OPN4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OPN4
Entrez Gene ID	94233
Full Name	opsin 4
Synonyms	MOP
General protein information	Preferred Names opsin 4 Names melanopsin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q23.2
Summary	Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Disorder MIM:	606665

mRNA and Protein(s)

mRNA	Protein	Name
NM_033282.3	NP_150598.1	melanopsin isoform 1
NM_001030015.2	NP_001025186.1	melanopsin isoform 2
NM_033282.4	NP_150598.1	melanopsin isoform 1
XM_017016957.1	XP_016872446.1	melanopsin isoform X3
XM_017016956.1	XP_016872445.1	melanopsin isoform X2
XM_017016955.1	XP_016872444.1	melanopsin isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	OPN4	NP_001025186.1
Pan troglodytes (chimpanzee)	OPN4	XP_001135445.1
Rattus norvegicus (Norway rat)	Opn4	NP_620215.1
Gallus gallus (chicken)	OPN4	NP_001038118.1
Drosophila melanogaster (fruit fly)	ninaE	NP_524407.1
	OPN4	XP_001088248.2
Xenopus tropicalis (tropical clawed frog)	LOC100491785	XP_002937616.1
Canis lupus familiaris (dog)	OPN4	XP_005619497.1
Bos taurus (cattle)	OPN4	NP_001179328.1
Mus musculus (house mouse)	Opn4	NP_001122071.1
Drosophila melanogaster (fruit fly)	Rh2	NP_524398.1

Gene Ontology
Bibliography

Related articles in PubMed

Seeing the light to change colour: An evolutionary perspective on the role of melanopsin in neuroendocrine circuits regulating light-mediated skin pigmentation.
Bertolesi GE, McFarlane S
Pigment cell & melanoma research(2017 Dec)

The distribution of melanopsin (OPN4) protein in the human brain.
Nissil? JS, M?ntt?ri SK, S?rkioja TT, Tuominen HJ, Takala TE, Kiviniemi VJ, Sormunen RT, Saarela SY, Timonen MJ
Chronobiology international34(1)37-44(2017)

Individual Differences in Sleep Timing Relate to Melanopsin-Based Phototransduction in Healthy Adolescents and Young Adults.
van der Meijden WP, Van Someren JL, Te Lindert BH, Bruijel J, van Oosterhout F, Coppens JE, Kalsbeek A, Cajochen C, Bourgin P, Van Someren EJ
Sleep39(6)1305-10(2016 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The wide distribution of OPN4 in central areas of the human brain evokes a question whether ambient light has important straight targets in the human brain outside the retinohypothalamic tract.
Title: The distribution of melanopsin (OPN4) protein in the human brain.

Trait-like individual differences in the melanopsin phototransduction circuitry contribute to individual differences in sleep timing. Blue light-sensitive young individuals are more prone to delayed sleep.
Title: Individual Differences in Sleep Timing Relate to Melanopsin-Based Phototransduction in Healthy Adolescents and Young Adults.

By broadening the tuning of intrinsically photosensitive retinal ganglion cells, melanopsin tristability produces signal integration.
Title: Melanopsin tristability for sustained and broadband phototransduction.

The response of the human pupil to the separate stimulation of the cones and melanopsin at a range of temporal frequencies under photopic conditions, was measured.
Title: Opponent melanopsin and S-cone signals in the human pupillary light response.

The light-induced FOS response in melanopsin expressing HEK-293 cells is correlated with melanopsin quantity and dependent on light duration and irradiance.
Title: The light-induced FOS response in melanopsin expressing HEK-293 cells is correlated with melanopsin quantity and dependent on light duration and irradiance.

The following OPN4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OPN4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25839	NM_001030015.2 Latest version!	Homo sapiens opsin 4 (OPN4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu25917	NM_033282.4 Latest version!	Homo sapiens opsin 4 (OPN4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu91835	XM_017016957.1 Latest version!	Homo sapiens opsin 4 (OPN4), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu91833	XM_017016955.1 Latest version!	Homo sapiens opsin 4 (OPN4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu91834	XM_017016956.1 Latest version!	Homo sapiens opsin 4 (OPN4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu25917	NM_033282.3	Homo sapiens opsin 4 (OPN4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OPN4 ( NM_001030015.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001025186.1 Homo sapiens opsin 4 (OPN4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu25839
Clone ID Related Accession (Same CDS sequence)	NM_001030015.2
Accession Version	NM_001030015.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1470bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	melanopsin isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD634966.1, CD634974.1, BC113558.1, AC067750.5 and BM672338.1. On Jan 10, 2007 this sequence version replaced NM_001030015.1. Transcript Variant: This variant (2) includes an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a longer protein (isoform 2) compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.76972.1, SRR1660803.130259.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743 [ECO:0000348] ##Evidence-Data-END##

