ADAMTS1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADAMTS1
Entrez Gene ID	9510
Full Name	ADAM metallopeptidase with thrombospondin type 1 motif 1
Synonyms	C3-C5,METH1
General protein information	Preferred Names ADAM metallopeptidase with thrombospondin type 1 motif 1 Names A disintegrin and metalloproteinase with thrombospondin motifs 1 ADAM-TS 1 ADAM-TS1 ADAMTS-1 METH-1 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1 human metalloproteinase with thrombospondin type 1 motifs
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q21.3
Summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008].
Disorder MIM:	605174

mRNA and Protein(s)

mRNA	Protein	Name
NM_006988.4	NP_008919.3	A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein
NM_006988.5	NP_008919.3	A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ADAMTS1	NP_001094550.1
Mus musculus (house mouse)	Adamts1	NP_033751.3
Pan troglodytes (chimpanzee)	ADAMTS1	XP_531406.2
	ADAMTS1	XP_001103864.1
Canis lupus familiaris (dog)	ADAMTS1	XP_003434043.3
Gallus gallus (chicken)	ADAMTS1	XP_416687.4
Danio rerio (zebrafish)	adamts1	XP_693535.6
Homo sapiens (human)	ADAMTS1	NP_008919.3
Xenopus tropicalis (tropical clawed frog)	adamts1	NP_001120905.1
Rattus norvegicus (Norway rat)	Adamts1	NP_077376.2

Gene Ontology
Bibliography

Related articles in PubMed

The role of serum ADAMTS-1 and aggrecan on polycystic ovary syndrome in adolescents and younger-aged females.
Tola EN, Koroglu ND, Yalcin SE, Oral HB
Archives of gynecology and obstetrics297(2)487-493(2018 Feb)

ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia.
Naml? Kalem M, Kalem Z, Y?ce T, Soylemez F
Hypertension in pregnancy1-9(2017 Nov)

Expression and Clinical Significance of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and a Disintegrin and Metalloproteinase with Thrombospondin Type 1 Motif 1 (ADAMTS1) in Post-Kidney-Transplant Bladder Tumors.
Xue W, Zhang Z, Zeng S, Xu Y, Zhang Q, Wang W, Zhang Y, Zhang X, Hu X
Annals of transplantation22622-630(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Taken together, our findings suggested that miR-362-3p inhibits the proliferation and migration of VSMCs by directly targeting ADAMTS1, which might provide novel insight into the molecular mechanisms underlying the action of miR-362-3p in atherosclerosis.
Title: MiR-362-3p inhibits the proliferation and migration of vascular smooth muscle cells in atherosclerosis by targeting ADAMTS1.

Our study demonstrated that altered levels of ADAMTS-1 and aggrecan may have a partial role in the etiopathogenesis of Polycystic ovary syndrome (PCOS), and ADAMTS-1 could be a predictive marker for implantation success in PCOS patients.
Title: Follicular ADAMTS-1 and aggrecan levels in polycystic ovary syndrome.

Patients with Marfan syndrome showed elevated NOS2 and decreased ADAMTS1 protein levels in the aorta.
Title: Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome.

ADAMTS1 has diverse roles in angiogenesis, tumor microenvironment and lymphangiogenesis.
Title: Diverse Functions of a Disintegrin and Metalloproteinase with Thrombospondin Motif-1.

This study showed that ADAMTS1, 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (gastric cancer)
Title: Differentially regulated ADAMTS1, 8, and 18 in gastric adenocarcinoma.

The following ADAMTS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADAMTS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu62902	NM_006988.5 Latest version!	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 1 (ADAMTS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu62902	NM_006988.4	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 1 (ADAMTS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADAMTS1 ( NM_006988.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_008919.3 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 1 (ADAMTS1), mRNA.

