
CDS	48..1142
Translation	MLRFLPDLAFSFLLILALGQAVQFQEYVFLQFLGLDKAPSPQKFQPVPYILKKIFQDREAAATTGVSRDLCYVKELGVRGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNLSAIKEREQLTLAQLGLDLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMFVLRSVPWPQGAVHFNLLDVAKDWNDNPRKNFGLFLEILVKEDRDSGVNFQPEDTCARLRCSLHASLLVVTLNPDQCHPSRKRRAAIPVPKLSCKNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGCG

Target ORF information:

RefSeq Version	NM_020634.3
Organism	Homo sapiens(human)
Definition	Homo sapiens growth differentiation factor 3 (GDF3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020634.3

ORF Insert Sequence:

ATGCTTCGTT TCTTGCCAGA TTTGGCTTTC AGCTTCCTGT TAATTCTGGC TTTGGGCCAG 
GCAGTCCAAT TTCAAGAATA TGTCTTTCTC CAATTTCTGG GCTTAGATAA GGCGCCTTCA 
CCCCAGAAGT TCCAACCTGT GCCTTATATC TTGAAGAAAA TTTTCCAGGA TCGCGAGGCA 
GCAGCGACCA CTGGGGTCTC CCGAGACTTA TGCTACGTAA AGGAGCTGGG CGTCCGCGGG 
AATGTACTTC GCTTTCTCCC AGACCAAGGT TTCTTTCTTT ACCCAAAGAA AATTTCCCAA 
GCTTCCTCCT GCCTGCAGAA GCTCCTCTAC TTTAACCTGT CTGCCATCAA AGAAAGGGAA 
CAGTTGACAT TGGCCCAGCT GGGCCTGGAC TTGGGGCCCA ATTCTTACTA TAACCTGGGA 
CCAGAGCTGG AACTGGCTCT GTTCCTGGTT CAGGAGCCTC ATGTGTGGGG CCAGACCACC 
CCTAAGCCAG GTAAAATGTT TGTGTTGCGG TCAGTCCCAT GGCCACAAGG TGCTGTTCAC 
TTCAACCTGC TGGATGTAGC TAAGGATTGG AATGACAACC CCCGGAAAAA TTTCGGGTTA 
TTCCTGGAGA TACTGGTCAA AGAAGATAGA GACTCAGGGG TGAATTTTCA GCCTGAAGAC 
ACCTGTGCCA GACTAAGATG CTCCCTTCAT GCTTCCCTGC TGGTGGTGAC TCTCAACCCT 
GATCAGTGCC ACCCTTCTCG GAAAAGGAGA GCAGCCATCC CTGTCCCCAA GCTTTCTTGT 
AAGAACCTCT GCCACCGTCA CCAGCTATTC ATTAACTTCC GGGACCTGGG TTGGCACAAG 
TGGATCATTG CCCCCAAGGG GTTCATGGCA AATTACTGCC ATGGAGAGTG TCCCTTCTCA 
CTGACCATCT CTCTCAACAG CTCCAATTAT GCTTTCATGC AAGCCCTGAT GCATGCCGTT 
GACCCAGAGA TCCCCCAGGC TGTGTGTATC CCCACCAAGC TGTCTCCCAT TTCCATGCTC 
TACCAGGACA ATAATGACAA TGTCATTCTA CGACATTATG AAGACATGGT AGTCGATGAA 
TGTGGGTGTG GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GDF3 ( NM_020634.1 ) cDNA ORF clone, Homo sapiens(Human) -> NP_065685.1 Homo sapiens growth differentiation factor 3 (GDF3), mRNA.

Price & Availability↑

CloneID	OHu18012
Clone ID Related Accession (Same CDS sequence)	NM_020634.2 , NM_020634.3 , NM_020634.1
Accession Version	NM_020634.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	growth/differentiation factor 3 precursor
Comment

ATGCTTCGTT TCTTGCCAGA TTTGGCTTTC AGCTTCCTGT TAATTCTGGC TTTGGGCCAG 
GCAGTCCAAT TTCAAGAATA TGTCTTTCTC CAATTTCTGG GCTTAGATAA GGCGCCTTCA 
CCCCAGAAGT TCCAACCTGT GCCTTATATC TTGAAGAAAA TTTTCCAGGA TCGCGAGGCA 
GCAGCGACCA CTGGGGTCTC CCGAGACTTA TGCTACGTAA AGGAGCTGGG CGTCCGCGGG 
AATGTACTTC GCTTTCTCCC AGACCAAGGT TTCTTTCTTT ACCCAAAGAA AATTTCCCAA 
GCTTCCTCCT GCCTGCAGAA GCTCCTCTAC TTTAACCTGT CTGCCATCAA AGAAAGGGAA 
CAGTTGACAT TGGCCCAGCT GGGCCTGGAC TTGGGGCCCA ATTCTTACTA TAACCTGGGA 
CCAGAGCTGG AACTGGCTCT GTTCCTGGTT CAGGAGCCTC ATGTGTGGGG CCAGACCACC 
CCTAAGCCAG GTAAAATGTT TGTGTTGCGG TCAGTCCCAT GGCCACAAGG TGCTGTTCAC 
TTCAACCTGC TGGATGTAGC TAAGGATTGG AATGACAACC CCCGGAAAAA TTTCGGGTTA 
TTCCTGGAGA TACTGGTCAA AGAAGATAGA GACTCAGGGG TGAATTTTCA GCCTGAAGAC 
ACCTGTGCCA GACTAAGATG CTCCCTTCAT GCTTCCCTGC TGGTGGTGAC TCTCAACCCT 
GATCAGTGCC ACCCTTCTCG GAAAAGGAGA GCAGCCATCC CTGTCCCCAA GCTTTCTTGT 
AAGAACCTCT GCCACCGTCA CCAGCTATTC ATTAACTTCC GGGACCTGGG TTGGCACAAG 
TGGATCATTG CCCCCAAGGG GTTCATGGCA AATTACTGCC ATGGAGAGTG TCCCTTCTCA 
CTGACCATCT CTCTCAACAG CTCCAATTAT GCTTTCATGC AAGCCCTGAT GCATGCCGTT 
GACCCAGAGA TCCCCCAGGC TGTGTGTATC CCCACCAAGC TGTCTCCCAT TTCCATGCTC 
TACCAGGACA ATAATGACAA TGTCATTCTA CGACATTATG AAGACATGGT AGTCGATGAA 
TGTGGGTGTG GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065685.1
Translation	MLRFLPDLAFSFLLILALGQAVQFQEYVFLQFLGLDKAPSPQKFQPVPYILKKIFQDREAAATTGVSRDLCYVKELGVRGNVLRFLPDQGFFLYPKKISQASSCLQKLLYFNLSAIKEREQLTLAQLGLDLGPNSYYNLGPELELALFLVQEPHVWGQTTPKPGKMFVLRSVPWPQGAVHFNLLDVAKDWNDNPRKNFGLFLEILVKEDRDSGVNFQPEDTCARLRCSLHASLLVVTLNPDQCHPSRKRRAAIPVPKLSCKNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGCG

