NR1D1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NR1D1
Entrez Gene ID	9572
Full Name	nuclear receptor subfamily 1 group D member 1
Synonyms	EAR1,THRA1,THRAL,ear-1,hRev
General protein information	Preferred Names nuclear receptor subfamily 1 group D member 1 Names nuclear receptor subfamily 1 group D member 1 Rev-ErbAalpha V-erbA-related protein 1 nuclear receptor Rev-ErbA-alpha rev-erbA-alpha
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.1
Summary	This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013].
Disorder MIM:	602408

mRNA and Protein(s)

mRNA	Protein	Name
NM_021724.4	NP_068370.1	nuclear receptor subfamily 1 group D member 1
NM_021724.5	NP_068370.1	nuclear receptor subfamily 1 group D member 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NR1D1	XP_003435298.1
Rattus norvegicus (Norway rat)	Nr1d1	NP_001106893.1
Danio rerio (zebrafish)	nr1d1	NP_991292.1
Homo sapiens (human)	NR1D1	NP_068370.1
Pan troglodytes (chimpanzee)	NR1D1	XP_511468.2
Bos taurus (cattle)	NR1D1	NP_001071568.1
Mus musculus (house mouse)	Nr1d1	NP_663409.2
Xenopus tropicalis (tropical clawed frog)	nr1d1	NP_001093675.1

Gene Ontology
Bibliography

Related articles in PubMed

The nuclear receptor and clock gene REV-ERB? regulates cigarette smoke-induced lung inflammation.
Sundar IK, Rashid K, Sellix MT, Rahman I
Biochemical and biophysical research communications493(4)1390-1395(2017 12)

NR1D1 Recruitment to Sites of DNA Damage Inhibits Repair and Is Associated with Chemosensitivity of Breast Cancer.
Ka NL, Na TY, Na H, Lee MH, Park HS, Hwang S, Kim IY, Seong JK, Lee MO
Cancer research77(9)2453-2463(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

To determine the impact of REV-ERBalpha activation in the cigarette smoke (CS)-induced lung inflammatory response, we treated primary small airway epithelial cells with CS extract or lipopolysaccharide in the absence or presence of pre-treatment with the REV-ERBalpha agonist GSK 4112.
Title: The nuclear receptor and clock gene REV-ERB? regulates cigarette smoke-induced lung inflammation.

Downregulation of NR1D1 in MCF7 cells resulted in resistance to doxorubicin, both in vitro and in vivo Analysis of four public patient data sets indicated that NR1D1 expression correlates positively with clinical outcome in breast cancer patients who received chemotherapy. Our findings suggest that NR1D1 and its ligands provide therapeutic options that could enhance the outcomes of chemotherapy in breast cancer patients
Title: NR1D1 Recruitment to Sites of DNA Damage Inhibits Repair and Is Associated with Chemosensitivity of Breast Cancer.

Data show that ubiquitin E3 ligase Siah2 depletion delays circadian degradation of nuclear hormone receptor RevErbalpha (Nr1d1) and lengthens period length.
Title: Ubiquitin ligase Siah2 regulates RevErb? degradation and the mammalian circadian clock.

Highly quantitative fluorescence anisotropy assays in competition mode revealed that the rev-erbA-alpha specificity for the NCoR corepressor lies in the first two residues of the beta-strand in Interaction Domain 1 of NCoR.
Title: Molecular mechanisms of transcriptional control by Rev-erb?: An energetic foundation for reconciling structure and binding with biological function.

the role of NR1D1 polymorphisms in the regulation of Nuclear receptor REV-ERBalpha and circadian rhythms regulation
Title: Associations between polymorphisms in the NR1D1 gene encoding for nuclear receptor REV-ERB? and circadian typologies.

The following NR1D1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NR1D1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21711	NM_021724.5 Latest version!	Homo sapiens nuclear receptor subfamily 1 group D member 1 (NR1D1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
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OHu21711	NM_021724.4	Homo sapiens nuclear receptor subfamily 1 group D member 1 (NR1D1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NR1D1 ( NM_021724.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_068370.1 Homo sapiens nuclear receptor subfamily 1 group D member 1 (NR1D1), mRNA.