Price & Availability↑

CloneID	OHu62902
Clone ID Related Accession (Same CDS sequence)	NM_006988.4 , NM_006988.5
Accession Version	NM_006988.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2904bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314475.1 and AF207664.1. On Dec 23, 2014 this sequence version replaced NM_006988.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX647388.1, SRR1660803.186240.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA2155371 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCAGCGAG CTGTGCCCGA GGGGTTCGGA AGGCGCAAGC TGGGCAGCGA CATGGGGAAC 
GCGGAGCGGG CTCCGGGGTC TCGGAGCTTT GGGCCAGTAC CCACGCTGCT GCTGCTCGCC 
GCGGCGCTAC TGGCCGTGTC GGACGCACTC GGGCGCCCCT CCGAGGAGGA CGAGGAGCTA 
GTGGTGCCGG AGCTGGAGCG CGCCCCGGGA CACGGGACCA CGCGCCTCCG CCTGCACGCC 
TTTGACCAGC AGCTGGATCT GGAGCTGCGG CCCGACAGCA GCTTTTTGGC GCCCGGCTTC 
ACGCTCCAGA ACGTGGGGCG CAAATCCGGG TCCGAGACGC CGCTTCCGGA AACCGACCTG 
GCGCACTGCT TCTACTCCGG CACCGTGAAT GGCGATCCCA GCTCGGCTGC CGCCCTCAGC 
CTCTGCGAGG GCGTGCGCGG CGCCTTCTAC CTGCTGGGGG AGGCGTATTT CATCCAGCCG 
CTGCCCGCCG CCAGCGAGCG CCTCGCCACC GCCGCCCCAG GGGAGAAGCC GCCGGCACCA 
CTACAGTTCC ACCTCCTGCG GCGGAATCGG CAGGGCGACG TCGGCGGCAC GTGCGGGGTC 
GTGGACGACG AGCCCCGGCC GACTGGGAAA GCGGAGACCG AAGACGAGGA CGAAGGGACT 
GAGGGCGAGG ACGAAGGGGC TCAGTGGTCG CCGCAGGACC CGGCACTGCA AGGCGTAGGA 
CAGCCCACAG GAACTGGAAG CATAAGAAAG AAGCGATTTG TGTCCAGTCA CCGCTATGTG 
GAAACCATGC TTGTGGCAGA CCAGTCGATG GCAGAATTCC ACGGCAGTGG TCTAAAGCAT 
TACCTTCTCA CGTTGTTTTC GGTGGCAGCC AGATTGTACA AACACCCCAG CATTCGTAAT 
TCAGTTAGCC TGGTGGTGGT GAAGATCTTG GTCATCCACG ATGAACAGAA GGGGCCGGAA 
GTGACCTCCA ATGCTGCCCT CACTCTGCGG AACTTTTGCA ACTGGCAGAA GCAGCACAAC 
CCACCCAGTG ACCGGGATGC AGAGCACTAT GACACAGCAA TTCTTTTCAC CAGACAGGAC 
TTGTGTGGGT CCCAGACATG TGATACTCTT GGGATGGCTG ATGTTGGAAC TGTGTGTGAT 
CCGAGCAGAA GCTGCTCCGT CATAGAAGAT GATGGTTTAC AAGCTGCCTT CACCACAGCC 
CATGAATTAG GCCACGTGTT TAACATGCCA CATGATGATG CAAAGCAGTG TGCCAGCCTT 
AATGGTGTGA ACCAGGATTC CCACATGATG GCGTCAATGC TTTCCAACCT GGACCACAGC 
