IL27RA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL27RA
Entrez Gene ID	9466
Full Name	interleukin 27 receptor subunit alpha
Synonyms	CRL1,IL-27RA,IL27R,TCCR,WSX1,zcytor1
General protein information	Preferred Names interleukin 27 receptor subunit alpha Names interleukin-27 receptor subunit alpha IL-27 receptor subunit alpha IL-27R subunit alpha IL-27R-alpha T-cell cytokine receptor type 1 class I cytokine receptor cytokine receptor WSX-1 cytokine receptor-like 1 interleukin 27 receptor, alpha type I T-cell cytokine receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.12
Summary	In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008].
Disorder MIM:	605350

mRNA and Protein(s)

mRNA	Protein	Name
NM_004843.3	NP_004834.1	interleukin-27 receptor subunit alpha precursor
NM_004843.4	NP_004834.1	interleukin-27 receptor subunit alpha precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	IL27RA	XP_005633266.1
Homo sapiens (human)	IL27RA	NP_004834.1
Bos taurus (cattle)	IL27RA	NP_001091497.1
Mus musculus (house mouse)	Il27ra	NP_057880.2
Pan troglodytes (chimpanzee)	IL27RA	XP_512969.2
	IL27RA	XP_001111176.1
Rattus norvegicus (Norway rat)	Il27ra	NP_001099413.1

Gene Ontology
Bibliography

Related articles in PubMed

IL-27 induces a pro-inflammatory response in human fetal membranes mediating preterm birth.
Yin N, Wang H, Zhang H, Ge H, Tan B, Yuan Y, Luo X, Olson DM, Baker PN, Qi H
International immunopharmacology50361-369(2017 Sep)

Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for
Ruiz-Riol M, Berdnik D, Llano A, Mothe B, G?lvez C, P?rez-?lvarez S, Oriol-Tordera B, Olvera A, Silva-Arrieta S, Meulbroek M, Pujol F, Coll J, Martinez-Picado J, Ganoza C, Sanchez J, G?mez G, Wyss-Coray T, Brander C
Journal of virology91(16)(2017 Aug)

Production of IL-27 in multiple sclerosis lesions by astrocytes and myeloid cells: Modulation of local immune responses.
S?n?cal V, Deblois G, Beauseigle D, Schneider R, Brandenburg J, Newcombe J, Moore CS, Prat A, Antel J, Arbour N
Glia64(4)553-69(2016 Apr)

Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection.
Torrado E, Fountain JJ, Liao M, Tighe M, Reiley WW, Lai RP, Meintjes G, Pearl JE, Chen X, Zak DE, Thompson EG, Aderem A, Ghilardi N, Solache A, McKinstry KK, Strutt TM, Wilkinson RJ, Swain SL, Cooper AM
The Journal of experimental medicine212(9)1449-63(2015 Aug)

A soluble form of IL-27R? is a natural IL-27 antagonist.
Dietrich C, Candon S, Ruemmele FM, Devergne O
Journal of immunology (Baltimore, Md. : 1950)192(11)5382-9(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results identify IL-27 and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection.
Title: Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for

Findings demonstrated that IL-27 and IL-27R were elevated in multiple sclerosis lesions and that local IL-27 can modulate immune properties of astrocytes and infiltrating immune cells
Title: Production of IL-27 in multiple sclerosis lesions by astrocytes and myeloid cells: Modulation of local immune responses.

The significant expression of IL-27 in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor pair is detrimental in TB.
Title: Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection.

natural sIL-27Ralpha binds rIL-27, inhibits IL-27 binding to its cell surface receptor, and is a potent inhibitor of IL-27 signaling, as shown by its ability to specifically block IL-27-mediated STAT activation, at low molar excess over IL-27.
Title: A soluble form of IL-27R? is a natural IL-27 antagonist.

Aberrant hypermethylation and reduced expression of IL27RA is associated with myelodysplastic syndromes.
Title: Genome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes.

The following IL27RA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL27RA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27514	NM_004843.4 Latest version!	Homo sapiens interleukin 27 receptor subunit alpha (IL27RA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu27514	NM_004843.3	Homo sapiens interleukin 27 receptor subunit alpha (IL27RA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL27RA ( NM_004843.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004834.1 Homo sapiens interleukin 27 receptor subunit alpha (IL27RA), mRNA.