ATGAACCCTC CTTCGGGGCC AAGAGTCCCG CCCAGCCCAA CCCAAGAGCC CAGCTGCATG 
GCCACCCCAG CACCACCCAG CTGGTGGGAC AGCTCCCAGA GCAGCATCTC CAGCCTGGGC 
CGGCTTCCAT CCATCAGTCC CACAGCACCT GGGACTTGGG CTGCTGCCTG GGTCCCCCTC 
CCCACGGTTG ATGTTCCAGA CCATGCCCAC TATACCCTGG GCACAGTGAT CTTGCTGGTG 
GGACTCACGG GGATGCTGGG CAACCTGACG GTCATCTATA CCTTCTGCAG AGCTGTGCTT 
CGTGGAGTCA CTGTGATGAT GCAGAGCAGA AGCCTCCGGA CACCTGCCAA CATGTTCATT 
ATCAACCTCG CGGTCAGCGA CTTCCTCATG TCCTTCACCC AGGCCCCTGT CTTCTTCACC 
AGTAGCCTCT ATAAGCAGTG GCTCTTTGGG GAGACAGGCT GCGAGTTCTA TGCCTTCTGT 
GGAGCTCTCT TTGGCATTTC CTCCATGATC ACCCTGACGG CCATCGCCCT GGACCGCTAC 
CTGGTAATCA CACGCCCGCT GGCCACCTTT GGTGTGGCGT CCAAGAGGCG TGCGGCATTT 
GTCCTGCTGG GCGTTTGGCT CTATGCCCTG GCCTGGAGTC TGCCACCCTT CTTCGGCTGG 
AGCGCCTACG TGCCCGAGGG GTTGCTGACA TCCTGCTCCT GGGACTACAT GAGCTTCACG 
CCGGCCGTGC GTGCCTACAC CATGCTTCTC TGCTGCTTCG TGTTCTTCCT CCCTCTGCTT 
ATCATCATCT ACTGCTACAT CTTCATCTTC AGGGCCATCC GGGAGACAGG ACGGGCTCTC 
CAGACCTTCG GGGCCTGCAA GGGCAATGGC GAGTCCCTGT GGCAGCGGCA GCGGCTGCAG 
AGCGAGTGCA AGATGGCCAA GATCATGCTG CTGGTCATCC TCCTCTTCGT GCTCTCCTGG 
GCTCCCTATT CCGCTGTGGC CCTGGTGGCC TTTGCTGGGT ACGCACACGT CCTGACACCC 
TACATGAGCT CGGTGCCAGC CGTCATCGCC AAGGCCTCTG CAATCCACAA CCCCATCATT 
TACGCCATCA CCCACCCCAA GTACAGGGTG GCCATTGCCC AGCACCTGCC CTGCCTGGGG 
GTGCTGCTGG GTGTATCACG CCGGCACAGT CGCCCCTACC CCAGCTACCG CTCCACCCAC 
CGCTCCACGC TGACCAGCCA CACCTCCAAC CTCAGCTGGA TCTCCATACG GAGGCGCCAG 
GAGTCCCTGG GCTCGGAGAG TGAGGTGGGC TGGACACACA TGGAGGCAGC AGCTGTGTGG 
GGAGCTGCCC AGCAAGCAAA TGGGCGGTCC CTCTACGGTC AGGGTCTGGA GGACTTGGAA 
GCCAAGGCAC CCCCCAGACC CCAGGGACAC GAAGCAGAGA CTCCAGGGAA GACCAAGGGG 
CTGATCCCCA GCCAGGACCC CAGGATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025186.1
CDS	228..1697
Translation	MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPTAPGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRAVLRGVTVMMQSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGRALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGSESEVGWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGKTKGLIPSQDPRM

Target ORF information:

RefSeq Version	NM_001030015.2
Organism	Homo sapiens(human)
Definition	Homo sapiens opsin 4 (OPN4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001030015.2

ORF Insert Sequence:

ATGAACCCTC CTTCGGGGCC AAGAGTCCCG CCCAGCCCAA CCCAAGAGCC CAGCTGCATG 
GCCACCCCAG CACCACCCAG CTGGTGGGAC AGCTCCCAGA GCAGCATCTC CAGCCTGGGC 
CGGCTTCCAT CCATCAGTCC CACAGCACCT GGGACTTGGG CTGCTGCCTG GGTCCCCCTC 
CCCACGGTTG ATGTTCCAGA CCATGCCCAC TATACCCTGG GCACAGTGAT CTTGCTGGTG 
GGACTCACGG GGATGCTGGG CAACCTGACG GTCATCTATA CCTTCTGCAG AGCTGTGCTT 
CGTGGAGTCA CTGTGATGAT GCAGAGCAGA AGCCTCCGGA CACCTGCCAA CATGTTCATT 
ATCAACCTCG CGGTCAGCGA CTTCCTCATG TCCTTCACCC AGGCCCCTGT CTTCTTCACC 
AGTAGCCTCT ATAAGCAGTG GCTCTTTGGG GAGACAGGCT GCGAGTTCTA TGCCTTCTGT 
GGAGCTCTCT TTGGCATTTC CTCCATGATC ACCCTGACGG CCATCGCCCT GGACCGCTAC 
CTGGTAATCA CACGCCCGCT GGCCACCTTT GGTGTGGCGT CCAAGAGGCG TGCGGCATTT 
GTCCTGCTGG GCGTTTGGCT CTATGCCCTG GCCTGGAGTC TGCCACCCTT CTTCGGCTGG 
AGCGCCTACG TGCCCGAGGG GTTGCTGACA TCCTGCTCCT GGGACTACAT GAGCTTCACG 
CCGGCCGTGC GTGCCTACAC CATGCTTCTC TGCTGCTTCG TGTTCTTCCT CCCTCTGCTT 
ATCATCATCT ACTGCTACAT CTTCATCTTC AGGGCCATCC GGGAGACAGG ACGGGCTCTC 
CAGACCTTCG GGGCCTGCAA GGGCAATGGC GAGTCCCTGT GGCAGCGGCA GCGGCTGCAG 
AGCGAGTGCA AGATGGCCAA GATCATGCTG CTGGTCATCC TCCTCTTCGT GCTCTCCTGG 
GCTCCCTATT CCGCTGTGGC CCTGGTGGCC TTTGCTGGGT ACGCACACGT CCTGACACCC 
TACATGAGCT CGGTGCCAGC CGTCATCGCC AAGGCCTCTG CAATCCACAA CCCCATCATT 
TACGCCATCA CCCACCCCAA GTACAGGGTG GCCATTGCCC AGCACCTGCC CTGCCTGGGG 
GTGCTGCTGG GTGTATCACG CCGGCACAGT CGCCCCTACC CCAGCTACCG CTCCACCCAC 
CGCTCCACGC TGACCAGCCA CACCTCCAAC CTCAGCTGGA TCTCCATACG GAGGCGCCAG 
GAGTCCCTGG GCTCGGAGAG TGAGGTGGGC TGGACACACA TGGAGGCAGC AGCTGTGTGG 
GGAGCTGCCC AGCAAGCAAA TGGGCGGTCC CTCTACGGTC AGGGTCTGGA GGACTTGGAA 
GCCAAGGCAC CCCCCAGACC CCAGGGACAC GAAGCAGAGA CTCCAGGGAA GACCAAGGGG 
CTGATCCCCA GCCAGGACCC CAGGATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPN4 ( NM_033282.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_150598.1 Homo sapiens opsin 4 (OPN4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25917
Clone ID Related Accession (Same CDS sequence)	NM_033282.3 , NM_033282.4
Accession Version	NM_033282.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	melanopsin isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD634966.1, BC113558.1, AC067750.5 and BM672338.1. On Jan 10, 2007 this sequence version replaced NM_033282.2. Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.159498.1, BC113558.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END##