Target ORF information:

RefSeq Version	NM_020634.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens growth differentiation factor 3 (GDF3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020634.1

ORF Insert Sequence:

ATGCTTCGTT TCTTGCCAGA TTTGGCTTTC AGCTTCCTGT TAATTCTGGC TTTGGGCCAG 
GCAGTCCAAT TTCAAGAATA TGTCTTTCTC CAATTTCTGG GCTTAGATAA GGCGCCTTCA 
CCCCAGAAGT TCCAACCTGT GCCTTATATC TTGAAGAAAA TTTTCCAGGA TCGCGAGGCA 
GCAGCGACCA CTGGGGTCTC CCGAGACTTA TGCTACGTAA AGGAGCTGGG CGTCCGCGGG 
AATGTACTTC GCTTTCTCCC AGACCAAGGT TTCTTTCTTT ACCCAAAGAA AATTTCCCAA 
GCTTCCTCCT GCCTGCAGAA GCTCCTCTAC TTTAACCTGT CTGCCATCAA AGAAAGGGAA 
CAGTTGACAT TGGCCCAGCT GGGCCTGGAC TTGGGGCCCA ATTCTTACTA TAACCTGGGA 
CCAGAGCTGG AACTGGCTCT GTTCCTGGTT CAGGAGCCTC ATGTGTGGGG CCAGACCACC 
CCTAAGCCAG GTAAAATGTT TGTGTTGCGG TCAGTCCCAT GGCCACAAGG TGCTGTTCAC 
TTCAACCTGC TGGATGTAGC TAAGGATTGG AATGACAACC CCCGGAAAAA TTTCGGGTTA 
TTCCTGGAGA TACTGGTCAA AGAAGATAGA GACTCAGGGG TGAATTTTCA GCCTGAAGAC 
ACCTGTGCCA GACTAAGATG CTCCCTTCAT GCTTCCCTGC TGGTGGTGAC TCTCAACCCT 
GATCAGTGCC ACCCTTCTCG GAAAAGGAGA GCAGCCATCC CTGTCCCCAA GCTTTCTTGT 
AAGAACCTCT GCCACCGTCA CCAGCTATTC ATTAACTTCC GGGACCTGGG TTGGCACAAG 
TGGATCATTG CCCCCAAGGG GTTCATGGCA AATTACTGCC ATGGAGAGTG TCCCTTCTCA 
CTGACCATCT CTCTCAACAG CTCCAATTAT GCTTTCATGC AAGCCCTGAT GCATGCCGTT 
GACCCAGAGA TCCCCCAGGC TGTGTGTATC CCCACCAAGC TGTCTCCCAT TTCCATGCTC 
TACCAGGACA ATAATGACAA TGTCATTCTA CGACATTATG AAGACATGGT AGTCGATGAA 
TGTGGGTGTG GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Growth and Differentiation Factor 3 Is Transcriptionally Regulated by OCT4 in Human Embryonic Carcinoma Cells.
Biological & pharmaceutical bulletin39(11)1802-1808(2016)
Han MH,Park SW,Do HJ,Chung HJ,Song H,Kim JH,Kim NH,Park KH,Kim JH

A novel variation of GDF3 in Chinese Han children with a broad phenotypic spectrum of non-syndromic CHDs.
Cardiology in the young25(7)1263-7(2015 Oct)
Xiao J,Kang G,Wang J,Li T,Chen J,Wang J,Li W,Wang B

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
The pharmacogenomics journal14(1)35-40(2014 Feb)
Del-Aguila JL,Beitelshees AL,Cooper-Dehoff RM,Chapman AB,Gums JG,Bailey K,Gong Y,Turner ST,Johnson JA,Boerwinkle E

Regulation of human growth and differentiation factor 3 gene expression by NANOG in human embryonic carcinoma NCCIT cells.
FEBS letters586(19)3529-35(2012 Sep)
Park SW,Lim HY,Do HJ,Sung B,Huh SH,Uhm SJ,Song H,Chung HJ,Kim JH,Kim NH,Kim JH

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GDF3 cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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