Price & Availability↑

CloneID	OHu27514
Clone ID Related Accession (Same CDS sequence)	NM_004843.3 , NM_004843.4
Accession Version	NM_004843.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1911bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	interleukin-27 receptor subunit alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF053004.1 and AF106912.1. On Jul 3, 2012 this sequence version replaced NM_004843.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF106912.1, AF053004.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGGGAG GCAGGGGCGC CCCTTTCTGG CTGTGGCCGC TGCCCAAGCT GGCGCTGCTG 
CCTCTGTTGT GGGTGCTTTT CCAGCGGACG CGTCCCCAGG GCAGCGCCGG GCCACTGCAG 
TGCTACGGAG TTGGACCCTT GGGCGACTTG AACTGCTCGT GGGAGCCTCT TGGGGACCTG 
GGAGCCCCCT CCGAGTTACA CCTCCAGAGC CAAAAGTACC GTTCCAACAA AACCCAGACT 
GTGGCAGTGG CAGCCGGACG GAGCTGGGTG GCCATTCCTC GGGAACAGCT CACCATGTCT 
GACAAACTCC TTGTCTGGGG CACTAAGGCA GGCCAGCCTC TCTGGCCCCC CGTCTTCGTG 
AACCTAGAAA CCCAAATGAA GCCAAACGCC CCCCGGCTGG GCCCTGACGT GGACTTTTCC 
GAGGATGACC CCCTGGAGGC CACTGTCCAT TGGGCCCCAC CTACATGGCC ATCTCATAAA 
GTTCTGATCT GCCAGTTCCA CTACCGAAGA TGTCAGGAGG CGGCCTGGAC CCTGCTGGAA 
CCGGAGCTGA AGACCATACC CCTGACCCCT GTTGAGATCC AAGATTTGGA GCTAGCCACT 
GGCTACAAAG TGTATGGCCG CTGCCGGATG GAGAAAGAAG AGGATTTGTG GGGCGAGTGG 
AGCCCCATTT TGTCCTTCCA GACACCGCCT TCTGCTCCAA AAGATGTGTG GGTATCAGGG 
AACCTCTGTG GGACGCCTGG AGGAGAGGAA CCTTTGCTTC TATGGAAGGC CCCAGGGCCC 
TGTGTGCAGG TGAGCTACAA AGTCTGGTTC TGGGTTGGAG GTCGTGAGCT GAGTCCAGAA 
GGAATTACCT GCTGCTGCTC CCTAATTCCC AGTGGGGCGG AGTGGGCCAG GGTGTCCGCT 
GTCAACGCCA CAAGCTGGGA GCCTCTCACC AACCTCTCTT TGGTCTGCTT GGATTCAGCC 
TCTGCCCCCC GTAGCGTGGC AGTCAGCAGC ATCGCTGGGA GCACGGAGCT ACTGGTGACC 
