BAG4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BAG4
Entrez Gene ID	9530
Full Name	BCL2 associated athanogene 4
Synonyms	BAG-4,SODD
General protein information	Preferred Names BCL2 associated athanogene 4 Names BAG family molecular chaperone regulator 4 bcl-2-associated athanogene 4 silencer of death domains
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p11.23
Summary	The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011].
Disorder MIM:	603884

mRNA and Protein(s)

mRNA	Protein	Name
NM_004874.3	NP_004865.1	BAG family molecular chaperone regulator 4 isoform 1
NM_001204878.2	NP_001191807.1	BAG family molecular chaperone regulator 4 isoform 2
NM_004874.4	NP_004865.1	BAG family molecular chaperone regulator 4 isoform 1
NM_001204878.1	NP_001191807.1	BAG family molecular chaperone regulator 4 isoform 2

Pathways from BioSystems

Homologies

	BAG4	XP_001092290.2
Bos taurus (cattle)	BAG4	NP_001104002.1
Homo sapiens (human)	BAG4	NP_004865.1
Canis lupus familiaris (dog)	BAG4	XP_849918.1
Mus musculus (house mouse)	Bag4	NP_080397.1
Xenopus tropicalis (tropical clawed frog)	bag4	XP_002932772.1
Rattus norvegicus (Norway rat)	Bag4	NP_001020301.1
Gallus gallus (chicken)	BAG4	XP_424388.4

Gene Ontology
Bibliography

Related articles in PubMed

Bcl?2 associated athanogene 4 promotes proliferation, migration and invasion of gastric cancer cells.
Yi L, Lv Z, Wang J, Zhong X
Molecular medicine reports16(4)3753-3760(2017 Oct)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Silencer-of-Death Domain Mediates Acid-Induced Decrease in Cell Apoptosis in Barrett's Associated Esophageal Adenocarcinoma Cells.
Li D, Hong J, Cao W
The Journal of pharmacology and experimental therapeutics360(1)14-22(2017 Jan)

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP
Molecular systems biology12(4)863(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

acid-induced increase in SODD expression and decrease in cell apoptosis may depend on the activation of NOX5-S and NF-kappaB1 p50 in FLO cells
Title: Silencer-of-Death Domain Mediates Acid-Induced Decrease in Cell Apoptosis in Barrett's Associated Esophageal Adenocarcinoma Cells.

SGK1.1 regulates gene transcription upon a different set of genes some of which participate in cell survival pathways (BAG-4) and others in intracellular vesicular traffic (Brox).
Title: The neuronal-specific SGK1.1 (SGK1_v2) kinase as a transcriptional modulator of BAG4, Brox, and PPP1CB genes expression.

SODD over-expression might be correlated with the clinical classification, curative effect, and prognosis of ALL cells.
Title: Significance of SODD expression in childhood acute lymphoblastic leukemia and its influence on chemotherapy.

MicroRNA-26a is strongly downregulated in melanoma and induces cell death through repression of silencer of death domains (SODD).
Title: MicroRNA-26a is strongly downregulated in melanoma and induces cell death through repression of silencer of death domains (SODD).

Observational study of gene-disease association. (HuGE Navigator)
Title: Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.