Price & Availability↑

CloneID	OHu21711
Clone ID Related Accession (Same CDS sequence)	NM_021724.4 , NM_021724.5
Accession Version	NM_021724.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	nuclear receptor subfamily 1 group D member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC068669.21, BC056148.1 and BM671861.1. This sequence is a reference standard in the RefSeqGene project. On Jan 3, 2013 this sequence version replaced NM_021724.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M24898.1, BC056148.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGACCC TGGACTCCAA CAACAACACA GGTGGCGTCA TCACCTACAT TGGCTCCAGT 
GGCTCCTCCC CAAGCCGCAC CAGCCCTGAA TCCCTCTATA GTGACAACTC CAATGGCAGC 
TTCCAGTCCC TGACCCAAGG CTGTCCCACC TACTTCCCAC CATCCCCCAC TGGCTCCCTC 
ACCCAAGACC CGGCTCGCTC CTTTGGGAGC ATTCCACCCA GCCTGAGTGA TGACGGCTCC 
CCTTCTTCCT CATCTTCCTC GTCGTCATCC TCCTCCTCCT TCTATAATGG GAGCCCCCCT 
GGGAGTCTAC AAGTGGCCAT GGAGGACAGC AGCCGAGTGT CCCCCAGCAA GAGCACCAGC 
AACATCACCA AGCTGAATGG CATGGTGTTA CTGTGTAAAG TGTGTGGGGA CGTTGCCTCG 
GGCTTCCACT ACGGTGTGCA CGCCTGCGAG GGCTGCAAGG GCTTTTTCCG TCGGAGCATC 
CAGCAGAACA TCCAGTACAA AAGGTGTCTG AAGAATGAGA ATTGCTCCAT CGTCCGCATC 
AATCGCAACC GCTGCCAGCA ATGTCGCTTC AAGAAGTGTC TCTCTGTGGG CATGTCTCGA 
GACGCTGTGC GTTTTGGGCG CATCCCCAAA CGAGAGAAGC AGCGGATGCT TGCTGAGATG 
CAGAGTGCCA TGAACCTGGC CAACAACCAG TTGAGCAGCC AGTGCCCGCT GGAGACTTCA 
CCCACCCAGC ACCCCACCCC AGGCCCCATG GGCCCCTCGC CACCCCCTGC TCCGGTCCCC 
TCACCCCTGG TGGGCTTCTC CCAGTTTCCA CAACAGCTGA CGCCTCCCAG ATCCCCAAGC 
CCTGAGCCCA CAGTGGAGGA TGTGATATCC CAGGTGGCCC GGGCCCATCG AGAGATCTTC 
ACCTACGCCC ATGACAAGCT GGGCAGCTCA CCTGGCAACT TCAATGCCAA CCATGCATCA 
GGTAGCCCTC CAGCCACCAC CCCACATCGC TGGGAAAATC AGGGCTGCCC ACCTGCCCCC 
AATGACAACA ACACCTTGGC TGCCCAGCGT CATAACGAGG CCCTAAATGG TCTGCGCCAG 
GCTCCCTCCT CCTACCCTCC CACCTGGCCT CCTGGCCCTG CACACCACAG CTGCCACCAG 
TCCAACAGCA ACGGGCACCG TCTATGCCCC ACCCACGTGT ATGCAGCCCC AGAAGGCAAG 
GCACCTGCCA ACAGTCCCCG GCAGGGCAAC TCAAAGAATG TTCTGCTGGC ATGTCCTATG 
AACATGTACC CGCATGGACG CAGTGGGCGA ACGGTGCAGG AGATCTGGGA GGATTTCTCC 
ATGAGCTTCA CGCCCGCTGT GCGGGAGGTG GTAGAGTTTG CCAAACACAT CCCGGGCTTC 
CGTGACCTTT CTCAGCATGA CCAAGTCACC CTGCTTAAGG CTGGCACCTT TGAGGTGCTG 
ATGGTGCGCT TTGCTTCGTT GTTCAACGTG AAGGACCAGA CAGTGATGTT CCTAAGCCGC 
ACCACCTACA GCCTGCAGGA GCTTGGTGCC ATGGGCATGG GAGACCTGCT CAGTGCCATG 
TTCGACTTCA GCGAGAAGCT CAACTCCCTG GCGCTTACCG AGGAGGAGCT GGGCCTCTTC 
ACCGCGGTGG TGCTTGTCTC TGCAGACCGC TCGGGCATGG AGAATTCCGC TTCGGTGGAG 
CAGCTCCAGG AGACGCTGCT GCGGGCTCTT CGGGCTCTGG TGCTGAAGAA CCGGCCCTTG 
GAGACTTCCC GCTTCACCAA GCTGCTGCTC AAGCTGCCGG ACCTGCGGAC CCTGAACAAC 
ATGCATTCCG AGAAGCTGCT GTCCTTCCGG GTGGACGCCC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068370.1
CDS	632..2476
Translation	MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQGCPTYFPPSPTGSLTQDPARSFGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQAPSSYPPTWPPGPAHHSCHQSNSNGHRLCPTHVYAAPEGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ

Target ORF information:

RefSeq Version	NM_021724.4
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 1 group D member 1 (NR1D1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021724.4

ORF Insert Sequence:

ATGACGACCC TGGACTCCAA CAACAACACA GGTGGCGTCA TCACCTACAT TGGCTCCAGT 
GGCTCCTCCC CAAGCCGCAC CAGCCCTGAA TCCCTCTATA GTGACAACTC CAATGGCAGC 
TTCCAGTCCC TGACCCAAGG CTGTCCCACC TACTTCCCAC CATCCCCCAC TGGCTCCCTC 
ACCCAAGACC CGGCTCGCTC CTTTGGGAGC ATTCCACCCA GCCTGAGTGA TGACGGCTCC 
CCTTCTTCCT CATCTTCCTC GTCGTCATCC TCCTCCTCCT TCTATAATGG GAGCCCCCCT 
GGGAGTCTAC AAGTGGCCAT GGAGGACAGC AGCCGAGTGT CCCCCAGCAA GAGCACCAGC 
AACATCACCA AGCTGAATGG CATGGTGTTA CTGTGTAAAG TGTGTGGGGA CGTTGCCTCG 
GGCTTCCACT ACGGTGTGCA CGCCTGCGAG GGCTGCAAGG GCTTTTTCCG TCGGAGCATC 
CAGCAGAACA TCCAGTACAA AAGGTGTCTG AAGAATGAGA ATTGCTCCAT CGTCCGCATC 
AATCGCAACC GCTGCCAGCA ATGTCGCTTC AAGAAGTGTC TCTCTGTGGG CATGTCTCGA 
GACGCTGTGC GTTTTGGGCG CATCCCCAAA CGAGAGAAGC AGCGGATGCT TGCTGAGATG 
CAGAGTGCCA TGAACCTGGC CAACAACCAG TTGAGCAGCC AGTGCCCGCT GGAGACTTCA 
CCCACCCAGC ACCCCACCCC AGGCCCCATG GGCCCCTCGC CACCCCCTGC TCCGGTCCCC 
TCACCCCTGG TGGGCTTCTC CCAGTTTCCA CAACAGCTGA CGCCTCCCAG ATCCCCAAGC 
CCTGAGCCCA CAGTGGAGGA TGTGATATCC CAGGTGGCCC GGGCCCATCG AGAGATCTTC 
ACCTACGCCC ATGACAAGCT GGGCAGCTCA CCTGGCAACT TCAATGCCAA CCATGCATCA 
GGTAGCCCTC CAGCCACCAC CCCACATCGC TGGGAAAATC AGGGCTGCCC ACCTGCCCCC 
AATGACAACA ACACCTTGGC TGCCCAGCGT CATAACGAGG CCCTAAATGG TCTGCGCCAG 
GCTCCCTCCT CCTACCCTCC CACCTGGCCT CCTGGCCCTG CACACCACAG CTGCCACCAG 
TCCAACAGCA ACGGGCACCG TCTATGCCCC ACCCACGTGT ATGCAGCCCC AGAAGGCAAG 
GCACCTGCCA ACAGTCCCCG GCAGGGCAAC TCAAAGAATG TTCTGCTGGC ATGTCCTATG 
AACATGTACC CGCATGGACG CAGTGGGCGA ACGGTGCAGG AGATCTGGGA GGATTTCTCC 
ATGAGCTTCA CGCCCGCTGT GCGGGAGGTG GTAGAGTTTG CCAAACACAT CCCGGGCTTC 
CGTGACCTTT CTCAGCATGA CCAAGTCACC CTGCTTAAGG CTGGCACCTT TGAGGTGCTG 
ATGGTGCGCT TTGCTTCGTT GTTCAACGTG AAGGACCAGA CAGTGATGTT CCTAAGCCGC 
ACCACCTACA GCCTGCAGGA GCTTGGTGCC ATGGGCATGG GAGACCTGCT CAGTGCCATG 
TTCGACTTCA GCGAGAAGCT CAACTCCCTG GCGCTTACCG AGGAGGAGCT GGGCCTCTTC 
ACCGCGGTGG TGCTTGTCTC TGCAGACCGC TCGGGCATGG AGAATTCCGC TTCGGTGGAG 
CAGCTCCAGG AGACGCTGCT GCGGGCTCTT CGGGCTCTGG TGCTGAAGAA CCGGCCCTTG 
GAGACTTCCC GCTTCACCAA GCTGCTGCTC AAGCTGCCGG ACCTGCGGAC CCTGAACAAC 
ATGCATTCCG AGAAGCTGCT GTCCTTCCGG GTGGACGCCC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NR1D1 ( NM_021724.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_068370.1 Homo sapiens nuclear receptor subfamily 1 group D member 1 (NR1D1), mRNA.