TGGCAACCGG GGCCTGGGGA ACCACTGGAG CATGTAGTGG ACTGGGCTCG AGATGGGGAC 
CCCCTGGAGA AACTCAACTG GGTCCGGCTT CCCCCTGGGA ACCTCAGTGC TCTGTTACCA 
GGGAATTTCA CTGTCGGGGT CCCCTATCGA ATCACTGTGA CCGCAGTCTC TGCTTCAGGC 
TTGGCCTCTG CATCCTCCGT CTGGGGGTTC AGGGAGGAAT TAGCACCCCT AGTGGGGCCA 
ACGCTTTGGC GACTCCAAGA TGCCCCTCCA GGGACCCCCG CCATAGCGTG GGGAGAGGTC 
CCAAGGCACC AGCTTCGAGG CCACCTCACC CACTACACCT TGTGTGCACA GAGTGGAACC 
AGCCCCTCCG TCTGCATGAA TGTGAGTGGC AACACACAGA GTGTCACCCT GCCTGACCTT 
CCTTGGGGTC CCTGTGAGCT GTGGGTGACA GCATCTACCA TCGCTGGACA GGGCCCTCCT 
GGTCCCATCC TCCGGCTTCA TCTACCAGAT AACACCCTGA GGTGGAAAGT TCTGCCGGGC 
ATCCTATTCT TGTGGGGCTT GTTCCTGTTG GGGTGTGGCC TGAGCCTGGC CACCTCTGGA 
AGGTGCTACC ACCTAAGGCA CAAAGTGCTG CCCCGCTGGG TCTGGGAGAA AGTTCCTGAT 
CCTGCCAACA GCAGTTCAGG CCAGCCCCAC ATGGAGCAAG TACCTGAGGC CCAGCCCCTT 
GGGGACTTGC CCATCCTGGA AGTGGAGGAG ATGGAGCCCC CGCCGGTTAT GGAGTCCTCC 
CAGCCCGCCC AGGCCACCGC CCCGCTTGAC TCTGGGTATG AGAAGCACTT CCTGCCCACA 
CCTGAGGAGC TGGGCCTTCT GGGGCCCCCC AGGCCACAGG TTCTGGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004834.1
CDS	134..2044
Translation	MRGGRGAPFWLWPLPKLALLPLLWVLFQRTRPQGSAGPLQCYGVGPLGDLNCSWEPLGDLGAPSELHLQSQKYRSNKTQTVAVAAGRSWVAIPREQLTMSDKLLVWGTKAGQPLWPPVFVNLETQMKPNAPRLGPDVDFSEDDPLEATVHWAPPTWPSHKVLICQFHYRRCQEAAWTLLEPELKTIPLTPVEIQDLELATGYKVYGRCRMEKEEDLWGEWSPILSFQTPPSAPKDVWVSGNLCGTPGGEEPLLLWKAPGPCVQVSYKVWFWVGGRELSPEGITCCCSLIPSGAEWARVSAVNATSWEPLTNLSLVCLDSASAPRSVAVSSIAGSTELLVTWQPGPGEPLEHVVDWARDGDPLEKLNWVRLPPGNLSALLPGNFTVGVPYRITVTAVSASGLASASSVWGFREELAPLVGPTLWRLQDAPPGTPAIAWGEVPRHQLRGHLTHYTLCAQSGTSPSVCMNVSGNTQSVTLPDLPWGPCELWVTASTIAGQGPPGPILRLHLPDNTLRWKVLPGILFLWGLFLLGCGLSLATSGRCYHLRHKVLPRWVWEKVPDPANSSSGQPHMEQVPEAQPLGDLPILEVEEMEPPPVMESSQPAQATAPLDSGYEKHFLPTPEELGLLGPPRPQVLA

