SPTLC2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SPTLC2
Entrez Gene ID	9517
Full Name	serine palmitoyltransferase long chain base subunit 2
Synonyms	HSN1C,LCB2,LCB2A,NSAN1C,SPT2,hLCB2a
General protein information	Preferred Names serine palmitoyltransferase long chain base subunit 2 Names serine palmitoyltransferase 2 LCB 2 SPT 2 long chain base biosynthesis protein 2a serine palmitoyltransferase, subunit II serine-palmitoyl-CoA transferase 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q24.3
Summary	This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011].
Disorder MIM:	605713
Disorder Html:	Neuropathy, hereditary sensory and autonomic, type IC, 613640 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011537384.2	XP_011535686.1	serine palmitoyltransferase 2 isoform X1
NM_004863.3	NP_004854.1	serine palmitoyltransferase 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SPTLC2	XP_510095.3
Caenorhabditis elegans (roundworm)	sptl-2	NP_505065.1
Magnaporthe oryzae (rice blast fungus)	MGG_05197	XP_003712740.1
Homo sapiens (human)	SPTLC2	NP_004854.1
Rattus norvegicus (Norway rat)	Sptlc2	NP_001032174.1
Gallus gallus (chicken)	SPTLC2	NP_001006483.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007941	XP_317536.4
Schizosaccharomyces pombe (fission yeast)	lcb2	XP_001713103.1
Arabidopsis thaliana (thale cress)	LCB2	NP_197756.1
Oryza sativa (rice)	Os01g0928700	NP_001045278.1
Oryza sativa (rice)	Os01g0928800	NP_001045279.1
Mus musculus (house mouse)	Sptlc2	NP_035609.1
Kluyveromyces lactis	KLLA0D02134g	XP_453163.1
Oryza sativa (rice)	Os11g0516000	NP_001067972.1
Danio rerio (zebrafish)	sptlc2a	NP_001018455.1
Saccharomyces cerevisiae (baker's yeast)	LCB2	NP_010347.1
Neurospora crassa	NCU00447	XP_956766.1
	LOC707625	XP_001096042.2
Canis lupus familiaris (dog)	SPTLC2	XP_537524.3
Bos taurus (cattle)	SPTLC2	NP_001092551.1
Drosophila melanogaster (fruit fly)	lace	NP_476614.1
Eremothecium gossypii	AGOS_AGR127C	NP_986793.2
Arabidopsis thaliana (thale cress)	SPT1	NP_190447.1
Xenopus tropicalis (tropical clawed frog)	sptlc2	XP_002938915.1

Gene Ontology
Bibliography

Related articles in PubMed

The Variant p.(Arg183Trp) in SPTLC2 Causes Late-Onset Hereditary Sensory Neuropathy.
Suriyanarayanan S, Auranen M, Toppila J, Paetau A, Shcherbii M, Palin E, Wei Y, Lohioja T, Schlotter-Weigel B, Sch?n U, Abicht A, Rautenstrauss B, Tyynismaa H, Walter MC, Hornemann T, Ylikallio E
Neuromolecular medicine18(1)81-90(2016 Mar)

ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis.
Siow D, Sunkara M, Dunn TM, Morris AJ, Wattenberg B
Journal of lipid research56(4)898-908(2015 Apr)

Autophagy regulates sphingolipid levels in the liver.
Alexaki A, Gupta SD, Majumder S, Kono M, Tuymetova G, Harmon JM, Dunn TM, Proia RL
Journal of lipid research55(12)2521-31(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

2 families had late-onset autosomal dominant HSAN1C caused by a new variant in SPTLC2, c.547C>T, p.(Arg183Trp). The variant changed a conserved amino acid.
Title: The Variant p.(Arg183Trp) in SPTLC2 Causes Late-Onset Hereditary Sensory Neuropathy.

Mutations in SPTLC2 are associated with increased deoxySL formation causing hereditary sensory and autonomic neuropathy type 1 (HSANI) in a familial study.
Title: Hereditary sensory and autonomic neuropathy type 1 (HSANI) caused by a novel mutation in SPTLC2.

The activities of the hLCB2a mutants were measured in the presence of ssSPTa and ssSPTb and was found that all decrease enzyme activity.
Title: The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT): effects of the small subunits and insights from bacterial mimics of human hLCB2a HSAN1 mutations.

Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I.
Title: Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following SPTLC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPTLC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu22400	NM_004863.3 Latest version!	Homo sapiens serine palmitoyltransferase long chain base subunit 2 (SPTLC2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu62913	XM_011537384.2 Latest version!	Homo sapiens serine palmitoyltransferase long chain base subunit 2 (SPTLC2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SPTLC2 ( NM_004863.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004854.1 Homo sapiens serine palmitoyltransferase long chain base subunit 2 (SPTLC2), mRNA.

Price & Availability↑

CloneID	OHu22400
Clone ID Related Accession (Same CDS sequence)	NM_004863.3
Accession Version	NM_004863.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1689bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	serine palmitoyltransferase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB011098.1, BQ338973.1 and AF111168.2. This sequence is a reference standard in the RefSeqGene project. On Apr 1, 2011 this sequence version replaced NM_004863.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB011098.1, SRR1803612.54785.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGGCCGG AGCCCGGAGG CTGCTGCTGC CGCCGCACGG TGCGGGCGAA TGGCTGCGTG 
GCGAACGGGG AAGTACGGAA CGGGTACGTG AGGAGCAGCG CTGCAGCCGC AGCCGCAGCC 
GCCGCCGGCC AGATCCATCA TGTTACACAA AATGGAGGAC TATATAAAAG ACCGTTTAAT 
GAAGCTTTTG AAGAAACACC AATGCTGGTT GCTGTGCTCA CGTATGTGGG GTATGGCGTA 
CTCACCCTCT TTGGATATCT TCGAGATTTC TTGAGGTATT GGAGAATTGA AAAGTGTCAC 
CATGCAACAG AAAGAGAAGA ACAAAAGGAC TTTGTGTCAT TGTATCAAGA TTTTGAAAAC 
TTTTATACAA GGAATCTGTA CATGAGGATA AGAGACAACT GGAATCGGCC AATCTGTAGT 
GTGCCTGGAG CCAGGGTGGA CATCATGGAG AGACAGTCTC ATGATTATAA CTGGTCCTTC 
AAGTATACAG GGAATATAAT AAAGGGTGTT ATAAACATGG GTTCCTACAA CTATCTTGGA 
TTTGCACGGA ATACTGGATC ATGTCAAGAA GCAGCCGCCA AAGTCCTTGA GGAGTATGGA 
GCTGGAGTGT GCAGTACTCG GCAGGAAATT GGAAACCTGG ACAAGCATGA AGAACTAGAG 
GAGCTTGTAG CAAGGTTCTT AGGAGTAGAA GCTGCTATGG CGTATGGCAT GGGATTTGCA 
ACGAATTCAA TGAACATTCC TGCTCTTGTT GGCAAAGGTT GCCTGATTCT GAGTGATGAA 
CTGAATCATG CATCACTGGT TCTGGGAGCC AGACTGTCAG GAGCAACCAT TAGAATCTTC 
AAACACAACA ATATGCAAAG CCTAGAGAAG CTATTGAAAG ATGCCATTGT TTATGGTCAG 
CCTCGGACAC GAAGGCCCTG GAAGAAAATT CTCATCCTTG TGGAAGGAAT ATATAGCATG 
GAGGGATCTA TTGTTCGTCT TCCTGAAGTG ATTGCCCTCA AGAAGAAATA CAAGGCATAC 
TTGTATCTGG ATGAGGCTCA CAGCATTGGC GCCCTGGGCC CCACAGGCCG GGGTGTGGTG 
GAGTACTTTG GCCTGGATCC CGAGGATGTG GATGTTATGA TGGGAACGTT CACAAAGAGT 
TTTGGTGCTT CTGGAGGATA TATTGGAGGC AAGAAGGAGC TGATAGACTA CCTGCGAACA 
CATTCTCATA GTGCAGTGTA TGCCACGTCA TTGTCACCTC CTGTAGTGGA GCAGATCATC 
ACCTCCATGA AGTGCATCAT GGGGCAGGAT GGCACCAGCC TTGGTAAAGA GTGTGTACAA 
CAGTTAGCTG AAAACACCAG GTATTTCAGG AGACGCCTGA AAGAGATGGG CTTCATCATC 
TATGGAAATG AAGACTCTCC AGTAGTGCCT TTGATGCTCT ACATGCCTGC CAAAATTGGC 
GCCTTTGGAC GGGAGATGCT GAAGCGGAAC ATCGGTGTCG TTGTGGTTGG ATTTCCTGCC 
ACCCCAATTA TTGAGTCCAG AGCCAGGTTT TGCCTGTCAG CAGCTCATAC CAAAGAAATA 
CTTGATACTG CTTTAAAGGA GATAGATGAA GTTGGGGACC TATTGCAGCT GAAGTATTCC 
CGTCATCGGT TGGTACCTCT ACTGGACAGG CCCTTTGACG AGACGACGTA TGAAGAAACA 
GAAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004854.1
CDS	189..1877
Translation	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED

