FHL5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FHL5
Entrez Gene ID	9457
Full Name	four and a half LIM domains 5
Synonyms	1700027G07Rik,ACT,FHL-5,dJ393D12.2
General protein information	Preferred Names four and a half LIM domains 5 Names four and a half LIM domains protein 5 LIM protein ACT activator of cAMP-responsive element modulator (CREM) in testis activator of cAMP-responsive element modulator in testis
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q16.1
Summary	The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016].
Disorder MIM:	605126

mRNA and Protein(s)

mRNA	Protein	Name
NM_001322466.1	NP_001309395.1	four and a half LIM domains protein 5
NM_001170807.2	NP_001164278.1	four and a half LIM domains protein 5
NM_001322467.1	NP_001309396.1	four and a half LIM domains protein 5
NM_020482.5	NP_065228.4	four and a half LIM domains protein 5

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Fhl5	NP_001013106.1
Gallus gallus (chicken)	FHL5	NP_001264652.1
	FHL5	XP_001100773.2
Canis lupus familiaris (dog)	FHL5	XP_532237.2
Pan troglodytes (chimpanzee)	FHL5	NP_001233299.1
Bos taurus (cattle)	FHL5	NP_001069847.1
Homo sapiens (human)	FHL5	NP_001164278.1
Mus musculus (house mouse)	Fhl5	NP_067293.1
Xenopus tropicalis (tropical clawed frog)	fhl5	NP_001116957.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Gene-based pleiotropy across migraine with aura and migraine without aura patient groups.
Zhao H, Eising E, de Vries B, Vijfhuizen LS, , Anttila V, Winsvold BS, Kurth T, Stefansson H, Kallela M, Malik R, Stam AH, Ikram MA, Ligthart L, Freilinger T, Alexander M, M?ller-Myhsok B, Schreiber S, Meitinger T, Aromas A, Eriksson JG, Boomsma DI, van Duijn CM, Zwart JA, Quaye L, Kubisch C, Dichgans M, Wessman M, Stefansson K, Chasman DI, Palotie A, Martin NG, Montgomery GW, Ferrari MD, Terwindt GM, van den Maagdenberg AM, Nyholt DR
Cephalalgia : an international journal of headache36(7)648-57(2016 Jun)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Association of genetic loci for migraine susceptibility in the she people of China.
Lin QF, Fu XG, Yao LT, Yang J, Cao LY, Xin YT, Hou JX, Ye LF, Huang GB
The journal of headache and pain16553(2015)

CREM-dependent transcription in male germ cells controlled by a kinesin.
Macho B, Brancorsini S, Fimia GM, Setou M, Hirokawa N, Sassone-Corsi P
Science (New York, N.Y.)298(5602)2388-90(2002 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Identified CREB activators MAPKAPK3 and FHL5 as mediators of intimal hyperplasia in vein graft samples.
Title: Cyclic adenosine monophosphate response-element binding protein activation by mitogen-activated protein kinase-activated protein kinase 3 and four-and-a-half LIM domains 5 plays a key role for vein graft intimal hyperplasia.

This protein has been found differentially expressed in thalami from patients with schizophrenia.
Title: Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Results indicate that SPAG8 acts as a regulator of ACT and plays an important role in CREM-ACT-mediated gene transcription during spermatogenesis.
Title: Sperm associated antigen 8 (SPAG8), a novel regulator of activator of CREM in testis during spermatogenesis.

Observational study of gene-disease association. (HuGE Navigator)
Title: Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.