Target ORF information:

RefSeq Version	NM_004843.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 27 receptor subunit alpha (IL27RA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004843.3

ORF Insert Sequence:

ATGCGGGGAG GCAGGGGCGC CCCTTTCTGG CTGTGGCCGC TGCCCAAGCT GGCGCTGCTG 
CCTCTGTTGT GGGTGCTTTT CCAGCGGACG CGTCCCCAGG GCAGCGCCGG GCCACTGCAG 
TGCTACGGAG TTGGACCCTT GGGCGACTTG AACTGCTCGT GGGAGCCTCT TGGGGACCTG 
GGAGCCCCCT CCGAGTTACA CCTCCAGAGC CAAAAGTACC GTTCCAACAA AACCCAGACT 
GTGGCAGTGG CAGCCGGACG GAGCTGGGTG GCCATTCCTC GGGAACAGCT CACCATGTCT 
GACAAACTCC TTGTCTGGGG CACTAAGGCA GGCCAGCCTC TCTGGCCCCC CGTCTTCGTG 
AACCTAGAAA CCCAAATGAA GCCAAACGCC CCCCGGCTGG GCCCTGACGT GGACTTTTCC 
GAGGATGACC CCCTGGAGGC CACTGTCCAT TGGGCCCCAC CTACATGGCC ATCTCATAAA 
GTTCTGATCT GCCAGTTCCA CTACCGAAGA TGTCAGGAGG CGGCCTGGAC CCTGCTGGAA 
CCGGAGCTGA AGACCATACC CCTGACCCCT GTTGAGATCC AAGATTTGGA GCTAGCCACT 
GGCTACAAAG TGTATGGCCG CTGCCGGATG GAGAAAGAAG AGGATTTGTG GGGCGAGTGG 
AGCCCCATTT TGTCCTTCCA GACACCGCCT TCTGCTCCAA AAGATGTGTG GGTATCAGGG 
AACCTCTGTG GGACGCCTGG AGGAGAGGAA CCTTTGCTTC TATGGAAGGC CCCAGGGCCC 
TGTGTGCAGG TGAGCTACAA AGTCTGGTTC TGGGTTGGAG GTCGTGAGCT GAGTCCAGAA 
GGAATTACCT GCTGCTGCTC CCTAATTCCC AGTGGGGCGG AGTGGGCCAG GGTGTCCGCT 
GTCAACGCCA CAAGCTGGGA GCCTCTCACC AACCTCTCTT TGGTCTGCTT GGATTCAGCC 
TCTGCCCCCC GTAGCGTGGC AGTCAGCAGC ATCGCTGGGA GCACGGAGCT ACTGGTGACC 
TGGCAACCGG GGCCTGGGGA ACCACTGGAG CATGTAGTGG ACTGGGCTCG AGATGGGGAC 
CCCCTGGAGA AACTCAACTG GGTCCGGCTT CCCCCTGGGA ACCTCAGTGC TCTGTTACCA 
GGGAATTTCA CTGTCGGGGT CCCCTATCGA ATCACTGTGA CCGCAGTCTC TGCTTCAGGC 
TTGGCCTCTG CATCCTCCGT CTGGGGGTTC AGGGAGGAAT TAGCACCCCT AGTGGGGCCA 
ACGCTTTGGC GACTCCAAGA TGCCCCTCCA GGGACCCCCG CCATAGCGTG GGGAGAGGTC 
CCAAGGCACC AGCTTCGAGG CCACCTCACC CACTACACCT TGTGTGCACA GAGTGGAACC 
AGCCCCTCCG TCTGCATGAA TGTGAGTGGC AACACACAGA GTGTCACCCT GCCTGACCTT 
CCTTGGGGTC CCTGTGAGCT GTGGGTGACA GCATCTACCA TCGCTGGACA GGGCCCTCCT 
GGTCCCATCC TCCGGCTTCA TCTACCAGAT AACACCCTGA GGTGGAAAGT TCTGCCGGGC 
ATCCTATTCT TGTGGGGCTT GTTCCTGTTG GGGTGTGGCC TGAGCCTGGC CACCTCTGGA 
AGGTGCTACC ACCTAAGGCA CAAAGTGCTG CCCCGCTGGG TCTGGGAGAA AGTTCCTGAT 
CCTGCCAACA GCAGTTCAGG CCAGCCCCAC ATGGAGCAAG TACCTGAGGC CCAGCCCCTT 
GGGGACTTGC CCATCCTGGA AGTGGAGGAG ATGGAGCCCC CGCCGGTTAT GGAGTCCTCC 
CAGCCCGCCC AGGCCACCGC CCCGCTTGAC TCTGGGTATG AGAAGCACTT CCTGCCCACA 
CCTGAGGAGC TGGGCCTTCT GGGGCCCCCC AGGCCACAGG TTCTGGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL27RA ( NM_004843.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004834.1 Homo sapiens interleukin 27 receptor subunit alpha (IL27RA), mRNA.

