PPP1R14A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PPP1R14A
Entrez Gene ID	94274
Full Name	protein phosphatase 1 regulatory inhibitor subunit 14A
Synonyms	CPI-17,CPI17,PPP1INL
General protein information	Preferred Names protein phosphatase 1 regulatory inhibitor subunit 14A Names protein phosphatase 1 regulatory subunit 14A 17 kDa PKC-potentiated inhibitory protein of PP1 17-KDa protein PKC-potentiated inhibitory protein of PP1 protein kinase C-potentiated inhibitor protein of 17 kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.2
Summary	The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011].
Disorder MIM:	608153

mRNA and Protein(s)

mRNA	Protein	Name
NM_033256.3	NP_150281.1	protein phosphatase 1 regulatory subunit 14A isoform 1
NM_001243947.1	NP_001230876.1	protein phosphatase 1 regulatory subunit 14A isoform 2
NM_033256.2	NP_150281.1	protein phosphatase 1 regulatory subunit 14A isoform 1
NM_001243947.2	NP_001230876.1	protein phosphatase 1 regulatory subunit 14A isoform 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PPP1R14A	XP_005616686.1
Mus musculus (house mouse)	Ppp1r14a	NP_081007.2
Homo sapiens (human)	PPP1R14A	NP_150281.1
Bos taurus (cattle)	PPP1R14A	NP_001179999.1
Xenopus tropicalis (tropical clawed frog)	ppp1r14a	NP_001007956.1
Rattus norvegicus (Norway rat)	Ppp1r14a	NP_569087.1

Gene Ontology
Bibliography

Related articles in PubMed

Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1).
Filter JJ, Williams BC, Eto M, Shalloway D, Goldberg ML
eLife6(2017 Apr)

The putative oncogene CPI-17 is up-regulated in schwannoma.
Hagel C, Dornblut C, Schulz A, Wiehl U, Friedrich RE, Huckhagel T, Mautner VF, Morrison H
Neuropathology and applied neurobiology42(7)664-668(2016 12)

CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.
Riecken LB, Zoch A, Wiehl U, Reichert S, Scholl I, Cui Y, Ziemer M, Anderegg U, Hagel C, Morrison H
Oncotarget7(48)78242-78254(2016 Nov)

Role of CPI-17 in restoring skin homoeostasis in cutaneous field of cancerization: effects of topical application of a film-forming medical device containing photolyase and UV filters.
Puig-Butill? JA, Malvehy J, Potrony M, Trullas C, Garcia-Garc?a F, Dopazo J, Puig S
Experimental dermatology22(7)494-6(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

analysis of the interaction between plakoglobin and CPI-17, which is affected by the phosphorylation status of CPI-17 in human lung microvascular endothelial cells
Title: Putative protein partners for the human CPI-17 protein revealed by bacterial two-hybrid screening.

CPI-17 has a role in restoring skin homoeostasis in cutaneous field of cancerization lesions
Title: Role of CPI-17 in restoring skin homoeostasis in cutaneous field of cancerization: effects of topical application of a film-forming medical device containing photolyase and UV filters.

The N-terminal 21-residue tail domain of CPI-17 is necessary for nuclear localization. Phospho-mimetic Asp-substitution of CPI-17 at Ser12 attenuates the nuclear import.
Title: Nuclear localization of CPI-17, a protein phosphatase-1 inhibitor protein, affects histone H3 phosphorylation and corresponds to proliferation of cancer and smooth muscle cells.

The study characterized the CPI-17 promoter and identified binding sites for GATA-6 and nuclear factor kappa B (NF-kappaB).
Title: GATA-6 and NF-?B activate CPI-17 gene transcription and regulate Ca2+ sensitization of smooth muscle contraction.

a novel signaling cascade that links RhoA-mediated calcium sensitivity to MEF2-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK, PP1alpha, and CPI-17.
Title: A novel RhoA/ROCK-CPI-17-MEF2C signaling pathway regulates vascular smooth muscle cell gene expression.