ATGAACCCTC CTTCGGGGCC AAGAGTCCCG CCCAGCCCAA CCCAAGAGCC CAGCTGCATG 
GCCACCCCAG CACCACCCAG CTGGTGGGAC AGCTCCCAGA GCAGCATCTC CAGCCTGGGC 
CGGCTTCCAT CCATCAGTCC CACAGCACCT GGGACTTGGG CTGCTGCCTG GGTCCCCCTC 
CCCACGGTTG ATGTTCCAGA CCATGCCCAC TATACCCTGG GCACAGTGAT CTTGCTGGTG 
GGACTCACGG GGATGCTGGG CAACCTGACG GTCATCTATA CCTTCTGCAG GAGCAGAAGC 
CTCCGGACAC CTGCCAACAT GTTCATTATC AACCTCGCGG TCAGCGACTT CCTCATGTCC 
TTCACCCAGG CCCCTGTCTT CTTCACCAGT AGCCTCTATA AGCAGTGGCT CTTTGGGGAG 
ACAGGCTGCG AGTTCTATGC CTTCTGTGGA GCTCTCTTTG GCATTTCCTC CATGATCACC 
CTGACGGCCA TCGCCCTGGA CCGCTACCTG GTAATCACAC GCCCGCTGGC CACCTTTGGT 
GTGGCGTCCA AGAGGCGTGC GGCATTTGTC CTGCTGGGCG TTTGGCTCTA TGCCCTGGCC 
TGGAGTCTGC CACCCTTCTT CGGCTGGAGC GCCTACGTGC CCGAGGGGTT GCTGACATCC 
TGCTCCTGGG ACTACATGAG CTTCACGCCG GCCGTGCGTG CCTACACCAT GCTTCTCTGC 
TGCTTCGTGT TCTTCCTCCC TCTGCTTATC ATCATCTACT GCTACATCTT CATCTTCAGG 
GCCATCCGGG AGACAGGACG GGCTCTCCAG ACCTTCGGGG CCTGCAAGGG CAATGGCGAG 
TCCCTGTGGC AGCGGCAGCG GCTGCAGAGC GAGTGCAAGA TGGCCAAGAT CATGCTGCTG 
GTCATCCTCC TCTTCGTGCT CTCCTGGGCT CCCTATTCCG CTGTGGCCCT GGTGGCCTTT 
GCTGGGTACG CACACGTCCT GACACCCTAC ATGAGCTCGG TGCCAGCCGT CATCGCCAAG 
GCCTCTGCAA TCCACAACCC CATCATTTAC GCCATCACCC ACCCCAAGTA CAGGGTGGCC 
ATTGCCCAGC ACCTGCCCTG CCTGGGGGTG CTGCTGGGTG TATCACGCCG GCACAGTCGC 
CCCTACCCCA GCTACCGCTC CACCCACCGC TCCACGCTGA CCAGCCACAC CTCCAACCTC 
AGCTGGATCT CCATACGGAG GCGCCAGGAG TCCCTGGGCT CGGAGAGTGA GGTGGGCTGG 
ACACACATGG AGGCAGCAGC TGTGTGGGGA GCTGCCCAGC AAGCAAATGG GCGGTCCCTC 
TACGGTCAGG GTCTGGAGGA CTTGGAAGCC AAGGCACCCC CCAGACCCCA GGGACACGAA 
GCAGAGACTC CAGGGAAGAC CAAGGGGCTG ATCCCCAGCC AGGACCCCAG GATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_150598.1
CDS	228..1664
Translation	MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPTAPGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGRALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGSESEVGWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGKTKGLIPSQDPRM

Target ORF information:

RefSeq Version	NM_033282.3
Organism	Homo sapiens(human)
Definition	Homo sapiens opsin 4 (OPN4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033282.3

ORF Insert Sequence:

ATGAACCCTC CTTCGGGGCC AAGAGTCCCG CCCAGCCCAA CCCAAGAGCC CAGCTGCATG 
GCCACCCCAG CACCACCCAG CTGGTGGGAC AGCTCCCAGA GCAGCATCTC CAGCCTGGGC 
CGGCTTCCAT CCATCAGTCC CACAGCACCT GGGACTTGGG CTGCTGCCTG GGTCCCCCTC 
CCCACGGTTG ATGTTCCAGA CCATGCCCAC TATACCCTGG GCACAGTGAT CTTGCTGGTG 
GGACTCACGG GGATGCTGGG CAACCTGACG GTCATCTATA CCTTCTGCAG GAGCAGAAGC 
CTCCGGACAC CTGCCAACAT GTTCATTATC AACCTCGCGG TCAGCGACTT CCTCATGTCC 
TTCACCCAGG CCCCTGTCTT CTTCACCAGT AGCCTCTATA AGCAGTGGCT CTTTGGGGAG 
ACAGGCTGCG AGTTCTATGC CTTCTGTGGA GCTCTCTTTG GCATTTCCTC CATGATCACC 
CTGACGGCCA TCGCCCTGGA CCGCTACCTG GTAATCACAC GCCCGCTGGC CACCTTTGGT 
GTGGCGTCCA AGAGGCGTGC GGCATTTGTC CTGCTGGGCG TTTGGCTCTA TGCCCTGGCC 
TGGAGTCTGC CACCCTTCTT CGGCTGGAGC GCCTACGTGC CCGAGGGGTT GCTGACATCC 
TGCTCCTGGG ACTACATGAG CTTCACGCCG GCCGTGCGTG CCTACACCAT GCTTCTCTGC 
TGCTTCGTGT TCTTCCTCCC TCTGCTTATC ATCATCTACT GCTACATCTT CATCTTCAGG 
GCCATCCGGG AGACAGGACG GGCTCTCCAG ACCTTCGGGG CCTGCAAGGG CAATGGCGAG 
TCCCTGTGGC AGCGGCAGCG GCTGCAGAGC GAGTGCAAGA TGGCCAAGAT CATGCTGCTG 
GTCATCCTCC TCTTCGTGCT CTCCTGGGCT CCCTATTCCG CTGTGGCCCT GGTGGCCTTT 
GCTGGGTACG CACACGTCCT GACACCCTAC ATGAGCTCGG TGCCAGCCGT CATCGCCAAG 
GCCTCTGCAA TCCACAACCC CATCATTTAC GCCATCACCC ACCCCAAGTA CAGGGTGGCC 
ATTGCCCAGC ACCTGCCCTG CCTGGGGGTG CTGCTGGGTG TATCACGCCG GCACAGTCGC 
CCCTACCCCA GCTACCGCTC CACCCACCGC TCCACGCTGA CCAGCCACAC CTCCAACCTC 
AGCTGGATCT CCATACGGAG GCGCCAGGAG TCCCTGGGCT CGGAGAGTGA GGTGGGCTGG 
ACACACATGG AGGCAGCAGC TGTGTGGGGA GCTGCCCAGC AAGCAAATGG GCGGTCCCTC 
TACGGTCAGG GTCTGGAGGA CTTGGAAGCC AAGGCACCCC CCAGACCCCA GGGACACGAA 
GCAGAGACTC CAGGGAAGAC CAAGGGGCTG ATCCCCAGCC AGGACCCCAG GATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPN4 ( NM_033282.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_150598.1 Homo sapiens opsin 4 (OPN4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25917
Clone ID Related Accession (Same CDS sequence)	NM_033282.3 , NM_033282.4
Accession Version	NM_033282.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	melanopsin isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC067750.5, CD634966.1, BC113558.1 and BM672338.1. On Nov 22, 2018 this sequence version replaced NM_033282.3. Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.159498.1, BC113558.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000241891.10/ ENSP00000241891.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACCCTC CTTCGGGGCC AAGAGTCCCG CCCAGCCCAA CCCAAGAGCC CAGCTGCATG 
GCCACCCCAG CACCACCCAG CTGGTGGGAC AGCTCCCAGA GCAGCATCTC CAGCCTGGGC 
CGGCTTCCAT CCATCAGTCC CACAGCACCT GGGACTTGGG CTGCTGCCTG GGTCCCCCTC 
CCCACGGTTG ATGTTCCAGA CCATGCCCAC TATACCCTGG GCACAGTGAT CTTGCTGGTG 
GGACTCACGG GGATGCTGGG CAACCTGACG GTCATCTATA CCTTCTGCAG GAGCAGAAGC 
CTCCGGACAC CTGCCAACAT GTTCATTATC AACCTCGCGG TCAGCGACTT CCTCATGTCC 
TTCACCCAGG CCCCTGTCTT CTTCACCAGT AGCCTCTATA AGCAGTGGCT CTTTGGGGAG 
ACAGGCTGCG AGTTCTATGC CTTCTGTGGA GCTCTCTTTG GCATTTCCTC CATGATCACC 
CTGACGGCCA TCGCCCTGGA CCGCTACCTG GTAATCACAC GCCCGCTGGC CACCTTTGGT 
GTGGCGTCCA AGAGGCGTGC GGCATTTGTC CTGCTGGGCG TTTGGCTCTA TGCCCTGGCC 
TGGAGTCTGC CACCCTTCTT CGGCTGGAGC GCCTACGTGC CCGAGGGGTT GCTGACATCC 
TGCTCCTGGG ACTACATGAG CTTCACGCCG GCCGTGCGTG CCTACACCAT GCTTCTCTGC 
TGCTTCGTGT TCTTCCTCCC TCTGCTTATC ATCATCTACT GCTACATCTT CATCTTCAGG 
GCCATCCGGG AGACAGGACG GGCTCTCCAG ACCTTCGGGG CCTGCAAGGG CAATGGCGAG 
TCCCTGTGGC AGCGGCAGCG GCTGCAGAGC GAGTGCAAGA TGGCCAAGAT CATGCTGCTG 
GTCATCCTCC TCTTCGTGCT CTCCTGGGCT CCCTATTCCG CTGTGGCCCT GGTGGCCTTT 
GCTGGGTACG CACACGTCCT GACACCCTAC ATGAGCTCGG TGCCAGCCGT CATCGCCAAG 
GCCTCTGCAA TCCACAACCC CATCATTTAC GCCATCACCC ACCCCAAGTA CAGGGTGGCC 
ATTGCCCAGC ACCTGCCCTG CCTGGGGGTG CTGCTGGGTG TATCACGCCG GCACAGTCGC 
CCCTACCCCA GCTACCGCTC CACCCACCGC TCCACGCTGA CCAGCCACAC CTCCAACCTC 
AGCTGGATCT CCATACGGAG GCGCCAGGAG TCCCTGGGCT CGGAGAGTGA GGTGGGCTGG 
ACACACATGG AGGCAGCAGC TGTGTGGGGA GCTGCCCAGC AAGCAAATGG GCGGTCCCTC 
TACGGTCAGG GTCTGGAGGA CTTGGAAGCC AAGGCACCCC CCAGACCCCA GGGACACGAA 
GCAGAGACTC CAGGGAAGAC CAAGGGGCTG ATCCCCAGCC AGGACCCCAG GATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_150598.1
CDS	238..1674
Translation	MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPTAPGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGRALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGSESEVGWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGKTKGLIPSQDPRM

Target ORF information:

RefSeq Version	NM_033282.4
Organism	Homo sapiens(human)
Definition	Homo sapiens opsin 4 (OPN4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033282.4

ORF Insert Sequence:

ATGAACCCTC CTTCGGGGCC AAGAGTCCCG CCCAGCCCAA CCCAAGAGCC CAGCTGCATG 
GCCACCCCAG CACCACCCAG CTGGTGGGAC AGCTCCCAGA GCAGCATCTC CAGCCTGGGC 
CGGCTTCCAT CCATCAGTCC CACAGCACCT GGGACTTGGG CTGCTGCCTG GGTCCCCCTC 
CCCACGGTTG ATGTTCCAGA CCATGCCCAC TATACCCTGG GCACAGTGAT CTTGCTGGTG 
GGACTCACGG GGATGCTGGG CAACCTGACG GTCATCTATA CCTTCTGCAG GAGCAGAAGC 
CTCCGGACAC CTGCCAACAT GTTCATTATC AACCTCGCGG TCAGCGACTT CCTCATGTCC 
TTCACCCAGG CCCCTGTCTT CTTCACCAGT AGCCTCTATA AGCAGTGGCT CTTTGGGGAG 
ACAGGCTGCG AGTTCTATGC CTTCTGTGGA GCTCTCTTTG GCATTTCCTC CATGATCACC 
CTGACGGCCA TCGCCCTGGA CCGCTACCTG GTAATCACAC GCCCGCTGGC CACCTTTGGT 
GTGGCGTCCA AGAGGCGTGC GGCATTTGTC CTGCTGGGCG TTTGGCTCTA TGCCCTGGCC 
TGGAGTCTGC CACCCTTCTT CGGCTGGAGC GCCTACGTGC CCGAGGGGTT GCTGACATCC 
TGCTCCTGGG ACTACATGAG CTTCACGCCG GCCGTGCGTG CCTACACCAT GCTTCTCTGC 
TGCTTCGTGT TCTTCCTCCC TCTGCTTATC ATCATCTACT GCTACATCTT CATCTTCAGG 
GCCATCCGGG AGACAGGACG GGCTCTCCAG ACCTTCGGGG CCTGCAAGGG CAATGGCGAG 
TCCCTGTGGC AGCGGCAGCG GCTGCAGAGC GAGTGCAAGA TGGCCAAGAT CATGCTGCTG 
GTCATCCTCC TCTTCGTGCT CTCCTGGGCT CCCTATTCCG CTGTGGCCCT GGTGGCCTTT 
GCTGGGTACG CACACGTCCT GACACCCTAC ATGAGCTCGG TGCCAGCCGT CATCGCCAAG 
GCCTCTGCAA TCCACAACCC CATCATTTAC GCCATCACCC ACCCCAAGTA CAGGGTGGCC 
ATTGCCCAGC ACCTGCCCTG CCTGGGGGTG CTGCTGGGTG TATCACGCCG GCACAGTCGC 
CCCTACCCCA GCTACCGCTC CACCCACCGC TCCACGCTGA CCAGCCACAC CTCCAACCTC 
AGCTGGATCT CCATACGGAG GCGCCAGGAG TCCCTGGGCT CGGAGAGTGA GGTGGGCTGG 
ACACACATGG AGGCAGCAGC TGTGTGGGGA GCTGCCCAGC AAGCAAATGG GCGGTCCCTC 
TACGGTCAGG GTCTGGAGGA CTTGGAAGCC AAGGCACCCC CCAGACCCCA GGGACACGAA 
GCAGAGACTC CAGGGAAGAC CAAGGGGCTG ATCCCCAGCC AGGACCCCAG GATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPN4 ( XM_017016957.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016872446.1 Homo sapiens opsin 4 (OPN4), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu91835
Clone ID Related Accession (Same CDS sequence)	XM_017016957.1
Accession Version	XM_017016957.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1218bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	melanopsin isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGGGCA ACCTGACGGT CATCTATACC TTCTGCAGAG CTGTGCTTCG TGGAGTCACT 
GTGATGATGC AGAGCAGAAG CCTCCGGACA CCTGCCAACA TGTTCATTAT CAACCTCGCG 
GTCAGCGACT TCCTCATGTC CTTCACCCAG GCCCCTGTCT TCTTCACCAG TAGCCTCTAT 
AAGCAGTGGC TCTTTGGGGA GACAGGCTGC GAGTTCTATG CCTTCTGTGG AGCTCTCTTT 
GGCATTTCCT CCATGATCAC CCTGACGGCC ATCGCCCTGG ACCGCTACCT GGTAATCACA 
CGCCCGCTGG CCACCTTTGG TGTGGCGTCC AAGAGGCGTG CGGCATTTGT CCTGCTGGGC 
GTTTGGCTCT ATGCCCTGGC CTGGAGTCTG CCACCCTTCT TCGGCTGGAG CGCCTACGTG 
CCCGAGGGGT TGCTGACATC CTGCTCCTGG GACTACATGA GCTTCACGCC GGCCGTGCGT 
GCCTACACCA TGCTTCTCTG CTGCTTCGTG TTCTTCCTCC CTCTGCTTAT CATCATCTAC 
TGCTACATCT TCATCTTCAG GGCCATCCGG GAGACAGGAC GGGCTCTCCA GACCTTCGGG 
GCCTGCAAGG GCAATGGCGA GTCCCTGTGG CAGCGGCAGC GGCTGCAGAG CGAGTGCAAG 
ATGGCCAAGA TCATGCTGCT GGTCATCCTC CTCTTCGTGC TCTCCTGGGC TCCCTATTCC 
GCTGTGGCCC TGGTGGCCTT TGCTGGGTAC GCACACGTCC TGACACCCTA CATGAGCTCG 
GTGCCAGCCG TCATCGCCAA GGCCTCTGCA ATCCACAACC CCATCATTTA CGCCATCACC 
CACCCCAAGT ACAGGGTGGC CATTGCCCAG CACCTGCCCT GCCTGGGGGT GCTGCTGGGT 
GTATCACGCC GGCACAGTCG CCCCTACCCC AGCTACCGCT CCACCCACCG CTCCACGCTG 
ACCAGCCACA CCTCCAACCT CAGCTGGATC TCCATACGGA GGCGCCAGGA GTCCCTGGGC 
TCGGAGAGTG AGGTGGGCTG GACACACATG GAGGCAGCAG CTGTGTGGGG AGCTGCCCAG 
CAAGCAAATG GGCGGTCCCT CTACGGTCAG GGTCTGGAGG ACTTGGAAGC CAAGGCACCC 
CCCAGACCCC AGGGACACGA AGCAGAGACT CCAGGGAAGA CCAAGGGGCT GATCCCCAGC 
CAGGACCCCA GGATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016872446.1
CDS	1277..2494
Translation	MLGNLTVIYTFCRAVLRGVTVMMQSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGRALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGSESEVGWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGKTKGLIPSQDPRM

Target ORF information:

RefSeq Version	XM_017016957.1
Organism	Homo sapiens(human)
Definition	Homo sapiens opsin 4 (OPN4), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017016957.1

ORF Insert Sequence:

ATGCTGGGCA ACCTGACGGT CATCTATACC TTCTGCAGAG CTGTGCTTCG TGGAGTCACT 
GTGATGATGC AGAGCAGAAG CCTCCGGACA CCTGCCAACA TGTTCATTAT CAACCTCGCG 
GTCAGCGACT TCCTCATGTC CTTCACCCAG GCCCCTGTCT TCTTCACCAG TAGCCTCTAT 
AAGCAGTGGC TCTTTGGGGA GACAGGCTGC GAGTTCTATG CCTTCTGTGG AGCTCTCTTT 
GGCATTTCCT CCATGATCAC CCTGACGGCC ATCGCCCTGG ACCGCTACCT GGTAATCACA 
CGCCCGCTGG CCACCTTTGG TGTGGCGTCC AAGAGGCGTG CGGCATTTGT CCTGCTGGGC 
GTTTGGCTCT ATGCCCTGGC CTGGAGTCTG CCACCCTTCT TCGGCTGGAG CGCCTACGTG 
CCCGAGGGGT TGCTGACATC CTGCTCCTGG GACTACATGA GCTTCACGCC GGCCGTGCGT 
GCCTACACCA TGCTTCTCTG CTGCTTCGTG TTCTTCCTCC CTCTGCTTAT CATCATCTAC 
TGCTACATCT TCATCTTCAG GGCCATCCGG GAGACAGGAC GGGCTCTCCA GACCTTCGGG 
GCCTGCAAGG GCAATGGCGA GTCCCTGTGG CAGCGGCAGC GGCTGCAGAG CGAGTGCAAG 
ATGGCCAAGA TCATGCTGCT GGTCATCCTC CTCTTCGTGC TCTCCTGGGC TCCCTATTCC 
GCTGTGGCCC TGGTGGCCTT TGCTGGGTAC GCACACGTCC TGACACCCTA CATGAGCTCG 
GTGCCAGCCG TCATCGCCAA GGCCTCTGCA ATCCACAACC CCATCATTTA CGCCATCACC 
CACCCCAAGT ACAGGGTGGC CATTGCCCAG CACCTGCCCT GCCTGGGGGT GCTGCTGGGT 
GTATCACGCC GGCACAGTCG CCCCTACCCC AGCTACCGCT CCACCCACCG CTCCACGCTG 
ACCAGCCACA CCTCCAACCT CAGCTGGATC TCCATACGGA GGCGCCAGGA GTCCCTGGGC 
TCGGAGAGTG AGGTGGGCTG GACACACATG GAGGCAGCAG CTGTGTGGGG AGCTGCCCAG 
CAAGCAAATG GGCGGTCCCT CTACGGTCAG GGTCTGGAGG ACTTGGAAGC CAAGGCACCC 
CCCAGACCCC AGGGACACGA AGCAGAGACT CCAGGGAAGA CCAAGGGGCT GATCCCCAGC 
CAGGACCCCA GGATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPN4 ( XM_017016955.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016872444.1 Homo sapiens opsin 4 (OPN4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu91833
Clone ID Related Accession (Same CDS sequence)	XM_017016955.1
Accession Version	XM_017016955.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1620bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	melanopsin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCCTC CTTCGGGGCC AAGAGTCCCG CCCAGCCCAA CCCAAGAGCC CAGCTGCATG 
GCCACCCCAG CACCACCCAG CTGGTGGGAC AGCTCCCAGA GCAGCATCTC CAGCCTGGGC 
CGGCTTCCAT CCATCAGTCC CACAGCACCT GGGACTTGGG CTGCTGCCTG GGTCCCCCTC 
CCCACGGTTG ATGTTCCAGA CCATGCCCAC TATACCCTGG GCACAGTGAT CTTGCTGGTG 
GGACTCACGG GGATGCTGGG CAACCTGACG GTCATCTATA CCTTCTGCAG AGCTGTGCTT 
CGTGGAGTCA CTGTGATGAT GCAGAGCAGA AGCCTCCGGA CACCTGCCAA CATGTTCATT 
ATCAACCTCG CGGTCAGCGA CTTCCTCATG TCCTTCACCC AGGCCCCTGT CTTCTTCACC 
AGTAGCCTCT ATAAGCAGTG GCTCTTTGGG GAGACAGGCT GCGAGTTCTA TGCCTTCTGT 
GGAGCTCTCT TTGGCATTTC CTCCATGATC ACCCTGACGG CCATCGCCCT GGACCGCTAC 
CTGGTAATCA CACGCCCGCT GGCCACCTTT GGTGTGGCGT CCAAGAGGCG TGCGGCATTT 
GTCCTGCTGG GCGTTTGGCT CTATGCCCTG GCCTGGAGTC TGCCACCCTT CTTCGGCTGG 
AGCGCCTACG TGCCCGAGGG GTTGCTGACA TCCTGCTCCT GGGACTACAT GAGCTTCACG 
CCGGCCGTGC GTGCCTACAC CATGCTTCTC TGCTGCTTCG TGTTCTTCCT CCCTCTGCTT 
ATCATCATCT ACTGCTACAT CTTCATCTTC AGGGCCATCC GGGAGACAGG ACGGGCTCTC 
CAGACCTTCG GGGCCTGCAA GGGCAATGGC GAGTCCCTGT GGCAGCGGCA GCGGCTGCAG 
AGCGAGTGCA AGATGGCCAA GATCATGCTG CTGGTCATCC TCCTCTTCGT GCTCTCCTGG 
GCTCCCTATT CCGCTGTGGC CCTGGTGGCC TTTGCTGGGT ACGCACACGT CCTGACACCC 
TACATGAGCT CGGTGCCAGC CGTCATCGCC AAGGCCTCTG CAATCCACAA CCCCATCATT 
TACGCCATCA CCCACCCCAA GTACAGGGTG GCCATTGCCC AGCACCTGCC CTGCCTGGGG 
GTGCTGCTGG GTGTATCACG CCGGCACAGT CGCCCCTACC CCAGCTACCG CTCCACCCAC 
CGCTCCACGC TGACCAGCCA CACCTCCAAC CTCAGCTGGA TCTCCATACG GAGGCGCCAG 
GAGTCCCTGG GCTCGGAGAG TGAGGTGGGC TGGACACACA TGGAGGCAGC AGCTGTGTGG 
GGAGCTGCCC AGCAAGCAAA TGGGCGGTCC CTCTACGGTC AGGGTCTGGA GGACTTGGAA 
GCCAAGGCAC CCCCCAGACC CCAGGGACAC GAAGCAGAGA CTCCAGGGAA GGTGACTGGG 
CCCGGTACCT GCCAATCCAC AAAGGGGTGG GGGTTAGGGG CCAGTAGCCC AGGGAGAGGC 
CAGGAAAGAG AGACTTGTTC TCATGGGCAG GGGCGATATC CTCCAGGAAT CACCTGCTCC 
CAGCACCTCC CAGCTTTTCC TTGTCTGCCT GGGGTTCTCT GTGACTCTGA GATGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016872444.1
CDS	1290..2909
Translation	MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPTAPGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRAVLRGVTVMMQSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGRALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGSESEVGWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGKVTGPGTCQSTKGWGLGASSPGRGQERETCSHGQGRYPPGITCSQHLPAFPCLPGVLCDSEML

Target ORF information:

RefSeq Version	XM_017016955.1
Organism	Homo sapiens(human)
Definition	Homo sapiens opsin 4 (OPN4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017016955.1

ORF Insert Sequence:

ATGAACCCTC CTTCGGGGCC AAGAGTCCCG CCCAGCCCAA CCCAAGAGCC CAGCTGCATG 
GCCACCCCAG CACCACCCAG CTGGTGGGAC AGCTCCCAGA GCAGCATCTC CAGCCTGGGC 
CGGCTTCCAT CCATCAGTCC CACAGCACCT GGGACTTGGG CTGCTGCCTG GGTCCCCCTC 
CCCACGGTTG ATGTTCCAGA CCATGCCCAC TATACCCTGG GCACAGTGAT CTTGCTGGTG 
GGACTCACGG GGATGCTGGG CAACCTGACG GTCATCTATA CCTTCTGCAG AGCTGTGCTT 
CGTGGAGTCA CTGTGATGAT GCAGAGCAGA AGCCTCCGGA CACCTGCCAA CATGTTCATT 
ATCAACCTCG CGGTCAGCGA CTTCCTCATG TCCTTCACCC AGGCCCCTGT CTTCTTCACC 
AGTAGCCTCT ATAAGCAGTG GCTCTTTGGG GAGACAGGCT GCGAGTTCTA TGCCTTCTGT 
GGAGCTCTCT TTGGCATTTC CTCCATGATC ACCCTGACGG CCATCGCCCT GGACCGCTAC 
CTGGTAATCA CACGCCCGCT GGCCACCTTT GGTGTGGCGT CCAAGAGGCG TGCGGCATTT 
GTCCTGCTGG GCGTTTGGCT CTATGCCCTG GCCTGGAGTC TGCCACCCTT CTTCGGCTGG 
AGCGCCTACG TGCCCGAGGG GTTGCTGACA TCCTGCTCCT GGGACTACAT GAGCTTCACG 
CCGGCCGTGC GTGCCTACAC CATGCTTCTC TGCTGCTTCG TGTTCTTCCT CCCTCTGCTT 
ATCATCATCT ACTGCTACAT CTTCATCTTC AGGGCCATCC GGGAGACAGG ACGGGCTCTC 
CAGACCTTCG GGGCCTGCAA GGGCAATGGC GAGTCCCTGT GGCAGCGGCA GCGGCTGCAG 
AGCGAGTGCA AGATGGCCAA GATCATGCTG CTGGTCATCC TCCTCTTCGT GCTCTCCTGG 
GCTCCCTATT CCGCTGTGGC CCTGGTGGCC TTTGCTGGGT ACGCACACGT CCTGACACCC 
TACATGAGCT CGGTGCCAGC CGTCATCGCC AAGGCCTCTG CAATCCACAA CCCCATCATT 
TACGCCATCA CCCACCCCAA GTACAGGGTG GCCATTGCCC AGCACCTGCC CTGCCTGGGG 
GTGCTGCTGG GTGTATCACG CCGGCACAGT CGCCCCTACC CCAGCTACCG CTCCACCCAC 
CGCTCCACGC TGACCAGCCA CACCTCCAAC CTCAGCTGGA TCTCCATACG GAGGCGCCAG 
GAGTCCCTGG GCTCGGAGAG TGAGGTGGGC TGGACACACA TGGAGGCAGC AGCTGTGTGG 
GGAGCTGCCC AGCAAGCAAA TGGGCGGTCC CTCTACGGTC AGGGTCTGGA GGACTTGGAA 
GCCAAGGCAC CCCCCAGACC CCAGGGACAC GAAGCAGAGA CTCCAGGGAA GGTGACTGGG 
CCCGGTACCT GCCAATCCAC AAAGGGGTGG GGGTTAGGGG CCAGTAGCCC AGGGAGAGGC 
CAGGAAAGAG AGACTTGTTC TCATGGGCAG GGGCGATATC CTCCAGGAAT CACCTGCTCC 
CAGCACCTCC CAGCTTTTCC TTGTCTGCCT GGGGTTCTCT GTGACTCTGA GATGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPN4 ( XM_017016956.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016872445.1 Homo sapiens opsin 4 (OPN4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu91834
Clone ID Related Accession (Same CDS sequence)	XM_017016956.1
Accession Version	XM_017016956.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1587bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	melanopsin isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCCTC CTTCGGGGCC AAGAGTCCCG CCCAGCCCAA CCCAAGAGCC CAGCTGCATG 
GCCACCCCAG CACCACCCAG CTGGTGGGAC AGCTCCCAGA GCAGCATCTC CAGCCTGGGC 
CGGCTTCCAT CCATCAGTCC CACAGCACCT GGGACTTGGG CTGCTGCCTG GGTCCCCCTC 
CCCACGGTTG ATGTTCCAGA CCATGCCCAC TATACCCTGG GCACAGTGAT CTTGCTGGTG 
GGACTCACGG GGATGCTGGG CAACCTGACG GTCATCTATA CCTTCTGCAG GAGCAGAAGC 
CTCCGGACAC CTGCCAACAT GTTCATTATC AACCTCGCGG TCAGCGACTT CCTCATGTCC 
TTCACCCAGG CCCCTGTCTT CTTCACCAGT AGCCTCTATA AGCAGTGGCT CTTTGGGGAG 
ACAGGCTGCG AGTTCTATGC CTTCTGTGGA GCTCTCTTTG GCATTTCCTC CATGATCACC 
CTGACGGCCA TCGCCCTGGA CCGCTACCTG GTAATCACAC GCCCGCTGGC CACCTTTGGT 
GTGGCGTCCA AGAGGCGTGC GGCATTTGTC CTGCTGGGCG TTTGGCTCTA TGCCCTGGCC 
TGGAGTCTGC CACCCTTCTT CGGCTGGAGC GCCTACGTGC CCGAGGGGTT GCTGACATCC 
TGCTCCTGGG ACTACATGAG CTTCACGCCG GCCGTGCGTG CCTACACCAT GCTTCTCTGC 
TGCTTCGTGT TCTTCCTCCC TCTGCTTATC ATCATCTACT GCTACATCTT CATCTTCAGG 
GCCATCCGGG AGACAGGACG GGCTCTCCAG ACCTTCGGGG CCTGCAAGGG CAATGGCGAG 
TCCCTGTGGC AGCGGCAGCG GCTGCAGAGC GAGTGCAAGA TGGCCAAGAT CATGCTGCTG 
GTCATCCTCC TCTTCGTGCT CTCCTGGGCT CCCTATTCCG CTGTGGCCCT GGTGGCCTTT 
GCTGGGTACG CACACGTCCT GACACCCTAC ATGAGCTCGG TGCCAGCCGT CATCGCCAAG 
GCCTCTGCAA TCCACAACCC CATCATTTAC GCCATCACCC ACCCCAAGTA CAGGGTGGCC 
ATTGCCCAGC ACCTGCCCTG CCTGGGGGTG CTGCTGGGTG TATCACGCCG GCACAGTCGC 
CCCTACCCCA GCTACCGCTC CACCCACCGC TCCACGCTGA CCAGCCACAC CTCCAACCTC 
AGCTGGATCT CCATACGGAG GCGCCAGGAG TCCCTGGGCT CGGAGAGTGA GGTGGGCTGG 
ACACACATGG AGGCAGCAGC TGTGTGGGGA GCTGCCCAGC AAGCAAATGG GCGGTCCCTC 
TACGGTCAGG GTCTGGAGGA CTTGGAAGCC AAGGCACCCC CCAGACCCCA GGGACACGAA 
GCAGAGACTC CAGGGAAGGT GACTGGGCCC GGTACCTGCC AATCCACAAA GGGGTGGGGG 
TTAGGGGCCA GTAGCCCAGG GAGAGGCCAG GAAAGAGAGA CTTGTTCTCA TGGGCAGGGG 
CGATATCCTC CAGGAATCAC CTGCTCCCAG CACCTCCCAG CTTTTCCTTG TCTGCCTGGG 
GTTCTCTGTG ACTCTGAGAT GCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016872445.1
CDS	1290..2876
Translation	MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPTAPGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGRALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGSESEVGWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGKVTGPGTCQSTKGWGLGASSPGRGQERETCSHGQGRYPPGITCSQHLPAFPCLPGVLCDSEML