CAGCCTTGGT CTCCTTGCAG TGCCTACATG ATTACATCAT TTCTGGATAA TGGTCATGGG 
GAATGTTTGA TGGACAAGCC TCAGAATCCC ATACAGCTCC CAGGCGATCT CCCTGGCACC 
TCGTACGATG CCAACCGGCA GTGCCAGTTT ACATTTGGGG AGGACTCCAA ACACTGCCCC 
GATGCAGCCA GCACATGTAG CACCTTGTGG TGTACCGGCA CCTCTGGTGG GGTGCTGGTG 
TGTCAAACCA AACACTTCCC GTGGGCGGAT GGCACCAGCT GTGGAGAAGG GAAATGGTGT 
ATCAACGGCA AGTGTGTGAA CAAAACCGAC AGAAAGCATT TTGATACGCC TTTTCATGGA 
AGCTGGGGAA TGTGGGGGCC TTGGGGAGAC TGTTCGAGAA CGTGCGGTGG AGGAGTCCAG 
TACACGATGA GGGAATGTGA CAACCCAGTC CCAAAGAATG GAGGGAAGTA CTGTGAAGGC 
AAACGAGTGC GCTACAGATC CTGTAACCTT GAGGACTGTC CAGACAATAA TGGAAAAACC 
TTTAGAGAGG AACAATGTGA AGCACACAAC GAGTTTTCAA AAGCTTCCTT TGGGAGTGGG 
CCTGCGGTGG AATGGATTCC CAAGTACGCT GGCGTCTCAC CAAAGGACAG GTGCAAGCTC 
ATCTGCCAAG CCAAAGGCAT TGGCTACTTC TTCGTTTTGC AGCCCAAGGT TGTAGATGGT 
ACTCCATGTA GCCCAGATTC CACCTCTGTC TGTGTGCAAG GACAGTGTGT AAAAGCTGGT 
TGTGATCGCA TCATAGACTC CAAAAAGAAG TTTGATAAAT GTGGTGTTTG CGGGGGAAAT 
GGATCTACTT GTAAAAAAAT ATCAGGATCA GTTACTAGTG CAAAACCTGG ATATCATGAT 
ATCATCACAA TTCCAACTGG AGCCACCAAC ATCGAAGTGA AACAGCGGAA CCAGAGGGGA 
TCCAGGAACA ATGGCAGCTT TCTTGCCATC AAAGCTGCTG ATGGCACATA TATTCTTAAT 
GGTGACTACA CTTTGTCCAC CTTAGAGCAA GACATTATGT ACAAAGGTGT TGTCTTGAGG 
TACAGCGGCT CCTCTGCGGC ATTGGAAAGA ATTCGCAGCT TTAGCCCTCT CAAAGAGCCC 
TTGACCATCC AGGTTCTTAC TGTGGGCAAT GCCCTTCGAC CTAAAATTAA ATACACCTAC 
TTCGTAAAGA AGAAGAAGGA ATCTTTCAAT GCTATCCCCA CTTTTTCAGC ATGGGTCATT 
GAAGAGTGGG GCGAATGTTC TAAGTCATGT GAATTGGGTT GGCAGAGAAG ACTGGTAGAA 
TGCCGAGACA TTAATGGACA GCCTGCTTCC GAGTGTGCAA AGGAAGTGAA GCCAGCCAGC 
ACCAGACCTT GTGCAGACCA TCCCTGCCCC CAGTGGCAGC TGGGGGAGTG GTCATCATGT 
TCTAAGACCT GTGGGAAGGG TTACAAAAAA AGAAGCTTGA AGTGTCTGTC CCATGATGGA 
GGGGTGTTAT CTCATGAGAG CTGTGATCCT TTAAAGAAAC CTAAACATTT CATAGACTTT 
TGCACAATGG CAGAATGCAG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008919.3
CDS	456..3359
Translation	MQRAVPEGFGRRKLGSDMGNAERAPGSRSFGPVPTLLLLAAALLAVSDALGRPSEEDEELVVPELERAPGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAECS

Target ORF information:

RefSeq Version	NM_006988.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 1 (ADAMTS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006988.4

ORF Insert Sequence:

ATGCAGCGAG CTGTGCCCGA GGGGTTCGGA AGGCGCAAGC TGGGCAGCGA CATGGGGAAC 
GCGGAGCGGG CTCCGGGGTC TCGGAGCTTT GGGCCAGTAC CCACGCTGCT GCTGCTCGCC 
GCGGCGCTAC TGGCCGTGTC GGACGCACTC GGGCGCCCCT CCGAGGAGGA CGAGGAGCTA 
GTGGTGCCGG AGCTGGAGCG CGCCCCGGGA CACGGGACCA CGCGCCTCCG CCTGCACGCC 
TTTGACCAGC AGCTGGATCT GGAGCTGCGG CCCGACAGCA GCTTTTTGGC GCCCGGCTTC 
ACGCTCCAGA ACGTGGGGCG CAAATCCGGG TCCGAGACGC CGCTTCCGGA AACCGACCTG 
GCGCACTGCT TCTACTCCGG CACCGTGAAT GGCGATCCCA GCTCGGCTGC CGCCCTCAGC 
CTCTGCGAGG GCGTGCGCGG CGCCTTCTAC CTGCTGGGGG AGGCGTATTT CATCCAGCCG 
CTGCCCGCCG CCAGCGAGCG CCTCGCCACC GCCGCCCCAG GGGAGAAGCC GCCGGCACCA 
CTACAGTTCC ACCTCCTGCG GCGGAATCGG CAGGGCGACG TCGGCGGCAC GTGCGGGGTC 
GTGGACGACG AGCCCCGGCC GACTGGGAAA GCGGAGACCG AAGACGAGGA CGAAGGGACT 
GAGGGCGAGG ACGAAGGGGC TCAGTGGTCG CCGCAGGACC CGGCACTGCA AGGCGTAGGA 
CAGCCCACAG GAACTGGAAG CATAAGAAAG AAGCGATTTG TGTCCAGTCA CCGCTATGTG 
GAAACCATGC TTGTGGCAGA CCAGTCGATG GCAGAATTCC ACGGCAGTGG TCTAAAGCAT 
TACCTTCTCA CGTTGTTTTC GGTGGCAGCC AGATTGTACA AACACCCCAG CATTCGTAAT 
TCAGTTAGCC TGGTGGTGGT GAAGATCTTG GTCATCCACG ATGAACAGAA GGGGCCGGAA 
GTGACCTCCA ATGCTGCCCT CACTCTGCGG AACTTTTGCA ACTGGCAGAA GCAGCACAAC 
CCACCCAGTG ACCGGGATGC AGAGCACTAT GACACAGCAA TTCTTTTCAC CAGACAGGAC 
TTGTGTGGGT CCCAGACATG TGATACTCTT GGGATGGCTG ATGTTGGAAC TGTGTGTGAT 
CCGAGCAGAA GCTGCTCCGT CATAGAAGAT GATGGTTTAC AAGCTGCCTT CACCACAGCC 
CATGAATTAG GCCACGTGTT TAACATGCCA CATGATGATG CAAAGCAGTG TGCCAGCCTT 
AATGGTGTGA ACCAGGATTC CCACATGATG GCGTCAATGC TTTCCAACCT GGACCACAGC 
CAGCCTTGGT CTCCTTGCAG TGCCTACATG ATTACATCAT TTCTGGATAA TGGTCATGGG 
GAATGTTTGA TGGACAAGCC TCAGAATCCC ATACAGCTCC CAGGCGATCT CCCTGGCACC 
TCGTACGATG CCAACCGGCA GTGCCAGTTT ACATTTGGGG AGGACTCCAA ACACTGCCCC 
GATGCAGCCA GCACATGTAG CACCTTGTGG TGTACCGGCA CCTCTGGTGG GGTGCTGGTG 
TGTCAAACCA AACACTTCCC GTGGGCGGAT GGCACCAGCT GTGGAGAAGG GAAATGGTGT 
ATCAACGGCA AGTGTGTGAA CAAAACCGAC AGAAAGCATT TTGATACGCC TTTTCATGGA 
AGCTGGGGAA TGTGGGGGCC TTGGGGAGAC TGTTCGAGAA CGTGCGGTGG AGGAGTCCAG 
TACACGATGA GGGAATGTGA CAACCCAGTC CCAAAGAATG GAGGGAAGTA CTGTGAAGGC 
AAACGAGTGC GCTACAGATC CTGTAACCTT GAGGACTGTC CAGACAATAA TGGAAAAACC 
TTTAGAGAGG AACAATGTGA AGCACACAAC GAGTTTTCAA AAGCTTCCTT TGGGAGTGGG 
CCTGCGGTGG AATGGATTCC CAAGTACGCT GGCGTCTCAC CAAAGGACAG GTGCAAGCTC 
ATCTGCCAAG CCAAAGGCAT TGGCTACTTC TTCGTTTTGC AGCCCAAGGT TGTAGATGGT 
ACTCCATGTA GCCCAGATTC CACCTCTGTC TGTGTGCAAG GACAGTGTGT AAAAGCTGGT 
TGTGATCGCA TCATAGACTC CAAAAAGAAG TTTGATAAAT GTGGTGTTTG CGGGGGAAAT 
GGATCTACTT GTAAAAAAAT ATCAGGATCA GTTACTAGTG CAAAACCTGG ATATCATGAT 
ATCATCACAA TTCCAACTGG AGCCACCAAC ATCGAAGTGA AACAGCGGAA CCAGAGGGGA 
TCCAGGAACA ATGGCAGCTT TCTTGCCATC AAAGCTGCTG ATGGCACATA TATTCTTAAT 
GGTGACTACA CTTTGTCCAC CTTAGAGCAA GACATTATGT ACAAAGGTGT TGTCTTGAGG 
TACAGCGGCT CCTCTGCGGC ATTGGAAAGA ATTCGCAGCT TTAGCCCTCT CAAAGAGCCC 
TTGACCATCC AGGTTCTTAC TGTGGGCAAT GCCCTTCGAC CTAAAATTAA ATACACCTAC 
TTCGTAAAGA AGAAGAAGGA ATCTTTCAAT GCTATCCCCA CTTTTTCAGC ATGGGTCATT 
GAAGAGTGGG GCGAATGTTC TAAGTCATGT GAATTGGGTT GGCAGAGAAG ACTGGTAGAA 
TGCCGAGACA TTAATGGACA GCCTGCTTCC GAGTGTGCAA AGGAAGTGAA GCCAGCCAGC 
ACCAGACCTT GTGCAGACCA TCCCTGCCCC CAGTGGCAGC TGGGGGAGTG GTCATCATGT 
TCTAAGACCT GTGGGAAGGG TTACAAAAAA AGAAGCTTGA AGTGTCTGTC CCATGATGGA 
GGGGTGTTAT CTCATGAGAG CTGTGATCCT TTAAAGAAAC CTAAACATTT CATAGACTTT 
TGCACAATGG CAGAATGCAG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADAMTS1 ( NM_006988.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_008919.3 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 1 (ADAMTS1), mRNA.

