Gene Symbol | BAG3 |
Entrez Gene ID | 9531 |
Full Name | BCL2 associated athanogene 3 |
Synonyms | BAG-3,BIS,CAIR-1,MFM6 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | Myopathy, myofibrillar, 6, 612954 (3); Cardiomyopathy, dilated, 1HH, 613881 (3) |