H2AZ2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2AZ2
Entrez Gene ID	94239
Full Name	H2A histone family member V
Synonyms	H2A.Z-2,H2AV
General protein information	Preferred Names H2A histone family member V Names histone H2A.V H2A.F/Z histone H2A.F/Z purine-rich binding element protein B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p13
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene. [provided by RefSeq, Oct 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012412.4	NP_036544.1	histone H2A.V isoform 1
NM_012412.5	NP_036544.1	histone H2A.V isoform 1
NM_201517.2	NP_958925.1	histone H2A.V isoform 5
NM_201516.2	NP_958924.1	histone H2A.V isoform 4
NM_138635.3	NP_619541.1	histone H2A.V isoform 2
NM_201436.2	NP_958844.1	histone H2A.V isoform 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	H2AFV	XP_510606.3
Kluyveromyces lactis	KLLA0C05918g	XP_452461.1
Arabidopsis thaliana (thale cress)	HTA8	NP_850299.1
Oryza sativa (rice)	Os03g0162200	NP_001049049.1
Bos taurus (cattle)	H2AFV	NP_001033286.1
Drosophila melanogaster (fruit fly)	His2Av	NP_524519.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000306	XP_310818.3
Arabidopsis thaliana (thale cress)	HTA11	NP_191019.1
Oryza sativa (rice)	Os03g0743400	NP_001051232.1
	LOC701962	XP_001097247.1
Rattus norvegicus (Norway rat)	LOC685909	NP_001099489.1
Danio rerio (zebrafish)	h2afva	NP_705930.1
Mus musculus (house mouse)	H2afv	NP_084214.1
Caenorhabditis elegans (roundworm)	htz-1	NP_500569.1
Eremothecium gossypii	AGOS_ACL017C	NP_983387.1
Homo sapiens (human)	H2AFV	NP_036544.1
Saccharomyces cerevisiae (baker's yeast)	HTZ1	NP_014631.1
Schizosaccharomyces pombe (fission yeast)	pht1	NP_595630.3
Neurospora crassa	NCU05347	XP_963338.1
Oryza sativa (rice)	Os10g0418000	NP_001064611.1
Xenopus tropicalis (tropical clawed frog)	h2afv	NP_001016178.1

Gene Ontology
Bibliography

Related articles in PubMed

Nucleosome adaptability conferred by sequence and structural variations in histone H2A-H2B dimers.
Shaytan AK, Landsman D, Panchenko AR
Current opinion in structural biology3248-57(2015 Jun)

A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants.
Sadakierska-Chudy A, Kostrzewa RM, Filip M
Neurotoxicity research27(1)84-97(2015 Jan)

Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2.
Horikoshi N, Sato K, Shimada K, Arimura Y, Osakabe A, Tachiwana H, Hayashi-Takanaka Y, Iwasaki W, Kagawa W, Harata M, Kimura H, Kurumizaka H
Acta crystallographica. Section D, Biological crystallography69(Pt 12)2431-9(2013 Dec)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

Identification and characterization of the two isoforms of the vertebrate H2A.Z histone variant.
Matsuda R, Hori T, Kitamura H, Takeuchi K, Fukagawa T, Harata M
Nucleic acids research38(13)4263-73(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A mutational analysis revealed that the amino-acid difference at position 38 is at least partially responsible for the structural polymorphism in the L1 loop region of H2A.Z.1 and H2A.Z.2.
Title: Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2.