Price & Availability↑

CloneID	OHu62902
Clone ID Related Accession (Same CDS sequence)	NM_006988.4 , NM_006988.5
Accession Version	NM_006988.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2904bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-20
Organism	Homo sapiens(human)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314475.1, AF207664.1 and AP001599.1. On Nov 23, 2018 this sequence version replaced NM_006988.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036515.2, SRR1803617.273049.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA2155371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000284984.8/ ENSP00000284984.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGCGAG CTGTGCCCGA GGGGTTCGGA AGGCGCAAGC TGGGCAGCGA CATGGGGAAC 
GCGGAGCGGG CTCCGGGGTC TCGGAGCTTT GGGCCAGTAC CCACGCTGCT GCTGCTCGCC 
GCGGCGCTAC TGGCCGTGTC GGACGCACTC GGGCGCCCCT CCGAGGAGGA CGAGGAGCTA 
GTGGTGCCGG AGCTGGAGCG CGCCCCGGGA CACGGGACCA CGCGCCTCCG CCTGCACGCC 
TTTGACCAGC AGCTGGATCT GGAGCTGCGG CCCGACAGCA GCTTTTTGGC GCCCGGCTTC 
ACGCTCCAGA ACGTGGGGCG CAAATCCGGG TCCGAGACGC CGCTTCCGGA AACCGACCTG 
GCGCACTGCT TCTACTCCGG CACCGTGAAT GGCGATCCCA GCTCGGCTGC CGCCCTCAGC 
CTCTGCGAGG GCGTGCGCGG CGCCTTCTAC CTGCTGGGGG AGGCGTATTT CATCCAGCCG 
CTGCCCGCCG CCAGCGAGCG CCTCGCCACC GCCGCCCCAG GGGAGAAGCC GCCGGCACCA 
CTACAGTTCC ACCTCCTGCG GCGGAATCGG CAGGGCGACG TCGGCGGCAC GTGCGGGGTC 
GTGGACGACG AGCCCCGGCC GACTGGGAAA GCGGAGACCG AAGACGAGGA CGAAGGGACT 
GAGGGCGAGG ACGAAGGGGC TCAGTGGTCG CCGCAGGACC CGGCACTGCA AGGCGTAGGA 
CAGCCCACAG GAACTGGAAG CATAAGAAAG AAGCGATTTG TGTCCAGTCA CCGCTATGTG 
GAAACCATGC TTGTGGCAGA CCAGTCGATG GCAGAATTCC ACGGCAGTGG TCTAAAGCAT 
TACCTTCTCA CGTTGTTTTC GGTGGCAGCC AGATTGTACA AACACCCCAG CATTCGTAAT 
TCAGTTAGCC TGGTGGTGGT GAAGATCTTG GTCATCCACG ATGAACAGAA GGGGCCGGAA 
GTGACCTCCA ATGCTGCCCT CACTCTGCGG AACTTTTGCA ACTGGCAGAA GCAGCACAAC 
CCACCCAGTG ACCGGGATGC AGAGCACTAT GACACAGCAA TTCTTTTCAC CAGACAGGAC 
TTGTGTGGGT CCCAGACATG TGATACTCTT GGGATGGCTG ATGTTGGAAC TGTGTGTGAT 
CCGAGCAGAA GCTGCTCCGT CATAGAAGAT GATGGTTTAC AAGCTGCCTT CACCACAGCC 
CATGAATTAG GCCACGTGTT TAACATGCCA CATGATGATG CAAAGCAGTG TGCCAGCCTT 
