HAND1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HAND1
Entrez Gene ID	9421
Full Name	heart and neural crest derivatives expressed 1
Synonyms	Hxt,Thing1,bHLHa27,eHand
General protein information	Preferred Names heart and neural crest derivatives expressed 1 Names heart- and neural crest derivatives-expressed protein 1 class A basic helix-loop-helix protein 27 extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q33.2
Summary	The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008].
Disorder MIM:	602406

mRNA and Protein(s)

mRNA	Protein	Name
NM_004821.2	NP_004812.1	heart- and neural crest derivatives-expressed protein 1
XM_005268531.1	XP_005268588.1	heart- and neural crest derivatives-expressed protein 1 isoform X1
NM_004821.3	NP_004812.1	heart- and neural crest derivatives-expressed protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	HAND1	NP_004812.1
Bos taurus (cattle)	HAND1	NP_001069229.1
Mus musculus (house mouse)	Hand1	NP_032239.1
Gallus gallus (chicken)	HAND1	NP_990296.1
	HAND1	XP_001111722.1
Xenopus tropicalis (tropical clawed frog)	hand1	NP_001016743.1
Pan troglodytes (chimpanzee)	HAND1	XP_518050.2
Rattus norvegicus (Norway rat)	Hand1	NP_067603.1
Drosophila melanogaster (fruit fly)	Hand	NP_609370.2

Gene Ontology
Bibliography

Related articles in PubMed

HAND1 Loss-of-Function Mutation Causes Tetralogy of Fallot.
Wang J, Hu XQ, Guo YH, Gu JY, Xu JH, Li YJ, Li N, Yang XX, Yang YQ
Pediatric cardiology38(3)547-557(2017 Mar)

HAND1 loss-of-function mutation contributes to congenital double outlet right ventricle.
Li L, Wang J, Liu XY, Liu H, Shi HY, Yang XX, Li N, Li YJ, Huang RT, Xue S, Qiu XB, Yang YQ
International journal of molecular medicine39(3)711-718(2017 Mar)

Hand1 overexpression inhibits medulloblastoma metastasis.
Asuthkar S, Guda MR, Martin SE, Antony R, Fernandez K, Lin J, Tsung AJ, Velpula KK
Biochemical and biophysical research communications477(2)215-21(2016 08)

HAND1 loss-of-function mutation associated with familial dilated cardiomyopathy.
Zhou YM, Dai XY, Qiu XB, Yuan F, Li RG, Xu YJ, Qu XK, Huang RT, Xue S, Yang YQ
Clinical chemistry and laboratory medicine54(7)1161-7(2016 Jul)

Directed differentiation of patient-specific induced pluripotent stem cells identifies the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 in hypoplastic left heart syndrome.
Kobayashi J, Yoshida M, Tarui S, Hirata M, Nagai Y, Kasahara S, Naruse K, Ito H, Sano S, Oh H
PloS one9(7)e102796(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

association of HAND1 loss-of-function mutation with increased susceptibility to Tetralogy of Fallot
Title: HAND1 Loss-of-Function Mutation Causes Tetralogy of Fallot.

These findings expand the phenotypic spectrum linked to HAND1 mutations, suggesting potential implications for the development of novelo prophylactic and therapeutic strategies for DORV.
Title: HAND1 loss-of-function mutation contributes to congenital double outlet right ventricle.

Strikingly, human pluripotent stem cell antibody array showed that Hand1 overexpression resulted in substantial decrease in pluripotency markers (Nanog, Oct3/4, Otx2, Flk1) suggesting that Hand1 expression may be essential to attenuate the EMT and our findings underscore a novel role for Hand1 in medulloblastoma metastasis.
Title: Hand1 overexpression inhibits medulloblastoma metastasis.

HAND1 loss-of-function mutation is associated with familial dilated cardiomyopathy.
Title: HAND1 loss-of-function mutation associated with familial dilated cardiomyopathy.

Combined expression of NKX2-5, HAND1, and NOTCH1 coordinately contribute to cardiac malformations in Hhypoplastic left heart syndrome.
Title: Directed differentiation of patient-specific induced pluripotent stem cells identifies the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 in hypoplastic left heart syndrome.

The following HAND1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HAND1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26705	NM_004821.3 Latest version!	Homo sapiens heart and neural crest derivatives expressed 1 (HAND1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu39917	XM_005268531.1 Latest version!	Homo sapiens heart and neural crest derivatives expressed 1 (HAND1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
View Old Accession Versions >>
OHu26705	NM_004821.2	Homo sapiens heart and neural crest derivatives expressed 1 (HAND1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HAND1 ( NM_004821.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004812.1 Homo sapiens heart and neural crest derivatives expressed 1 (HAND1), mRNA.