Target ORF information:

RefSeq Version	NM_004863.3
Organism	Homo sapiens(human)
Definition	Homo sapiens serine palmitoyltransferase long chain base subunit 2 (SPTLC2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004863.3

ORF Insert Sequence:

ATGCGGCCGG AGCCCGGAGG CTGCTGCTGC CGCCGCACGG TGCGGGCGAA TGGCTGCGTG 
GCGAACGGGG AAGTACGGAA CGGGTACGTG AGGAGCAGCG CTGCAGCCGC AGCCGCAGCC 
GCCGCCGGCC AGATCCATCA TGTTACACAA AATGGAGGAC TATATAAAAG ACCGTTTAAT 
GAAGCTTTTG AAGAAACACC AATGCTGGTT GCTGTGCTCA CGTATGTGGG GTATGGCGTA 
CTCACCCTCT TTGGATATCT TCGAGATTTC TTGAGGTATT GGAGAATTGA AAAGTGTCAC 
CATGCAACAG AAAGAGAAGA ACAAAAGGAC TTTGTGTCAT TGTATCAAGA TTTTGAAAAC 
TTTTATACAA GGAATCTGTA CATGAGGATA AGAGACAACT GGAATCGGCC AATCTGTAGT 
GTGCCTGGAG CCAGGGTGGA CATCATGGAG AGACAGTCTC ATGATTATAA CTGGTCCTTC 
AAGTATACAG GGAATATAAT AAAGGGTGTT ATAAACATGG GTTCCTACAA CTATCTTGGA 
TTTGCACGGA ATACTGGATC ATGTCAAGAA GCAGCCGCCA AAGTCCTTGA GGAGTATGGA 
GCTGGAGTGT GCAGTACTCG GCAGGAAATT GGAAACCTGG ACAAGCATGA AGAACTAGAG 
GAGCTTGTAG CAAGGTTCTT AGGAGTAGAA GCTGCTATGG CGTATGGCAT GGGATTTGCA 
ACGAATTCAA TGAACATTCC TGCTCTTGTT GGCAAAGGTT GCCTGATTCT GAGTGATGAA 
CTGAATCATG CATCACTGGT TCTGGGAGCC AGACTGTCAG GAGCAACCAT TAGAATCTTC 
AAACACAACA ATATGCAAAG CCTAGAGAAG CTATTGAAAG ATGCCATTGT TTATGGTCAG 
CCTCGGACAC GAAGGCCCTG GAAGAAAATT CTCATCCTTG TGGAAGGAAT ATATAGCATG 
GAGGGATCTA TTGTTCGTCT TCCTGAAGTG ATTGCCCTCA AGAAGAAATA CAAGGCATAC 
TTGTATCTGG ATGAGGCTCA CAGCATTGGC GCCCTGGGCC CCACAGGCCG GGGTGTGGTG 
GAGTACTTTG GCCTGGATCC CGAGGATGTG GATGTTATGA TGGGAACGTT CACAAAGAGT 
TTTGGTGCTT CTGGAGGATA TATTGGAGGC AAGAAGGAGC TGATAGACTA CCTGCGAACA 
CATTCTCATA GTGCAGTGTA TGCCACGTCA TTGTCACCTC CTGTAGTGGA GCAGATCATC 
ACCTCCATGA AGTGCATCAT GGGGCAGGAT GGCACCAGCC TTGGTAAAGA GTGTGTACAA 
CAGTTAGCTG AAAACACCAG GTATTTCAGG AGACGCCTGA AAGAGATGGG CTTCATCATC 
TATGGAAATG AAGACTCTCC AGTAGTGCCT TTGATGCTCT ACATGCCTGC CAAAATTGGC 
GCCTTTGGAC GGGAGATGCT GAAGCGGAAC ATCGGTGTCG TTGTGGTTGG ATTTCCTGCC 
ACCCCAATTA TTGAGTCCAG AGCCAGGTTT TGCCTGTCAG CAGCTCATAC CAAAGAAATA 
CTTGATACTG CTTTAAAGGA GATAGATGAA GTTGGGGACC TATTGCAGCT GAAGTATTCC 
CGTCATCGGT TGGTACCTCT ACTGGACAGG CCCTTTGACG AGACGACGTA TGAAGAAACA 
GAAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPTLC2 ( XM_011537384.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011535686.1 Homo sapiens serine palmitoyltransferase long chain base subunit 2 (SPTLC2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu62913