AATGGTGTGA ACCAGGATTC CCACATGATG GCGTCAATGC TTTCCAACCT GGACCACAGC 
CAGCCTTGGT CTCCTTGCAG TGCCTACATG ATTACATCAT TTCTGGATAA TGGTCATGGG 
GAATGTTTGA TGGACAAGCC TCAGAATCCC ATACAGCTCC CAGGCGATCT CCCTGGCACC 
TCGTACGATG CCAACCGGCA GTGCCAGTTT ACATTTGGGG AGGACTCCAA ACACTGCCCC 
GATGCAGCCA GCACATGTAG CACCTTGTGG TGTACCGGCA CCTCTGGTGG GGTGCTGGTG 
TGTCAAACCA AACACTTCCC GTGGGCGGAT GGCACCAGCT GTGGAGAAGG GAAATGGTGT 
ATCAACGGCA AGTGTGTGAA CAAAACCGAC AGAAAGCATT TTGATACGCC TTTTCATGGA 
AGCTGGGGAA TGTGGGGGCC TTGGGGAGAC TGTTCGAGAA CGTGCGGTGG AGGAGTCCAG 
TACACGATGA GGGAATGTGA CAACCCAGTC CCAAAGAATG GAGGGAAGTA CTGTGAAGGC 
AAACGAGTGC GCTACAGATC CTGTAACCTT GAGGACTGTC CAGACAATAA TGGAAAAACC 
TTTAGAGAGG AACAATGTGA AGCACACAAC GAGTTTTCAA AAGCTTCCTT TGGGAGTGGG 
CCTGCGGTGG AATGGATTCC CAAGTACGCT GGCGTCTCAC CAAAGGACAG GTGCAAGCTC 
ATCTGCCAAG CCAAAGGCAT TGGCTACTTC TTCGTTTTGC AGCCCAAGGT TGTAGATGGT 
ACTCCATGTA GCCCAGATTC CACCTCTGTC TGTGTGCAAG GACAGTGTGT AAAAGCTGGT 
TGTGATCGCA TCATAGACTC CAAAAAGAAG TTTGATAAAT GTGGTGTTTG CGGGGGAAAT 
GGATCTACTT GTAAAAAAAT ATCAGGATCA GTTACTAGTG CAAAACCTGG ATATCATGAT 
ATCATCACAA TTCCAACTGG AGCCACCAAC ATCGAAGTGA AACAGCGGAA CCAGAGGGGA 
TCCAGGAACA ATGGCAGCTT TCTTGCCATC AAAGCTGCTG ATGGCACATA TATTCTTAAT 
GGTGACTACA CTTTGTCCAC CTTAGAGCAA GACATTATGT ACAAAGGTGT TGTCTTGAGG 
TACAGCGGCT CCTCTGCGGC ATTGGAAAGA ATTCGCAGCT TTAGCCCTCT CAAAGAGCCC 
TTGACCATCC AGGTTCTTAC TGTGGGCAAT GCCCTTCGAC CTAAAATTAA ATACACCTAC 
TTCGTAAAGA AGAAGAAGGA ATCTTTCAAT GCTATCCCCA CTTTTTCAGC ATGGGTCATT 
GAAGAGTGGG GCGAATGTTC TAAGTCATGT GAATTGGGTT GGCAGAGAAG ACTGGTAGAA 
TGCCGAGACA TTAATGGACA GCCTGCTTCC GAGTGTGCAA AGGAAGTGAA GCCAGCCAGC 
ACCAGACCTT GTGCAGACCA TCCCTGCCCC CAGTGGCAGC TGGGGGAGTG GTCATCATGT 
TCTAAGACCT GTGGGAAGGG TTACAAAAAA AGAAGCTTGA AGTGTCTGTC CCATGATGGA 
GGGGTGTTAT CTCATGAGAG CTGTGATCCT TTAAAGAAAC CTAAACATTT CATAGACTTT 
TGCACAATGG CAGAATGCAG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008919.3
CDS	456..3359
Translation	MQRAVPEGFGRRKLGSDMGNAERAPGSRSFGPVPTLLLLAAALLAVSDALGRPSEEDEELVVPELERAPGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAECS

Target ORF information:

RefSeq Version	NM_006988.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 1 (ADAMTS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006988.5

ORF Insert Sequence:

ATGCAGCGAG CTGTGCCCGA GGGGTTCGGA AGGCGCAAGC TGGGCAGCGA CATGGGGAAC 
GCGGAGCGGG CTCCGGGGTC TCGGAGCTTT GGGCCAGTAC CCACGCTGCT GCTGCTCGCC 
GCGGCGCTAC TGGCCGTGTC GGACGCACTC GGGCGCCCCT CCGAGGAGGA CGAGGAGCTA 
GTGGTGCCGG AGCTGGAGCG CGCCCCGGGA CACGGGACCA CGCGCCTCCG CCTGCACGCC 
TTTGACCAGC AGCTGGATCT GGAGCTGCGG CCCGACAGCA GCTTTTTGGC GCCCGGCTTC 
ACGCTCCAGA ACGTGGGGCG CAAATCCGGG TCCGAGACGC CGCTTCCGGA AACCGACCTG 
GCGCACTGCT TCTACTCCGG CACCGTGAAT GGCGATCCCA GCTCGGCTGC CGCCCTCAGC 
CTCTGCGAGG GCGTGCGCGG CGCCTTCTAC CTGCTGGGGG AGGCGTATTT CATCCAGCCG 
CTGCCCGCCG CCAGCGAGCG CCTCGCCACC GCCGCCCCAG GGGAGAAGCC GCCGGCACCA 
CTACAGTTCC ACCTCCTGCG GCGGAATCGG CAGGGCGACG TCGGCGGCAC GTGCGGGGTC 
GTGGACGACG AGCCCCGGCC GACTGGGAAA GCGGAGACCG AAGACGAGGA CGAAGGGACT 
GAGGGCGAGG ACGAAGGGGC TCAGTGGTCG CCGCAGGACC CGGCACTGCA AGGCGTAGGA 
CAGCCCACAG GAACTGGAAG CATAAGAAAG AAGCGATTTG TGTCCAGTCA CCGCTATGTG 
GAAACCATGC TTGTGGCAGA CCAGTCGATG GCAGAATTCC ACGGCAGTGG TCTAAAGCAT 
TACCTTCTCA CGTTGTTTTC GGTGGCAGCC AGATTGTACA AACACCCCAG CATTCGTAAT 
TCAGTTAGCC TGGTGGTGGT GAAGATCTTG GTCATCCACG ATGAACAGAA GGGGCCGGAA 
GTGACCTCCA ATGCTGCCCT CACTCTGCGG AACTTTTGCA ACTGGCAGAA GCAGCACAAC 
CCACCCAGTG ACCGGGATGC AGAGCACTAT GACACAGCAA TTCTTTTCAC CAGACAGGAC 
TTGTGTGGGT CCCAGACATG TGATACTCTT GGGATGGCTG ATGTTGGAAC TGTGTGTGAT 
CCGAGCAGAA GCTGCTCCGT CATAGAAGAT GATGGTTTAC AAGCTGCCTT CACCACAGCC 
CATGAATTAG GCCACGTGTT TAACATGCCA CATGATGATG CAAAGCAGTG TGCCAGCCTT 
AATGGTGTGA ACCAGGATTC CCACATGATG GCGTCAATGC TTTCCAACCT GGACCACAGC 
CAGCCTTGGT CTCCTTGCAG TGCCTACATG ATTACATCAT TTCTGGATAA TGGTCATGGG 
GAATGTTTGA TGGACAAGCC TCAGAATCCC ATACAGCTCC CAGGCGATCT CCCTGGCACC 
TCGTACGATG CCAACCGGCA GTGCCAGTTT ACATTTGGGG AGGACTCCAA ACACTGCCCC 
GATGCAGCCA GCACATGTAG CACCTTGTGG TGTACCGGCA CCTCTGGTGG GGTGCTGGTG 
TGTCAAACCA AACACTTCCC GTGGGCGGAT GGCACCAGCT GTGGAGAAGG GAAATGGTGT 
ATCAACGGCA AGTGTGTGAA CAAAACCGAC AGAAAGCATT TTGATACGCC TTTTCATGGA 
AGCTGGGGAA TGTGGGGGCC TTGGGGAGAC TGTTCGAGAA CGTGCGGTGG AGGAGTCCAG 