Price & Availability↑

CloneID	OHu26705
Clone ID Related Accession (Same CDS sequence)	NM_004821.2 , NM_004821.3
Accession Version	NM_004821.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	heart- and neural crest derivatives-expressed protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF061756.1. This sequence is a reference standard in the RefSeqGene project. On Aug 16, 2008 this sequence version replaced NM_004821.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF061756.1, ERR279859.2478.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148874, SAMEA2153932 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCTCG TGGGCAGCTA CGCACACCAT CACCACCATC ACCACCCGCA CCCTGCGCAC 
CCCATGCTCC ACGAACCCTT CCTCTTCGGT CCGGCCTCGC GCTGTCATCA GGAAAGGCCC 
TACTTCCAGA GCTGGCTGCT GAGCCCGGCT GACGCTGCCC CGGACTTCCC TGCGGGCGGG 
CCGCCGCCCG CGGCCGCTGC AGCCGCCACC GCCTATGGTC CTGACGCCAG GCCTGGGCAG 
AGCCCCGGGC GGCTGGAGGC GCTTGGCGGC CGTCTTGGCC GGCGGAAAGG CTCAGGACCC 
AAGAAGGAGC GGAGACGCAC TGAGAGCATT AACAGCGCAT TCGCGGAGTT GCGCGAGTGC 
ATCCCCAACG TGCCGGCCGA CACCAAGCTC TCCAAGATCA AGACTCTGCG CCTAGCCACC 
AGCTACATCG CCTACCTGAT GGACGTGCTG GCCAAGGATG CACAGTCTGG CGATCCCGAG 
GCCTTCAAGG CTGAACTCAA GAAGGCGGAT GGCGGCCGTG AGAGCAAGCG GAAAAGGGAG 
CTGCAGCAGC ACGAAGGTTT TCCTCCTGCC CTGGGCCCAG TCGAGAAGAG GATTAAAGGA 
CGCACCGGCT GGCCGCAGCA AGTCTGGGCG CTGGAGTTAA ACCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004812.1
CDS	257..904
Translation	MNLVGSYAHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWPQQVWALELNQ

Target ORF information:

RefSeq Version	NM_004821.2
Organism	Homo sapiens(human)
Definition	Homo sapiens heart and neural crest derivatives expressed 1 (HAND1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004821.2

ORF Insert Sequence:

ATGAACCTCG TGGGCAGCTA CGCACACCAT CACCACCATC ACCACCCGCA CCCTGCGCAC 
CCCATGCTCC ACGAACCCTT CCTCTTCGGT CCGGCCTCGC GCTGTCATCA GGAAAGGCCC 
TACTTCCAGA GCTGGCTGCT GAGCCCGGCT GACGCTGCCC CGGACTTCCC TGCGGGCGGG 
CCGCCGCCCG CGGCCGCTGC AGCCGCCACC GCCTATGGTC CTGACGCCAG GCCTGGGCAG 
AGCCCCGGGC GGCTGGAGGC GCTTGGCGGC CGTCTTGGCC GGCGGAAAGG CTCAGGACCC 
AAGAAGGAGC GGAGACGCAC TGAGAGCATT AACAGCGCAT TCGCGGAGTT GCGCGAGTGC 
ATCCCCAACG TGCCGGCCGA CACCAAGCTC TCCAAGATCA AGACTCTGCG CCTAGCCACC 
AGCTACATCG CCTACCTGAT GGACGTGCTG GCCAAGGATG CACAGTCTGG CGATCCCGAG 
GCCTTCAAGG CTGAACTCAA GAAGGCGGAT GGCGGCCGTG AGAGCAAGCG GAAAAGGGAG 
CTGCAGCAGC ACGAAGGTTT TCCTCCTGCC CTGGGCCCAG TCGAGAAGAG GATTAAAGGA 
CGCACCGGCT GGCCGCAGCA AGTCTGGGCG CTGGAGTTAA ACCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HAND1 ( NM_004821.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004812.1 Homo sapiens heart and neural crest derivatives expressed 1 (HAND1), mRNA.