Price & Availability↑

CloneID	OHu27514
Clone ID Related Accession (Same CDS sequence)	NM_004843.3 , NM_004843.4
Accession Version	NM_004843.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1911bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	interleukin-27 receptor subunit alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF053004.1, AF106912.1 and AC022098.9. On Nov 22, 2018 this sequence version replaced NM_004843.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF106912.1, AY358876.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000263379.4/ ENSP00000263379.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGGGGAG GCAGGGGCGC CCCTTTCTGG CTGTGGCCGC TGCCCAAGCT GGCGCTGCTG 
CCTCTGTTGT GGGTGCTTTT CCAGCGGACG CGTCCCCAGG GCAGCGCCGG GCCACTGCAG 
TGCTACGGAG TTGGACCCTT GGGCGACTTG AACTGCTCGT GGGAGCCTCT TGGGGACCTG 
GGAGCCCCCT CCGAGTTACA CCTCCAGAGC CAAAAGTACC GTTCCAACAA AACCCAGACT 
GTGGCAGTGG CAGCCGGACG GAGCTGGGTG GCCATTCCTC GGGAACAGCT CACCATGTCT 
GACAAACTCC TTGTCTGGGG CACTAAGGCA GGCCAGCCTC TCTGGCCCCC CGTCTTCGTG 
AACCTAGAAA CCCAAATGAA GCCAAACGCC CCCCGGCTGG GCCCTGACGT GGACTTTTCC 
GAGGATGACC CCCTGGAGGC CACTGTCCAT TGGGCCCCAC CTACATGGCC ATCTCATAAA 
GTTCTGATCT GCCAGTTCCA CTACCGAAGA TGTCAGGAGG CGGCCTGGAC CCTGCTGGAA 
CCGGAGCTGA AGACCATACC CCTGACCCCT GTTGAGATCC AAGATTTGGA GCTAGCCACT 
GGCTACAAAG TGTATGGCCG CTGCCGGATG GAGAAAGAAG AGGATTTGTG GGGCGAGTGG 
AGCCCCATTT TGTCCTTCCA GACACCGCCT TCTGCTCCAA AAGATGTGTG GGTATCAGGG 
AACCTCTGTG GGACGCCTGG AGGAGAGGAA CCTTTGCTTC TATGGAAGGC CCCAGGGCCC 
TGTGTGCAGG TGAGCTACAA AGTCTGGTTC TGGGTTGGAG GTCGTGAGCT GAGTCCAGAA 
GGAATTACCT GCTGCTGCTC CCTAATTCCC AGTGGGGCGG AGTGGGCCAG GGTGTCCGCT 
GTCAACGCCA CAAGCTGGGA GCCTCTCACC AACCTCTCTT TGGTCTGCTT GGATTCAGCC 
TCTGCCCCCC GTAGCGTGGC AGTCAGCAGC ATCGCTGGGA GCACGGAGCT ACTGGTGACC 