The following PPP1R14A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPP1R14A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18074	NM_033256.3 Latest version!	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18540	NM_001243947.2 Latest version!	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18074	NM_033256.2	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18540	NM_001243947.1	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PPP1R14A ( NM_033256.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_150281.1 Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18074
Clone ID Related Accession (Same CDS sequence)	NM_033256.3 , NM_033256.2
Accession Version	NM_033256.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 444bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-22
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 14A isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB056508.1. On Nov 22, 2018 this sequence version replaced NM_033256.2. Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1, also known as CPI-17alpha). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB056508.1, AY050670.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000301242.9/ ENSP00000301242.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGCTC AGCGGCTGGG CAAGCGCGTG CTGAGCAAGC TGCAGTCTCC ATCGCGGGCC 
CGCGGGCCAG GGGGCAGTCC CGGGGGGCTG CAGAAGCGGC ACGCGCGCGT CACCGTCAAG 
TATGACCGGC GGGAGCTGCA GCGGCGGCTG GACGTGGAGA AGTGGATCGA CGGGCGCCTG 
GAGGAGCTGT ACCGCGGCAT GGAGGCAGAC ATGCCCGATG AGATCAACAT TGATGAATTG 
TTGGAGTTAG AGAGTGAAGA GGAGAGAAGC CGGAAAATCC AGGGACTCCT GAAGTCATGT 
GGGAAACCTG TCGAGGACTT CATCCAGGAG CTGCTGGCAA AGCTTCAAGG CCTCCACAGG 
CAGCCCGGCC TCCGCCAGCC AAGCCCCTCC CACGACGGCA GCCTCAGCCC CCTCCAGGAC 
CGGGCCCGGA CTGCTCACCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_150281.1
CDS	36..479
Translation	MAAQRLGKRVLSKLQSPSRARGPGGSPGGLQKRHARVTVKYDRRELQRRLDVEKWIDGRLEELYRGMEADMPDEINIDELLELESEEERSRKIQGLLKSCGKPVEDFIQELLAKLQGLHRQPGLRQPSPSHDGSLSPLQDRARTAHP

Target ORF information:

RefSeq Version	NM_033256.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033256.3

ORF Insert Sequence:

ATGGCAGCTC AGCGGCTGGG CAAGCGCGTG CTGAGCAAGC TGCAGTCTCC ATCGCGGGCC 
CGCGGGCCAG GGGGCAGTCC CGGGGGGCTG CAGAAGCGGC ACGCGCGCGT CACCGTCAAG 
TATGACCGGC GGGAGCTGCA GCGGCGGCTG GACGTGGAGA AGTGGATCGA CGGGCGCCTG 
GAGGAGCTGT ACCGCGGCAT GGAGGCAGAC ATGCCCGATG AGATCAACAT TGATGAATTG 
TTGGAGTTAG AGAGTGAAGA GGAGAGAAGC CGGAAAATCC AGGGACTCCT GAAGTCATGT 
GGGAAACCTG TCGAGGACTT CATCCAGGAG CTGCTGGCAA AGCTTCAAGG CCTCCACAGG 
CAGCCCGGCC TCCGCCAGCC AAGCCCCTCC CACGACGGCA GCCTCAGCCC CCTCCAGGAC 
CGGGCCCGGA CTGCTCACCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R14A ( NM_033256.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_150281.1 Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18074
Clone ID Related Accession (Same CDS sequence)	NM_033256.3 , NM_033256.2
Accession Version	NM_033256.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 444bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 14A isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from ES314242.1 and AB056508.1. On Sep 2, 2011 this sequence version replaced NM_033256.1. Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1, also known as CPI-17alpha). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX463416.2, BM541475.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCTC AGCGGCTGGG CAAGCGCGTG CTGAGCAAGC TGCAGTCTCC ATCGCGGGCC 
CGCGGGCCAG GGGGCAGTCC CGGGGGGCTG CAGAAGCGGC ACGCGCGCGT CACCGTCAAG 
TATGACCGGC GGGAGCTGCA GCGGCGGCTG GACGTGGAGA AGTGGATCGA CGGGCGCCTG 
GAGGAGCTGT ACCGCGGCAT GGAGGCAGAC ATGCCCGATG AGATCAACAT TGATGAATTG 
TTGGAGTTAG AGAGTGAAGA GGAGAGAAGC CGGAAAATCC AGGGACTCCT GAAGTCATGT 
GGGAAACCTG TCGAGGACTT CATCCAGGAG CTGCTGGCAA AGCTTCAAGG CCTCCACAGG 
CAGCCCGGCC TCCGCCAGCC AAGCCCCTCC CACGACGGCA GCCTCAGCCC CCTCCAGGAC 
CGGGCCCGGA CTGCTCACCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_150281.1
CDS	253..696
Translation	MAAQRLGKRVLSKLQSPSRARGPGGSPGGLQKRHARVTVKYDRRELQRRLDVEKWIDGRLEELYRGMEADMPDEINIDELLELESEEERSRKIQGLLKSCGKPVEDFIQELLAKLQGLHRQPGLRQPSPSHDGSLSPLQDRARTAHP