Target ORF information:

RefSeq Version	XM_017016956.1
Organism	Homo sapiens(human)
Definition	Homo sapiens opsin 4 (OPN4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017016956.1

ORF Insert Sequence:

ATGAACCCTC CTTCGGGGCC AAGAGTCCCG CCCAGCCCAA CCCAAGAGCC CAGCTGCATG 
GCCACCCCAG CACCACCCAG CTGGTGGGAC AGCTCCCAGA GCAGCATCTC CAGCCTGGGC 
CGGCTTCCAT CCATCAGTCC CACAGCACCT GGGACTTGGG CTGCTGCCTG GGTCCCCCTC 
CCCACGGTTG ATGTTCCAGA CCATGCCCAC TATACCCTGG GCACAGTGAT CTTGCTGGTG 
GGACTCACGG GGATGCTGGG CAACCTGACG GTCATCTATA CCTTCTGCAG GAGCAGAAGC 
CTCCGGACAC CTGCCAACAT GTTCATTATC AACCTCGCGG TCAGCGACTT CCTCATGTCC 
TTCACCCAGG CCCCTGTCTT CTTCACCAGT AGCCTCTATA AGCAGTGGCT CTTTGGGGAG 
ACAGGCTGCG AGTTCTATGC CTTCTGTGGA GCTCTCTTTG GCATTTCCTC CATGATCACC 
CTGACGGCCA TCGCCCTGGA CCGCTACCTG GTAATCACAC GCCCGCTGGC CACCTTTGGT 
GTGGCGTCCA AGAGGCGTGC GGCATTTGTC CTGCTGGGCG TTTGGCTCTA TGCCCTGGCC 
TGGAGTCTGC CACCCTTCTT CGGCTGGAGC GCCTACGTGC CCGAGGGGTT GCTGACATCC 
TGCTCCTGGG ACTACATGAG CTTCACGCCG GCCGTGCGTG CCTACACCAT GCTTCTCTGC 
TGCTTCGTGT TCTTCCTCCC TCTGCTTATC ATCATCTACT GCTACATCTT CATCTTCAGG 
GCCATCCGGG AGACAGGACG GGCTCTCCAG ACCTTCGGGG CCTGCAAGGG CAATGGCGAG 
TCCCTGTGGC AGCGGCAGCG GCTGCAGAGC GAGTGCAAGA TGGCCAAGAT CATGCTGCTG 
GTCATCCTCC TCTTCGTGCT CTCCTGGGCT CCCTATTCCG CTGTGGCCCT GGTGGCCTTT 
GCTGGGTACG CACACGTCCT GACACCCTAC ATGAGCTCGG TGCCAGCCGT CATCGCCAAG 
GCCTCTGCAA TCCACAACCC CATCATTTAC GCCATCACCC ACCCCAAGTA CAGGGTGGCC 
ATTGCCCAGC ACCTGCCCTG CCTGGGGGTG CTGCTGGGTG TATCACGCCG GCACAGTCGC 
CCCTACCCCA GCTACCGCTC CACCCACCGC TCCACGCTGA CCAGCCACAC CTCCAACCTC 
AGCTGGATCT CCATACGGAG GCGCCAGGAG TCCCTGGGCT CGGAGAGTGA GGTGGGCTGG 
ACACACATGG AGGCAGCAGC TGTGTGGGGA GCTGCCCAGC AAGCAAATGG GCGGTCCCTC 
TACGGTCAGG GTCTGGAGGA CTTGGAAGCC AAGGCACCCC CCAGACCCCA GGGACACGAA 
GCAGAGACTC CAGGGAAGGT GACTGGGCCC GGTACCTGCC AATCCACAAA GGGGTGGGGG 
TTAGGGGCCA GTAGCCCAGG GAGAGGCCAG GAAAGAGAGA CTTGTTCTCA TGGGCAGGGG 
CGATATCCTC CAGGAATCAC CTGCTCCCAG CACCTCCCAG CTTTTCCTTG TCTGCCTGGG 
GTTCTCTGTG ACTCTGAGAT GCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Seeing the light to change colour: An evolutionary perspective on the role of melanopsin in neuroendocrine circuits regulating light-mediated skin pigmentation.
Pigment cell & melanoma research(2017 Dec)
Bertolesi GE,McFarlane S

The distribution of melanopsin (OPN4) protein in the human brain.
Chronobiology international34(1)37-44(2017)
Nissil? JS,M?ntt?ri SK,S?rkioja TT,Tuominen HJ,Takala TE,Kiviniemi VJ,Sormunen RT,Saarela SY,Timonen MJ

Individual Differences in Sleep Timing Relate to Melanopsin-Based Phototransduction in Healthy Adolescents and Young Adults.
Sleep39(6)1305-10(2016 06)
van der Meijden WP,Van Someren JL,Te Lindert BH,Bruijel J,van Oosterhout F,Coppens JE,Kalsbeek A,Cajochen C,Bourgin P,Van Someren EJ

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OPN4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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