The following BAG4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BAG4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08297	NM_001204878.2 Latest version!	Homo sapiens BAG cochaperone 4 (BAG4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu08466	NM_004874.4 Latest version!	Homo sapiens BAG cochaperone 4 (BAG4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu08466	NM_004874.3	Homo sapiens BCL2 associated athanogene 4 (BAG4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu08297	NM_001204878.1	Homo sapiens BCL2 associated athanogene 4 (BAG4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BAG4 ( NM_001204878.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001191807.1 Homo sapiens BAG cochaperone 4 (BAG4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08297
Clone ID Related Accession (Same CDS sequence)	NM_001204878.2 , NM_001204878.1
Accession Version	NM_001204878.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	BAG family molecular chaperone regulator 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000800.1, AC084024.17 and BM683128.1. On Jun 1, 2019 this sequence version replaced NM_001204878.1. Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.1556746.1, SRR1803611.166821.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGTCGGCCC TGAGGCGCTC GGGCTACGGC CCCAGTGACG GTCCGTCCTA CGGCCGCTAC 
TACGGGCCTG GGGGTGGAGA TGTGCCGGTA CACCCACCTC CACCCTTATA TCCTCTTCGC 
CCTGAACCTC CCCAGCCTCC CATTTCCTGG CGGGTGCGCG GGGGCGGCCC GGCGGAGACC 
ACCTGGCTGG GAGAAGGCGG AGGAGGCGAT GGCTACTATC CCTCGGGAGG CGCCTGGCCA 
GAGCCTGGTC GAGCCGGAGG AAGCCACCAG AGTTTGAATT CTTATACAAA TGGAGCGTAT 
GGTCCAACAT ACCCCCCAGG CCCTGGGGCA AATACTGCCT CATACTCAGG GGCTTATTAT 
GCACCTGGTT ATACTCAGAC CAGTTACTCC ACAGAAGTTC CAAGTACTTA CCGTTCATCT 
GGCAACAGCC CAACTCCAGT CTCTCGTTGG ATCTATCCCC AGCAGGACTG TCAGACTGAA 
GCACCCCCTC TTAGGGGGCA GGTTCCAGGA TATCCGCCTT CACAGAACCC TGGAATGACC 
CTGCCCCATT ATCCTTATGG AGATGGTAAT CGTAGTGTTC CACAATCAGG ACCGACTGTA 
CGACCACAAG AAGATGCGTG GGCTTCTCCT GGTGCTTATG GAATGGGTGG CCGTTATCCC 
TGGCCTTCAT CAGCGCCCTC AGCACCACCC GGCAATCTCT ACATGACTGA AAGTACTTCA 
CCATGGCCTA GCAGTGGCTC TCCCCAGTCA CCCCCTTCAC CCCCAGTCCA GCAGCCCAAG 
GATTCTTCAT ACCCCTATAG CCAATCAGAT CAAAGCATGA ACCGGCACAA CTTTCCTTGC 
AGTGTCCATC AGTACGAATC CTCGGGGACA GTGAACAATG ATGATTCAGA TCTTTTGGAT 
TCCCAAGTCC AGTATAGTGC TGAGCCTCAG CTGTATGGTA ATGCCACCAG TGACCATCCC 
AACAATCAAG ATCAAAGTAG CAGTCTTCCT GAAGAATGTG TACCTTCAGA TGAAAGTACT 
CCTCCGAGTA TTAAAAAAAT CATACATGTG CTGGAGAAGG TCCAGTATCT TGAACAAGAA 
GTAGAAGAAT TTGTAGGAAA AAAGACAGAC AAAGCATACT GGCTTCTGGA AGAAATGCTA 
ACCAAGGAAC TTTTGGAACT GGATTCAGTT GAAACTGGGG GCCAGGACTC TGTACGGCAG 
GCCAGAAAAG AGGCTGTTTG TAAGATTCAG GCCATACTGG AAAAATTAGA AAAAAAAGGA 
TTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001191807.1
CDS	16..1281
Translation	MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPISWRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGYTQTSYSTEVPSTYRSSGNSPTPVSRWIYPQQDCQTEAPPLRGQVPGYPPSQNPGMTLPHYPYGDGNRSVPQSGPTVRPQEDAWASPGAYGMGGRYPWPSSAPSAPPGNLYMTESTSPWPSSGSPQSPPSPPVQQPKDSSYPYSQSDQSMNRHNFPCSVHQYESSGTVNNDDSDLLDSQVQYSAEPQLYGNATSDHPNNQDQSSSLPEECVPSDESTPPSIKKIIHVLEKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL

Target ORF information:

RefSeq Version	NM_001204878.2
Organism	Homo sapiens(human)
Definition	Homo sapiens BAG cochaperone 4 (BAG4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001204878.2

ORF Insert Sequence:

ATGTCGGCCC TGAGGCGCTC GGGCTACGGC CCCAGTGACG GTCCGTCCTA CGGCCGCTAC 
TACGGGCCTG GGGGTGGAGA TGTGCCGGTA CACCCACCTC CACCCTTATA TCCTCTTCGC 
CCTGAACCTC CCCAGCCTCC CATTTCCTGG CGGGTGCGCG GGGGCGGCCC GGCGGAGACC 
ACCTGGCTGG GAGAAGGCGG AGGAGGCGAT GGCTACTATC CCTCGGGAGG CGCCTGGCCA 
GAGCCTGGTC GAGCCGGAGG AAGCCACCAG AGTTTGAATT CTTATACAAA TGGAGCGTAT 
GGTCCAACAT ACCCCCCAGG CCCTGGGGCA AATACTGCCT CATACTCAGG GGCTTATTAT 
GCACCTGGTT ATACTCAGAC CAGTTACTCC ACAGAAGTTC CAAGTACTTA CCGTTCATCT 
GGCAACAGCC CAACTCCAGT CTCTCGTTGG ATCTATCCCC AGCAGGACTG TCAGACTGAA 
GCACCCCCTC TTAGGGGGCA GGTTCCAGGA TATCCGCCTT CACAGAACCC TGGAATGACC 
CTGCCCCATT ATCCTTATGG AGATGGTAAT CGTAGTGTTC CACAATCAGG ACCGACTGTA 
CGACCACAAG AAGATGCGTG GGCTTCTCCT GGTGCTTATG GAATGGGTGG CCGTTATCCC 
TGGCCTTCAT CAGCGCCCTC AGCACCACCC GGCAATCTCT ACATGACTGA AAGTACTTCA 
CCATGGCCTA GCAGTGGCTC TCCCCAGTCA CCCCCTTCAC CCCCAGTCCA GCAGCCCAAG 
GATTCTTCAT ACCCCTATAG CCAATCAGAT CAAAGCATGA ACCGGCACAA CTTTCCTTGC 
AGTGTCCATC AGTACGAATC CTCGGGGACA GTGAACAATG ATGATTCAGA TCTTTTGGAT 
TCCCAAGTCC AGTATAGTGC TGAGCCTCAG CTGTATGGTA ATGCCACCAG TGACCATCCC 
AACAATCAAG ATCAAAGTAG CAGTCTTCCT GAAGAATGTG TACCTTCAGA TGAAAGTACT 
CCTCCGAGTA TTAAAAAAAT CATACATGTG CTGGAGAAGG TCCAGTATCT TGAACAAGAA 
GTAGAAGAAT TTGTAGGAAA AAAGACAGAC AAAGCATACT GGCTTCTGGA AGAAATGCTA 
ACCAAGGAAC TTTTGGAACT GGATTCAGTT GAAACTGGGG GCCAGGACTC TGTACGGCAG 
GCCAGAAAAG AGGCTGTTTG TAAGATTCAG GCCATACTGG AAAAATTAGA AAAAAAAGGA 
TTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BAG4 ( NM_001204878.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001191807.1 Homo sapiens BCL2 associated athanogene 4 (BAG4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08297
Clone ID Related Accession (Same CDS sequence)	NM_001204878.2 , NM_001204878.1
Accession Version	NM_001204878.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-14
Organism	Homo sapiens(human)
Product	BAG family molecular chaperone regulator 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000800.1, AC084024.17 and BM683128.1. Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000800.1, SRR1803615.128889.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGTCGGCCC TGAGGCGCTC GGGCTACGGC CCCAGTGACG GTCCGTCCTA CGGCCGCTAC 
TACGGGCCTG GGGGTGGAGA TGTGCCGGTA CACCCACCTC CACCCTTATA TCCTCTTCGC 
CCTGAACCTC CCCAGCCTCC CATTTCCTGG CGGGTGCGCG GGGGCGGCCC GGCGGAGACC 
ACCTGGCTGG GAGAAGGCGG AGGAGGCGAT GGCTACTATC CCTCGGGAGG CGCCTGGCCA 
GAGCCTGGTC GAGCCGGAGG AAGCCACCAG AGTTTGAATT CTTATACAAA TGGAGCGTAT 
GGTCCAACAT ACCCCCCAGG CCCTGGGGCA AATACTGCCT CATACTCAGG GGCTTATTAT 
GCACCTGGTT ATACTCAGAC CAGTTACTCC ACAGAAGTTC CAAGTACTTA CCGTTCATCT 
GGCAACAGCC CAACTCCAGT CTCTCGTTGG ATCTATCCCC AGCAGGACTG TCAGACTGAA 
GCACCCCCTC TTAGGGGGCA GGTTCCAGGA TATCCGCCTT CACAGAACCC TGGAATGACC 
CTGCCCCATT ATCCTTATGG AGATGGTAAT CGTAGTGTTC CACAATCAGG ACCGACTGTA 
CGACCACAAG AAGATGCGTG GGCTTCTCCT GGTGCTTATG GAATGGGTGG CCGTTATCCC 
TGGCCTTCAT CAGCGCCCTC AGCACCACCC GGCAATCTCT ACATGACTGA AAGTACTTCA 
CCATGGCCTA GCAGTGGCTC TCCCCAGTCA CCCCCTTCAC CCCCAGTCCA GCAGCCCAAG 
GATTCTTCAT ACCCCTATAG CCAATCAGAT CAAAGCATGA ACCGGCACAA CTTTCCTTGC 
AGTGTCCATC AGTACGAATC CTCGGGGACA GTGAACAATG ATGATTCAGA TCTTTTGGAT 
TCCCAAGTCC AGTATAGTGC TGAGCCTCAG CTGTATGGTA ATGCCACCAG TGACCATCCC 
AACAATCAAG ATCAAAGTAG CAGTCTTCCT GAAGAATGTG TACCTTCAGA TGAAAGTACT 
CCTCCGAGTA TTAAAAAAAT CATACATGTG CTGGAGAAGG TCCAGTATCT TGAACAAGAA 
GTAGAAGAAT TTGTAGGAAA AAAGACAGAC AAAGCATACT GGCTTCTGGA AGAAATGCTA 
ACCAAGGAAC TTTTGGAACT GGATTCAGTT GAAACTGGGG GCCAGGACTC TGTACGGCAG 
GCCAGAAAAG AGGCTGTTTG TAAGATTCAG GCCATACTGG AAAAATTAGA AAAAAAAGGA 
TTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001191807.1
CDS	283..1548
Translation	MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPISWRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGYTQTSYSTEVPSTYRSSGNSPTPVSRWIYPQQDCQTEAPPLRGQVPGYPPSQNPGMTLPHYPYGDGNRSVPQSGPTVRPQEDAWASPGAYGMGGRYPWPSSAPSAPPGNLYMTESTSPWPSSGSPQSPPSPPVQQPKDSSYPYSQSDQSMNRHNFPCSVHQYESSGTVNNDDSDLLDSQVQYSAEPQLYGNATSDHPNNQDQSSSLPEECVPSDESTPPSIKKIIHVLEKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL

Target ORF information:

RefSeq Version	NM_001204878.1
Organism	Homo sapiens(human)
Definition	Homo sapiens BCL2 associated athanogene 4 (BAG4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001204878.1

ORF Insert Sequence:

ATGTCGGCCC TGAGGCGCTC GGGCTACGGC CCCAGTGACG GTCCGTCCTA CGGCCGCTAC 
TACGGGCCTG GGGGTGGAGA TGTGCCGGTA CACCCACCTC CACCCTTATA TCCTCTTCGC 
CCTGAACCTC CCCAGCCTCC CATTTCCTGG CGGGTGCGCG GGGGCGGCCC GGCGGAGACC 
ACCTGGCTGG GAGAAGGCGG AGGAGGCGAT GGCTACTATC CCTCGGGAGG CGCCTGGCCA 
GAGCCTGGTC GAGCCGGAGG AAGCCACCAG AGTTTGAATT CTTATACAAA TGGAGCGTAT 
GGTCCAACAT ACCCCCCAGG CCCTGGGGCA AATACTGCCT CATACTCAGG GGCTTATTAT 
GCACCTGGTT ATACTCAGAC CAGTTACTCC ACAGAAGTTC CAAGTACTTA CCGTTCATCT 
GGCAACAGCC CAACTCCAGT CTCTCGTTGG ATCTATCCCC AGCAGGACTG TCAGACTGAA 
GCACCCCCTC TTAGGGGGCA GGTTCCAGGA TATCCGCCTT CACAGAACCC TGGAATGACC 
CTGCCCCATT ATCCTTATGG AGATGGTAAT CGTAGTGTTC CACAATCAGG ACCGACTGTA 
CGACCACAAG AAGATGCGTG GGCTTCTCCT GGTGCTTATG GAATGGGTGG CCGTTATCCC 
TGGCCTTCAT CAGCGCCCTC AGCACCACCC GGCAATCTCT ACATGACTGA AAGTACTTCA 
CCATGGCCTA GCAGTGGCTC TCCCCAGTCA CCCCCTTCAC CCCCAGTCCA GCAGCCCAAG 
GATTCTTCAT ACCCCTATAG CCAATCAGAT CAAAGCATGA ACCGGCACAA CTTTCCTTGC 
AGTGTCCATC AGTACGAATC CTCGGGGACA GTGAACAATG ATGATTCAGA TCTTTTGGAT 
TCCCAAGTCC AGTATAGTGC TGAGCCTCAG CTGTATGGTA ATGCCACCAG TGACCATCCC 
AACAATCAAG ATCAAAGTAG CAGTCTTCCT GAAGAATGTG TACCTTCAGA TGAAAGTACT 
CCTCCGAGTA TTAAAAAAAT CATACATGTG CTGGAGAAGG TCCAGTATCT TGAACAAGAA 
GTAGAAGAAT TTGTAGGAAA AAAGACAGAC AAAGCATACT GGCTTCTGGA AGAAATGCTA 
ACCAAGGAAC TTTTGGAACT GGATTCAGTT GAAACTGGGG GCCAGGACTC TGTACGGCAG 
GCCAGAAAAG AGGCTGTTTG TAAGATTCAG GCCATACTGG AAAAATTAGA AAAAAAAGGA 
TTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BAG4 ( NM_004874.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004865.1 Homo sapiens BCL2 associated athanogene 4 (BAG4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu08466
Clone ID Related Accession (Same CDS sequence)	NM_004874.3 , NM_004874.4
Accession Version	NM_004874.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1374bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	BAG family molecular chaperone regulator 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000800.1, AF095194.2, AC084024.17 and BM683128.1. On Mar 11, 2011 this sequence version replaced NM_004874.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC038505.1, SRR1660803.164268.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGCCC TGAGGCGCTC GGGCTACGGC CCCAGTGACG GTCCGTCCTA CGGCCGCTAC 