The following H2AZ2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2AZ2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02860	NM_201436.2 Latest version!	Homo sapiens H2A.Z variant histone 2 (H2AZ2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu02871	NM_201516.2 Latest version!	Homo sapiens H2A.Z variant histone 2 (H2AZ2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu06218	NM_012412.5 Latest version!	Homo sapiens H2A.Z variant histone 2 (H2AZ2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01833	NM_138635.3 Latest version!	Homo sapiens H2A.Z variant histone 2 (H2AZ2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu31198	NM_201517.2 Latest version!	Homo sapiens H2A.Z variant histone 2 (H2AZ2), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu06218	NM_012412.4	Homo sapiens H2A histone family member V (H2AFV), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2AZ2 ( NM_201436.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_958844.1 Homo sapiens H2A.Z variant histone 2 (H2AZ2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu02860
Clone ID Related Accession (Same CDS sequence)	NM_201436.2
Accession Version	NM_201436.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-24
Organism	Homo sapiens(human)
Product	histone H2A.V isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB460745.1, AB209001.1 and BM850777.1. On Jun 28, 2007 this sequence version replaced NM_201436.1. Transcript Variant: This variant (3) lacks an internal exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279855.1234.1, SRR1163658.7311.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-independent histone :: PMID: 25731851 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTTCCTG TGGGCCGCAT CCACAGACAC TTGAAGACTC GCACCACAAG CCATGGAAGG 
GTGGGTGCCA CTGCTGCCGT GTACAGTGCT GCGATTCTGG AGTACCTCAC TGCAGAGGTG 
CTGGAGCTGG CAGGTAATGC TTCTAAGGAT CTCAAAGTAA AGCGTATCAC TCCGCGTCAC 
TTGCAGCTTG CAATCCGTGG TGATGAAGAG TTGGATTCTC TTATCAAGGC TACCATAGCT 
GGGGGTGGTG TGATCCCTCA CATCCACAAA TCTCTGATTG GAAAGAAGGG ACAGCAGAAA 
ACTGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_958844.1
CDS	156..464
Translation	MFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTA

Target ORF information:

RefSeq Version	NM_201436.2
Organism	Homo sapiens(human)
Definition	Homo sapiens H2A.Z variant histone 2 (H2AZ2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_201436.2

ORF Insert Sequence:

ATGTTTCCTG TGGGCCGCAT CCACAGACAC TTGAAGACTC GCACCACAAG CCATGGAAGG 
GTGGGTGCCA CTGCTGCCGT GTACAGTGCT GCGATTCTGG AGTACCTCAC TGCAGAGGTG 
CTGGAGCTGG CAGGTAATGC TTCTAAGGAT CTCAAAGTAA AGCGTATCAC TCCGCGTCAC 
TTGCAGCTTG CAATCCGTGG TGATGAAGAG TTGGATTCTC TTATCAAGGC TACCATAGCT 
GGGGGTGGTG TGATCCCTCA CATCCACAAA TCTCTGATTG GAAAGAAGGG ACAGCAGAAA 
ACTGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2AZ2 ( NM_201516.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_958924.1 Homo sapiens H2A.Z variant histone 2 (H2AZ2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu02871
Clone ID Related Accession (Same CDS sequence)	NM_201516.2
Accession Version	NM_201516.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 201bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	histone H2A.V isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB460745.1, AB209001.1 and BM850777.1. On Jun 28, 2007 this sequence version replaced NM_201516.1. Transcript Variant: This variant (4) lacks a 3' exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 4) compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB148943.1, SRR1163655.207929.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-independent histone :: PMID: 25731851 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGGAG GCAAAGCTGG AAAGGACAGT GGGAAGGCCA AGGCTAAGGC AGTATCTCGC 
TCACAGAGAG CTGGGCTACA GTTTCCTGTG GGCCGCATCC ACAGACACTT GAAGACTCGC 
ACCACAAGCC ATGGAAGGGT GGGTGCCACT GCTGCCGTGT ACAGTGCTGC GATTCTGGAG 
TACCTCACTG CAGAGGTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_958924.1
CDS	156..356
Translation	MAGGKAGKDSGKAKAKAVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEV

Target ORF information:

RefSeq Version	NM_201516.2
Organism	Homo sapiens(human)
Definition	Homo sapiens H2A.Z variant histone 2 (H2AZ2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_201516.2