Clone ID Related Accession (Same CDS sequence)	XM_011537384.2
Accession Version	XM_011537384.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1413bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	serine palmitoyltransferase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000014.9) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011537384.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGGCCGG AGCCCGGAGG CTGCTGCTGC CGCCGCACGG TGCGGGCGAA TGGCTGCGTG 
GCGAACGGGG AAGTACGGAA CGGGTACGTG AGGAGCAGCG CTGCAGCCGC AGCCGCAGCC 
GCCGCCGGCC AGATCCATCA TGTTACACAA AATGGAGGAC TATATAAAAG ACCGTTTAAT 
GAAGCTTTTG AAGAAACACC AATGCTGGTT GCTGTGCTCA CGTATGTGGG GTATGGCGTA 
CTCACCCTCT TTGGATATCT TCGAGATTTC TTGAGGTATT GGAGAATTGA AAAGTGTCAC 
CATGCAACAG AAAGAGAAGA ACAAAAGGAC TTTGTGTCAT TGTATCAAGA TTTTGAAAAC 
TTTTATACAA GGAATCTGTA CATGAGGATA AGAGACAACT GGAATCGGCC AATCTGTAGT 
GTGCCTGGAG CCAGGGTGGA CATCATGGAG AGACAGTCTC ATGATTATAA CTGGTCCTTC 
AAGTATACAG GGAATATAAT AAAGGGTGTT ATAAACATGG GTTCCTACAA CTATCTTGGA 
TTTGCACGGA ATACTGGATC ATGTCAAGAA GCAGCCGCCA AAGTCCTTGA GGAGTATGGA 
GCTGGAGTGT GCAGTACTCG GCAGGAAATT GGAAACCTGG ACAAGCATGA AGAACTAGAG 
GAGCTTGTAG CAAGGTTCTT AGGAGTAGAA GCTGCTATGG CGTATGGCAT GGGATTTGCA 
ACGAATTCAA TGAACATTCC TGCTCTTGTT GGCAAAGGTT GCCTGATTCT GAGTGATGAA 
CTGAATCATG CATCACTGGT TCTGGGAGCC AGACTGTCAG GAGCAACCAT TAGAATCTTC 
AAACACAACA ATATGCAAAG CCTAGAGAAG CTATTGAAAG ATGCCATTGT TTATGGTCAG 
CCTCGGACAC GAAGGCCCTG GAAGAAAATT CTCATCCTTG TGGAAGGAAT ATATAGCATG 
GAGGGATCTA TTGTTCGTCT TCCTGAAGTG ATTGCCCTCA AGAAGAAATA CAAGGCATAC 
TTGTATCTGG ATGAGGCTCA CAGCATTGGC GCCCTGGGCC CCACAGGCCG GGGTGTGGTG 
GAGTACTTTG GCCTGGATCC CGAGGATGTG GATGTTATGA TGGGAACGTT CACAAAGAGT 
TTTGGTGCTT CTGGAGGATA TATTGGAGGC AAGAAGGAGC TGATAGACTA CCTGCGAACA 
CATTCTCATA GTGCAGTGTA TGCCACGTCA TTGTCACCTC CTGTAGTGGA GCAGATCATC 
ACCTCCATGA AGTGCATCAT GGGGCAGGAT GGCACCAGCC TTGGTAATGG CATCACTATT 
CATGAAGTTG TCCAAACAAG AAATACCTAT CATCGTTTCT CTCCTTTATC CCCTGTATTT 
AGTCACCAGT GCCTATGGAT CATGCTTCCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011535686.1
CDS	85..1497
Translation	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDGTSLGNGITIHEVVQTRNTYHRFSPLSPVFSHQCLWIMLP

Target ORF information:

RefSeq Version	XM_011537384.2
Organism	Homo sapiens(human)
Definition	Homo sapiens serine palmitoyltransferase long chain base subunit 2 (SPTLC2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011537384.2