TACGGGCCTG GGGGTGGAGA TGTGCCGGTA CACCCACCTC CACCCTTATA TCCTCTTCGC 
CCTGAACCTC CCCAGCCTCC CATTTCCTGG CGGGTGCGCG GGGGCGGCCC GGCGGAGACC 
ACCTGGCTGG GAGAAGGCGG AGGAGGCGAT GGCTACTATC CCTCGGGAGG CGCCTGGCCA 
GAGCCTGGTC GAGCCGGAGG AAGCCACCAG GAGCAGCCAC CATATCCTAG CTACAATTCT 
AACTATTGGA ATTCTACTGC GAGATCTAGG GCTCCTTACC CAAGTACATA TCCTGTAAGA 
CCAGAATTGC AAGGCCAGAG TTTGAATTCT TATACAAATG GAGCGTATGG TCCAACATAC 
CCCCCAGGCC CTGGGGCAAA TACTGCCTCA TACTCAGGGG CTTATTATGC ACCTGGTTAT 
ACTCAGACCA GTTACTCCAC AGAAGTTCCA AGTACTTACC GTTCATCTGG CAACAGCCCA 
ACTCCAGTCT CTCGTTGGAT CTATCCCCAG CAGGACTGTC AGACTGAAGC ACCCCCTCTT 
AGGGGGCAGG TTCCAGGATA TCCGCCTTCA CAGAACCCTG GAATGACCCT GCCCCATTAT 
CCTTATGGAG ATGGTAATCG TAGTGTTCCA CAATCAGGAC CGACTGTACG ACCACAAGAA 
GATGCGTGGG CTTCTCCTGG TGCTTATGGA ATGGGTGGCC GTTATCCCTG GCCTTCATCA 
GCGCCCTCAG CACCACCCGG CAATCTCTAC ATGACTGAAA GTACTTCACC ATGGCCTAGC 
AGTGGCTCTC CCCAGTCACC CCCTTCACCC CCAGTCCAGC AGCCCAAGGA TTCTTCATAC 
CCCTATAGCC AATCAGATCA AAGCATGAAC CGGCACAACT TTCCTTGCAG TGTCCATCAG 
TACGAATCCT CGGGGACAGT GAACAATGAT GATTCAGATC TTTTGGATTC CCAAGTCCAG 
TATAGTGCTG AGCCTCAGCT GTATGGTAAT GCCACCAGTG ACCATCCCAA CAATCAAGAT 
CAAAGTAGCA GTCTTCCTGA AGAATGTGTA CCTTCAGATG AAAGTACTCC TCCGAGTATT 
AAAAAAATCA TACATGTGCT GGAGAAGGTC CAGTATCTTG AACAAGAAGT AGAAGAATTT 
GTAGGAAAAA AGACAGACAA AGCATACTGG CTTCTGGAAG AAATGCTAAC CAAGGAACTT 
TTGGAACTGG ATTCAGTTGA AACTGGGGGC CAGGACTCTG TACGGCAGGC CAGAAAAGAG 
GCTGTTTGTA AGATTCAGGC CATACTGGAA AAATTAGAAA AAAAAGGATT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004865.1
CDS	283..1656
Translation	MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPISWRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQEQPPYPSYNSNYWNSTARSRAPYPSTYPVRPELQGQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGYTQTSYSTEVPSTYRSSGNSPTPVSRWIYPQQDCQTEAPPLRGQVPGYPPSQNPGMTLPHYPYGDGNRSVPQSGPTVRPQEDAWASPGAYGMGGRYPWPSSAPSAPPGNLYMTESTSPWPSSGSPQSPPSPPVQQPKDSSYPYSQSDQSMNRHNFPCSVHQYESSGTVNNDDSDLLDSQVQYSAEPQLYGNATSDHPNNQDQSSSLPEECVPSDESTPPSIKKIIHVLEKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL

Target ORF information:

RefSeq Version	NM_004874.3
Organism	Homo sapiens(human)
Definition	Homo sapiens BCL2 associated athanogene 4 (BAG4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004874.3

ORF Insert Sequence:

ATGTCGGCCC TGAGGCGCTC GGGCTACGGC CCCAGTGACG GTCCGTCCTA CGGCCGCTAC 
TACGGGCCTG GGGGTGGAGA TGTGCCGGTA CACCCACCTC CACCCTTATA TCCTCTTCGC 
CCTGAACCTC CCCAGCCTCC CATTTCCTGG CGGGTGCGCG GGGGCGGCCC GGCGGAGACC 
ACCTGGCTGG GAGAAGGCGG AGGAGGCGAT GGCTACTATC CCTCGGGAGG CGCCTGGCCA 
GAGCCTGGTC GAGCCGGAGG AAGCCACCAG GAGCAGCCAC CATATCCTAG CTACAATTCT 
AACTATTGGA ATTCTACTGC GAGATCTAGG GCTCCTTACC CAAGTACATA TCCTGTAAGA 
CCAGAATTGC AAGGCCAGAG TTTGAATTCT TATACAAATG GAGCGTATGG TCCAACATAC 
CCCCCAGGCC CTGGGGCAAA TACTGCCTCA TACTCAGGGG CTTATTATGC ACCTGGTTAT 
ACTCAGACCA GTTACTCCAC AGAAGTTCCA AGTACTTACC GTTCATCTGG CAACAGCCCA 
ACTCCAGTCT CTCGTTGGAT CTATCCCCAG CAGGACTGTC AGACTGAAGC ACCCCCTCTT 
AGGGGGCAGG TTCCAGGATA TCCGCCTTCA CAGAACCCTG GAATGACCCT GCCCCATTAT 
CCTTATGGAG ATGGTAATCG TAGTGTTCCA CAATCAGGAC CGACTGTACG ACCACAAGAA 
GATGCGTGGG CTTCTCCTGG TGCTTATGGA ATGGGTGGCC GTTATCCCTG GCCTTCATCA 
GCGCCCTCAG CACCACCCGG CAATCTCTAC ATGACTGAAA GTACTTCACC ATGGCCTAGC 
AGTGGCTCTC CCCAGTCACC CCCTTCACCC CCAGTCCAGC AGCCCAAGGA TTCTTCATAC 
CCCTATAGCC AATCAGATCA AAGCATGAAC CGGCACAACT TTCCTTGCAG TGTCCATCAG 
TACGAATCCT CGGGGACAGT GAACAATGAT GATTCAGATC TTTTGGATTC CCAAGTCCAG 
TATAGTGCTG AGCCTCAGCT GTATGGTAAT GCCACCAGTG ACCATCCCAA CAATCAAGAT 
CAAAGTAGCA GTCTTCCTGA AGAATGTGTA CCTTCAGATG AAAGTACTCC TCCGAGTATT 
AAAAAAATCA TACATGTGCT GGAGAAGGTC CAGTATCTTG AACAAGAAGT AGAAGAATTT 
GTAGGAAAAA AGACAGACAA AGCATACTGG CTTCTGGAAG AAATGCTAAC CAAGGAACTT 
TTGGAACTGG ATTCAGTTGA AACTGGGGGC CAGGACTCTG TACGGCAGGC CAGAAAAGAG 
GCTGTTTGTA AGATTCAGGC CATACTGGAA AAATTAGAAA AAAAAGGATT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BAG4 ( NM_004874.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004865.1 Homo sapiens BAG cochaperone 4 (BAG4), transcript variant 1, mRNA.