The following FHL5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FHL5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13610	NM_001170807.2 Latest version!	Homo sapiens four and a half LIM domains 5 (FHL5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu13610	NM_001322466.1 Latest version!	Homo sapiens four and a half LIM domains 5 (FHL5), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu13610	NM_001322467.1 Latest version!	Homo sapiens four and a half LIM domains 5 (FHL5), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu13610	NM_020482.5 Latest version!	Homo sapiens four and a half LIM domains 5 (FHL5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FHL5 ( NM_001322466.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001309395.1 Homo sapiens four and a half LIM domains 5 (FHL5), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu13610
Clone ID Related Accession (Same CDS sequence)	NM_001322466.1 , NM_001170807.2 , NM_001322467.1 , NM_020482.5
Accession Version	NM_001322466.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	four and a half LIM domains protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA234984.1, AK223539.1, AL132776.11 and BX118342.1. Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.276963.1, SRR1803616.261232.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACAACTG CTCACTTTTA CTGTCAATAC TGCACAGCAT CACTTCTTGG GAAGAAATAT 
GTACTAAAGG ATGACAGTCC ATACTGTGTT ACATGTTATG ATCGTGTATT TTCTAACTAT 
TGCGAGGAAT GCAAAAAACC AATTGAATCT GATTCTAAGG ATCTTTGTTA CAAAGACCGG 
CACTGGCATG AAGGATGCTT CAAGTGCACC AAATGCAATC ACTCTTTGGT GGAAAAGCCT 
TTTGCTGCCA AGGATGAGCG CCTGCTGTGC ACGGAGTGCT ATTCTAACGA GTGCTCCTCC 
AAGTGCTTCC ACTGCAAGAG GACCATCATG CCTGGTTCCC GCAAAATGGA ATTTAAGGGA 
AACTACTGGC ATGAAACCTG TTTTGTGTGT GAGAATTGCC GACAACCTAT AGGGACAAAG 
CCTTTGATCT CCAAAGAGAG TGGCAATTAT TGTGTGCCAT GTTTTGAGAA GGAGTTTGCT 
CACTACTGCA ACTTTTGTAA GAAGGTGATA ACTTCAGGTG GGATAACATT TTGTGACCAG 
CTATGGCATA AAGAGTGTTT TCTGTGTAGT GGCTGTAGGA AAGATCTCTG TGAAGAACAG 
TTCATGTCCA GAGACGACTA TCCATTCTGC GTGGACTGCT ACAACCATCT TTATGCCAAC 
AAGTGTGTAG CCTGTTCCAA ACCCATTAGT GGTCTCACAG GTGCCAAGTT TATCTGCTTT 
CAAGACAGCC AGTGGCATAG CGAATGCTTT AACTGCGGGA AATGCTCTGT CTCCTTGGTG 
GGTAAAGGCT TCCTGACCCA GAACAAGGAA ATCTTCTGCC AAAAATGTGG CTCCGGAATG 
GACACTGACA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001309395.1
CDS	346..1200
Translation	MTTAHFYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDRHWHEGCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEFKGNYWHETCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITSGGITFCDQLWHKECFLCSGCRKDLCEEQFMSRDDYPFCVDCYNHLYANKCVACSKPISGLTGAKFICFQDSQWHSECFNCGKCSVSLVGKGFLTQNKEIFCQKCGSGMDTDI

Target ORF information:

RefSeq Version	NM_001322466.1
Organism	Homo sapiens(human)
Definition	Homo sapiens four and a half LIM domains 5 (FHL5), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001322466.1

ORF Insert Sequence:

ATGACAACTG CTCACTTTTA CTGTCAATAC TGCACAGCAT CACTTCTTGG GAAGAAATAT 
GTACTAAAGG ATGACAGTCC ATACTGTGTT ACATGTTATG ATCGTGTATT TTCTAACTAT 
TGCGAGGAAT GCAAAAAACC AATTGAATCT GATTCTAAGG ATCTTTGTTA CAAAGACCGG 
CACTGGCATG AAGGATGCTT CAAGTGCACC AAATGCAATC ACTCTTTGGT GGAAAAGCCT 
TTTGCTGCCA AGGATGAGCG CCTGCTGTGC ACGGAGTGCT ATTCTAACGA GTGCTCCTCC 
AAGTGCTTCC ACTGCAAGAG GACCATCATG CCTGGTTCCC GCAAAATGGA ATTTAAGGGA 
AACTACTGGC ATGAAACCTG TTTTGTGTGT GAGAATTGCC GACAACCTAT AGGGACAAAG 
CCTTTGATCT CCAAAGAGAG TGGCAATTAT TGTGTGCCAT GTTTTGAGAA GGAGTTTGCT 
CACTACTGCA ACTTTTGTAA GAAGGTGATA ACTTCAGGTG GGATAACATT TTGTGACCAG 
CTATGGCATA AAGAGTGTTT TCTGTGTAGT GGCTGTAGGA AAGATCTCTG TGAAGAACAG 
TTCATGTCCA GAGACGACTA TCCATTCTGC GTGGACTGCT ACAACCATCT TTATGCCAAC 
AAGTGTGTAG CCTGTTCCAA ACCCATTAGT GGTCTCACAG GTGCCAAGTT TATCTGCTTT 
CAAGACAGCC AGTGGCATAG CGAATGCTTT AACTGCGGGA AATGCTCTGT CTCCTTGGTG 
GGTAAAGGCT TCCTGACCCA GAACAAGGAA ATCTTCTGCC AAAAATGTGG CTCCGGAATG 
GACACTGACA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FHL5 ( NM_001170807.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001164278.1 Homo sapiens four and a half LIM domains 5 (FHL5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13610
Clone ID Related Accession (Same CDS sequence)	NM_001322466.1 , NM_001170807.2 , NM_001322467.1 , NM_020482.5
Accession Version	NM_001170807.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	four and a half LIM domains protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY020942.1, BC021723.2, AK223539.1, AL132776.11 and BX118342.1. On Apr 13, 2016 this sequence version replaced NM_001170807.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC021723.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACAACTG CTCACTTTTA CTGTCAATAC TGCACAGCAT CACTTCTTGG GAAGAAATAT 
GTACTAAAGG ATGACAGTCC ATACTGTGTT ACATGTTATG ATCGTGTATT TTCTAACTAT 
TGCGAGGAAT GCAAAAAACC AATTGAATCT GATTCTAAGG ATCTTTGTTA CAAAGACCGG 
CACTGGCATG AAGGATGCTT CAAGTGCACC AAATGCAATC ACTCTTTGGT GGAAAAGCCT 
TTTGCTGCCA AGGATGAGCG CCTGCTGTGC ACGGAGTGCT ATTCTAACGA GTGCTCCTCC 
AAGTGCTTCC ACTGCAAGAG GACCATCATG CCTGGTTCCC GCAAAATGGA ATTTAAGGGA 
AACTACTGGC ATGAAACCTG TTTTGTGTGT GAGAATTGCC GACAACCTAT AGGGACAAAG 
CCTTTGATCT CCAAAGAGAG TGGCAATTAT TGTGTGCCAT GTTTTGAGAA GGAGTTTGCT 
CACTACTGCA ACTTTTGTAA GAAGGTGATA ACTTCAGGTG GGATAACATT TTGTGACCAG 
CTATGGCATA AAGAGTGTTT TCTGTGTAGT GGCTGTAGGA AAGATCTCTG TGAAGAACAG 
TTCATGTCCA GAGACGACTA TCCATTCTGC GTGGACTGCT ACAACCATCT TTATGCCAAC 
AAGTGTGTAG CCTGTTCCAA ACCCATTAGT GGTCTCACAG GTGCCAAGTT TATCTGCTTT 
CAAGACAGCC AGTGGCATAG CGAATGCTTT AACTGCGGGA AATGCTCTGT CTCCTTGGTG 
GGTAAAGGCT TCCTGACCCA GAACAAGGAA ATCTTCTGCC AAAAATGTGG CTCCGGAATG 
GACACTGACA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001164278.1
CDS	209..1063
Translation	MTTAHFYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDRHWHEGCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEFKGNYWHETCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITSGGITFCDQLWHKECFLCSGCRKDLCEEQFMSRDDYPFCVDCYNHLYANKCVACSKPISGLTGAKFICFQDSQWHSECFNCGKCSVSLVGKGFLTQNKEIFCQKCGSGMDTDI

Target ORF information:

RefSeq Version	NM_001170807.2
Organism	Homo sapiens(human)
Definition	Homo sapiens four and a half LIM domains 5 (FHL5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001170807.2

ORF Insert Sequence:

ATGACAACTG CTCACTTTTA CTGTCAATAC TGCACAGCAT CACTTCTTGG GAAGAAATAT 
GTACTAAAGG ATGACAGTCC ATACTGTGTT ACATGTTATG ATCGTGTATT TTCTAACTAT 
TGCGAGGAAT GCAAAAAACC AATTGAATCT GATTCTAAGG ATCTTTGTTA CAAAGACCGG 
CACTGGCATG AAGGATGCTT CAAGTGCACC AAATGCAATC ACTCTTTGGT GGAAAAGCCT 
TTTGCTGCCA AGGATGAGCG CCTGCTGTGC ACGGAGTGCT ATTCTAACGA GTGCTCCTCC 
AAGTGCTTCC ACTGCAAGAG GACCATCATG CCTGGTTCCC GCAAAATGGA ATTTAAGGGA 
AACTACTGGC ATGAAACCTG TTTTGTGTGT GAGAATTGCC GACAACCTAT AGGGACAAAG 
CCTTTGATCT CCAAAGAGAG TGGCAATTAT TGTGTGCCAT GTTTTGAGAA GGAGTTTGCT 
CACTACTGCA ACTTTTGTAA GAAGGTGATA ACTTCAGGTG GGATAACATT TTGTGACCAG 
CTATGGCATA AAGAGTGTTT TCTGTGTAGT GGCTGTAGGA AAGATCTCTG TGAAGAACAG 
TTCATGTCCA GAGACGACTA TCCATTCTGC GTGGACTGCT ACAACCATCT TTATGCCAAC 
AAGTGTGTAG CCTGTTCCAA ACCCATTAGT GGTCTCACAG GTGCCAAGTT TATCTGCTTT 
CAAGACAGCC AGTGGCATAG CGAATGCTTT AACTGCGGGA AATGCTCTGT CTCCTTGGTG 
GGTAAAGGCT TCCTGACCCA GAACAAGGAA ATCTTCTGCC AAAAATGTGG CTCCGGAATG 
GACACTGACA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FHL5 ( NM_001322467.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001309396.1 Homo sapiens four and a half LIM domains 5 (FHL5), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu13610
Clone ID Related Accession (Same CDS sequence)	NM_001322466.1 , NM_001170807.2 , NM_001322467.1 , NM_020482.5
Accession Version	NM_001322467.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	four and a half LIM domains protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA099831.1, AK223539.1, AL132776.11 and BX118342.1. On Apr 13, 2016 this sequence version replaced XM_006715613.2. Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.26770.1, SRR1803613.116601.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACAACTG CTCACTTTTA CTGTCAATAC TGCACAGCAT CACTTCTTGG GAAGAAATAT 
GTACTAAAGG ATGACAGTCC ATACTGTGTT ACATGTTATG ATCGTGTATT TTCTAACTAT 
TGCGAGGAAT GCAAAAAACC AATTGAATCT GATTCTAAGG ATCTTTGTTA CAAAGACCGG 
CACTGGCATG AAGGATGCTT CAAGTGCACC AAATGCAATC ACTCTTTGGT GGAAAAGCCT 
TTTGCTGCCA AGGATGAGCG CCTGCTGTGC ACGGAGTGCT ATTCTAACGA GTGCTCCTCC 
AAGTGCTTCC ACTGCAAGAG GACCATCATG CCTGGTTCCC GCAAAATGGA ATTTAAGGGA 
AACTACTGGC ATGAAACCTG TTTTGTGTGT GAGAATTGCC GACAACCTAT AGGGACAAAG 
CCTTTGATCT CCAAAGAGAG TGGCAATTAT TGTGTGCCAT GTTTTGAGAA GGAGTTTGCT 
CACTACTGCA ACTTTTGTAA GAAGGTGATA ACTTCAGGTG GGATAACATT TTGTGACCAG 
CTATGGCATA AAGAGTGTTT TCTGTGTAGT GGCTGTAGGA AAGATCTCTG TGAAGAACAG 
TTCATGTCCA GAGACGACTA TCCATTCTGC GTGGACTGCT ACAACCATCT TTATGCCAAC 
AAGTGTGTAG CCTGTTCCAA ACCCATTAGT GGTCTCACAG GTGCCAAGTT TATCTGCTTT 
CAAGACAGCC AGTGGCATAG CGAATGCTTT AACTGCGGGA AATGCTCTGT CTCCTTGGTG 
GGTAAAGGCT TCCTGACCCA GAACAAGGAA ATCTTCTGCC AAAAATGTGG CTCCGGAATG 
GACACTGACA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001309396.1
CDS	344..1198
Translation	MTTAHFYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDRHWHEGCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEFKGNYWHETCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITSGGITFCDQLWHKECFLCSGCRKDLCEEQFMSRDDYPFCVDCYNHLYANKCVACSKPISGLTGAKFICFQDSQWHSECFNCGKCSVSLVGKGFLTQNKEIFCQKCGSGMDTDI

Target ORF information:

RefSeq Version	NM_001322467.1
Organism	Homo sapiens(human)
Definition	Homo sapiens four and a half LIM domains 5 (FHL5), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001322467.1

ORF Insert Sequence:

ATGACAACTG CTCACTTTTA CTGTCAATAC TGCACAGCAT CACTTCTTGG GAAGAAATAT 
GTACTAAAGG ATGACAGTCC ATACTGTGTT ACATGTTATG ATCGTGTATT TTCTAACTAT 
TGCGAGGAAT GCAAAAAACC AATTGAATCT GATTCTAAGG ATCTTTGTTA CAAAGACCGG 
CACTGGCATG AAGGATGCTT CAAGTGCACC AAATGCAATC ACTCTTTGGT GGAAAAGCCT 
TTTGCTGCCA AGGATGAGCG CCTGCTGTGC ACGGAGTGCT ATTCTAACGA GTGCTCCTCC 
AAGTGCTTCC ACTGCAAGAG GACCATCATG CCTGGTTCCC GCAAAATGGA ATTTAAGGGA 
AACTACTGGC ATGAAACCTG TTTTGTGTGT GAGAATTGCC GACAACCTAT AGGGACAAAG 
CCTTTGATCT CCAAAGAGAG TGGCAATTAT TGTGTGCCAT GTTTTGAGAA GGAGTTTGCT 
CACTACTGCA ACTTTTGTAA GAAGGTGATA ACTTCAGGTG GGATAACATT TTGTGACCAG 
CTATGGCATA AAGAGTGTTT TCTGTGTAGT GGCTGTAGGA AAGATCTCTG TGAAGAACAG 
TTCATGTCCA GAGACGACTA TCCATTCTGC GTGGACTGCT ACAACCATCT TTATGCCAAC 
AAGTGTGTAG CCTGTTCCAA ACCCATTAGT GGTCTCACAG GTGCCAAGTT TATCTGCTTT 
CAAGACAGCC AGTGGCATAG CGAATGCTTT AACTGCGGGA AATGCTCTGT CTCCTTGGTG 
GGTAAAGGCT TCCTGACCCA GAACAAGGAA ATCTTCTGCC AAAAATGTGG CTCCGGAATG 
GACACTGACA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FHL5 ( NM_020482.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_065228.4 Homo sapiens four and a half LIM domains 5 (FHL5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13610
Clone ID Related Accession (Same CDS sequence)	NM_001322466.1 , NM_001170807.2 , NM_001322467.1 , NM_020482.5
Accession Version	NM_020482.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	four and a half LIM domains protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY020942.1, AK223539.1, AL132776.11 and BX118342.1. On Apr 13, 2016 this sequence version replaced NM_020482.4. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 all encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK058175.1, BC029490.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACAACTG CTCACTTTTA CTGTCAATAC TGCACAGCAT CACTTCTTGG GAAGAAATAT 
GTACTAAAGG ATGACAGTCC ATACTGTGTT ACATGTTATG ATCGTGTATT TTCTAACTAT 
TGCGAGGAAT GCAAAAAACC AATTGAATCT GATTCTAAGG ATCTTTGTTA CAAAGACCGG 
CACTGGCATG AAGGATGCTT CAAGTGCACC AAATGCAATC ACTCTTTGGT GGAAAAGCCT 
TTTGCTGCCA AGGATGAGCG CCTGCTGTGC ACGGAGTGCT ATTCTAACGA GTGCTCCTCC 
AAGTGCTTCC ACTGCAAGAG GACCATCATG CCTGGTTCCC GCAAAATGGA ATTTAAGGGA 
AACTACTGGC ATGAAACCTG TTTTGTGTGT GAGAATTGCC GACAACCTAT AGGGACAAAG 
CCTTTGATCT CCAAAGAGAG TGGCAATTAT TGTGTGCCAT GTTTTGAGAA GGAGTTTGCT 
CACTACTGCA ACTTTTGTAA GAAGGTGATA ACTTCAGGTG GGATAACATT TTGTGACCAG 
CTATGGCATA AAGAGTGTTT TCTGTGTAGT GGCTGTAGGA AAGATCTCTG TGAAGAACAG 
TTCATGTCCA GAGACGACTA TCCATTCTGC GTGGACTGCT ACAACCATCT TTATGCCAAC 
AAGTGTGTAG CCTGTTCCAA ACCCATTAGT GGTCTCACAG GTGCCAAGTT TATCTGCTTT 
CAAGACAGCC AGTGGCATAG CGAATGCTTT AACTGCGGGA AATGCTCTGT CTCCTTGGTG 
GGTAAAGGCT TCCTGACCCA GAACAAGGAA ATCTTCTGCC AAAAATGTGG CTCCGGAATG 
GACACTGACA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065228.4
CDS	440..1294
Translation	MTTAHFYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDRHWHEGCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEFKGNYWHETCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITSGGITFCDQLWHKECFLCSGCRKDLCEEQFMSRDDYPFCVDCYNHLYANKCVACSKPISGLTGAKFICFQDSQWHSECFNCGKCSVSLVGKGFLTQNKEIFCQKCGSGMDTDI