TGGCAACCGG GGCCTGGGGA ACCACTGGAG CATGTAGTGG ACTGGGCTCG AGATGGGGAC 
CCCCTGGAGA AACTCAACTG GGTCCGGCTT CCCCCTGGGA ACCTCAGTGC TCTGTTACCA 
GGGAATTTCA CTGTCGGGGT CCCCTATCGA ATCACTGTGA CCGCAGTCTC TGCTTCAGGC 
TTGGCCTCTG CATCCTCCGT CTGGGGGTTC AGGGAGGAAT TAGCACCCCT AGTGGGGCCA 
ACGCTTTGGC GACTCCAAGA TGCCCCTCCA GGGACCCCCG CCATAGCGTG GGGAGAGGTC 
CCAAGGCACC AGCTTCGAGG CCACCTCACC CACTACACCT TGTGTGCACA GAGTGGAACC 
AGCCCCTCCG TCTGCATGAA TGTGAGTGGC AACACACAGA GTGTCACCCT GCCTGACCTT 
CCTTGGGGTC CCTGTGAGCT GTGGGTGACA GCATCTACCA TCGCTGGACA GGGCCCTCCT 
GGTCCCATCC TCCGGCTTCA TCTACCAGAT AACACCCTGA GGTGGAAAGT TCTGCCGGGC 
ATCCTATTCT TGTGGGGCTT GTTCCTGTTG GGGTGTGGCC TGAGCCTGGC CACCTCTGGA 
AGGTGCTACC ACCTAAGGCA CAAAGTGCTG CCCCGCTGGG TCTGGGAGAA AGTTCCTGAT 
CCTGCCAACA GCAGTTCAGG CCAGCCCCAC ATGGAGCAAG TACCTGAGGC CCAGCCCCTT 
GGGGACTTGC CCATCCTGGA AGTGGAGGAG ATGGAGCCCC CGCCGGTTAT GGAGTCCTCC 
CAGCCCGCCC AGGCCACCGC CCCGCTTGAC TCTGGGTATG AGAAGCACTT CCTGCCCACA 
CCTGAGGAGC TGGGCCTTCT GGGGCCCCCC AGGCCACAGG TTCTGGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004834.1
CDS	112..2022
Translation	MRGGRGAPFWLWPLPKLALLPLLWVLFQRTRPQGSAGPLQCYGVGPLGDLNCSWEPLGDLGAPSELHLQSQKYRSNKTQTVAVAAGRSWVAIPREQLTMSDKLLVWGTKAGQPLWPPVFVNLETQMKPNAPRLGPDVDFSEDDPLEATVHWAPPTWPSHKVLICQFHYRRCQEAAWTLLEPELKTIPLTPVEIQDLELATGYKVYGRCRMEKEEDLWGEWSPILSFQTPPSAPKDVWVSGNLCGTPGGEEPLLLWKAPGPCVQVSYKVWFWVGGRELSPEGITCCCSLIPSGAEWARVSAVNATSWEPLTNLSLVCLDSASAPRSVAVSSIAGSTELLVTWQPGPGEPLEHVVDWARDGDPLEKLNWVRLPPGNLSALLPGNFTVGVPYRITVTAVSASGLASASSVWGFREELAPLVGPTLWRLQDAPPGTPAIAWGEVPRHQLRGHLTHYTLCAQSGTSPSVCMNVSGNTQSVTLPDLPWGPCELWVTASTIAGQGPPGPILRLHLPDNTLRWKVLPGILFLWGLFLLGCGLSLATSGRCYHLRHKVLPRWVWEKVPDPANSSSGQPHMEQVPEAQPLGDLPILEVEEMEPPPVMESSQPAQATAPLDSGYEKHFLPTPEELGLLGPPRPQVLA