ORF Insert Sequence:

ATGGCTGGAG GCAAAGCTGG AAAGGACAGT GGGAAGGCCA AGGCTAAGGC AGTATCTCGC 
TCACAGAGAG CTGGGCTACA GTTTCCTGTG GGCCGCATCC ACAGACACTT GAAGACTCGC 
ACCACAAGCC ATGGAAGGGT GGGTGCCACT GCTGCCGTGT ACAGTGCTGC GATTCTGGAG 
TACCTCACTG CAGAGGTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2AZ2 ( NM_012412.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036544.1 Homo sapiens H2A histone family member V (H2AFV), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06218
Clone ID Related Accession (Same CDS sequence)	NM_012412.4 , NM_012412.5
Accession Version	NM_012412.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Homo sapiens(human)
Product	histone H2A.V isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB460745.1, AB209001.1 and BM850777.1. On Jun 28, 2007 this sequence version replaced NM_012412.3. Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.382894.1, SRR1163655.228504.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein replication-independent histone :: PMID: 25731851 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGGAG GCAAAGCTGG AAAGGACAGT GGGAAGGCCA AGGCTAAGGC AGTATCTCGC 
TCACAGAGAG CTGGGCTACA GTTTCCTGTG GGCCGCATCC ACAGACACTT GAAGACTCGC 
ACCACAAGCC ATGGAAGGGT GGGTGCCACT GCTGCCGTGT ACAGTGCTGC GATTCTGGAG 
TACCTCACTG CAGAGGTGCT GGAGCTGGCA GGTAATGCTT CTAAGGATCT CAAAGTAAAG 
CGTATCACTC CGCGTCACTT GCAGCTTGCA ATCCGTGGTG ATGAAGAGTT GGATTCTCTT 
ATCAAGGCTA CCATAGCTGG GGGTGGTGTG ATCCCTCACA TCCACAAATC TCTGATTGGA 
AAGAAGGGAC AGCAGAAAAC TGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036544.1
CDS	156..542
Translation	MAGGKAGKDSGKAKAKAVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTA

Target ORF information:

RefSeq Version	NM_012412.4
Organism	Homo sapiens(human)
Definition	Homo sapiens H2A histone family member V (H2AFV), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012412.4

ORF Insert Sequence:

ATGGCTGGAG GCAAAGCTGG AAAGGACAGT GGGAAGGCCA AGGCTAAGGC AGTATCTCGC 
TCACAGAGAG CTGGGCTACA GTTTCCTGTG GGCCGCATCC ACAGACACTT GAAGACTCGC 
ACCACAAGCC ATGGAAGGGT GGGTGCCACT GCTGCCGTGT ACAGTGCTGC GATTCTGGAG 
TACCTCACTG CAGAGGTGCT GGAGCTGGCA GGTAATGCTT CTAAGGATCT CAAAGTAAAG 
CGTATCACTC CGCGTCACTT GCAGCTTGCA ATCCGTGGTG ATGAAGAGTT GGATTCTCTT 
ATCAAGGCTA CCATAGCTGG GGGTGGTGTG ATCCCTCACA TCCACAAATC TCTGATTGGA 
AAGAAGGGAC AGCAGAAAAC TGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2AZ2 ( NM_012412.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_036544.1 Homo sapiens H2A.Z variant histone 2 (H2AZ2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06218
Clone ID Related Accession (Same CDS sequence)	NM_012412.4 , NM_012412.5
Accession Version	NM_012412.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	histone H2A.V isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004854.3. On Dec 3, 2019 this sequence version replaced NM_012412.4. Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB209001.1, SRR1660807.693.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein replication-independent histone :: PMID: 25731851 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGGAG GCAAAGCTGG AAAGGACAGT GGGAAGGCCA AGGCTAAGGC AGTATCTCGC 
TCACAGAGAG CTGGGCTACA GTTTCCTGTG GGCCGCATCC ACAGACACTT GAAGACTCGC 
ACCACAAGCC ATGGAAGGGT GGGTGCCACT GCTGCCGTGT ACAGTGCTGC GATTCTGGAG 
TACCTCACTG CAGAGGTGCT GGAGCTGGCA GGTAATGCTT CTAAGGATCT CAAAGTAAAG 
CGTATCACTC CGCGTCACTT GCAGCTTGCA ATCCGTGGTG ATGAAGAGTT GGATTCTCTT 
ATCAAGGCTA CCATAGCTGG GGGTGGTGTG ATCCCTCACA TCCACAAATC TCTGATTGGA 
AAGAAGGGAC AGCAGAAAAC TGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036544.1
CDS	117..503
Translation	MAGGKAGKDSGKAKAKAVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTA

Target ORF information:

RefSeq Version	NM_012412.5
Organism	Homo sapiens(human)
Definition	Homo sapiens H2A.Z variant histone 2 (H2AZ2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012412.5

ORF Insert Sequence:

ATGGCTGGAG GCAAAGCTGG AAAGGACAGT GGGAAGGCCA AGGCTAAGGC AGTATCTCGC 
TCACAGAGAG CTGGGCTACA GTTTCCTGTG GGCCGCATCC ACAGACACTT GAAGACTCGC 
ACCACAAGCC ATGGAAGGGT GGGTGCCACT GCTGCCGTGT ACAGTGCTGC GATTCTGGAG 
TACCTCACTG CAGAGGTGCT GGAGCTGGCA GGTAATGCTT CTAAGGATCT CAAAGTAAAG 
CGTATCACTC CGCGTCACTT GCAGCTTGCA ATCCGTGGTG ATGAAGAGTT GGATTCTCTT 
ATCAAGGCTA CCATAGCTGG GGGTGGTGTG ATCCCTCACA TCCACAAATC TCTGATTGGA 
AAGAAGGGAC AGCAGAAAAC TGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2AZ2 ( NM_138635.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_619541.1 Homo sapiens H2A.Z variant histone 2 (H2AZ2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01833
Clone ID Related Accession (Same CDS sequence)	NM_138635.3
Accession Version	NM_138635.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-24
Organism	Homo sapiens(human)
Product	histone H2A.V isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB460745.1, AB209001.1, AK023973.1, DA456475.1 and AC004854.3. On Jun 28, 2007 this sequence version replaced NM_138635.2. Transcript Variant: This variant (2) utilizes an alternate exon in the 3' coding region and 3' UTR, compared to variant 1. It encodes a shorter protein (isoform 2) compared to that encoded by variant 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no quality transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.239073.1, SRR1803613.48635.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-independent histone :: PMID: 25731851 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGGAG GCAAAGCTGG AAAGGACAGT GGGAAGGCCA AGGCTAAGGC AGTATCTCGC 
TCACAGAGAG CTGGGCTACA GTTTCCTGTG GGCCGCATCC ACAGACACTT GAAGACTCGC 
ACCACAAGCC ATGGAAGGGT GGGTGCCACT GCTGCCGTGT ACAGTGCTGC GATTCTGGAG 
TACCTCACTG CAGAGGTGCT GGAGCTGGCA GGTAATGCTT CTAAGGATCT CAAAGTAAAG 
CGTATCACTC CGCGTCACTT GCAGCTTGCA ATCCGTGGTG ATGAAGAGTT GGATTCTCTT 
ATCAAGGCTA CCATAGCTGG GGGTGAGAAG AGAAGGTGTT CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_619541.1
CDS	156..500
Translation	MAGGKAGKDSGKAKAKAVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGEKRRCS

Target ORF information:

RefSeq Version	NM_138635.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H2A.Z variant histone 2 (H2AZ2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138635.3

ORF Insert Sequence:

ATGGCTGGAG GCAAAGCTGG AAAGGACAGT GGGAAGGCCA AGGCTAAGGC AGTATCTCGC 
TCACAGAGAG CTGGGCTACA GTTTCCTGTG GGCCGCATCC ACAGACACTT GAAGACTCGC 
ACCACAAGCC ATGGAAGGGT GGGTGCCACT GCTGCCGTGT ACAGTGCTGC GATTCTGGAG 
TACCTCACTG CAGAGGTGCT GGAGCTGGCA GGTAATGCTT CTAAGGATCT CAAAGTAAAG 
CGTATCACTC CGCGTCACTT GCAGCTTGCA ATCCGTGGTG ATGAAGAGTT GGATTCTCTT 
ATCAAGGCTA CCATAGCTGG GGGTGAGAAG AGAAGGTGTT CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2AZ2 ( NM_201517.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_958925.1 Homo sapiens H2A.Z variant histone 2 (H2AZ2), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu31198
Clone ID Related Accession (Same CDS sequence)	NM_201517.2
Accession Version	NM_201517.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 273bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	histone H2A.V isoform 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB460745.1, AB209001.1 and BM850777.1. On Jun 28, 2007 this sequence version replaced NM_201517.1. Transcript Variant: This variant (5) lacks an internal exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 5) compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.341519.1, BE742590.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-independent histone :: PMID: 25731851 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGGAG GCAAAGCTGG AAAGGACAGT GGGAAGGCCA AGGCTAAGGC AGTATCTCGC 
TCACAGAGAG CTGGGCTACA GGTGCTGGAG CTGGCAGGTA ATGCTTCTAA GGATCTCAAA 
GTAAAGCGTA TCACTCCGCG TCACTTGCAG CTTGCAATCC GTGGTGATGA AGAGTTGGAT 
TCTCTTATCA AGGCTACCAT AGCTGGGGGT GGTGTGATCC CTCACATCCA CAAATCTCTG 
ATTGGAAAGA AGGGACAGCA GAAAACTGCT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_958925.1
CDS	156..428
Translation	MAGGKAGKDSGKAKAKAVSRSQRAGLQVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTA

Target ORF information:

RefSeq Version	NM_201517.2
Organism	Homo sapiens(human)
Definition	Homo sapiens H2A.Z variant histone 2 (H2AZ2), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_201517.2

ORF Insert Sequence:

ATGGCTGGAG GCAAAGCTGG AAAGGACAGT GGGAAGGCCA AGGCTAAGGC AGTATCTCGC 
TCACAGAGAG CTGGGCTACA GGTGCTGGAG CTGGCAGGTA ATGCTTCTAA GGATCTCAAA 
GTAAAGCGTA TCACTCCGCG TCACTTGCAG CTTGCAATCC GTGGTGATGA AGAGTTGGAT 
TCTCTTATCA AGGCTACCAT AGCTGGGGGT GGTGTGATCC CTCACATCCA CAAATCTCTG 
ATTGGAAAGA AGGGACAGCA GAAAACTGCT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nucleosome adaptability conferred by sequence and structural variations in histone H2A-H2B dimers.
Current opinion in structural biology3248-57(2015 Jun)
Shaytan AK,Landsman D,Panchenko AR

A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants.
Neurotoxicity research27(1)84-97(2015 Jan)
Sadakierska-Chudy A,Kostrzewa RM,Filip M

Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2.
Acta crystallographica. Section D, Biological crystallography69(Pt 12)2431-9(2013 Dec)
Horikoshi N,Sato K,Shimada K,Arimura Y,Osakabe A,Tachiwana H,Hayashi-Takanaka Y,Iwasaki W,Kagawa W,Harata M,Kimura H,Kurumizaka H

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

Identification and characterization of the two isoforms of the vertebrate H2A.Z histone variant.
Nucleic acids research38(13)4263-73(2010 Jul)
Matsuda R,Hori T,Kitamura H,Takeuchi K,Fukagawa T,Harata M

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H2AZ2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

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