Price & Availability↑

CloneID	OHu26705
Clone ID Related Accession (Same CDS sequence)	NM_004821.2 , NM_004821.3
Accession Version	NM_004821.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	heart- and neural crest derivatives-expressed protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF061756.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004821.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC021190.2, AF061756.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148874, SAMEA2153932 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000231121.3/ ENSP00000231121.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACCTCG TGGGCAGCTA CGCACACCAT CACCACCATC ACCACCCGCA CCCTGCGCAC 
CCCATGCTCC ACGAACCCTT CCTCTTCGGT CCGGCCTCGC GCTGTCATCA GGAAAGGCCC 
TACTTCCAGA GCTGGCTGCT GAGCCCGGCT GACGCTGCCC CGGACTTCCC TGCGGGCGGG 
CCGCCGCCCG CGGCCGCTGC AGCCGCCACC GCCTATGGTC CTGACGCCAG GCCTGGGCAG 
AGCCCCGGGC GGCTGGAGGC GCTTGGCGGC CGTCTTGGCC GGCGGAAAGG CTCAGGACCC 
AAGAAGGAGC GGAGACGCAC TGAGAGCATT AACAGCGCAT TCGCGGAGTT GCGCGAGTGC 
ATCCCCAACG TGCCGGCCGA CACCAAGCTC TCCAAGATCA AGACTCTGCG CCTAGCCACC 
AGCTACATCG CCTACCTGAT GGACGTGCTG GCCAAGGATG CACAGTCTGG CGATCCCGAG 
GCCTTCAAGG CTGAACTCAA GAAGGCGGAT GGCGGCCGTG AGAGCAAGCG GAAAAGGGAG 
CTGCAGCAGC ACGAAGGTTT TCCTCCTGCC CTGGGCCCAG TCGAGAAGAG GATTAAAGGA 
CGCACCGGCT GGCCGCAGCA AGTCTGGGCG CTGGAGTTAA ACCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004812.1
CDS	220..867
Translation	MNLVGSYAHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWPQQVWALELNQ

Target ORF information:

RefSeq Version	NM_004821.3
Organism	Homo sapiens(human)
Definition	Homo sapiens heart and neural crest derivatives expressed 1 (HAND1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004821.3

ORF Insert Sequence:

ATGAACCTCG TGGGCAGCTA CGCACACCAT CACCACCATC ACCACCCGCA CCCTGCGCAC 
CCCATGCTCC ACGAACCCTT CCTCTTCGGT CCGGCCTCGC GCTGTCATCA GGAAAGGCCC 
TACTTCCAGA GCTGGCTGCT GAGCCCGGCT GACGCTGCCC CGGACTTCCC TGCGGGCGGG 
CCGCCGCCCG CGGCCGCTGC AGCCGCCACC GCCTATGGTC CTGACGCCAG GCCTGGGCAG 
AGCCCCGGGC GGCTGGAGGC GCTTGGCGGC CGTCTTGGCC GGCGGAAAGG CTCAGGACCC 
AAGAAGGAGC GGAGACGCAC TGAGAGCATT AACAGCGCAT TCGCGGAGTT GCGCGAGTGC 
ATCCCCAACG TGCCGGCCGA CACCAAGCTC TCCAAGATCA AGACTCTGCG CCTAGCCACC 
AGCTACATCG CCTACCTGAT GGACGTGCTG GCCAAGGATG CACAGTCTGG CGATCCCGAG 
GCCTTCAAGG CTGAACTCAA GAAGGCGGAT GGCGGCCGTG AGAGCAAGCG GAAAAGGGAG 
CTGCAGCAGC ACGAAGGTTT TCCTCCTGCC CTGGGCCCAG TCGAGAAGAG GATTAAAGGA 
CGCACCGGCT GGCCGCAGCA AGTCTGGGCG CTGGAGTTAA ACCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HAND1 ( XM_005268531.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005268588.1 Homo sapiens heart and neural crest derivatives expressed 1 (HAND1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu39917
Clone ID Related Accession (Same CDS sequence)	XM_005268531.1
Accession Version	XM_005268531.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	heart- and neural crest derivatives-expressed protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCTCG TGGGCAGCTA CGCACACCAT CACCACCATC ACCACCCGCA CCCTGCGCAC 
CCCATGCTCC ACGAACCCTT CCTCTTCGGT CCGGCCTCGC GCTGTCATCA GGAAAGGCCC 
TACTTCCAGA GCTGGCTGCT GAGCCCGGCT GACGCTGCCC CGGACTTCCC TGCGGGCGGG 
CCGCCGCCCG CGGCCGCTGC AGCCGCCACC GCCTATGGTC CTGACGCCAG GCCTGGGCAG 
AGCCCCGGGC GGCTGGAGGC GCTTGGCGGC CGTCTTGGCC GGCGGAAAGG CTCAGGACCC 
AAGAAGGAGC GGAGACGCAC TGAGAGCATT AACAGCGCAT TCGCGGAGTT GCGCGAGTGC 
ATCCCCAACG TGCCGGCCGA CACCAAGCTC TCCAAGATCA AGACTCTGCG CCTAGCCACC 
AGCTACATCG CCTACCTGAT GGACGTGCTG GCCAAGGATG CACAGTCTGG CGATCCCGAG 
GCCTTCAAGG CTGAACTCAA GAAGGCGGAT GGCGGCCGTG AGAGCAAGCG GAAAAGGGAG 
CTGCAGCACG AAGGTTTTCC TCCTGCCCTG GGCCCAGTCG AGAAGAGGAT TAAAGGACGC 
ACCGGCTGGC CGCAGCAAGT CTGGGCGCTG GAGTTAAACC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005268588.1
CDS	202..846
Translation	MNLVGSYAHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRELQHEGFPPALGPVEKRIKGRTGWPQQVWALELNQ