Target ORF information:

RefSeq Version	NM_004843.4
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 27 receptor subunit alpha (IL27RA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004843.4

ORF Insert Sequence:

ATGCGGGGAG GCAGGGGCGC CCCTTTCTGG CTGTGGCCGC TGCCCAAGCT GGCGCTGCTG 
CCTCTGTTGT GGGTGCTTTT CCAGCGGACG CGTCCCCAGG GCAGCGCCGG GCCACTGCAG 
TGCTACGGAG TTGGACCCTT GGGCGACTTG AACTGCTCGT GGGAGCCTCT TGGGGACCTG 
GGAGCCCCCT CCGAGTTACA CCTCCAGAGC CAAAAGTACC GTTCCAACAA AACCCAGACT 
GTGGCAGTGG CAGCCGGACG GAGCTGGGTG GCCATTCCTC GGGAACAGCT CACCATGTCT 
GACAAACTCC TTGTCTGGGG CACTAAGGCA GGCCAGCCTC TCTGGCCCCC CGTCTTCGTG 
AACCTAGAAA CCCAAATGAA GCCAAACGCC CCCCGGCTGG GCCCTGACGT GGACTTTTCC 
GAGGATGACC CCCTGGAGGC CACTGTCCAT TGGGCCCCAC CTACATGGCC ATCTCATAAA 
GTTCTGATCT GCCAGTTCCA CTACCGAAGA TGTCAGGAGG CGGCCTGGAC CCTGCTGGAA 
CCGGAGCTGA AGACCATACC CCTGACCCCT GTTGAGATCC AAGATTTGGA GCTAGCCACT 
GGCTACAAAG TGTATGGCCG CTGCCGGATG GAGAAAGAAG AGGATTTGTG GGGCGAGTGG 
AGCCCCATTT TGTCCTTCCA GACACCGCCT TCTGCTCCAA AAGATGTGTG GGTATCAGGG 
AACCTCTGTG GGACGCCTGG AGGAGAGGAA CCTTTGCTTC TATGGAAGGC CCCAGGGCCC 
TGTGTGCAGG TGAGCTACAA AGTCTGGTTC TGGGTTGGAG GTCGTGAGCT GAGTCCAGAA 
GGAATTACCT GCTGCTGCTC CCTAATTCCC AGTGGGGCGG AGTGGGCCAG GGTGTCCGCT 
GTCAACGCCA CAAGCTGGGA GCCTCTCACC AACCTCTCTT TGGTCTGCTT GGATTCAGCC 
TCTGCCCCCC GTAGCGTGGC AGTCAGCAGC ATCGCTGGGA GCACGGAGCT ACTGGTGACC 
TGGCAACCGG GGCCTGGGGA ACCACTGGAG CATGTAGTGG ACTGGGCTCG AGATGGGGAC 
CCCCTGGAGA AACTCAACTG GGTCCGGCTT CCCCCTGGGA ACCTCAGTGC TCTGTTACCA 
GGGAATTTCA CTGTCGGGGT CCCCTATCGA ATCACTGTGA CCGCAGTCTC TGCTTCAGGC 
TTGGCCTCTG CATCCTCCGT CTGGGGGTTC AGGGAGGAAT TAGCACCCCT AGTGGGGCCA 
ACGCTTTGGC GACTCCAAGA TGCCCCTCCA GGGACCCCCG CCATAGCGTG GGGAGAGGTC 
CCAAGGCACC AGCTTCGAGG CCACCTCACC CACTACACCT TGTGTGCACA GAGTGGAACC 
AGCCCCTCCG TCTGCATGAA TGTGAGTGGC AACACACAGA GTGTCACCCT GCCTGACCTT 
CCTTGGGGTC CCTGTGAGCT GTGGGTGACA GCATCTACCA TCGCTGGACA GGGCCCTCCT 
GGTCCCATCC TCCGGCTTCA TCTACCAGAT AACACCCTGA GGTGGAAAGT TCTGCCGGGC 
ATCCTATTCT TGTGGGGCTT GTTCCTGTTG GGGTGTGGCC TGAGCCTGGC CACCTCTGGA 
AGGTGCTACC ACCTAAGGCA CAAAGTGCTG CCCCGCTGGG TCTGGGAGAA AGTTCCTGAT 
CCTGCCAACA GCAGTTCAGG CCAGCCCCAC ATGGAGCAAG TACCTGAGGC CCAGCCCCTT 
GGGGACTTGC CCATCCTGGA AGTGGAGGAG ATGGAGCCCC CGCCGGTTAT GGAGTCCTCC 
CAGCCCGCCC AGGCCACCGC CCCGCTTGAC TCTGGGTATG AGAAGCACTT CCTGCCCACA 
CCTGAGGAGC TGGGCCTTCT GGGGCCCCCC AGGCCACAGG TTCTGGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IL-27 induces a pro-inflammatory response in human fetal membranes mediating preterm birth.
International immunopharmacology50361-369(2017 Sep)
Yin N,Wang H,Zhang H,Ge H,Tan B,Yuan Y,Luo X,Olson DM,Baker PN,Qi H

Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for
Journal of virology91(16)(2017 Aug)
Ruiz-Riol M,Berdnik D,Llano A,Mothe B,G?lvez C,P?rez-?lvarez S,Oriol-Tordera B,Olvera A,Silva-Arrieta S,Meulbroek M,Pujol F,Coll J,Martinez-Picado J,Ganoza C,Sanchez J,G?mez G,Wyss-Coray T,Brander C

Production of IL-27 in multiple sclerosis lesions by astrocytes and myeloid cells: Modulation of local immune responses.
Glia64(4)553-69(2016 Apr)
S?n?cal V,Deblois G,Beauseigle D,Schneider R,Brandenburg J,Newcombe J,Moore CS,Prat A,Antel J,Arbour N

Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection.
The Journal of experimental medicine212(9)1449-63(2015 Aug)
Torrado E,Fountain JJ,Liao M,Tighe M,Reiley WW,Lai RP,Meintjes G,Pearl JE,Chen X,Zak DE,Thompson EG,Aderem A,Ghilardi N,Solache A,McKinstry KK,Strutt TM,Wilkinson RJ,Swain SL,Cooper AM

A soluble form of IL-27R? is a natural IL-27 antagonist.
Journal of immunology (Baltimore, Md. : 1950)192(11)5382-9(2014 Jun)
Dietrich C,Candon S,Ruemmele FM,Devergne O

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IL27RA cDNA ORF clone, Homo sapiens(human)

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