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CloneID	OHu08466
Clone ID Related Accession (Same CDS sequence)	NM_004874.3 , NM_004874.4
Accession Version	NM_004874.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1374bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	BAG family molecular chaperone regulator 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF095194.2, AC084024.17 and BM683128.1. On Nov 22, 2018 this sequence version replaced NM_004874.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.40234.1, BC038505.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000287322.5/ ENSP00000287322.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGCCC TGAGGCGCTC GGGCTACGGC CCCAGTGACG GTCCGTCCTA CGGCCGCTAC 
TACGGGCCTG GGGGTGGAGA TGTGCCGGTA CACCCACCTC CACCCTTATA TCCTCTTCGC 
CCTGAACCTC CCCAGCCTCC CATTTCCTGG CGGGTGCGCG GGGGCGGCCC GGCGGAGACC 
ACCTGGCTGG GAGAAGGCGG AGGAGGCGAT GGCTACTATC CCTCGGGAGG CGCCTGGCCA 
GAGCCTGGTC GAGCCGGAGG AAGCCACCAG GAGCAGCCAC CATATCCTAG CTACAATTCT 
AACTATTGGA ATTCTACTGC GAGATCTAGG GCTCCTTACC CAAGTACATA TCCTGTAAGA 
CCAGAATTGC AAGGCCAGAG TTTGAATTCT TATACAAATG GAGCGTATGG TCCAACATAC 
CCCCCAGGCC CTGGGGCAAA TACTGCCTCA TACTCAGGGG CTTATTATGC ACCTGGTTAT 
ACTCAGACCA GTTACTCCAC AGAAGTTCCA AGTACTTACC GTTCATCTGG CAACAGCCCA 
ACTCCAGTCT CTCGTTGGAT CTATCCCCAG CAGGACTGTC AGACTGAAGC ACCCCCTCTT 
AGGGGGCAGG TTCCAGGATA TCCGCCTTCA CAGAACCCTG GAATGACCCT GCCCCATTAT 
CCTTATGGAG ATGGTAATCG TAGTGTTCCA CAATCAGGAC CGACTGTACG ACCACAAGAA 
GATGCGTGGG CTTCTCCTGG TGCTTATGGA ATGGGTGGCC GTTATCCCTG GCCTTCATCA 
GCGCCCTCAG CACCACCCGG CAATCTCTAC ATGACTGAAA GTACTTCACC ATGGCCTAGC 
AGTGGCTCTC CCCAGTCACC CCCTTCACCC CCAGTCCAGC AGCCCAAGGA TTCTTCATAC 
CCCTATAGCC AATCAGATCA AAGCATGAAC CGGCACAACT TTCCTTGCAG TGTCCATCAG 
TACGAATCCT CGGGGACAGT GAACAATGAT GATTCAGATC TTTTGGATTC CCAAGTCCAG 
TATAGTGCTG AGCCTCAGCT GTATGGTAAT GCCACCAGTG ACCATCCCAA CAATCAAGAT 
CAAAGTAGCA GTCTTCCTGA AGAATGTGTA CCTTCAGATG AAAGTACTCC TCCGAGTATT 
AAAAAAATCA TACATGTGCT GGAGAAGGTC CAGTATCTTG AACAAGAAGT AGAAGAATTT 
GTAGGAAAAA AGACAGACAA AGCATACTGG CTTCTGGAAG AAATGCTAAC CAAGGAACTT 
TTGGAACTGG ATTCAGTTGA AACTGGGGGC CAGGACTCTG TACGGCAGGC CAGAAAAGAG 
GCTGTTTGTA AGATTCAGGC CATACTGGAA AAATTAGAAA AAAAAGGATT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004865.1
CDS	16..1389
Translation	MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPISWRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQEQPPYPSYNSNYWNSTARSRAPYPSTYPVRPELQGQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGYTQTSYSTEVPSTYRSSGNSPTPVSRWIYPQQDCQTEAPPLRGQVPGYPPSQNPGMTLPHYPYGDGNRSVPQSGPTVRPQEDAWASPGAYGMGGRYPWPSSAPSAPPGNLYMTESTSPWPSSGSPQSPPSPPVQQPKDSSYPYSQSDQSMNRHNFPCSVHQYESSGTVNNDDSDLLDSQVQYSAEPQLYGNATSDHPNNQDQSSSLPEECVPSDESTPPSIKKIIHVLEKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL

Target ORF information:

RefSeq Version	NM_004874.4
Organism	Homo sapiens(human)
Definition	Homo sapiens BAG cochaperone 4 (BAG4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004874.4