Target ORF information:

RefSeq Version	NM_033256.2
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033256.2

ORF Insert Sequence:

ATGGCAGCTC AGCGGCTGGG CAAGCGCGTG CTGAGCAAGC TGCAGTCTCC ATCGCGGGCC 
CGCGGGCCAG GGGGCAGTCC CGGGGGGCTG CAGAAGCGGC ACGCGCGCGT CACCGTCAAG 
TATGACCGGC GGGAGCTGCA GCGGCGGCTG GACGTGGAGA AGTGGATCGA CGGGCGCCTG 
GAGGAGCTGT ACCGCGGCAT GGAGGCAGAC ATGCCCGATG AGATCAACAT TGATGAATTG 
TTGGAGTTAG AGAGTGAAGA GGAGAGAAGC CGGAAAATCC AGGGACTCCT GAAGTCATGT 
GGGAAACCTG TCGAGGACTT CATCCAGGAG CTGCTGGCAA AGCTTCAAGG CCTCCACAGG 
CAGCCCGGCC TCCGCCAGCC AAGCCCCTCC CACGACGGCA GCCTCAGCCC CCTCCAGGAC 
CGGGCCCGGA CTGCTCACCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R14A ( NM_001243947.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230876.1 Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18540
Clone ID Related Accession (Same CDS sequence)	NM_001243947.1 , NM_001243947.2
Accession Version	NM_001243947.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 363bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 14A isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from ES314242.1 and AB056509.1. Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2, also known as CPI-17beta) missing an internal protein segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB056509.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2152568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCTC AGCGGCTGGG CAAGCGCGTG CTGAGCAAGC TGCAGTCTCC ATCGCGGGCC 
CGCGGGCCAG GGGGCAGTCC CGGGGGGCTG CAGAAGCGGC ACGCGCGCGT CACCGTCAAG 
TATGACCGGC GGGAGCTGCA GCGGCGGCTG GACGTGGAGA AGTGGATCGA CGGGCGCCTG 
GAGGAGCTGT ACCGCGGCAT GGGACTCCTG AAGTCATGTG GGAAACCTGT CGAGGACTTC 
ATCCAGGAGC TGCTGGCAAA GCTTCAAGGC CTCCACAGGC AGCCCGGCCT CCGCCAGCCA 
AGCCCCTCCC ACGACGGCAG CCTCAGCCCC CTCCAGGACC GGGCCCGGAC TGCTCACCCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230876.1
CDS	253..615
Translation	MAAQRLGKRVLSKLQSPSRARGPGGSPGGLQKRHARVTVKYDRRELQRRLDVEKWIDGRLEELYRGMGLLKSCGKPVEDFIQELLAKLQGLHRQPGLRQPSPSHDGSLSPLQDRARTAHP

Target ORF information:

RefSeq Version	NM_001243947.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243947.1

ORF Insert Sequence:

ATGGCAGCTC AGCGGCTGGG CAAGCGCGTG CTGAGCAAGC TGCAGTCTCC ATCGCGGGCC 
CGCGGGCCAG GGGGCAGTCC CGGGGGGCTG CAGAAGCGGC ACGCGCGCGT CACCGTCAAG 
TATGACCGGC GGGAGCTGCA GCGGCGGCTG GACGTGGAGA AGTGGATCGA CGGGCGCCTG 
GAGGAGCTGT ACCGCGGCAT GGGACTCCTG AAGTCATGTG GGAAACCTGT CGAGGACTTC 
ATCCAGGAGC TGCTGGCAAA GCTTCAAGGC CTCCACAGGC AGCCCGGCCT CCGCCAGCCA 
AGCCCCTCCC ACGACGGCAG CCTCAGCCCC CTCCAGGACC GGGCCCGGAC TGCTCACCCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R14A ( NM_001243947.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230876.1 Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18540
Clone ID Related Accession (Same CDS sequence)	NM_001243947.1 , NM_001243947.2
Accession Version	NM_001243947.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 363bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-22
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 14A isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB056509.1. On May 31, 2019 this sequence version replaced NM_001243947.1. Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2, also known as CPI-17beta) missing an internal protein segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB056509.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2152568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCTC AGCGGCTGGG CAAGCGCGTG CTGAGCAAGC TGCAGTCTCC ATCGCGGGCC 
CGCGGGCCAG GGGGCAGTCC CGGGGGGCTG CAGAAGCGGC ACGCGCGCGT CACCGTCAAG 
TATGACCGGC GGGAGCTGCA GCGGCGGCTG GACGTGGAGA AGTGGATCGA CGGGCGCCTG 
GAGGAGCTGT ACCGCGGCAT GGGACTCCTG AAGTCATGTG GGAAACCTGT CGAGGACTTC 
ATCCAGGAGC TGCTGGCAAA GCTTCAAGGC CTCCACAGGC AGCCCGGCCT CCGCCAGCCA 
AGCCCCTCCC ACGACGGCAG CCTCAGCCCC CTCCAGGACC GGGCCCGGAC TGCTCACCCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230876.1
CDS	36..398
Translation	MAAQRLGKRVLSKLQSPSRARGPGGSPGGLQKRHARVTVKYDRRELQRRLDVEKWIDGRLEELYRGMGLLKSCGKPVEDFIQELLAKLQGLHRQPGLRQPSPSHDGSLSPLQDRARTAHP

Target ORF information:

RefSeq Version	NM_001243947.2
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243947.2

ORF Insert Sequence:

ATGGCAGCTC AGCGGCTGGG CAAGCGCGTG CTGAGCAAGC TGCAGTCTCC ATCGCGGGCC 
CGCGGGCCAG GGGGCAGTCC CGGGGGGCTG CAGAAGCGGC ACGCGCGCGT CACCGTCAAG 
TATGACCGGC GGGAGCTGCA GCGGCGGCTG GACGTGGAGA AGTGGATCGA CGGGCGCCTG 
GAGGAGCTGT ACCGCGGCAT GGGACTCCTG AAGTCATGTG GGAAACCTGT CGAGGACTTC 
ATCCAGGAGC TGCTGGCAAA GCTTCAAGGC CTCCACAGGC AGCCCGGCCT CCGCCAGCCA 
AGCCCCTCCC ACGACGGCAG CCTCAGCCCC CTCCAGGACC GGGCCCGGAC TGCTCACCCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1).
eLife6(2017 Apr)
Filter JJ,Williams BC,Eto M,Shalloway D,Goldberg ML

The putative oncogene CPI-17 is up-regulated in schwannoma.
Neuropathology and applied neurobiology42(7)664-668(2016 12)
Hagel C,Dornblut C,Schulz A,Wiehl U,Friedrich RE,Huckhagel T,Mautner VF,Morrison H

CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.
Oncotarget7(48)78242-78254(2016 Nov)
Riecken LB,Zoch A,Wiehl U,Reichert S,Scholl I,Cui Y,Ziemer M,Anderegg U,Hagel C,Morrison H

Role of CPI-17 in restoring skin homoeostasis in cutaneous field of cancerization: effects of topical application of a film-forming medical device containing photolyase and UV filters.
Experimental dermatology22(7)494-6(2013 Jul)
Puig-Butill? JA,Malvehy J,Potrony M,Trullas C,Garcia-Garc?a F,Dopazo J,Puig S

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PPP1R14A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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