ORF Insert Sequence:

ATGCGGCCGG AGCCCGGAGG CTGCTGCTGC CGCCGCACGG TGCGGGCGAA TGGCTGCGTG 
GCGAACGGGG AAGTACGGAA CGGGTACGTG AGGAGCAGCG CTGCAGCCGC AGCCGCAGCC 
GCCGCCGGCC AGATCCATCA TGTTACACAA AATGGAGGAC TATATAAAAG ACCGTTTAAT 
GAAGCTTTTG AAGAAACACC AATGCTGGTT GCTGTGCTCA CGTATGTGGG GTATGGCGTA 
CTCACCCTCT TTGGATATCT TCGAGATTTC TTGAGGTATT GGAGAATTGA AAAGTGTCAC 
CATGCAACAG AAAGAGAAGA ACAAAAGGAC TTTGTGTCAT TGTATCAAGA TTTTGAAAAC 
TTTTATACAA GGAATCTGTA CATGAGGATA AGAGACAACT GGAATCGGCC AATCTGTAGT 
GTGCCTGGAG CCAGGGTGGA CATCATGGAG AGACAGTCTC ATGATTATAA CTGGTCCTTC 
AAGTATACAG GGAATATAAT AAAGGGTGTT ATAAACATGG GTTCCTACAA CTATCTTGGA 
TTTGCACGGA ATACTGGATC ATGTCAAGAA GCAGCCGCCA AAGTCCTTGA GGAGTATGGA 
GCTGGAGTGT GCAGTACTCG GCAGGAAATT GGAAACCTGG ACAAGCATGA AGAACTAGAG 
GAGCTTGTAG CAAGGTTCTT AGGAGTAGAA GCTGCTATGG CGTATGGCAT GGGATTTGCA 
ACGAATTCAA TGAACATTCC TGCTCTTGTT GGCAAAGGTT GCCTGATTCT GAGTGATGAA 
CTGAATCATG CATCACTGGT TCTGGGAGCC AGACTGTCAG GAGCAACCAT TAGAATCTTC 
AAACACAACA ATATGCAAAG CCTAGAGAAG CTATTGAAAG ATGCCATTGT TTATGGTCAG 
CCTCGGACAC GAAGGCCCTG GAAGAAAATT CTCATCCTTG TGGAAGGAAT ATATAGCATG 
GAGGGATCTA TTGTTCGTCT TCCTGAAGTG ATTGCCCTCA AGAAGAAATA CAAGGCATAC 
TTGTATCTGG ATGAGGCTCA CAGCATTGGC GCCCTGGGCC CCACAGGCCG GGGTGTGGTG 
GAGTACTTTG GCCTGGATCC CGAGGATGTG GATGTTATGA TGGGAACGTT CACAAAGAGT 
TTTGGTGCTT CTGGAGGATA TATTGGAGGC AAGAAGGAGC TGATAGACTA CCTGCGAACA 
CATTCTCATA GTGCAGTGTA TGCCACGTCA TTGTCACCTC CTGTAGTGGA GCAGATCATC 
ACCTCCATGA AGTGCATCAT GGGGCAGGAT GGCACCAGCC TTGGTAATGG CATCACTATT 
CATGAAGTTG TCCAAACAAG AAATACCTAT CATCGTTTCT CTCCTTTATC CCCTGTATTT 
AGTCACCAGT GCCTATGGAT CATGCTTCCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Variant p.(Arg183Trp) in SPTLC2 Causes Late-Onset Hereditary Sensory Neuropathy.
Neuromolecular medicine18(1)81-90(2016 Mar)
Suriyanarayanan S,Auranen M,Toppila J,Paetau A,Shcherbii M,Palin E,Wei Y,Lohioja T,Schlotter-Weigel B,Sch?n U,Abicht A,Rautenstrauss B,Tyynismaa H,Walter MC,Hornemann T,Ylikallio E

ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis.
Journal of lipid research56(4)898-908(2015 Apr)
Siow D,Sunkara M,Dunn TM,Morris AJ,Wattenberg B

Autophagy regulates sphingolipid levels in the liver.
Journal of lipid research55(12)2521-31(2014 Dec)
Alexaki A,Gupta SD,Majumder S,Kono M,Tuymetova G,Harmon JM,Dunn TM,Proia RL

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

SPTLC2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報