Price & Availability↑

CloneID	OHu21711
Clone ID Related Accession (Same CDS sequence)	NM_021724.4 , NM_021724.5
Accession Version	NM_021724.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	nuclear receptor subfamily 1 group D member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC056148.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_021724.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC056148.1, M24898.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000246672.4/ ENSP00000246672.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACGACCC TGGACTCCAA CAACAACACA GGTGGCGTCA TCACCTACAT TGGCTCCAGT 
GGCTCCTCCC CAAGCCGCAC CAGCCCTGAA TCCCTCTATA GTGACAACTC CAATGGCAGC 
TTCCAGTCCC TGACCCAAGG CTGTCCCACC TACTTCCCAC CATCCCCCAC TGGCTCCCTC 
ACCCAAGACC CGGCTCGCTC CTTTGGGAGC ATTCCACCCA GCCTGAGTGA TGACGGCTCC 
CCTTCTTCCT CATCTTCCTC GTCGTCATCC TCCTCCTCCT TCTATAATGG GAGCCCCCCT 
GGGAGTCTAC AAGTGGCCAT GGAGGACAGC AGCCGAGTGT CCCCCAGCAA GAGCACCAGC 
AACATCACCA AGCTGAATGG CATGGTGTTA CTGTGTAAAG TGTGTGGGGA CGTTGCCTCG 
GGCTTCCACT ACGGTGTGCA CGCCTGCGAG GGCTGCAAGG GCTTTTTCCG TCGGAGCATC 
CAGCAGAACA TCCAGTACAA AAGGTGTCTG AAGAATGAGA ATTGCTCCAT CGTCCGCATC 
AATCGCAACC GCTGCCAGCA ATGTCGCTTC AAGAAGTGTC TCTCTGTGGG CATGTCTCGA 
GACGCTGTGC GTTTTGGGCG CATCCCCAAA CGAGAGAAGC AGCGGATGCT TGCTGAGATG 
CAGAGTGCCA TGAACCTGGC CAACAACCAG TTGAGCAGCC AGTGCCCGCT GGAGACTTCA 
CCCACCCAGC ACCCCACCCC AGGCCCCATG GGCCCCTCGC CACCCCCTGC TCCGGTCCCC 
TCACCCCTGG TGGGCTTCTC CCAGTTTCCA CAACAGCTGA CGCCTCCCAG ATCCCCAAGC 
CCTGAGCCCA CAGTGGAGGA TGTGATATCC CAGGTGGCCC GGGCCCATCG AGAGATCTTC 