Target ORF information:

RefSeq Version	XM_005268531.1
Organism	Homo sapiens(human)
Definition	Homo sapiens heart and neural crest derivatives expressed 1 (HAND1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005268531.1

ORF Insert Sequence:

ATGAACCTCG TGGGCAGCTA CGCACACCAT CACCACCATC ACCACCCGCA CCCTGCGCAC 
CCCATGCTCC ACGAACCCTT CCTCTTCGGT CCGGCCTCGC GCTGTCATCA GGAAAGGCCC 
TACTTCCAGA GCTGGCTGCT GAGCCCGGCT GACGCTGCCC CGGACTTCCC TGCGGGCGGG 
CCGCCGCCCG CGGCCGCTGC AGCCGCCACC GCCTATGGTC CTGACGCCAG GCCTGGGCAG 
AGCCCCGGGC GGCTGGAGGC GCTTGGCGGC CGTCTTGGCC GGCGGAAAGG CTCAGGACCC 
AAGAAGGAGC GGAGACGCAC TGAGAGCATT AACAGCGCAT TCGCGGAGTT GCGCGAGTGC 
ATCCCCAACG TGCCGGCCGA CACCAAGCTC TCCAAGATCA AGACTCTGCG CCTAGCCACC 
AGCTACATCG CCTACCTGAT GGACGTGCTG GCCAAGGATG CACAGTCTGG CGATCCCGAG 
GCCTTCAAGG CTGAACTCAA GAAGGCGGAT GGCGGCCGTG AGAGCAAGCG GAAAAGGGAG 
CTGCAGCACG AAGGTTTTCC TCCTGCCCTG GGCCCAGTCG AGAAGAGGAT TAAAGGACGC 
ACCGGCTGGC CGCAGCAAGT CTGGGCGCTG GAGTTAAACC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HAND1 Loss-of-Function Mutation Causes Tetralogy of Fallot.
Pediatric cardiology38(3)547-557(2017 Mar)
Wang J,Hu XQ,Guo YH,Gu JY,Xu JH,Li YJ,Li N,Yang XX,Yang YQ

HAND1 loss-of-function mutation contributes to congenital double outlet right ventricle.
International journal of molecular medicine39(3)711-718(2017 Mar)
Li L,Wang J,Liu XY,Liu H,Shi HY,Yang XX,Li N,Li YJ,Huang RT,Xue S,Qiu XB,Yang YQ

Hand1 overexpression inhibits medulloblastoma metastasis.
Biochemical and biophysical research communications477(2)215-21(2016 08)
Asuthkar S,Guda MR,Martin SE,Antony R,Fernandez K,Lin J,Tsung AJ,Velpula KK

HAND1 loss-of-function mutation associated with familial dilated cardiomyopathy.
Clinical chemistry and laboratory medicine54(7)1161-7(2016 Jul)
Zhou YM,Dai XY,Qiu XB,Yuan F,Li RG,Xu YJ,Qu XK,Huang RT,Xue S,Yang YQ

Directed differentiation of patient-specific induced pluripotent stem cells identifies the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 in hypoplastic left heart syndrome.
PloS one9(7)e102796(2014)
Kobayashi J,Yoshida M,Tarui S,Hirata M,Nagai Y,Kasahara S,Naruse K,Ito H,Sano S,Oh H

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HAND1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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