Target ORF information:

RefSeq Version	NM_020482.5
Organism	Homo sapiens(human)
Definition	Homo sapiens four and a half LIM domains 5 (FHL5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020482.5

ORF Insert Sequence:

ATGACAACTG CTCACTTTTA CTGTCAATAC TGCACAGCAT CACTTCTTGG GAAGAAATAT 
GTACTAAAGG ATGACAGTCC ATACTGTGTT ACATGTTATG ATCGTGTATT TTCTAACTAT 
TGCGAGGAAT GCAAAAAACC AATTGAATCT GATTCTAAGG ATCTTTGTTA CAAAGACCGG 
CACTGGCATG AAGGATGCTT CAAGTGCACC AAATGCAATC ACTCTTTGGT GGAAAAGCCT 
TTTGCTGCCA AGGATGAGCG CCTGCTGTGC ACGGAGTGCT ATTCTAACGA GTGCTCCTCC 
AAGTGCTTCC ACTGCAAGAG GACCATCATG CCTGGTTCCC GCAAAATGGA ATTTAAGGGA 
AACTACTGGC ATGAAACCTG TTTTGTGTGT GAGAATTGCC GACAACCTAT AGGGACAAAG 
CCTTTGATCT CCAAAGAGAG TGGCAATTAT TGTGTGCCAT GTTTTGAGAA GGAGTTTGCT 
CACTACTGCA ACTTTTGTAA GAAGGTGATA ACTTCAGGTG GGATAACATT TTGTGACCAG 
CTATGGCATA AAGAGTGTTT TCTGTGTAGT GGCTGTAGGA AAGATCTCTG TGAAGAACAG 
TTCATGTCCA GAGACGACTA TCCATTCTGC GTGGACTGCT ACAACCATCT TTATGCCAAC 
AAGTGTGTAG CCTGTTCCAA ACCCATTAGT GGTCTCACAG GTGCCAAGTT TATCTGCTTT 
CAAGACAGCC AGTGGCATAG CGAATGCTTT AACTGCGGGA AATGCTCTGT CTCCTTGGTG 
GGTAAAGGCT TCCTGACCCA GAACAAGGAA ATCTTCTGCC AAAAATGTGG CTCCGGAATG 
GACACTGACA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Gene-based pleiotropy across migraine with aura and migraine without aura patient groups.
Cephalalgia : an international journal of headache36(7)648-57(2016 Jun)
Zhao H,Eising E,de Vries B,Vijfhuizen LS,,Anttila V,Winsvold BS,Kurth T,Stefansson H,Kallela M,Malik R,Stam AH,Ikram MA,Ligthart L,Freilinger T,Alexander M,M?ller-Myhsok B,Schreiber S,Meitinger T,Aromas A,Eriksson JG,Boomsma DI,van Duijn CM,Zwart JA,Quaye L,Kubisch C,Dichgans M,Wessman M,Stefansson K,Chasman DI,Palotie A,Martin NG,Montgomery GW,Ferrari MD,Terwindt GM,van den Maagdenberg AM,Nyholt DR

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Association of genetic loci for migraine susceptibility in the she people of China.
The journal of headache and pain16553(2015)
Lin QF,Fu XG,Yao LT,Yang J,Cao LY,Xin YT,Hou JX,Ye LF,Huang GB

CREM-dependent transcription in male germ cells controlled by a kinesin.
Science (New York, N.Y.)298(5602)2388-90(2002 Dec)
Macho B,Brancorsini S,Fimia GM,Setou M,Hirokawa N,Sassone-Corsi P

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FHL5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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