TACACGATGA GGGAATGTGA CAACCCAGTC CCAAAGAATG GAGGGAAGTA CTGTGAAGGC 
AAACGAGTGC GCTACAGATC CTGTAACCTT GAGGACTGTC CAGACAATAA TGGAAAAACC 
TTTAGAGAGG AACAATGTGA AGCACACAAC GAGTTTTCAA AAGCTTCCTT TGGGAGTGGG 
CCTGCGGTGG AATGGATTCC CAAGTACGCT GGCGTCTCAC CAAAGGACAG GTGCAAGCTC 
ATCTGCCAAG CCAAAGGCAT TGGCTACTTC TTCGTTTTGC AGCCCAAGGT TGTAGATGGT 
ACTCCATGTA GCCCAGATTC CACCTCTGTC TGTGTGCAAG GACAGTGTGT AAAAGCTGGT 
TGTGATCGCA TCATAGACTC CAAAAAGAAG TTTGATAAAT GTGGTGTTTG CGGGGGAAAT 
GGATCTACTT GTAAAAAAAT ATCAGGATCA GTTACTAGTG CAAAACCTGG ATATCATGAT 
ATCATCACAA TTCCAACTGG AGCCACCAAC ATCGAAGTGA AACAGCGGAA CCAGAGGGGA 
TCCAGGAACA ATGGCAGCTT TCTTGCCATC AAAGCTGCTG ATGGCACATA TATTCTTAAT 
GGTGACTACA CTTTGTCCAC CTTAGAGCAA GACATTATGT ACAAAGGTGT TGTCTTGAGG 
TACAGCGGCT CCTCTGCGGC ATTGGAAAGA ATTCGCAGCT TTAGCCCTCT CAAAGAGCCC 
TTGACCATCC AGGTTCTTAC TGTGGGCAAT GCCCTTCGAC CTAAAATTAA ATACACCTAC 
TTCGTAAAGA AGAAGAAGGA ATCTTTCAAT GCTATCCCCA CTTTTTCAGC ATGGGTCATT 
GAAGAGTGGG GCGAATGTTC TAAGTCATGT GAATTGGGTT GGCAGAGAAG ACTGGTAGAA 
TGCCGAGACA TTAATGGACA GCCTGCTTCC GAGTGTGCAA AGGAAGTGAA GCCAGCCAGC 
ACCAGACCTT GTGCAGACCA TCCCTGCCCC CAGTGGCAGC TGGGGGAGTG GTCATCATGT 
TCTAAGACCT GTGGGAAGGG TTACAAAAAA AGAAGCTTGA AGTGTCTGTC CCATGATGGA 
GGGGTGTTAT CTCATGAGAG CTGTGATCCT TTAAAGAAAC CTAAACATTT CATAGACTTT 
TGCACAATGG CAGAATGCAG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of serum ADAMTS-1 and aggrecan on polycystic ovary syndrome in adolescents and younger-aged females.
Archives of gynecology and obstetrics297(2)487-493(2018 Feb)
Tola EN,Koroglu ND,Yalcin SE,Oral HB

ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia.
Hypertension in pregnancy1-9(2017 Nov)
Naml? Kalem M,Kalem Z,Y?ce T,Soylemez F

Expression and Clinical Significance of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and a Disintegrin and Metalloproteinase with Thrombospondin Type 1 Motif 1 (ADAMTS1) in Post-Kidney-Transplant Bladder Tumors.
Annals of transplantation22622-630(2017 Oct)
Xue W,Zhang Z,Zeng S,Xu Y,Zhang Q,Wang W,Zhang Y,Zhang X,Hu X

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ADAMTS1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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