ORF Insert Sequence:

ATGTCGGCCC TGAGGCGCTC GGGCTACGGC CCCAGTGACG GTCCGTCCTA CGGCCGCTAC 
TACGGGCCTG GGGGTGGAGA TGTGCCGGTA CACCCACCTC CACCCTTATA TCCTCTTCGC 
CCTGAACCTC CCCAGCCTCC CATTTCCTGG CGGGTGCGCG GGGGCGGCCC GGCGGAGACC 
ACCTGGCTGG GAGAAGGCGG AGGAGGCGAT GGCTACTATC CCTCGGGAGG CGCCTGGCCA 
GAGCCTGGTC GAGCCGGAGG AAGCCACCAG GAGCAGCCAC CATATCCTAG CTACAATTCT 
AACTATTGGA ATTCTACTGC GAGATCTAGG GCTCCTTACC CAAGTACATA TCCTGTAAGA 
CCAGAATTGC AAGGCCAGAG TTTGAATTCT TATACAAATG GAGCGTATGG TCCAACATAC 
CCCCCAGGCC CTGGGGCAAA TACTGCCTCA TACTCAGGGG CTTATTATGC ACCTGGTTAT 
ACTCAGACCA GTTACTCCAC AGAAGTTCCA AGTACTTACC GTTCATCTGG CAACAGCCCA 
ACTCCAGTCT CTCGTTGGAT CTATCCCCAG CAGGACTGTC AGACTGAAGC ACCCCCTCTT 
AGGGGGCAGG TTCCAGGATA TCCGCCTTCA CAGAACCCTG GAATGACCCT GCCCCATTAT 
CCTTATGGAG ATGGTAATCG TAGTGTTCCA CAATCAGGAC CGACTGTACG ACCACAAGAA 
GATGCGTGGG CTTCTCCTGG TGCTTATGGA ATGGGTGGCC GTTATCCCTG GCCTTCATCA 
GCGCCCTCAG CACCACCCGG CAATCTCTAC ATGACTGAAA GTACTTCACC ATGGCCTAGC 
AGTGGCTCTC CCCAGTCACC CCCTTCACCC CCAGTCCAGC AGCCCAAGGA TTCTTCATAC 
CCCTATAGCC AATCAGATCA AAGCATGAAC CGGCACAACT TTCCTTGCAG TGTCCATCAG 
TACGAATCCT CGGGGACAGT GAACAATGAT GATTCAGATC TTTTGGATTC CCAAGTCCAG 
TATAGTGCTG AGCCTCAGCT GTATGGTAAT GCCACCAGTG ACCATCCCAA CAATCAAGAT 
CAAAGTAGCA GTCTTCCTGA AGAATGTGTA CCTTCAGATG AAAGTACTCC TCCGAGTATT 
AAAAAAATCA TACATGTGCT GGAGAAGGTC CAGTATCTTG AACAAGAAGT AGAAGAATTT 
GTAGGAAAAA AGACAGACAA AGCATACTGG CTTCTGGAAG AAATGCTAAC CAAGGAACTT 
TTGGAACTGG ATTCAGTTGA AACTGGGGGC CAGGACTCTG TACGGCAGGC CAGAAAAGAG 
GCTGTTTGTA AGATTCAGGC CATACTGGAA AAATTAGAAA AAAAAGGATT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bcl?2 associated athanogene 4 promotes proliferation, migration and invasion of gastric cancer cells.
Molecular medicine reports16(4)3753-3760(2017 Oct)
Yi L,Lv Z,Wang J,Zhong X

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Silencer-of-Death Domain Mediates Acid-Induced Decrease in Cell Apoptosis in Barrett's Associated Esophageal Adenocarcinoma Cells.
The Journal of pharmacology and experimental therapeutics360(1)14-22(2017 Jan)
Li D,Hong J,Cao W

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Molecular systems biology12(4)863(2016 Apr)
Yachie N,Petsalaki E,Mellor JC,Weile J,Jacob Y,Verby M,Ozturk SB,Li S,Cote AG,Mosca R,Knapp JJ,Ko M,Yu A,Gebbia M,Sahni N,Yi S,Tyagi T,Sheykhkarimli D,Roth JF,Wong C,Musa L,Snider J,Liu YC,Yu H,Braun P,Stagljar I,Hao T,Calderwood MA,Pelletier L,Aloy P,Hill DE,Vidal M,Roth FP

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BAG4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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