ACCTACGCCC ATGACAAGCT GGGCAGCTCA CCTGGCAACT TCAATGCCAA CCATGCATCA 
GGTAGCCCTC CAGCCACCAC CCCACATCGC TGGGAAAATC AGGGCTGCCC ACCTGCCCCC 
AATGACAACA ACACCTTGGC TGCCCAGCGT CATAACGAGG CCCTAAATGG TCTGCGCCAG 
GCTCCCTCCT CCTACCCTCC CACCTGGCCT CCTGGCCCTG CACACCACAG CTGCCACCAG 
TCCAACAGCA ACGGGCACCG TCTATGCCCC ACCCACGTGT ATGCAGCCCC AGAAGGCAAG 
GCACCTGCCA ACAGTCCCCG GCAGGGCAAC TCAAAGAATG TTCTGCTGGC ATGTCCTATG 
AACATGTACC CGCATGGACG CAGTGGGCGA ACGGTGCAGG AGATCTGGGA GGATTTCTCC 
ATGAGCTTCA CGCCCGCTGT GCGGGAGGTG GTAGAGTTTG CCAAACACAT CCCGGGCTTC 
CGTGACCTTT CTCAGCATGA CCAAGTCACC CTGCTTAAGG CTGGCACCTT TGAGGTGCTG 
ATGGTGCGCT TTGCTTCGTT GTTCAACGTG AAGGACCAGA CAGTGATGTT CCTAAGCCGC 
ACCACCTACA GCCTGCAGGA GCTTGGTGCC ATGGGCATGG GAGACCTGCT CAGTGCCATG 
TTCGACTTCA GCGAGAAGCT CAACTCCCTG GCGCTTACCG AGGAGGAGCT GGGCCTCTTC 
ACCGCGGTGG TGCTTGTCTC TGCAGACCGC TCGGGCATGG AGAATTCCGC TTCGGTGGAG 
CAGCTCCAGG AGACGCTGCT GCGGGCTCTT CGGGCTCTGG TGCTGAAGAA CCGGCCCTTG 
GAGACTTCCC GCTTCACCAA GCTGCTGCTC AAGCTGCCGG ACCTGCGGAC CCTGAACAAC 
ATGCATTCCG AGAAGCTGCT GTCCTTCCGG GTGGACGCCC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068370.1
CDS	496..2340
Translation	MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQGCPTYFPPSPTGSLTQDPARSFGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQAPSSYPPTWPPGPAHHSCHQSNSNGHRLCPTHVYAAPEGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ

Target ORF information:

RefSeq Version	NM_021724.5
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 1 group D member 1 (NR1D1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021724.5

ORF Insert Sequence:

ATGACGACCC TGGACTCCAA CAACAACACA GGTGGCGTCA TCACCTACAT TGGCTCCAGT 
GGCTCCTCCC CAAGCCGCAC CAGCCCTGAA TCCCTCTATA GTGACAACTC CAATGGCAGC 
TTCCAGTCCC TGACCCAAGG CTGTCCCACC TACTTCCCAC CATCCCCCAC TGGCTCCCTC 
ACCCAAGACC CGGCTCGCTC CTTTGGGAGC ATTCCACCCA GCCTGAGTGA TGACGGCTCC 
CCTTCTTCCT CATCTTCCTC GTCGTCATCC TCCTCCTCCT TCTATAATGG GAGCCCCCCT 
GGGAGTCTAC AAGTGGCCAT GGAGGACAGC AGCCGAGTGT CCCCCAGCAA GAGCACCAGC 
AACATCACCA AGCTGAATGG CATGGTGTTA CTGTGTAAAG TGTGTGGGGA CGTTGCCTCG 
GGCTTCCACT ACGGTGTGCA CGCCTGCGAG GGCTGCAAGG GCTTTTTCCG TCGGAGCATC 
CAGCAGAACA TCCAGTACAA AAGGTGTCTG AAGAATGAGA ATTGCTCCAT CGTCCGCATC 
AATCGCAACC GCTGCCAGCA ATGTCGCTTC AAGAAGTGTC TCTCTGTGGG CATGTCTCGA 
GACGCTGTGC GTTTTGGGCG CATCCCCAAA CGAGAGAAGC AGCGGATGCT TGCTGAGATG 
CAGAGTGCCA TGAACCTGGC CAACAACCAG TTGAGCAGCC AGTGCCCGCT GGAGACTTCA 
CCCACCCAGC ACCCCACCCC AGGCCCCATG GGCCCCTCGC CACCCCCTGC TCCGGTCCCC 
TCACCCCTGG TGGGCTTCTC CCAGTTTCCA CAACAGCTGA CGCCTCCCAG ATCCCCAAGC 
CCTGAGCCCA CAGTGGAGGA TGTGATATCC CAGGTGGCCC GGGCCCATCG AGAGATCTTC 
ACCTACGCCC ATGACAAGCT GGGCAGCTCA CCTGGCAACT TCAATGCCAA CCATGCATCA 
GGTAGCCCTC CAGCCACCAC CCCACATCGC TGGGAAAATC AGGGCTGCCC ACCTGCCCCC 
AATGACAACA ACACCTTGGC TGCCCAGCGT CATAACGAGG CCCTAAATGG TCTGCGCCAG 
GCTCCCTCCT CCTACCCTCC CACCTGGCCT CCTGGCCCTG CACACCACAG CTGCCACCAG 
TCCAACAGCA ACGGGCACCG TCTATGCCCC ACCCACGTGT ATGCAGCCCC AGAAGGCAAG 
GCACCTGCCA ACAGTCCCCG GCAGGGCAAC TCAAAGAATG TTCTGCTGGC ATGTCCTATG 
AACATGTACC CGCATGGACG CAGTGGGCGA ACGGTGCAGG AGATCTGGGA GGATTTCTCC 
ATGAGCTTCA CGCCCGCTGT GCGGGAGGTG GTAGAGTTTG CCAAACACAT CCCGGGCTTC 
CGTGACCTTT CTCAGCATGA CCAAGTCACC CTGCTTAAGG CTGGCACCTT TGAGGTGCTG 
ATGGTGCGCT TTGCTTCGTT GTTCAACGTG AAGGACCAGA CAGTGATGTT CCTAAGCCGC 
ACCACCTACA GCCTGCAGGA GCTTGGTGCC ATGGGCATGG GAGACCTGCT CAGTGCCATG 
TTCGACTTCA GCGAGAAGCT CAACTCCCTG GCGCTTACCG AGGAGGAGCT GGGCCTCTTC 
ACCGCGGTGG TGCTTGTCTC TGCAGACCGC TCGGGCATGG AGAATTCCGC TTCGGTGGAG 
CAGCTCCAGG AGACGCTGCT GCGGGCTCTT CGGGCTCTGG TGCTGAAGAA CCGGCCCTTG 
GAGACTTCCC GCTTCACCAA GCTGCTGCTC AAGCTGCCGG ACCTGCGGAC CCTGAACAAC 
ATGCATTCCG AGAAGCTGCT GTCCTTCCGG GTGGACGCCC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The nuclear receptor and clock gene REV-ERB? regulates cigarette smoke-induced lung inflammation.
Biochemical and biophysical research communications493(4)1390-1395(2017 12)
Sundar IK,Rashid K,Sellix MT,Rahman I

NR1D1 Recruitment to Sites of DNA Damage Inhibits Repair and Is Associated with Chemosensitivity of Breast Cancer.
Cancer research77(9)2453-2463(2017 May)
Ka NL,Na TY,Na H,Lee MH,Park HS,Hwang S,Kim IY,Seong JK,Lee MO

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NR1D1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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